General Information:

Id: 1,519
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Obesity - [OMIM]
Mus musculus
male
ob/ob mouse
article
Reference: Gonzalez-Periz A et al.(2009) Obesity-induced insulin resistance and hepatic steatosis are alleviated by omega-3 fatty acids: a role for resolvins and protectins FASEB J. 23: 1946-1957 [PMID: 19211925]

Interaction Information:

Comment In addition to severe obesity and hypercholesterolemia, ob/ob mice showed progressive hepatic steatosis.
Formal Description
Interaction-ID: 10761

organism model

ob/ob mouse

increases_activity of

disease

Obesity

Comment In addition to severe obesity and hypercholesterolemia, ob/ob mice showed progressive hepatic steatosis.
Formal Description
Interaction-ID: 10763

organism model

ob/ob mouse

increases_activity of

Comment In addition to severe obesity and hypercholesterolemia, ob/ob mice showed progressive hepatic steatosis.
Formal Description
Interaction-ID: 10764

organism model

ob/ob mouse

increases_activity of

disease

Fatty liver disease, nonalcoholic

Comment The degree of hepatic steatosis in obese ob/ob mice was significantly alleviated by the intake of dietary omega-3-PUFA-enriched diet for 5 weeks.
Formal Description
Interaction-ID: 10765

environment

omega-3 polyunsaturated fatty acid-rich diet

decreases_activity of

disease

Fatty liver disease, nonalcoholic

in ob/ob mice
Comment The antisteatotic effect was associated with changes in the expression of genes governing hepatic lipogenesis and fatty acid oxidation. Omega-3-PUFAs down-regulated FASN, a lipogenic factor, and up-regulated PPAR-alpha, a transcription factor that functions as a gatekeeper of fatty acid oxidation. The expression of SREBP-1c and SCD-1 remained unchanged.
Formal Description
Interaction-ID: 10766

drug/chemical compound

Polyunsaturated fatty acid, omega-3

decreases_expression of

gene/protein

FASN

Drugbank entries Show/Hide entries for FASN
Comment The antisteatotic effect was associated with changes in the expression of genes governing hepatic lipogenesis and fatty acid oxidation. Omega-3-PUFAs down-regulated FASN, a lipogenic factor, and up-regulated PPAR-alpha, a transcription factor that functions as a gatekeeper of fatty acid oxidation. The expression of SREBP-1c and SCD-1 remained unchanged.
Formal Description
Interaction-ID: 10767

drug/chemical compound

Polyunsaturated fatty acid, omega-3

decreases_expression of

gene/protein

PPARA

Drugbank entries Show/Hide entries for PPARA
Comment The antisteatotic effect was associated with changes in the expression of genes governing hepatic lipogenesis and fatty acid oxidation. Omega-3-PUFAs down-regulated FASN, a lipogenic factor, and up-regulated PPAR-alpha, a transcription factor that functions as a gatekeeper of fatty acid oxidation. The expression of SREBP-1c and SCD-1 remained unchanged.
Formal Description
Interaction-ID: 10768

drug/chemical compound

Polyunsaturated fatty acid, omega-3

NOT affects_expression of

mRNA/protein variant

SREBF1c

Comment The antisteatotic effect was associated with changes in the expression of genes governing hepatic lipogenesis and fatty acid oxidation. Omega-3-PUFAs down-regulated FASN, a lipogenic factor, and up-regulated PPAR-alpha, a transcription factor that functions as a gatekeeper of fatty acid oxidation. The expression of SREBP-1c and SCD-1 remained unchanged.
Formal Description
Interaction-ID: 10769

drug/chemical compound

Polyunsaturated fatty acid, omega-3

NOT affects_expression of

gene/protein

SCD

Comment The antisteatotic effect was associated with changes in the expression of genes governing hepatic lipogenesis and fatty acid oxidation. Omega-3-PUFAs down-regulated FASN, a lipogenic factor, and up-regulated PPAR-alpha, a transcription factor that functions as a gatekeeper of fatty acid oxidation. The expression of SREBP-1c and SCD-1 remained unchanged.
Formal Description
Interaction-ID: 10770

