General Information:

Id: 1,582 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mus musculus
Tg2576 mouse
BTO:0001976 Neuro-2a cell
article
Reference: Manczak M et al.(2006) Mitochondria are a direct site of A beta accumulation in Alzheimers disease neurons: implications for free radical generation and oxidative damage in disease progression Hum. Mol. Genet. 15: 1437-1449 [PMID: 16551656]

Interaction Information:

Comment In the 2-month-old Tg2576 mice, we detected both soluble Abeta (1-40) and Abeta (1-42) intraneuronally, but no insoluble Abeta. In the 12-month-old Tg2576 mice, we found both soluble and insoluble Abeta, and in the 17-month-old Tg2576 mice, we found increased levels of both soluble and insoluble Abeta.
Formal Description
Interaction-ID: 11412

increases_quantity of