General Information:

Id: 1,257 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Butterfield DA et al.(2001) Evidence of oxidative damage in Alzheimers disease brain: central role for amyloid beta-peptide Trends Mol Med 7: 548-554 [PMID: 11733217]

Interaction Information:

Comment Amyloid beta peptide (1-42) significantly decreased glutamine synthetase (GS) activity in cytosolic fractions of brain homogenates and in cultured hippocampal neurons and astrocytes.
Formal Description
Interaction-ID: 8504

decreases_activity of

gene/protein

GLUL

in cytosolic fractions of brain homogenates and in cultured hippocampal neurons and astrocytes
Drugbank entries Show/Hide entries for GLUL
Comment A significant decline in creatine kinase (CK) activity in AD was observed. Earlier studies showed that amyloid beta peptide could inactivate CK, a process that was inhibited by vitamin E.
Formal Description
Interaction-ID: 8506

decreases_activity of

gene/protein

Creatine kinase

Comment A significant decline in creatine kinase (CK) activity in AD was observed. Earlier studies showed that amyloid beta peptide could inactivate CK, a process that was inhibited by vitamin E.
Formal Description
Interaction-ID: 8507

drug/chemical compound

alpha-Tocopherol

decreases_activity of

Comment Individuals with genetic alterations in one of the genes that code for three transmembrane proteins - amyloid precursor protein, presenilin-1 and presenilin-2 - deposit large amounts of the amyloid fragment Abeta (1-42) in the brain and invariably develop AD.
Formal Description
Interaction-ID: 8513

increases_activity of

Comment Individuals with genetic alterations in one of the genes that code for three transmembrane proteins - amyloid precursor protein, presenilin-1 and presenilin-2 - deposit large amounts of the amyloid fragment Abeta (1-42) in the brain and invariably develop AD.
Formal Description
Interaction-ID: 8514

gene/protein mutant

APP-mut

affects_quantity of

Comment Individuals with genetic alterations in one of the genes that code for three transmembrane proteins - amyloid precursor protein, presenilin-1 and presenilin-2 - deposit large amounts of the amyloid fragment Abeta (1-42) in the brain and invariably develop AD.
Formal Description
Interaction-ID: 8515

gene/protein mutant

PSEN1-mut

affects_quantity of

Comment Individuals with genetic alterations in one of the genes that code for three transmembrane proteins - amyloid precursor protein, presenilin-1 and presenilin-2 - deposit large amounts of the amyloid fragment Abeta (1-42) in the brain and invariably develop AD.
Formal Description
Interaction-ID: 8516

gene/protein mutant

PSEN2-mut

affects_quantity of

Comment Abeta (42) is toxic to neurons.
Formal Description
Interaction-ID: 8517

increases_activity of

process

neuron death