drug/chemical compound

Polyunsaturated fatty acid, omega-3

affects_activity of

in liver
Comment The antisteatotic effect was associated with changes in the expression of genes governing hepatic lipogenesis and fatty acid oxidation. Omega-3-PUFAs down-regulated FASN, a lipogenic factor, and up-regulated PPAR-alpha, a transcription factor that functions as a gatekeeper of fatty acid oxidation. The expression of SREBP-1c and SCD-1 remained unchanged.
Formal Description
Interaction-ID: 10771

drug/chemical compound

Polyunsaturated fatty acid, omega-3

affects_activity of

in liver
Comment Serum cholesterol levels were significantly reduced in ob/ob mice fed an omega-3-PUFA-enriched diet.
Formal Description
Interaction-ID: 10772

drug/chemical compound

Polyunsaturated fatty acid, omega-3

decreases_activity of

in blood
Comment The mRNA expression of adiponectin, an adipokine with antidiabetic, antilipogenic, and anti-inflammatory properties, was significantly increased in adipose tissue from ob/ob mice receiving omega-3-PUFAs.
Formal Description
Interaction-ID: 10773

drug/chemical compound

Polyunsaturated fatty acid, omega-3

increases_expression of

gene/protein

ADIPOQ

in adipose tissue
Comment No changes were observed in resistin, MCP-1, TNF-alpha, and IL-6 in adipose tissue from ob/ob mice receiving omega-3-PUFAs.
Formal Description
Interaction-ID: 10774

drug/chemical compound

Polyunsaturated fatty acid, omega-3

NOT affects_expression of

gene/protein

RETN

in adipose tissue
Comment No changes were observed in resistin, MCP-1, TNF-alpha, and IL-6 in adipose tissue from ob/ob mice receiving omega-3-PUFAs.
Formal Description
Interaction-ID: 10775

drug/chemical compound

Polyunsaturated fatty acid, omega-3

NOT affects_expression of

gene/protein

CCL2

in adipose tissue
Drugbank entries Show/Hide entries for CCL2
Comment No changes were observed in resistin, MCP-1, TNF-alpha, and IL-6 in adipose tissue from ob/ob mice receiving omega-3-PUFAs.
Formal Description
Interaction-ID: 10776

drug/chemical compound

Polyunsaturated fatty acid, omega-3

NOT affects_expression of

gene/protein

TNF

in adipose tissue
Drugbank entries Show/Hide entries for TNF
Comment No changes were observed in resistin, MCP-1, TNF-alpha, and IL-6 in adipose tissue from ob/ob mice receiving omega-3-PUFAs.
Formal Description
Interaction-ID: 10777

drug/chemical compound

Polyunsaturated fatty acid, omega-3

NOT affects_expression of

gene/protein

IL6

in adipose tissue
Drugbank entries Show/Hide entries for IL6
Comment Increased adiponectin expression in mice fed omega-3-PUFAs was associated with up-regulation in the adipose tissue of insulin-sensitizing genes (i.e., PPAR-gamma) and genes coding for insulin receptor signaling (i.e., IRS-1, the substrate protein for the insulin receptor) as well as glucose transport (i.e., GLUT-4, the glucose transporter).
Formal Description
Interaction-ID: 10778

drug/chemical compound

Polyunsaturated fatty acid, omega-3

increases_expression of

gene/protein

PPARG

in adipose tissue
Drugbank entries Show/Hide entries for PPARG
Comment Increased adiponectin expression in mice fed omega-3-PUFAs was associated with up-regulation in the adipose tissue of insulin-sensitizing genes (i.e., PPAR-gamma) and genes coding for insulin receptor signaling (i.e., IRS-1, the substrate protein for the insulin receptor) as well as glucose transport (i.e., GLUT-4, the glucose transporter).
Formal Description
Interaction-ID: 10779

drug/chemical compound

Polyunsaturated fatty acid, omega-3

increases_expression of

gene/protein

IRS1

in adipose tissue
Drugbank entries Show/Hide entries for IRS1
Comment Increased adiponectin expression in mice fed omega-3-PUFAs was associated with up-regulation in the adipose tissue of insulin-sensitizing genes (i.e., PPAR-gamma) and genes coding for insulin receptor signaling (i.e., IRS-1, the substrate protein for the insulin receptor) as well as glucose transport (i.e., GLUT-4, the glucose transporter).
Formal Description
Interaction-ID: 10780

