Pubmed ID Article Details
12722831 Ishizawa T et al.: Colocalization of tau and alpha-synuclein epitopes in Lewy bodies. J. Neuropathol. Exp. Neurol. 2003 62: 389-397
9930729 Lesort M et al.: Insulin transiently increases tau phosphorylation: involvement of glycogen synthase kinase-3beta and Fyn tyrosine kinase. J. Neurochem. 1999 72: 576-584
8250835 Sutherland C et al.: Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling. Biochem. J. 1993 296: 15-19
8382613 Hughes K et al.: Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation. EMBO J. 1993 12: 803-808
9685326 Pap M et al.: Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway. J. Biol. Chem. 1998 273
8978681 Alessi DR et al.: Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J. 1996 15: 6541-6551
8978681 Alessi DR et al.: Mechanism of activation of protein kinase B by insulin and IGF-1 EMBO J. 1996 15: 6541-6551
8978681 Alessi DR et al.: Mechanism of activation of protein kinase B by insulin and IGF-1 EMBO J. 1996 15: 6541-6551
11527574 Grimes CA et al.: The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling Prog. Neurobiol. 2001 65: 391-426
9468292 Welsh GI et al.: Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase-3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin. FEBS Lett. 1998 421: 125-130
18852354 Schaffer BA et al.: Association of GSK3B with Alzheimer disease and frontotemporal dementia Arch. Neurol. 2008 65: 1368-1374
1899151 Moore CK et al.: Cardiac allograft cellular rejection during OKT3 prophylaxis in the absence of sensitization Transplant. Proc. 1991 23: 1055-1058
18932008 Mendes CT et al.: Lithium reduces Gsk3b mRNA levels: implications for Alzheimer Disease Eur Arch Psychiatry Clin Neurosci 2009 259: 16-22
16944319 Verdile G et al.: The role of presenilin and its interacting proteins in the biogenesis of Alzheimers beta amyloid. Neurochem. Res. 2007 32: 609-623
16641999 Chen F et al.: TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity Nature 2006 440: 1208-1212
16641999 Chen F et al.: TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity. Nature 2006 440: 1208-1212
19779148 Kang JE et al.: Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle. Science 2009 326: 1005-1007
10993067 Yu G et al.: Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing Nature 2000 407: 48-54
10993067 Yu G et al.: Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature 2000 407: 48-54
12660785 Takasugi N et al.: The role of presenilin cofactors in the gamma-secretase complex. Nature 2003 422: 438-441
12032140 Yang DS et al.: Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins. J. Biol. Chem. 2002 277
12032140 Yang DS et al.: Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins J. Biol. Chem. 2002 277
12044882 Tomita T et al.: Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments. FEBS Lett. 2002 520: 117-121
12048259 Edbauer D et al.: Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation. Proc. Natl. Acad. Sci. U.S.A. 2002 99: 8666-8671
14981233 Schubert M et al.: Role for neuronal insulin resistance in neurodegenerative diseases Proc. Natl. Acad. Sci. U.S.A. 2004 101: 3100-3105
19144826 Lee HK et al.: The insulin/Akt signaling pathway is targeted by intracellular beta-amyloid. Mol. Biol. Cell 2009 20: 1533-1544
19144826 Lee HK et al.: The insulin/Akt signaling pathway is targeted by intracellular beta-amyloid Mol. Biol. Cell 2009 20: 1533-1544
19712582 de la Monte SM et al.: Insulin resistance and Alzheimers disease BMB Rep 2009 42: 475-481
12904469 Schubert M et al.: Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation J. Neurosci. 2003 23: 7084-7092
1904481 Perry G et al.: Neuropil threads of Alzheimers disease show a marked alteration of the normal cytoskeleton J. Neurosci. 1991 11: 1748-1755
8592647 Takashima A et al.: Amyloid beta peptide induces cytoplasmic accumulation of amyloid protein precursor via tau protein kinase I/glycogen synthase kinase-3 beta in rat hippocampal neurons. Neurosci. Lett. 1995 198: 83-86
