General Information:

Id: 11,612 (click here to show other Interactions for entry)
Diseases: Glass syndrome - [OMIM]
Mammalia
review
Reference: Zhao X et al.(2014) The role of SATB2 in skeletogenesis and human disease Cytokine Growth Factor Rev. 25: 35-44 [PMID: 24411565]

Interaction Information:

Comment GeneSpringGX7.3 and real-time RT-PCR confirmed the significant up-and down-regulation of genes closely associated with osteoblast differentiation, including SOX2, Runx2, WNT11 and MEN1 (up-regulated genes), and ILK, FGF23, FGFR2, and SNAI1 (down-regulated genes) at the mRNA level in SATB2-overexpressing MC3T3-E1cells. This implies that SATB2 promotes osteoblast differentiation through modulating osteoblastogenesis signals such as Wnt and BMP signaling pathways.
Formal Description
Interaction-ID: 115701

gene/protein

SATB2

decreases_expression of

gene/protein

ILK