drug/chemical compound

Polyunsaturated fatty acid, omega-3

increases_expression of

gene/protein

SLC2A4

in adipose tissue
Comment Insulin-sensitizing actions in response to omega-3-PUFAs were observed in the liver with the induction of PPAR-gamma, IRS-2 and GLUT-2 expression.
Formal Description
Interaction-ID: 10781

drug/chemical compound

Polyunsaturated fatty acid, omega-3

increases_expression of

gene/protein

PPARG

in liver
Drugbank entries Show/Hide entries for PPARG
Comment Insulin-sensitizing actions in response to omega-3-PUFAs were observed in the liver with the induction of PPAR-gamma, IRS-2 and GLUT-2 expression.
Formal Description
Interaction-ID: 10782

drug/chemical compound

Polyunsaturated fatty acid, omega-3

increases_expression of

gene/protein

IRS2

in liver
Comment Insulin-sensitizing actions in response to omega-3-PUFAs were observed in the liver with the induction of PPAR-gamma, IRS-2 and GLUT-2 expression.
Formal Description
Interaction-ID: 10783

drug/chemical compound

Polyunsaturated fatty acid, omega-3

increases_expression of

gene/protein

SLC2A2

in liver
Drugbank entries Show/Hide entries for SLC2A2
Comment Compared with lean wild-type mice, ob/ob mice showed a pronounced decrease in insulin sensitivity.
Formal Description
Interaction-ID: 10784

organism model

ob/ob mouse

increases_activity of

disease

Insulin resistance

Comment The administration of the omega-3-PUFA docosahexaenoic acid (DHA) markedly improved insulin sensitivity in these obese mic.
Formal Description
Interaction-ID: 10785

drug/chemical compound

Docosahexaenoic acid

decreases_activity of

disease

Insulin resistance

in ob/ob mice
Comment AMPK activity was significantly increased by the omega-3-PUFA docosahexaenoic acid (DHA) in adipose and muscle tissues from ob/ob mic.
Formal Description
Interaction-ID: 10789

drug/chemical compound

Docosahexaenoic acid

increases_activity of

complex/PPI

AMPK

in adipose tissue, in muscle
Comment The omega-3-PUFA-derived bioactive lipid mediators 17-HDHA, protectin D1, and resolvin D1 were detected under normal conditions in adipose tissue from obese mice. Enriching omega-3-PUFAs through diet triggered the formation of 17-HDHA as well as the levels of protectin D1 and resolvin D1 in the adipose tissue of ob/ob mice.
Formal Description
Interaction-ID: 10791

environment

omega-3 polyunsaturated fatty acid-rich diet

increases_quantity of

drug/chemical compound

17-HDHA

in adipose tissue
Comment The omega-3-PUFA-derived bioactive lipid mediators 17-HDHA, protectin D1, and resolvin D1 were detected under normal conditions in adipose tissue from obese mice. Enriching omega-3-PUFAs through diet triggered the formation of 17-HDHA as well as the levels of protectin D1 and resolvin D1 in the adipose tissue of ob/ob mice.
Formal Description
Interaction-ID: 10804

environment

omega-3 polyunsaturated fatty acid-rich diet

increases_quantity of

drug/chemical compound

Protectin D1

in adipose tissue
Comment The omega-3-PUFA-derived bioactive lipid mediators 17-HDHA, protectin D1, and resolvin D1 were detected under normal conditions in adipose tissue from obese mice. Enriching omega-3-PUFAs through diet triggered the formation of 17-HDHA as well as the levels of protectin D1 and resolvin D1 in the adipose tissue of ob/ob mice.
Formal Description
Interaction-ID: 10805

environment

omega-3 polyunsaturated fatty acid-rich diet

increases_quantity of

drug/chemical compound

Resolvin D1

in adipose tissue
Comment Under normal conditions in adipose tissue from obese mice significant levels of eicosanoids derived from the omega-6-PUFA arachidonic acid such as those produced through the cyclooxygenase [i.e., prostaglandin (PG) E2, PGF2-alpha, and thromboxane (TX) B2] and lipoxygenase pathways [5-hydroxyeicosatetraenoic acid (5-HETE), 12-HETE, and 15-HETE] were found. Interestingly, products derived from the 12/15-LO were among the most abundant eicosanoids in the adipose tissue. Endogenous formation of omega-6-PUFA-derived inflammatory mediators, including the cyclooxygenase products PGE2, PGF2-alpha, and TXB2, the 5-LO product 5-HETE, and the 12/15-LO products 12-HETE and 15-HETE, was inhibited in ob/ob mice fed the omega-3-PUFA diet.
Formal Description
Interaction-ID: 10806

