General Information:

Id: 1,663
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mus musculus
IL-6Ralpha(L-KO) mouse: mouse with hepatocyte-specific IL-6 receptor (IL-6R) alpha deficiency
article
Reference: Wunderlich FT et al.(2010) Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action Cell Metab. 12: 237-249 [PMID: 20816090]

Interaction Information:

Comment Hepatocyte-specific disruption of IL-6Ralpha signaling does not result in alterations of body weight, adiposity, and energy homeostasis.
Formal Description
Interaction-ID: 12222

gene/protein

IL6R

NOT affects_activity of

disease

Obesity

in IL-6Ralpha(L-KO) mouse
Drugbank entries Show/Hide entries for IL6R
Comment Hepatocyte-specific disruption of IL-6Ralpha signaling does not result in alterations of body weight, adiposity, and energy homeostasis.
Formal Description
Interaction-ID: 12223

gene/protein

IL6R

NOT affects_activity of

in IL-6Ralpha(L-KO) mouse
Drugbank entries Show/Hide entries for IL6R
Comment Disruption of IL-6 signaling specifically in hepatocytes leads to the development of insulin resistance and, in parallel, impairs the ability of pancreatic b cells to mount an appropriate compensatory insulin secretory response, leading to impaired glucose tolerance in the absence of alterations in body weight and adiposity.
Formal Description
Interaction-ID: 12224

affects_activity of

disease

Insulin resistance

in mice with hepatocyte-specific IL6 receptor alpha deficiency
Comment Disruption of IL-6 signaling specifically in hepatocytes leads to the development of insulin resistance and, in parallel, impairs the ability of pancreatic b cells to mount an appropriate compensatory insulin secretory response, leading to impaired glucose tolerance in the absence of alterations in body weight and adiposity.
Formal Description
Interaction-ID: 12225

gene/protein

IL6R

affects_activity of

disease

Insulin resistance

in mice with hepatocyte-specific IL6 receptor alpha deficiency
Drugbank entries Show/Hide entries for IL6R
Comment Disruption of IL-6 signaling specifically in hepatocytes leads to the development of insulin resistance and, in parallel, impairs the ability of pancreatic b cells to mount an appropriate compensatory insulin secretory response, leading to impaired glucose tolerance in the absence of alterations in body weight and adiposity.
Formal Description
Interaction-ID: 12228

affects_activity of

in mice with hepatocyte-specific IL6 receptor alpha deficiency
Comment Disruption of IL-6 signaling specifically in hepatocytes leads to the development of insulin resistance and, in parallel, impairs the ability of pancreatic b cells to mount an appropriate compensatory insulin secretory response, leading to impaired glucose tolerance in the absence of alterations in body weight and adiposity.
Formal Description
Interaction-ID: 12229

gene/protein

IL6R

affects_activity of

in mice with hepatocyte-specific IL6 receptor alpha deficiency
Drugbank entries Show/Hide entries for IL6R
Comment In liver IL-6 shows partly counteracting actions on glucose metabolism by simultaneously suppressing enzymes required for gluconeogenesis, glycogenolysis, and glycogen synthesis. Nevertheless, as a consequence of this, the overall effect of IL6 disruption on hepatic glucose metabolism appears largely balanced.
Formal Description
Interaction-ID: 12230

gene/protein

IL6

decreases_activity of

process

gluconeogenesis

in liver
Drugbank entries Show/Hide entries for IL6
Comment In liver IL-6 shows partly counteracting actions on glucose metabolism by simultaneously suppressing enzymes required for gluconeogenesis, glycogenolysis, and glycogen synthesis. Nevertheless, as a consequence of this, the overall effect of IL6 disruption on hepatic glucose metabolism appears largely balanced.
Formal Description
Interaction-ID: 12231

gene/protein

IL6

decreases_activity of

in liver
Drugbank entries Show/Hide entries for IL6
Comment In liver IL-6 shows partly counteracting actions on glucose metabolism by simultaneously suppressing enzymes required for gluconeogenesis, glycogenolysis, and glycogen synthesis. Nevertheless, as a consequence of this, the overall effect of IL6 disruption on hepatic glucose metabolism appears largely balanced.
Formal Description
Interaction-ID: 12232

gene/protein

IL6

decreases_activity of

in liver
Drugbank entries Show/Hide entries for IL6
Comment Hepatic IL-6 resistance causes a minor degree of insulin resistance in liver but results in a more pronounced impairment of insulin action in skeletal muscle and WAT.
Formal Description
Interaction-ID: 12233

gene/protein

IL6

affects_activity of

disease

Insulin resistance

in skeletal muscle, in white adipose tissue, in liver; in mice with hepatic IL-6 resistance
Drugbank entries Show/Hide entries for IL6
Comment Hepatic IL-6Ralpha-disruption caused an exaggerated inflammatory response during euglycemic hyperinsulinemic clamp analysis, as revealed by increased expression of IL-6, TNF-alpha, and IL-10, as well as enhanced activation of inflammatory signaling such as phosphorylation of IkappaBalpha.
Formal Description
Interaction-ID: 12234

affects_activity of

in liver
Comment Hepatic IL-6Ralpha-disruption caused an exaggerated inflammatory response during euglycemic hyperinsulinemic clamp analysis, as revealed by increased expression of IL-6, TNF-alpha, and IL-10, as well as enhanced activation of inflammatory signaling such as phosphorylation of IkappaBalpha.
Formal Description
Interaction-ID: 12235

gene/protein

IL6R

affects_activity of

in liver
Drugbank entries Show/Hide entries for IL6R
Comment Hepatic IL-6Ralpha-disruption caused an exaggerated inflammatory response during euglycemic hyperinsulinemic clamp analysis, as revealed by increased expression of IL-6, TNF-alpha, and IL-10, as well as enhanced activation of inflammatory signaling such as phosphorylation of IkappaBalpha.
Formal Description
Interaction-ID: 12236

gene/protein

IL6R

affects_expression of

gene/protein

IL6

in liver
Drugbank entries Show/Hide entries for IL6R or IL6
Comment Hepatic IL-6Ralpha-disruption caused an exaggerated inflammatory response during euglycemic hyperinsulinemic clamp analysis, as revealed by increased expression of IL-6, TNF-alpha, and IL-10, as well as enhanced activation of inflammatory signaling such as phosphorylation of IkappaBalpha.
Formal Description
Interaction-ID: 12237

gene/protein

IL6R

affects_expression of

gene/protein

TNF

in liver
Drugbank entries Show/Hide entries for IL6R or TNF
Comment Hepatic IL-6Ralpha-disruption caused an exaggerated inflammatory response during euglycemic hyperinsulinemic clamp analysis, as revealed by increased expression of IL-6, TNF-alpha, and IL-10, as well as enhanced activation of inflammatory signaling such as phosphorylation of IkappaBalpha.
Formal Description
Interaction-ID: 12238

gene/protein

IL6R

affects_prenylation of

gene/protein

NFKBIA

in liver
Drugbank entries Show/Hide entries for IL6R
Comment Hepatic IL-6 signaling to limits hepatic inflammation and to protects from local and systemic insulin resistance.
Formal Description
Interaction-ID: 12239

decreases_activity of

phenotype

liver inflammation

in liver
Comment Hepatic IL-6 signaling to limits hepatic inflammation and to protects from local and systemic insulin resistance.
Formal Description
Interaction-ID: 12240

decreases_activity of

disease

Insulin resistance