General Information:

Id: 2,141
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
article
Reference: Kimura T et al.(2010) Mechanism and role of high density lipoprotein-induced activation of AMP-activated protein kinase in endothelial cells J. Biol. Chem. 7: 4387-4397 [PMID: 20018878]

Interaction Information:

Comment Native HDL and S1P stimulated AMPK phosphorylation, reflecting enzyme activation.
Formal Description
Interaction-ID: 17725

complex/PPI

HDL

increases_activity of

complex/PPI

AMPK

Comment Native HDL and S1P stimulated AMPK phosphorylation, reflecting enzyme activation.
Formal Description
Interaction-ID: 17761

drug/chemical compound

Sphingosine 1-phosphate

increases_activity of

complex/PPI

AMPK

Comment S1P-induced phosphorylation and hence the activation of AMPK, Akt, and eNOS were all almost completely inhibited by STO-609, a specific inhibitor of CaMKK. Similarly to the S1P-induced actions, HDL-induced activation of AMPK, Akt, and eNOS were also suppressed by the CaMKK inhibitor.
Formal Description
Interaction-ID: 17765

drug/chemical compound

Sphingosine 1-phosphate

increases_activity of

gene/protein

AKT1

Drugbank entries Show/Hide entries for AKT1
Comment S1P-induced phosphorylation and hence the activation of AMPK, Akt, and eNOS were all almost completely inhibited by STO-609, a specific inhibitor of CaMKK. Similarly to the S1P-induced actions, HDL-induced activation of AMPK, Akt, and eNOS were also suppressed by the CaMKK inhibitor.
Formal Description
Interaction-ID: 17766

drug/chemical compound

Sphingosine 1-phosphate

increases_activity of

gene/protein

NOS3

Drugbank entries Show/Hide entries for NOS3
Comment S1P-induced phosphorylation and hence the activation of AMPK, Akt, and eNOS were all almost completely inhibited by STO-609, a specific inhibitor of CaMKK. Similarly to the S1P-induced actions, HDL-induced activation of AMPK, Akt, and eNOS were also suppressed by the CaMKK inhibitor.
Formal Description
Interaction-ID: 17767

gene/protein

CAMKK2

affects_activity of

complex/PPI

AMPK

if induced by S1P or HDL
Comment S1P-induced phosphorylation and hence the activation of AMPK, Akt, and eNOS were all almost completely inhibited by STO-609, a specific inhibitor of CaMKK. Similarly to the S1P-induced actions, HDL-induced activation of AMPK, Akt, and eNOS were also suppressed by the CaMKK inhibitor.
Formal Description
Interaction-ID: 17769

gene/protein

CAMKK2

affects_activity of

gene/protein

AKT1

if induced by S1P or HDL
Drugbank entries Show/Hide entries for AKT1
Comment S1P-induced phosphorylation and hence the activation of AMPK, Akt, and eNOS were all almost completely inhibited by STO-609, a specific inhibitor of CaMKK. Similarly to the S1P-induced actions, HDL-induced activation of AMPK, Akt, and eNOS were also suppressed by the CaMKK inhibitor.
Formal Description
Interaction-ID: 17770

gene/protein

CAMKK2

affects_activity of

gene/protein

NOS3

if induced by S1P or HDL
Drugbank entries Show/Hide entries for NOS3
Comment S1P-induced phosphorylation and hence the activation of AMPK, Akt, and eNOS were all almost completely inhibited by STO-609, a specific inhibitor of CaMKK. Similarly to the S1P-induced actions, HDL-induced activation of AMPK, Akt, and eNOS were also suppressed by the CaMKK inhibitor.
Formal Description
Interaction-ID: 17771

complex/PPI

HDL

increases_activity of

gene/protein

AKT1

Drugbank entries Show/Hide entries for AKT1
Comment S1P-induced phosphorylation and hence the activation of AMPK, Akt, and eNOS were all almost completely inhibited by STO-609, a specific inhibitor of CaMKK. Similarly to the S1P-induced actions, HDL-induced activation of AMPK, Akt, and eNOS were also suppressed by the CaMKK inhibitor.
Formal Description
Interaction-ID: 17772

complex/PPI

HDL

increases_activity of

gene/protein

NOS3

Drugbank entries Show/Hide entries for NOS3
Comment LKB1 is involved in the SR-BI-mediated, but not the S1P receptor-mediated, activation of AMPK, Akt, and eNOS.
Formal Description
Interaction-ID: 17773

gene/protein

STK11

affects_activity of

complex/PPI

AMPK

if SR-BI-mediated
Comment LKB1 is involved in the SR-BI-mediated, but not the S1P receptor-mediated, activation of AMPK, Akt, and eNOS.
Formal Description
Interaction-ID: 17776

