General Information:

Id: 1,582 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mus musculus
Tg2576 mouse
BTO:0001976 Neuro-2a cell
article
Reference: Manczak M et al.(2006) Mitochondria are a direct site of A beta accumulation in Alzheimers disease neurons: implications for free radical generation and oxidative damage in disease progression Hum. Mol. Genet. 15: 1437-1449 [PMID: 16551656]

Interaction Information:

Comment Abbeta (1-40) and Abeta (1-42) bands were found in isolated mitochondria from the cortical tissues of the Tg2576 mice. Abeta is primarily localized to the mitoplast (inner membrane plus matrix).
Formal Description
Interaction-ID: 11394

is localized in

cellular component

mitochondrial inner membrane