General Information:

Id: 1,257 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Butterfield DA et al.(2001) Evidence of oxidative damage in Alzheimers disease brain: central role for amyloid beta-peptide Trends Mol Med 7: 548-554 [PMID: 11733217]

Interaction Information:

Comment Individuals with genetic alterations in one of the genes that code for three transmembrane proteins - amyloid precursor protein, presenilin-1 and presenilin-2 - deposit large amounts of the amyloid fragment Abeta (1-42) in the brain and invariably develop AD.
Formal Description
Interaction-ID: 8513

increases_activity of