General Information:

Id: 1,618
Diseases: Neurological
Homo sapiens
FHL124 cell; BTO:0000007 HEK-293 cell
article
Reference: Grocott T et al.(2007) The MH1 domain of Smad3 interacts with Pax6 and represses autoregulation of the Pax6 P1 promoter Nucleic Acids Res. 35: 890-901 [PMID: 17251190]

Interaction Information:

Comment Pax6 transcription is under the control of two main promoters (P0 and P1), and these are autoregulated by Pax6.
Formal Description
Interaction-ID: 11848

gene/protein

PAX6

affects_expression of

gene/protein

PAX6

Comment TGFbeta1 and TGFbeta2 caused significant reductions in endogenous Pax6 mRNA expression.
Formal Description
Interaction-ID: 11849

gene/protein

TGFB1

decreases_expression of

gene/protein

PAX6

Drugbank entries Show/Hide entries for TGFB1
Comment TGFbeta1 and TGFbeta2 caused significant reductions in endogenous Pax6 mRNA expression.
Formal Description
Interaction-ID: 11850

gene/protein

TGFB2

decreases_expression of

gene/protein

PAX6

Comment TGFbeta1 and TGFbeta2 caused significant reductions in endogenous Pax6 mRNA expression.
Formal Description
Interaction-ID: 11851

decreases_expression of

gene/protein

PAX6

Comment None of the Smad proteins investigated were observed to interact with Pax6 in the absence of constitutively activated TGFbeta receptor I. Following TGFbeta pathway activation however, Smad3 but not Smad2 or 4 was seen to interact with Pax6. Smad3 prevents Pax6 paired domain from binding DNA.
Formal Description
Interaction-ID: 11854

gene/protein

PAX6

interacts (colocalizes) with

gene/protein

SMAD3

only in the presence of active TGFbeta signaling
Comment None of the Smad proteins investigated were observed to interact with Pax6 in the absence of constitutively activated TGFbeta receptor I. Following TGFbeta pathway activation however, Smad3 but not Smad2 or 4 was seen to interact with Pax6.
Formal Description
Interaction-ID: 11855

gene/protein

PAX6

NOT interacts (colocalizes) with

gene/protein

SMAD2

Drugbank entries Show/Hide entries for SMAD2
Comment None of the Smad proteins investigated were observed to interact with Pax6 in the absence of constitutively activated TGFbeta receptor I. Following TGFbeta pathway activation however, Smad3 but not Smad2 or 4 was seen to interact with Pax6.
Formal Description
Interaction-ID: 11858

gene/protein

PAX6

NOT interacts (colocalizes) with

gene/protein

SMAD4

although an interaction of PAX6 and SMAD4 in vitro has been observed
Comment Smad3 prevents Pax6 paired domain from binding DNA.
Formal Description
Interaction-ID: 11860

gene/protein

SMAD3

decreases_activity of

gene/protein

PAX6

by preventing PAX6 from binding to DNA