General Information:

Id: 2,070
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
male
Diabetes induced in Sprague–Dawley rats by a single intraperitoneal injection of streptozotocin
article
Reference: Castoldi G et al.(2010) Prevention of myocardial fibrosis by N-acetyl-seryl-aspartyl-lysyl-proline in diabetic rats. Clin. Sci. 118: 211-220 [PMID: 20310083]

Interaction Information:

Comment Ac-SDKP did not modify blood glucose levels in control, diabetic, ramipril-treated diabetic and insulin-treated diabetic rats.
Formal Description
Interaction-ID: 16663

gene/protein

AcSDKP

NOT affects_quantity of

drug/chemical compound

Glucose

in blood
Comment Diabetic rats had a significant increase in blood glucose levels. Left ventricular interstitial and perivascular fibrosis, and TGF-beta1 (transforming growth factor-beta1) protein levels were increased in diabetic rats, but not in insulin-treated diabetic rats and ramipril-treated diabetic rats, compared with control rats. Ac-SDKP administration significantly reduced left ventricular interstitial and perivascular fibrosis in diabetic rats and in diabetic rats treated with ramipril. This was accompanied by a significant reduction in active TGF-beta1 and phospho-Smad2/3 protein levels in myocardial tissue of diabetic rats.
Formal Description
Interaction-ID: 16665

increases_activity of

phenotype

fibrosis

in cardiac left ventricle
Comment Diabetic rats had a significant increase in blood glucose levels. Left ventricular interstitial and perivascular fibrosis, and TGF-beta1 (transforming growth factor-beta1) protein levels were increased in diabetic rats, but not in insulin-treated diabetic rats and ramipril-treated diabetic rats, compared with control rats. Ac-SDKP administration significantly reduced left ventricular interstitial and perivascular fibrosis in diabetic rats and in diabetic rats treated with ramipril. This was accompanied by a significant reduction in active TGF-beta1 and phospho-Smad2/3 protein levels in myocardial tissue of diabetic rats.
Formal Description
Interaction-ID: 16685

increases_quantity of

gene/protein

TGFB1

Drugbank entries Show/Hide entries for TGFB1
Comment Diabetic rats had a significant increase in blood glucose levels. Left ventricular interstitial and perivascular fibrosis, and TGF-beta1 (transforming growth factor-beta1) protein levels were increased in diabetic rats, but not in insulin-treated diabetic rats and ramipril-treated diabetic rats, compared with control rats. Ac-SDKP administration significantly reduced left ventricular interstitial and perivascular fibrosis in diabetic rats and in diabetic rats treated with ramipril. This was accompanied by a significant reduction in active TGF-beta1 and phospho-Smad2/3 protein levels in myocardial tissue of diabetic rats.
Formal Description
Interaction-ID: 16686

drug/chemical compound

Ramipril

NOT increases_activity of

phenotype

fibrosis

in cardiac left ventricle; in diabetic rats
Drugbank entries Show/Hide entries for Ramipril
Comment Diabetic rats had a significant increase in blood glucose levels. Left ventricular interstitial and perivascular fibrosis, and TGF-beta1 (transforming growth factor-beta1) protein levels were increased in diabetic rats, but not in insulin-treated diabetic rats and ramipril-treated diabetic rats, compared with control rats. Ac-SDKP administration significantly reduced left ventricular interstitial and perivascular fibrosis in diabetic rats and in diabetic rats treated with ramipril. This was accompanied by a significant reduction in active TGF-beta1 and phospho-Smad2/3 protein levels in myocardial tissue of diabetic rats.
Formal Description
Interaction-ID: 16687

drug/chemical compound

Ramipril

NOT increases_quantity of

gene/protein

TGFB1

in diabetic rats
Drugbank entries Show/Hide entries for Ramipril or TGFB1
Comment Diabetic rats had a significant increase in blood glucose levels. Left ventricular interstitial and perivascular fibrosis, and TGF-beta1 (transforming growth factor-beta1) protein levels were increased in diabetic rats, but not in insulin-treated diabetic rats and ramipril-treated diabetic rats, compared with control rats. Ac-SDKP administration significantly reduced left ventricular interstitial and perivascular fibrosis in diabetic rats and in diabetic rats treated with ramipril. This was accompanied by a significant reduction in active TGF-beta1 and phospho-Smad2/3 protein levels in myocardial tissue of diabetic rats.
Formal Description
Interaction-ID: 16688

