General Information:

Id: 156
Diseases: Parkinson disease
Homo sapiens
BTO:0000793 SH-SY5Y cell
article
Reference: Dagda RK et al.(2009) Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. J. Biol. Chem. 284 [PMID: 19279012]

Interaction Information:

Comment Knockdown of endogenous PINK1 gave rise to mitochondrial fragmentation and increased autophagy and mitophagy, whereas stable or transient overexpression of PINK1 had the opposite effect.
Formal Description
Interaction-ID: 596

gene/protein

PINK1

decreases_activity of

Comment Knockdown of endogenous PINK1 gave rise to mitochondrial fragmentation and increased autophagy and mitophagy, whereas stable or transient overexpression of PINK1 had the opposite effect.
Formal Description
Interaction-ID: 597

gene/protein

PINK1

decreases_activity of

process

autophagy

Comment Knockdown of endogenous PINK1 gave rise to mitochondrial fragmentation and increased autophagy and mitophagy, whereas stable or transient overexpression of PINK1 had the opposite effect.
Formal Description
Interaction-ID: 599

gene/protein

PINK1

decreases_activity of

Comment Knockdown of PINK1 induced a fragmentation of the mitochondrial network. Conversely, overexpression of PINK1 increased mitochondrial interconnectivity.
Formal Description
Interaction-ID: 2614

gene/protein

PINK1

affects_activity of

Comment Knockdown of PINK1 significantly increased mitochondrial superoxide generation, contributing to both mitochondrial fragmentation and autophagy.
Formal Description
Interaction-ID: 2622

gene/protein

PINK1

affects_quantity of

drug/chemical compound

O2-

in mitochondria
Comment Knockdown of PINK1 increases cell death.
Formal Description
Interaction-ID: 2624

gene/protein

PINK1

affects_activity of

process

neuron death

Comment Transient expression of Parkin significantly reversed cell death induced by loss of PINK1.
Formal Description
Interaction-ID: 2626

gene/protein

PRKN

decreases_activity of

process

neuron death

if cell death has been induced by loss of PINK1
Comment Transient expression of Parkin significantly reversed cell death induced by loss of PINK1.
Formal Description
Interaction-ID: 2653

gene/protein

PRKN

affects_activity of

gene/protein

PINK1

Comment Knockdown of PINK1 significantly increased mitochondrial superoxide generation, contributing to both mitochondrial fragmentation and autophagy.
Formal Description
Interaction-ID: 11732

drug/chemical compound

O2-

increases_activity of

Comment Knockdown of PINK1 significantly increased mitochondrial superoxide generation, contributing to both mitochondrial fragmentation and autophagy.
Formal Description
Interaction-ID: 11733

drug/chemical compound

O2-

increases_activity of

process

autophagy