General Information:

Id: 1,330
Diseases: Disease-related-protein CtBP
Leukemia
Homo sapiens
BTO:0000007 HEK-293 cell; PC12 cell; BTO:0000664 K-562 cell
article
Reference: Chan CB et al.(2009) NGF inhibits human leukemia proliferation by downregulating cyclin A1 expression through promoting acinus/CtBP2 association Oncogene 28: 3825-3836 [PMID: 19668232]

Interaction Information:

Comment CtBP2 interacts with acinus-S. NAD+ binding to CtBP2 is essential for its association with acinus-S and changes of [NAD+]i affect this interaction.
Formal Description
Interaction-ID: 9088

gene/protein

CTBP2

interacts (colocalizes) with

gene/protein

ACIN1

in the presence of NAD+ and if ACIN1 has been phosphorylated by AKT1
Comment CtBP2 interacts with acinus-S. NAD+ binding to CtBP2 is essential for its association with acinus-S and changes of [NAD+]i affect this interaction. Phosphorylation of acinus-S by Akt is required for interaction with CtBP2.
Formal Description
Interaction-ID: 9089

gene/protein

AKT1

increases_phosphorylation of

gene/protein

ACIN1

phosphorylation of ACIN1 is necessary for interaction with CtBP2
Drugbank entries Show/Hide entries for AKT1
Comment CtBP2 interacts with acinus-S. NAD+ binding to CtBP2 is essential for its association with acinus-S and changes of [NAD+]i affect this interaction. Phosphorylation of acinus-S by Akt is required for interaction with CtBP2.
Formal Description
Interaction-ID: 9090

increases_phosphorylation of

gene/protein

ACIN1

phosphorylation of ACIN1 is necessary for interaction with CtBP2
Comment CtBP2 is a repressor that downregulates acinus-S-mediated cyclin A1 expression in a NAD+-dependent manner.
Formal Description
Interaction-ID: 9091

gene/protein

ACIN1

increases_expression of

gene/protein

CCNA1

Comment CtBP2 is a repressor that downregulates acinus-S-mediated cyclin A1 expression in a NAD+-dependent manner.
Formal Description
Interaction-ID: 9092

gene/protein

CTBP2

decreases_expression of

gene/protein

CCNA1

via inhibition of acinus-S, which is essential for cyclin A1 expression
Comment CtBP2 inhibits cyclin A1 expression by downregulating the transcriptional stimulatory activity of acinus-S.
Formal Description
Interaction-ID: 9093

gene/protein

CTBP2

decreases_activity of

gene/protein

ACIN1

Comment NGF specifically downregulated cyclin A1, but not cyclin A2 or cyclin D1, by enhancing acinus-S/CtBP2 association.
Formal Description
Interaction-ID: 9094

gene/protein

NGF

decreases_expression of

gene/protein

CCNA1

by enhancing acinus-S/CtBP2 association
Drugbank entries Show/Hide entries for NGF
Comment NGF specifically downregulated cyclin A1, but not cyclin A2 or cyclin D1, by enhancing acinus-S/CtBP2 association.
Formal Description
Interaction-ID: 9104

gene/protein

NGF

NOT decreases_expression of

gene/protein

CCNA2

by enhancing acinus-S/CtBP2 association
Drugbank entries Show/Hide entries for NGF or CCNA2
Comment NGF specifically downregulated cyclin A1, but not cyclin A2 or cyclin D1, by enhancing acinus-S/CtBP2 association.
Formal Description
Interaction-ID: 9105

gene/protein

NGF

NOT decreases_expression of

gene/protein

CCND1

by enhancing acinus-S/CtBP2 association
Drugbank entries Show/Hide entries for NGF or CCND1
Comment NGF specifically downregulated cyclin A1, but not cyclin A2 or cyclin D1, by enhancing acinus-S/CtBP2 association.
Formal Description
Interaction-ID: 9106

gene/protein

NGF

increases_activity of

gene/protein

CTBP2

by enhancing acinus-S/CtBP2 association
Drugbank entries Show/Hide entries for NGF
Comment Downregulation of cyclin A1 by NGF leads to a reduction of Leukemia cell proliferation.
Formal Description
Interaction-ID: 9107

gene/protein

NGF

decreases_activity of

of Leukemia cells
Drugbank entries Show/Hide entries for NGF
Comment Downregulation of cyclin A1 by NGF leads to a reduction of Leukemia cell proliferation.
Formal Description
Interaction-ID: 9109

gene/protein

NGF

decreases_activity of

disease

Leukemia

via reduction of leukemia cell proliferation
Drugbank entries Show/Hide entries for NGF
Comment TrkA agonist gambogic amide inhibits leukemia cell proliferation via cyclin A1 reduction by enhancing the formation of CtBP2/acinus-S complex.
Formal Description
Interaction-ID: 9110

drug/chemical compound

Gambogic amide

increases_phosphorylation of

gene/protein

NTRK1

Drugbank entries Show/Hide entries for NTRK1
Comment TrkA agonist gambogic amide inhibits leukemia cell proliferation via cyclin A1 reduction by enhancing the formation of CtBP2/acinus-S complex.
Formal Description
Interaction-ID: 9112

drug/chemical compound

Gambogic amide

increases_activity of

gene/protein

CTBP2

by enhancing acinus-S/CtBP2 association
Comment TrkA agonist gambogic amide inhibits leukemia cell proliferation via cyclin A1 reduction by enhancing the formation of CtBP2/acinus-S complex.
Formal Description
Interaction-ID: 9113

drug/chemical compound

Gambogic amide

decreases_activity of

disease

Leukemia

via reduction of leukemia cell proliferation