General Information:

Id: 1,057 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mus musculus
PS cDKO mouse (= double knock-out mice lacking both presenilins in the postnatal forebrain)
Reference: Beglopoulos V et al.(2004) Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice. J. Biol. Chem. 279 [PMID: 15345711]

Interaction Information:

Comment Abeta peptides and particularly Abeta42 are known to have neurotoxic properties at increased levels, which could be relevant to the deficits observed in PS cDKO mice. The data, however, argue against this idea because the levels of Abeta40 and Abeta42 are significantly reduced in the PS cDKO cerebral cortex.
Formal Description
Interaction-ID: 6704

organism model

PS cDKO mouse

decreases_expression of

in cerebral cortex