General Information:

Id: 1,333 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Robakis NK(2011) Mechanisms of AD neurodegeneration may be independent of Abeta and its derivatives Neurobiol. Aging 32: 372-379 [PMID: 20594619]

Interaction Information:

Comment FAD mutations of PS1 increase the production of neurotoxic Abeta42 by causing an increase of gamma-secretase function.
Formal Description
Interaction-ID: 9114

gene/protein mutant

PSEN1-mut

increases_quantity of

Comment Conflicting results: More recent work, however, showed that many PS1 FAD mutants fail to increase production of amyloid beta peptide (42), suggesting that not all FAD mutations increase the amyloidogenic processing of APP.
Formal Description
Interaction-ID: 9122

gene/protein mutant

PSEN1-mut

NOT increases_activity of