15094077 Watson GS et al.: Modulation of memory by insulin and glucose: neuropsychological observations in Alzheimers disease Eur. J. Pharmacol. 2004 490: 97-113
10672254 Hoyer S et al.: Inhibition of the neuronal insulin receptor causes Alzheimer-like disturbances in oxidative/energy brain metabolism and in behavior in adult rats Ann. N. Y. Acad. Sci. 1999 893: 301-303
11943765 Leem JY et al.: Presenilin 1 is required for maturation and cell surface accumulation of nicastrin. J. Biol. Chem. 2002 277
11146649 Sato N et al.: Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression. Nat. Cell Biol. 2000 2: 863-870
19940183 Rudrabhatla P et al.: Peptidyl-prolyl isomerase 1 regulates protein phosphatase 2A-mediated topographic phosphorylation of neurofilament proteins. J. Neurosci. 2009 29
12846562 Beher D et al.: In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand Biochemistry 2003 42: 8133-8142
15189355 Shirotani K et al.: Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1. J. Neurochem. 2004 89: 1520-1527
15676027 Uchida Y et al.: Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3beta phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimers disease. Genes Cells 2005 10: 165-179
18635547 Rudrabhatla P et al.: Pin1-dependent prolyl isomerization modulates the stress-induced phosphorylation of high molecular weight neurofilament protein. J. Biol. Chem. 2008 283
18635547 Rudrabhatla P et al.: Pin1-dependent prolyl isomerization modulates the stress-induced phosphorylation of high molecular weight neurofilament protein J. Biol. Chem. 2008 283
19661622 Popp J et al.: Homocysteine metabolism and cerebrospinal fluid markers for Alzheimers disease. J. Alzheimers Dis. 2009 18: 819-828
19661623 Goni-Oliver P et al.: Memantine inhibits calpain-mediated truncation of GSK-3 induced by NMDA: implications in Alzheimers disease J. Alzheimers Dis. 2009 18: 843-848
17626162 Kesavapany S et al.: Inhibition of Pin1 reduces glutamate-induced perikaryal accumulation of phosphorylated neurofilament-H in neurons Mol. Biol. Cell 2007 18: 3645-3655
17626162 Kesavapany S et al.: Inhibition of Pin1 reduces glutamate-induced perikaryal accumulation of phosphorylated neurofilament-H in neurons. Mol. Biol. Cell 2007 18: 3645-3655
10672251 Frolich L et al.: A disturbance in the neuronal insulin receptor signal transduction in sporadic Alzheimers disease. Ann. N. Y. Acad. Sci. 1999 893: 290-293
10231383 Li BS et al.: Activation of mitogen-activated protein kinases (Erk1 and Erk2) cascade results in phosphorylation of NF-M tail domains in transfected NIH 3T3 cells. Eur. J. Biochem. 1999 262: 211-217
10670439 Boyt AA et al.: The effect of insulin and glucose on the plasma concentration of Alzheimers amyloid precursor protein. Neuroscience 2000 95: 727-734
17298085 Zhou S et al.: Regulation of gamma-secretase activity in Alzheimers disease. Biochemistry 2007 46: 2553-2563
12761548 Phiel CJ et al.: GSK-3alpha regulates production of Alzheimers disease amyloid-beta peptides Nature 2003 423: 435-439
19090986 Cashman JR et al.: Immune defects in Alzheimers disease: new medications development. BMC Neurosci 2008 9: S13
10341227 Kang DE et al.: Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimers disease-linked PS1 mutants in the beta-catenin-signaling pathway J. Neurosci. 1999 19: 4229-4237
12297048 Kang DE et al.: Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis Cell 2002 110: 751-762
11554609 Klunk WE et al.: Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain. Life Sci. 2001 69: 1471-1484
14651959 Ryder J et al.: Divergent roles of GSK3 and CDK5 in APP processing Biochem. Biophys. Res. Commun. 2003 312: 922-929
14651959 Ryder J et al.: Divergent roles of GSK3 and CDK5 in APP processing. Biochem. Biophys. Res. Commun. 2003 312: 922-929
18189321 Chen Q et al.: Loss of presenilin function causes Alzheimers disease-like neurodegeneration in the mouse. J. Neurosci. Res. 2008 86: 1615-1625