gene/protein

STK11

affects_activity of

gene/protein

AKT1

if SR-BI-mediated
Drugbank entries Show/Hide entries for AKT1
Comment LKB1 is involved in the SR-BI-mediated, but not the S1P receptor-mediated, activation of AMPK, Akt, and eNOS.
Formal Description
Interaction-ID: 17777

gene/protein

STK11

affects_activity of

gene/protein

NOS3

if SR-BI-mediated
Drugbank entries Show/Hide entries for NOS3
Comment LKB1 is involved in the SR-BI-mediated, but not the S1P receptor-mediated, activation of AMPK, Akt, and eNOS.
Formal Description
Interaction-ID: 17814

gene/protein

STK11

affects_activity of

gene/protein

SCARB1

Drugbank entries Show/Hide entries for SCARB1
Comment LKB1 is involved in the SR-BI-mediated, but not the S1P receptor-mediated, activation of AMPK, Akt, and eNOS.
Formal Description
Interaction-ID: 17815

gene/protein

STK11

NOT affects_activity of

gene/protein

S1PR

Comment AICAR stimulated the phosphorylation of AMPK and eNOS, in association with NOS activation. AICAR also inhibited TNF-alpha induced VCAM-1 expression, which was accompanied by the inhibition of cytokine-induced monocyte adhesion.
Formal Description
Interaction-ID: 17816

complex/PPI

AMPK

increases_activity of

gene/protein

NOS3

Drugbank entries Show/Hide entries for NOS3
Comment AICAR stimulated the phosphorylation of AMPK and eNOS, in association with NOS activation. AICAR also inhibited TNF-alpha induced VCAM-1 expression, which was accompanied by the inhibition of cytokine-induced monocyte adhesion.
Formal Description
Interaction-ID: 17817

gene/protein

NOS3

decreases_expression of

gene/protein

VCAM1

Drugbank entries Show/Hide entries for NOS3 or VCAM1
Comment AICAR stimulated the phosphorylation of AMPK and eNOS, in association with NOS activation. AICAR also inhibited TNF-alpha induced VCAM-1 expression, which was accompanied by the inhibition of cytokine-induced monocyte adhesion.
Formal Description
Interaction-ID: 17818

gene/protein

NOS3

decreases_activity of

process

monocyte adhesion

Drugbank entries Show/Hide entries for NOS3
Comment Stimulation of extracellular signal-regulated kinase (ERK) and proliferation were hardly affected by AMPK knockdown but completely inhibited by an N17Ras, whereas the dominant-negative Ras was ineffective for AMPK activation.
Formal Description
Interaction-ID: 17819

complex/PPI

AMPK

NOT affects_activity of

gene/protein

MAPK

Comment Stimulation of extracellular signal-regulated kinase (ERK) and proliferation were hardly affected by AMPK knockdown but completely inhibited by an N17Ras, whereas the dominant-negative Ras was ineffective for AMPK activation.
Formal Description
Interaction-ID: 17820

complex/PPI

AMPK

NOT affects_activity of

Comment Stimulation of extracellular signal-regulated kinase (ERK) and proliferation were hardly affected by AMPK knockdown but completely inhibited by an N17Ras, whereas the dominant-negative Ras was ineffective for AMPK activation.
Formal Description
Interaction-ID: 17821

gene/protein

RAS

NOT affects_activity of

complex/PPI

AMPK

Comment Stimulation of extracellular signal-regulated kinase (ERK) and proliferation were hardly affected by AMPK knockdown but completely inhibited by an N17Ras, whereas the dominant-negative Ras was ineffective for AMPK activation.
Formal Description
Interaction-ID: 17822

gene/protein

RAS

affects_activity of

gene/protein

MAPK

Comment Stimulation of extracellular signal-regulated kinase (ERK) and proliferation were hardly affected by AMPK knockdown but completely inhibited by an N17Ras, whereas the dominant-negative Ras was ineffective for AMPK activation.
Formal Description
Interaction-ID: 17823

gene/protein

RAS

affects_activity of

Comment HDL stimulated AMPK activation through both S1P receptors/Gi proteins and SR-BI/PDZK1.
Formal Description
Interaction-ID: 17825

complex/PPI

HDL

affects_activity of

gene/protein

S1PR

Comment HDL stimulated AMPK activation through both S1P receptors/Gi proteins and SR-BI/PDZK1.
Formal Description
Interaction-ID: 17826

complex/PPI

HDL

affects_activity of

gene/protein

SCARB1

Drugbank entries Show/Hide entries for SCARB1
Comment HDL-induced activation of AMPK resulted in eNOS activation, through PI3K/Akt.
Formal Description
Interaction-ID: 17828

complex/PPI

AMPK

increases_activity of

Comment HDL-induced activation of AMPK resulted in eNOS activation, through PI3K/Akt.
Formal Description
Interaction-ID: 17829

increases_activity of

gene/protein

NOS3

Drugbank entries Show/Hide entries for NOS3