General Information:

Id: 1,901
Diseases: Hematological
Mus musculus
BTO:0000664 K-562 cell
article
Reference: Lidonnici MR et al.(2010) Expression of the transcriptional repressor Gfi-1 is regulated by C/EBP{alpha} and is involved in its proliferation and colony formation-inhibitory effects in p210BCR/ABL-expressing cells. Cancer Res. 70: 7949-7959 [PMID: 20924107]

Interaction Information:

Comment Gfi-1 expression is required for C/EBPalpha-dependent inhibition of proliferation but not induction of differentiation in K562 cells.
Formal Description
Interaction-ID: 14532

gene/protein

CEBPA

increases_activity of

irrespective of GIF1
Comment Gfi-1 expression is required for C/EBPalpha-dependent inhibition of proliferation but not induction of differentiation in K562 cells.
Formal Description
Interaction-ID: 14533

gene/protein

CEBPA

decreases_activity of

together with GIF1
Comment Gfi-1 expression is required for C/EBPalpha-dependent inhibition of proliferation but not induction of differentiation in K562 cells.
Formal Description
Interaction-ID: 14535

gene/protein

GFI1

increases_activity of

gene/protein

CEBPA

thus increasing C/EBPalpha-dependent inhibition of cell proliferation