19337449 Gotz J et al.: An update on the toxicity of Abeta in Alzheimers disease. Neuropsychiatr Dis Treat 2008 4: 1033-1042
17708691 Crouch PJ et al.: Mitochondria in aging and Alzheimers disease. Rejuvenation Res 2007 10: 349-357
19268425 Celsi F et al.: Mitochondria, calcium and cell death: a deadly triad in neurodegeneration Biochim. Biophys. Acta 2009 1787: 335-344
9051814 Guo Q et al.: Alzheimers PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide Neuroreport 1996 8: 379-383
16394273 Lee SY et al.: PS2 mutation increases neuronal cell vulnerability to neurotoxicants through activation of caspase-3 by enhancing of ryanodine receptor-mediated calcium release FASEB J. 2006 20: 151-153
15659604 Crouch PJ et al.: Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42 J. Neurosci. 2005 25: 672-679
15170327 Su Y et al.: Lithium, a common drug for bipolar disorder treatment, regulates amyloid-beta precursor protein processing Biochemistry 2004 43: 6899-6908
15170327 Su Y et al.: Lithium, a common drug for bipolar disorder treatment, regulates amyloid-beta precursor protein processing Biochemistry 2004 43: 6899-6908
16014628 Feyt C et al.: Lithium chloride increases the production of amyloid-beta peptide independently from its inhibition of glycogen synthase kinase 3. J. Biol. Chem. 2005 280
15485501 Good PF et al.: A role for semaphorin 3A signaling in the degeneration of hippocampal neurons during Alzheimers disease. J. Neurochem. 2004 91: 716-736
15634781 Ma G et al.: APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development. J. Neurosci. 2005 25: 192-198
19478559 Yoon EJ et al.: Intracellular amyloid beta interacts with SOD1 and impairs the enzymatic activity of SOD1: implications for the pathogenesis of amyotrophic lateral sclerosis Exp. Mol. Med. 2009 41: 611-617
15466863 Cole AR et al.: GSK-3 phosphorylation of the Alzheimer epitope within collapsin response mediator proteins regulates axon elongation in primary neurons. J. Biol. Chem. 2004 279
15466863 Cole AR et al.: GSK-3 phosphorylation of the Alzheimer epitope within collapsin response mediator proteins regulates axon elongation in primary neurons J. Biol. Chem. 2004 279
19793966 Jinwal UK et al.: Chemical manipulation of hsp70 ATPase activity regulates tau stability J. Neurosci. 2009 29
19449461 Koren J 3rd et al.: Chaperone signalling complexes in Alzheimers disease J. Cell. Mol. Med. 2009 13: 619-630
16724068 Uehara T et al.: S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration Nature 2006 441: 513-517
16724068 Uehara T et al.: S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration Nature 2006 441: 513-517
16724068 Uehara T et al.: S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration. Nature 2006 441: 513-517
12522269 Dou F et al.: Chaperones increase association of tau protein with microtubules. Proc. Natl. Acad. Sci. U.S.A. 2003 100: 721-726
12522269 Dou F et al.: Chaperones increase association of tau protein with microtubules Proc. Natl. Acad. Sci. U.S.A. 2003 100: 721-726
14962978 Petrucelli L et al.: CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation Hum. Mol. Genet. 2004 13: 703-714
18061943 Bjorkdahl C et al.: Small heat shock proteins Hsp27 or alphaB-crystallin and the protein components of neurofibrillary tangles: tau and neurofilaments. J. Neurosci. Res. 2008 86: 1343-1352
18061943 Bjorkdahl C et al.: Small heat shock proteins Hsp27 or alphaB-crystallin and the protein components of neurofibrillary tangles: tau and neurofilaments J. Neurosci. Res. 2008 86: 1343-1352
19946466 Bonda DJ et al.: Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease Aging (Albany NY) 2009 1: 382-388
20237268 Biswas SC et al.: Sertad1 plays an essential role in developmental and pathological neuron death J. Neurosci. 2010 30: 3973-3982
