General Information:

Id: 1,333 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Reference: Robakis NK(2011) Mechanisms of AD neurodegeneration may be independent of Abeta and its derivatives Neurobiol. Aging 32: 372-379 [PMID: 20594619]

Interaction Information:

Comment FAD mutations of PS1 increase the production of neurotoxic Abeta42 by causing an increase of gamma-secretase function.
Formal Description
Interaction-ID: 9114

gene/protein mutant


increases_quantity of