General Information:

Id: 1,092 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mammalia
article
Reference: de Luca C and Olefsky JM(2008) Inflammation and insulin resistance FEBS Lett. 582: 97-105 [PMID: 18053812]

Interaction Information:

Comment In skeletal muscle insulin promotes glucose uptake by stimulating translocation of the GLUT4 glucose transporter to the plasma membrane, and impaired skeletal muscle insulin signaling results in decreased glucose disposal.
Formal Description
Interaction-ID: 6917

complex/PPI

Insulin

increases_activity of

gene/protein

SLC2A4

in skeletal muscle
Comment In skeletal muscle insulin promotes glucose uptake by stimulating translocation of the GLUT4 glucose transporter to the plasma membrane, and impaired skeletal muscle insulin signaling results in decreased glucose disposal.
Formal Description
Interaction-ID: 6923

gene/protein

SLC2A4

increases_activity of

process

glucose import

in skeletal muscle
Comment The proto-oncogene product, Cbl, is recruited to the insulin receptor by the adapter protein Cbl associated protein (CAP) and the CAP/Cbl complex can mediate cell surface translocation of GLUT4 independent of PI3K activity.
Formal Description
Interaction-ID: 7061

complex/PPI

CAP-CBL complex

increases_activity of

gene/protein

SLC2A4

via translocation of GLUT4 to the membrane
Comment Treatment of cultured 3T3-L1 adipocytes with Tnf leads to reduced expression of the insulin receptor, IRS1 and Glut4 genes, as well as a decrease in insulin stimulated glucose uptake.
Formal Description
Interaction-ID: 7091

gene/protein

TNF

decreases_expression of

gene/protein

SLC2A4

in adipose tissue
Drugbank entries Show/Hide entries for TNF
Comment A Tnf-induced decrease in 3T3-L1 adipocyte genes has been found, including GLUT4, Hormone Sensitive Lipase (HSL), long-chain fatty acyl CoA synthetase, adiponectin (ADIPOQ), the transcription factor CCAAT/enhancer binding protein-alpha (C/EBP), and the nuclear receptors Pparg and retinoic acid x receptor (RXR). These genes all contribute to glucose homeostasis, both directly and indirectly.
Formal Description
Interaction-ID: 7100

gene/protein

SLC2A4

affects_activity of