19647374 Bajic VP et al.: The X-chromosome instability phenotype in Alzheimers disease: a clinical sign of accelerating aging? }, authors { names std { { name ml Bajic VP, affil str Institute of Biomedical Research, Galenika ad, 11000 Belgrade, Serbia. vladanbajic@yahoo.com }, { name ml Spremo-Potparevic B }, { name ml Zivkovic L }, { name ml Bonda DJ }, { name ml Siedlak SL }, { name ml Casadesus G }, { name ml Lee HG }, { name ml Smith MA } } }, from journal { title { iso-jta Med. Hypotheses, ml-jta Med Hypotheses, issn 1532-2777, name Medical hypotheses }, imp { date std { year 2009, month 12 }, volume 73, issue 6, pages 917-920, language eng, pubstatus ppublish, history { { pubstatus received, date std { year 2009, month 6, day 23 } }, { pubstatus accepted, date std { year 2009, month 6, day 24 } }, { pubstatus aheadofprint, date std { year 2009, month 7, day 31 } }, { pubstatus other, date std { year 2009, month 8, day 4, hour 9, minute 0 } }, { pubstatus pubmed, date std { year 2009, month 8, day 4, hour 9, minute 0 } }, { pubstatus medline, date std { year 2010, month 3, day 2, hour 6, minute 0 } } } } }, ids { pii S0306-9877(09)00478-2, doi 10.1016/j.mehy.2009.06.046, pubmed 19647374, other { db pmc, tag str PMC2787990 }, other { db mid, tag str NIHMS136441 }, other { db ELocationID doi, tag str 10.1016/j.mehy.2009.06.046 } } }, abstract Premature centromere division, or premature centromere separation (PCS), occurs when chromatid separation is dysfunctional, occurring earlier than usual during the interphase stage of mitosis. This phenomenon, seen in Roberts syndrome and various cancers, has also been documented in peripheral as well as neuronal cells of Alzheimers disease (AD). In the latter instances, fluorescent in situ hybridization (FISH), applied to the centromere region of the X-chromosome in interphase nuclei of lymphocytes from peripheral blood in AD patients, demonstrated premature chromosomal separation before mitotic metaphase directly after completion of DNA replication in G(2) phase of the cell cycle. Furthermore, and perhaps unexpectedly given the presumptive post-mitotic status of terminally differentiated neurons, neurons in AD patients also showed significantly increased levels of PCS of the X-chromosome. Taken together with other phenomena such as cell cycle re-activation and ectopic re-expression of cyclins and cyclin dependent proteins, we propose that AD is an oncogenic phenotype leading to accelerated aging of the affected brain Med. Hypotheses 2009 73: 917-920
12624792 Pei JJ et al.: Role of protein kinase B in Alzheimers neurofibrillary pathology. Acta Neuropathol. 2003 105: 381-392
17276679 Ansar S et al.: A non-toxic Hsp90 inhibitor protects neurons from Abeta-induced toxicity. Bioorg. Med. Chem. Lett. 2007 17: 1984-1990
14963027 Shimura H et al.: Binding of tau to heat shock protein 27 leads to decreased concentration of hyperphosphorylated tau and enhanced cell survival. J. Biol. Chem. 2004 279
15132984 Nemes Z et al.: Cross-linking of ubiquitin, HSP27, parkin, and alpha-synuclein by gamma-glutamyl-epsilon-lysine bonds in Alzheimers neurofibrillary tangles. FASEB J. 2004 18: 1135-1137
15615647 Kosik KS et al.: Phosphorylated tau and the neurodegenerative foldopathies. Biochim. Biophys. Acta 2005 1739: 298-310
14612456 Shimura H et al.: CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival J. Biol. Chem. 2004 279: 4869-4876
12888622 Gamblin TC et al.: Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimers disease Proc. Natl. Acad. Sci. U.S.A. 2003 100
20357768 de Calignon A et al.: Caspase activation precedes and leads to tangles. Nature 2010 464: 1201-1204
19191039 Sun AY et al.: Botanical phenolics and brain health Neuromolecular Med. 2008 10: 259-274
12793519 Joseph JA et al.: Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model. Nutr Neurosci 2003 6: 153-162
16177050 Rezai-Zadeh K et al.: Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice J. Neurosci. 2005 25: 8807-8814
16177050 Rezai-Zadeh K et al.: Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice J. Neurosci. 2005 25: 8807-8814
16624814 Obregon DF et al.: ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor protein J. Biol. Chem. 2006 281