complex/PPI

Insulin

NOT increases_activity of

phenotype

fibrosis

in cardiac left ventricle; in diabetic rats
Comment Diabetic rats had a significant increase in blood glucose levels. Left ventricular interstitial and perivascular fibrosis, and TGF-beta1 (transforming growth factor-beta1) protein levels were increased in diabetic rats, but not in insulin-treated diabetic rats and ramipril-treated diabetic rats, compared with control rats. Ac-SDKP administration significantly reduced left ventricular interstitial and perivascular fibrosis in diabetic rats and in diabetic rats treated with ramipril. This was accompanied by a significant reduction in active TGF-beta1 and phospho-Smad2/3 protein levels in myocardial tissue of diabetic rats.
Formal Description
Interaction-ID: 16689

complex/PPI

Insulin

NOT increases_quantity of

gene/protein

TGFB1

in diabetic rats
Drugbank entries Show/Hide entries for TGFB1
Comment Diabetic rats had a significant increase in blood glucose levels. Left ventricular interstitial and perivascular fibrosis, and TGF-beta1 (transforming growth factor-beta1) protein levels were increased in diabetic rats, but not in insulin-treated diabetic rats and ramipril-treated diabetic rats, compared with control rats. Ac-SDKP administration significantly reduced left ventricular interstitial and perivascular fibrosis in diabetic rats and in diabetic rats treated with ramipril. This was accompanied by a significant reduction in active TGF-beta1 and phospho-Smad2/3 protein levels in myocardial tissue of diabetic rats.
Formal Description
Interaction-ID: 16692

gene/protein

AcSDKP

decreases_activity of

phenotype

fibrosis

in cardiac left ventricle; in diabetic rats, in diabetic rats treated with ramipril
Comment Diabetic rats had a significant increase in blood glucose levels. Left ventricular interstitial and perivascular fibrosis, and TGF-beta1 (transforming growth factor-beta1) protein levels were increased in diabetic rats, but not in insulin-treated diabetic rats and ramipril-treated diabetic rats, compared with control rats. Ac-SDKP administration significantly reduced left ventricular interstitial and perivascular fibrosis in diabetic rats and in diabetic rats treated with ramipril. This was accompanied by a significant reduction in active TGF-beta1 and phospho-Smad2/3 protein levels in myocardial tissue of diabetic rats.
Formal Description
Interaction-ID: 16693

gene/protein

AcSDKP

decreases_quantity of

gene/protein

TGFB1

in cardiac muscle; in diabetic rats
Drugbank entries Show/Hide entries for TGFB1
Comment Diabetic rats had a significant increase in blood glucose levels. Left ventricular interstitial and perivascular fibrosis, and TGF-beta1 (transforming growth factor-beta1) protein levels were increased in diabetic rats, but not in insulin-treated diabetic rats and ramipril-treated diabetic rats, compared with control rats. Ac-SDKP administration significantly reduced left ventricular interstitial and perivascular fibrosis in diabetic rats and in diabetic rats treated with ramipril. This was accompanied by a significant reduction in active TGF-beta1 and phospho-Smad2/3 protein levels in myocardial tissue of diabetic rats.
Formal Description
Interaction-ID: 16694

gene/protein

AcSDKP

decreases_quantity of

gene/protein

SMAD2/3-phos

in cardiac muscle; in diabetic rats
Comment By inhibiting theTGF-beta/Smad pathway, Ac-SDKP protects against the development of diabetic cardiomyopathy.
Formal Description
Interaction-ID: 16695

gene/protein

AcSDKP

decreases_activity of

Comment By inhibiting theTGF-beta/Smad pathway, Ac-SDKP protects against the development of diabetic cardiomyopathy.
Formal Description
Interaction-ID: 16696

gene/protein

AcSDKP

decreases_activity of

disease

Cardiomyopathy, diabetic