General Information:

Id: 1,825 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
L6-GLUT4myc: L6 rat skeletal muscle cell line, stably transfected with a construct encoding GLUT4 with an exofacial myc epitope
article
Reference: Hommelberg PP et al.(2009) Fatty acid-induced NF-kappaB activation and insulin resistance in skeletal muscle are chain length dependent. Am. J. Physiol. Endocrinol. Metab. 296: E114-E120 [PMID: 18957619]

Interaction Information:

Comment Palmitate (C16:0) and stearate (C18:0), but not caprylate (C8:0) and laurate (C12:0), reduce insulin-induced glucose transporter 4 (GLUT4) translocation in myotubes.
Formal Description
Interaction-ID: 13817

drug/chemical compound

Stearic acid

decreases transport of

gene/protein

SLC2A4

in skeletal muscle; to the plasma membrane; if GLUT4 transport is induced by insulin
Drugbank entries Show/Hide entries for Stearic acid