15579468 Kanekura K et al.: A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death J. Biol. Chem. 2005 280: 4532-4543
16636099 Chen F et al.: Reductions in levels of the Alzheimers amyloid beta peptide after oral administration of ginsenosides FASEB J. 2006 20: 1269-1271
16636099 Chen F et al.: Reductions in levels of the Alzheimers amyloid beta peptide after oral administration of ginsenosides FASEB J. 2006 20: 1269-1271
15277073 Chauhan NB et al.: Anti-amyloidogenic effect of Allium sativum in Alzheimers transgenic model Tg2576 J Herb Pharmacother 2003 3: 95-107
20385830 Han W et al.: Linking type 2 diabetes and Alzheimers disease Proc. Natl. Acad. Sci. U.S.A. 2010 107: 6557-6558
20231468 Takeda S et al.: Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes Proc. Natl. Acad. Sci. U.S.A. 2010 107: 7036-7041
11880515 Westerman MA et al.: The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimers disease J. Neurosci. 2002 22: 1858-1867
19242462 Cisse M et al.: Alzheimers disease: A prion protein connection. Nature 2009 457: 1090-1091
19829367 Mucke L et al.: Neuroscience: Alzheimers disease Nature 2009 461: 895-897
17082448 Roberson ED et al.: 100 years and counting: prospects for defeating Alzheimers disease. Science 2006 314: 781-784
16842945 Chauhan NB et al.: Effect of aged garlic extract on APP processing and tau phosphorylation in Alzheimers transgenic model Tg2576 J Ethnopharmacol 2006 108: 385-394
17380553 Chauhan NB et al.: Amelioration of early cognitive deficits by aged garlic extract in Alzheimers transgenic mice Phytother Res 2007 21: 629-640
17380553 Chauhan NB et al.: Amelioration of early cognitive deficits by aged garlic extract in Alzheimers transgenic mice. Phytother Res 2007 21: 629-640
14637120 Stackman RW et al.: Prevention of age-related spatial memory deficits in a transgenic mouse model of Alzheimers disease by chronic Ginkgo biloba treatment Exp. Neurol. 2003 184: 510-520
17086105 Garcia-Alloza M et al.: Plaque-derived oxidative stress mediates distorted neurite trajectories in the Alzheimer mouse model J. Neuropathol. Exp. Neurol. 2006 65: 1082-1089
15010693 Tohda C et al.: Abeta(25-35)-induced memory impairment, axonal atrophy, and synaptic loss are ameliorated by M1, A metabolite of protopanaxadiol-type saponins. Neuropsychopharmacology 2004 29: 860-868
17010630 Hartman RE et al.: Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimers disease Neurobiol. Dis. 2006 24: 506-515
19104446 Julien C et al.: Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease. J. Neuropathol. Exp. Neurol. 2009 68: 48-58
19548013 Tong Y et al.: COL25A1 triggers and promotes Alzheimers disease-like pathology in vivo Neurogenetics 2010 11: 41-52
20126630 Frykman S et al.: Synaptic and endosomal localization of active gamma-secretase in rat brain. PLoS ONE 2010 5: E8948
16183991 Chen J et al.: SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling J. Biol. Chem. 2005 280
20061625 Huesa G et al.: Altered distribution of RhoA in Alzheimers disease and AbetaPP overexpressing mice J. Alzheimers Dis. 2010 19: 37-56
12603837 Siman R et al.: Localization of presenilin-nicastrin complexes and gamma-secretase activity to the trans-Golgi network. J. Neurochem. 2003 84: 1143-1153
19712581 Chung SH et al.: Aberrant phosphorylation in the pathogenesis of Alzheimers disease BMB Rep 2009 42: 467-474
10814741 Yasojima K et al.: Casein kinase 1 delta mRNA is upregulated in Alzheimer disease brain. Brain Res. 2000 865: 116-120
10412011 Yasojima K et al.: Tangled areas of Alzheimer brain have upregulated levels of exon 10 containing tau mRNA. Brain Res. 1999 831: 301-305
10924763 Schwab C et al.: Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases Neurobiol. Aging 2000 21: 503-510
15345711 Beglopoulos V et al.: Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice. J. Biol. Chem. 2004 279
19521544 Engmann O et al.: Crosstalk between Cdk5 and GSK3beta: Implications for Alzheimers Disease. Front Mol Neurosci 2009 2: 2
