General Information:

Id: 1,153 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
BTO:0000011 3T3-L1 cell
article
Reference: Stephens JM et al.(1997) Tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction J. Biol. Chem. 272: 971-976 [PMID: 8995390]

Interaction Information:

Comment Prolonged exposure (72-96 h) of 3T3-L1 adipocytes to TNF-alpha causes a substantial reduction in IRS-1 and GLUT4 mRNA and protein as well as a lesser reduction in the amount of the insulin receptor.
Formal Description
Interaction-ID: 7569

gene/protein

TNF

decreases_expression of

gene/protein

SLC2A4

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