General Information:

Id: 11,751
Diseases: Endocrine
Homo sapiens
CHO cells transfected with human ACE, ACE2, MME
article
Reference: Rice GI et al.(2004) Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism Biochem. J. 383: 45-51 [PMID: 15283675]

Interaction Information:

Comment ACE and NEP hydrolysed Ang I efficiently, whereas ACE2 hydrolysed Ang I only very slowly.
Formal Description
Interaction-ID: 116385

gene/protein

MME

decreases_quantity of

gene/protein

Angiotensin I

Drugbank entries Show/Hide entries for MME
Comment Ang I can be cleaved by NEP to Ang (1–7).
Formal Description
Interaction-ID: 116894

gene/protein

Angiotensin I

increases_quantity of

gene/protein

Angiotensin (1-7)

via catalytic action of MME (NEP)
Comment Ang (1–7) can be generated by the action of ACE2 on Ang II or by the metabolism of Ang (1–9) by ACE and NEP (MME).
Formal Description
Interaction-ID: 116895

gene/protein

Angiotensin (1-9)

increases_quantity of

gene/protein

Angiotensin (1-7)

via catalytic action of MME (NEP)
Comment Ang (1–7) can be generated by the action of ACE2 on Ang II or by the metabolism of Ang (1–9) by ACE and NEP (MME).
Formal Description
Interaction-ID: 116896

gene/protein

MME

increases_quantity of

gene/protein

Angiotensin (1-7)

Drugbank entries Show/Hide entries for MME
Comment Ang (1–7) can be generated by the action of ACE2 on Ang II or by the metabolism of Ang (1–9) by ACE and NEP (MME).
Formal Description
Interaction-ID: 116897

gene/protein

MME

decreases_quantity of

gene/protein

Angiotensin (1-9)

Drugbank entries Show/Hide entries for MME
Comment ACE and NEP hydrolysed Ang I efficiently, whereas ACE2 hydrolysed Ang I only very slowly.
Formal Description
Interaction-ID: 117231

gene/protein

ACE

decreases_quantity of

gene/protein

Angiotensin I

Drugbank entries Show/Hide entries for ACE