18691386 Sun KH et al.: Deregulated Cdk5 promotes oxidative stress and mitochondrial dysfunction J. Neurochem. 2008 107: 265-278
9038181 Poon RY et al.: Identification of functional domains in the neuronal Cdk5 activator protein. J. Biol. Chem. 1997 272: 5703-5708
10604467 Patrick GN et al.: Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration Nature 1999 402: 615-622
19776350 Sun KH et al.: Direct and indirect roles of cyclin-dependent kinase 5 as an upstream regulator in the c-Jun NH2-terminal kinase cascade: relevance to neurotoxic insults in Alzheimers disease. Mol. Biol. Cell 2009 20: 4611-4619
20462385 Candore G et al.: Inflammation, cytokines, immune response, apolipoprotein E, cholesterol, and oxidative stress in Alzheimer disease: therapeutic implications Rejuvenation Res 2010 13: 301-313
11329064 Wyss-Coray T et al.: TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice Nat. Med. 2001 7: 612-618
18801740 Lukiw WJ et al.: An NF-kappaB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells J. Biol. Chem. 2008 283
17905482 Letiembre M et al.: Screening of innate immune receptors in neurodegenerative diseases: a similar pattern Neurobiol. Aging 2009 30: 759-768
11749806 Zeng HH et al.: Antioxidant properties of phenolic diterpenes from Rosmarinus officinalis Acta Pharmacol. Sin. 2001 22: 1094-1098
2529544 Griffin WS et al.: Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease Proc. Natl. Acad. Sci. U.S.A. 1989 86: 7611-7615
15290893 Mrak RE et al.: Trisomy 21 and the brain J. Neuropathol. Exp. Neurol. 2004 63: 679-685
17360493 Flajolet M et al.: Regulation of Alzheimers disease amyloid-beta formation by casein kinase I Proc. Natl. Acad. Sci. U.S.A. 2007 104: 4159-4164
17094809 Wilkinson BL et al.: The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimers disease J Neuroinflammation 2006 3: 30
20552018 Schonrock N et al.: Neuronal microRNA deregulation in response to Alzheimers disease amyloid-beta PLoS ONE 2010 5
20552018 Schonrock N et al.: Neuronal microRNA deregulation in response to Alzheimers disease amyloid-beta. PLoS ONE 2010 5
19406203 Sethi P et al.: Micro-RNA abundance and stability in human brain: specific alterations in Alzheimers disease temporal lobe neocortex Neurosci. Lett. 2009 459: 100-104
20489155 Wang WX et al.: miR-107 regulates granulin/progranulin with implications for traumatic brain injury and neurodegenerative disease. Am. J. Pathol. 2010 177: 334-345
20126538 Nunez-Iglesias J et al.: Joint genome-wide profiling of miRNA and mRNA expression in Alzheimers disease cortex reveals altered miRNA regulation PLoS ONE 2010 5: E8898
20202123 Shioya M et al.: Aberrant microRNA expression in the brains of neurodegenerative diseases: miR-29a decreased in Alzheimer disease brains targets neurone navigator 3 Neuropathol. Appl. Neurobiol. 2010 36: 320-330
12787059 Castegna A et al.: Proteomic identification of nitrated proteins in Alzheimers disease brain J. Neurochem. 2003 85: 1394-1401
20472889 Arendt T et al.: Selective cell death of hyperploid neurons in Alzheimers disease Am. J. Pathol. 2010 177: 15-20
10867782 Hock C et al.: Region-specific neurotrophin imbalances in Alzheimer disease: decreased levels of brain-derived neurotrophic factor and increased levels of nerve growth factor in hippocampus and cortical areas Arch. Neurol. 2000 57: 846-851
15857398 Wang J et al.: Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimers disease J. Neurochem. 2005 93: 953-962
11733217 Butterfield DA et al.: Evidence of oxidative damage in Alzheimers disease brain: central role for amyloid beta-peptide Trends Mol Med 2001 7: 548-554
19654187 Wang Y et al.: Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing Hum. Mol. Genet. 2009 18: 4153-4170
17485462 Ko MH et al.: The sterol carrier protein SCP-x/pro-SCP-2 gene has transcriptional activity and regulates the Alzheimer disease gamma-secretase J. Biol. Chem. 2007 282
20451302 Persengiev S et al.: Genome-wide analysis of miRNA expression reveals a potential role for miR-144 in brain aging and spinocerebellar ataxia pathogenesis Neurobiol. Aging 2011 32: 2316
