General Information:

Id: 1,983 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
KK-Ay/Ta and C57BL/6J mouse
article
Reference: Shiuchi T et al.(2004) Angiotensin II type-1 receptor blocker valsartan enhances insulin sensitivity in skeletal muscles of diabetic mice Hypertension 43: 1003-1010 [PMID: 15037562]

Interaction Information:

Comment The protein level of GLUT4 in the plasma membrane was higher and insulin-mediated translocation of GLUT4 was exaggerated in valsartan-treated mice compared with those in vehicle-treated mice.
Formal Description
Interaction-ID: 15561

drug/chemical compound

Valsartan

increases_transport of

gene/protein

SLC2A4

in skeletal muscle; to the plasma membrane
Drugbank entries Show/Hide entries for Valsartan
Comment Total protein levels of the insulin receptor, IRS-1, the p85 regulatory subunit of PI 3-kinase, and GLUT4 were not changed in valsartan-treated mice, however valsartan treatment decreased TNF-alpha expression in skeletal muscle of KK-Ay mice.
Formal Description
Interaction-ID: 15565

drug/chemical compound

Valsartan

NOT affects_quantity of

gene/protein

SLC2A4

in skeletal muscle
Drugbank entries Show/Hide entries for Valsartan