General Information:

Id: 1,663 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mus musculus
IL-6Ralpha(L-KO) mouse: mouse with hepatocyte-specific IL-6 receptor (IL-6R) alpha deficiency
Reference: Wunderlich FT et al.(2010) Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action Cell Metab. 12: 237-249 [PMID: 20816090]

Interaction Information:

Comment In liver IL-6 shows partly counteracting actions on glucose metabolism by simultaneously suppressing enzymes required for gluconeogenesis, glycogenolysis, and glycogen synthesis. Nevertheless, as a consequence of this, the overall effect of IL6 disruption on hepatic glucose metabolism appears largely balanced.
Formal Description
Interaction-ID: 12230



decreases_activity of



in liver
Drugbank entries Show/Hide entries for IL6