environment

omega-3 polyunsaturated fatty acid-rich diet

decreases_quantity of

drug/chemical compound

Prostaglandin E2

in adipose tissue
Comment Under normal conditions in adipose tissue from obese mice significant levels of eicosanoids derived from the omega-6-PUFA arachidonic acid such as those produced through the cyclooxygenase [i.e., prostaglandin (PG) E2, PGF2-alpha, and thromboxane (TX) B2] and lipoxygenase pathways [5-hydroxyeicosatetraenoic acid (5-HETE), 12-HETE, and 15-HETE] were found. Interestingly, products derived from the 12/15-LO were among the most abundant eicosanoids in the adipose tissue. Endogenous formation of omega-6-PUFA-derived inflammatory mediators, including the cyclooxygenase products PGE2, PGF2-alpha, and TXB2, the 5-LO product 5-HETE, and the 12/15-LO products 12-HETE and 15-HETE, was inhibited in ob/ob mice fed the omega-3-PUFA diet.
Formal Description
Interaction-ID: 10807

environment

omega-3 polyunsaturated fatty acid-rich diet

decreases_quantity of

drug/chemical compound

Prostaglandin F2alpha

in adipose tissue
Comment Under normal conditions in adipose tissue from obese mice significant levels of eicosanoids derived from the omega-6-PUFA arachidonic acid such as those produced through the cyclooxygenase [i.e., prostaglandin (PG) E2, PGF2-alpha, and thromboxane (TX) B2] and lipoxygenase pathways [5-hydroxyeicosatetraenoic acid (5-HETE), 12-HETE, and 15-HETE] were found. Interestingly, products derived from the 12/15-LO were among the most abundant eicosanoids in the adipose tissue. Endogenous formation of omega-6-PUFA-derived inflammatory mediators, including the cyclooxygenase products PGE2, PGF2-alpha, and TXB2, the 5-LO product 5-HETE, and the 12/15-LO products 12-HETE and 15-HETE, was inhibited in ob/ob mice fed the omega-3-PUFA diet.
Formal Description
Interaction-ID: 10808

environment

omega-3 polyunsaturated fatty acid-rich diet

decreases_quantity of

drug/chemical compound

Thromboxane B2

in adipose tissue
Comment Under normal conditions in adipose tissue from obese mice significant levels of eicosanoids derived from the omega-6-PUFA arachidonic acid such as those produced through the cyclooxygenase [i.e., prostaglandin (PG) E2, PGF2-alpha, and thromboxane (TX) B2] and lipoxygenase pathways [5-hydroxyeicosatetraenoic acid (5-HETE), 12-HETE, and 15-HETE] were found. Interestingly, products derived from the 12/15-LO were among the most abundant eicosanoids in the adipose tissue. Endogenous formation of omega-6-PUFA-derived inflammatory mediators, including the cyclooxygenase products PGE2, PGF2-alpha, and TXB2, the 5-LO product 5-HETE, and the 12/15-LO products 12-HETE and 15-HETE, was inhibited in ob/ob mice fed the omega-3-PUFA diet.
Formal Description
Interaction-ID: 10809

environment

omega-3 polyunsaturated fatty acid-rich diet

decreases_quantity of

drug/chemical compound

5(S)-HETE

in adipose tissue
Comment Under normal conditions in adipose tissue from obese mice significant levels of eicosanoids derived from the omega-6-PUFA arachidonic acid such as those produced through the cyclooxygenase [i.e., prostaglandin (PG) E2, PGF2-alpha, and thromboxane (TX) B2] and lipoxygenase pathways [5-hydroxyeicosatetraenoic acid (5-HETE), 12-HETE, and 15-HETE] were found. Interestingly, products derived from the 12/15-LO were among the most abundant eicosanoids in the adipose tissue. Endogenous formation of omega-6-PUFA-derived inflammatory mediators, including the cyclooxygenase products PGE2, PGF2-alpha, and TXB2, the 5-LO product 5-HETE, and the 12/15-LO products 12-HETE and 15-HETE, was inhibited in ob/ob mice fed the omega-3-PUFA diet.
Formal Description
Interaction-ID: 10810

