General Information:

Id: 2,373
Diseases: Alzheimer disease - [OMIM]
Mus musculus
AbetaPP/PS1 double transgenic mouse
article
Reference: Perez-Gonzalez R et al.(2011) Leptin induces proliferation of neuronal progenitors and neuroprotection in a mouse model of Alzheimers disease. J. Alzheimers Dis. 24: 17-25 [PMID: 21335656]

Interaction Information:

Comment Leptin led to an attenuation of Abeta-induced neurodegeneration.
Formal Description
Interaction-ID: 20834

gene/protein

LEP

decreases_activity of

phenotype

neurodegeneration

attenuation of Abeta-induced neurodegeneration
Comment Leptin induces the proliferation of neuronal progenitors.
Formal Description
Interaction-ID: 20835

gene/protein

LEP

increases_activity of

proliferation of neuronal progenitors
Comment Leptin induces the proliferation of neuronal progenitors.
Formal Description
Interaction-ID: 20836

gene/protein

LEP

increases_activity of

process

neurogenesis

proliferation of neuronal progenitors
Comment Human postmortem brains of AD patients and AbetaPP (amyloid beta precursor protein)/PS1 double transgenic mice show increased neurodegeneration.
Formal Description
Interaction-ID: 20837

increases_activity of

phenotype

neurodegeneration

in postmortem brains of AD patients and AbetaPP/PS1 double transgenic mice