General Information:

Id: 1,183 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mus musculus
BTO:0001976 Neuro-2a cell
Reference: Flajolet M et al.(2007) Regulation of Alzheimers disease amyloid-beta formation by casein kinase I Proc. Natl. Acad. Sci. U.S.A. 104: 4159-4164 [PMID: 17360493]

Interaction Information:

Comment Overexpression of constitutively active CK1epsilon, one of the CK1 isoforms expressed in brain, leads to an increase in Abeta peptide production.
Formal Description
Interaction-ID: 11489



increases_quantity of

in brain (BTO:0000142); if CSNK1E is overexpressed
Comment CK1 inhibitor IC261 abolishes CK1epsilon-271-dependent Abeta40/Abeta42 increase in a dose- and time-dependent manner.
Formal Description
Interaction-ID: 11490

drug/chemical compound


decreases_quantity of

in brain (BTO:0000142)
Drugbank entries Show/Hide entries for IC261