environment

omega-3 polyunsaturated fatty acid-rich diet

decreases_quantity of

drug/chemical compound

12(S)-HETE

in adipose tissue
Comment Under normal conditions in adipose tissue from obese mice significant levels of eicosanoids derived from the omega-6-PUFA arachidonic acid such as those produced through the cyclooxygenase [i.e., prostaglandin (PG) E2, PGF2-alpha, and thromboxane (TX) B2] and lipoxygenase pathways [5-hydroxyeicosatetraenoic acid (5-HETE), 12-HETE, and 15-HETE] were found. Interestingly, products derived from the 12/15-LO were among the most abundant eicosanoids in the adipose tissue. Endogenous formation of omega-6-PUFA-derived inflammatory mediators, including the cyclooxygenase products PGE2, PGF2-alpha, and TXB2, the 5-LO product 5-HETE, and the 12/15-LO products 12-HETE and 15-HETE, was inhibited in ob/ob mice fed the omega-3-PUFA diet.
Formal Description
Interaction-ID: 10811

environment

omega-3 polyunsaturated fatty acid-rich diet

decreases_quantity of

drug/chemical compound

15(S)-HETE

in adipose tissue
Comment Representative members of the omega-3-PUFA-derived lipid mediators, namely resolvin E1 and protectin D1, mimicked the insulin-sensitizing and antisteatotic effects of omega-3-PUFAs and induced adiponectin expression to a similar extent that of rosiglitazone, a member of the thiazolidinedione family of antidiabetic drugs.
Formal Description
Interaction-ID: 10812

drug/chemical compound

Resolvin D1

decreases_activity of

disease

Fatty liver disease, nonalcoholic

Comment Representative members of the omega-3-PUFA-derived lipid mediators, namely resolvin E1 and protectin D1, mimicked the insulin-sensitizing and antisteatotic effects of omega-3-PUFAs and induced adiponectin expression to a similar extent that of rosiglitazone, a member of the thiazolidinedione family of antidiabetic drugs.
Formal Description
Interaction-ID: 10813

drug/chemical compound

Protectin D1

decreases_activity of

disease

Fatty liver disease, nonalcoholic

Comment Representative members of the omega-3-PUFA-derived lipid mediators, namely resolvin E1 and protectin D1, mimicked the insulin-sensitizing and antisteatotic effects of omega-3-PUFAs and induced adiponectin expression to a similar extent that of rosiglitazone, a member of the thiazolidinedione family of antidiabetic drugs.
Formal Description
Interaction-ID: 10814

drug/chemical compound

Resolvin D1

increases_activity of

Comment Representative members of the omega-3-PUFA-derived lipid mediators, namely resolvin E1 and protectin D1, mimicked the insulin-sensitizing and antisteatotic effects of omega-3-PUFAs and induced adiponectin expression to a similar extent that of rosiglitazone, a member of the thiazolidinedione family of antidiabetic drugs.
Formal Description
Interaction-ID: 10815

drug/chemical compound

Protectin D1

increases_activity of

Comment Representative members of the omega-3-PUFA-derived lipid mediators, namely resolvin E1 and protectin D1, mimicked the insulin-sensitizing and antisteatotic effects of omega-3-PUFAs and induced adiponectin expression to a similar extent that of rosiglitazone, a member of the thiazolidinedione family of antidiabetic drugs.
Formal Description
Interaction-ID: 10816

drug/chemical compound

Resolvin D1

increases_expression of

gene/protein

ADIPOQ

Comment Representative members of the omega-3-PUFA-derived lipid mediators, namely resolvin E1 and protectin D1, mimicked the insulin-sensitizing and antisteatotic effects of omega-3-PUFAs and induced adiponectin expression to a similar extent that of rosiglitazone, a member of the thiazolidinedione family of antidiabetic drugs.
Formal Description
Interaction-ID: 10818

drug/chemical compound

Protectin D1

increases_expression of

gene/protein

ADIPOQ