General Information:

Id: 1,810
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
SH-SY5Y cell
article
Reference: Wang H et al.(2010) miR-106b aberrantly expressed in a double transgenic mouse model for Alzheimers disease targets TGF-beta type II receptor. Brain Res. 1357: 166-174 [PMID: 20709030]

Interaction Information:

Comment Levels of Smad2/3, p-Smad2/3, and Smad6/7 were altered in SH-SY5Y cells stably transfected with the miR-106b expression vector.
Formal Description
Interaction-ID: 13553

ncRNA/miRNA

mir-106b

affects_quantity of

gene/protein

SMAD2

Drugbank entries Show/Hide entries for SMAD2
Comment Levels of Smad2/3, p-Smad2/3, and Smad6/7 were altered in SH-SY5Y cells stably transfected with the miR-106b expression vector.
Formal Description
Interaction-ID: 13554

ncRNA/miRNA

mir-106b

affects_quantity of

gene/protein

SMAD3

Comment Levels of Smad2/3, p-Smad2/3, and Smad6/7 were altered in SH-SY5Y cells stably transfected with the miR-106b expression vector.
Formal Description
Interaction-ID: 13556

ncRNA/miRNA

mir-106b

affects_quantity of

gene/protein

SMAD6

Comment Levels of Smad2/3, p-Smad2/3, and Smad6/7 were altered in SH-SY5Y cells stably transfected with the miR-106b expression vector.
Formal Description
Interaction-ID: 13557

ncRNA/miRNA

mir-106b

affects_quantity of

gene/protein

SMAD7

Comment Levels of Smad2/3, p-Smad2/3, and Smad6/7 were altered in SH-SY5Y cells stably transfected with the miR-106b expression vector.
Formal Description
Interaction-ID: 13617

ncRNA/miRNA

mir-106b

affects_quantity of

complex/PPI

SMAD2-SMAD3 complex

Comment There is a significant neurodegeneration in SH-SY5Y cells stably transfected with miR-106b.
Formal Description
Interaction-ID: 13619

ncRNA/miRNA

mir-106b

increases_activity of

phenotype

neurodegeneration

in SH-SY5Y cells
Comment Exposure of SH-SY5Y cells to amyloid beta peptide oligomers (42) led to the expression of miR-106b. mirR106b level was first increased and then decreased and TGFBR2 level was reduced.
Formal Description
Interaction-ID: 13620

complex/PPI

Amyloid beta peptide (42, oligomer)

affects_expression of

ncRNA/miRNA

mir-106b

in SH-SY5Y cells
Comment Exposure of SH-SY5Y cells to amyloid beta peptide oligomers (42) led to the expression of miR-106b. mirR106b level was first increased and then decreased and TGFBR2 level was reduced.
Formal Description
Interaction-ID: 13621

complex/PPI

Amyloid beta peptide (42, oligomer)

decreases_expression of

gene/protein

TGFBR2

in SH-SY5Y cells
Drugbank entries Show/Hide entries for TGFBR2
Comment Abeta 42 oligomer-induced miR-106b leads to impairment in TGFBR signaling through TGFBR2.
Formal Description
Interaction-ID: 13622

ncRNA/miRNA

mir-106b

affects_activity of

Abeta 42 oligomer-induced
Comment Levels of Smad2/3, p-Smad2/3, and Smad6/7 were altered in SH-SY5Y cells stably transfected with the miR-106b expression vector.
Formal Description
Interaction-ID: 13624

ncRNA/miRNA

mir-106b

affects_quantity of

complex/PPI

SMAD6-SMAD7 complex