20413881 Nelson PT et al.: MiR-107 is reduced in Alzheimers disease brain neocortex: validation study J. Alzheimers Dis. 2010 21: 75-79
20110602 Ciaramella A et al.: Increased pro-inflammatory response by dendritic cells from patients with Alzheimers disease J. Alzheimers Dis. 2010 19: 559-572
20134203 Morales I et al.: Neuroimmunomodulation in the pathogenesis of Alzheimers disease Neuroimmunomodulation 2010 17: 202-204
20122289 Zotova E et al.: Inflammation in Alzheimers disease: relevance to pathogenesis and therapy Alzheimers Res Ther 2010 2: 1
20696495 Wilkinson BL et al.: Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimers disease Neurobiol. Aging 2012 33: 197
20696495 Wilkinson BL et al.: Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimers disease Neurobiol. Aging 2012 33: 197
16645044 Wang R et al.: Transcriptional regulation of APH-1A and increased gamma-secretase cleavage of APP and Notch by HIF-1 and hypoxia FASEB J. 2006 20: 1275-1277
16645641 Xu Y et al.: Intracellular domains of amyloid precursor-like protein 2 interact with CP2 transcription factor in the nucleus and induce glycogen synthase kinase-3beta expression Cell Death Differ. 2007 14: 79-91
20594619 Robakis NK et al.: Mechanisms of AD neurodegeneration may be independent of Abeta and its derivatives Neurobiol. Aging 2011 32: 372-379
19641596 Zhang C et al.: Presenilins are essential for regulating neurotransmitter release Nature 2009 460: 632-636
18184791 Baki L et al.: Wild-type but not FAD mutant presenilin-1 prevents neuronal degeneration by promoting phosphatidylinositol 3-kinase neuroprotective signaling J. Neurosci. 2008 28: 483-490
19261853 Liu Z et al.: Membrane-associated farnesylated UCH-L1 promotes alpha-synuclein neurotoxicity and is a therapeutic target for Parkinsons disease Proc. Natl. Acad. Sci. U.S.A. 2009 106: 4635-4640
20739979 Ledford H et al.: Key Alzheimers findings questioned. Nature 2010 466: 1031
20552043 Guglielmotto M et al.: Oxidative stress mediates the pathogenic effect of different Alzheimers disease risk factors Front Aging Neurosci 2010 2: 3
20817278 Duce JA et al.: Iron-export ferroxidase activity of beta-amyloid precursor protein is inhibited by zinc in Alzheimers disease Cell 2010 142: 857-867
19021541 Rogers JT et al.: Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimers disease Biochem. Soc. Trans. 2008 36: 1282-1287
20631161 Brewer GJ et al.: Copper and ceruloplasmin abnormalities in Alzheimers disease Am J Alzheimers Dis Other Demen 2010 25: 490-497
19166904 Cahill CM et al.: Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases Biochim. Biophys. Acta 2009 1790: 615-628
19631630 Yao L et al.: Influence of the Pro12Ala polymorphism of PPAR-gamma on age at onset and sRAGE levels in Alzheimers disease Brain Res. 2009 1291: 133-139
18400211 Cheng CY et al.: Ferulic acid provides neuroprotection against oxidative stress-related apoptosis after cerebral ischemia/reperfusion injury by inhibiting ICAM-1 mRNA expression in rats Brain Res. 2008 1209: 136-150
16205720 Gaeta A et al.: The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy Br. J. Pharmacol. 2005 146: 1041-1059
18687504 Jo DG et al.: Evidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimers disease Neurobiol. Aging 2010 31: 917-925
18687504 Jo DG et al.: Evidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimers disease Neurobiol. Aging 2010 31: 917-925
19965584 Vedin I et al.: Reduced prostaglandin F2 alpha release from blood mononuclear leukocytes after oral supplementation of omega3 fatty acids: the OmegAD study J. Lipid Res. 2010 51: 1179-1185
17014365 Andrews NC et al.: Iron homeostasis Annu. Rev. Physiol. 2007 69: 69-85
19225519 Nikolaev A et al.: APP binds DR6 to trigger axon pruning and neuron death via distinct caspases Nature 2009 457: 981-989
19898775 Wang SM et al.: Role of hepcidin in murine brain iron metabolism Cell. Mol. Life Sci. 2010 67: 123-133
18585350 Dreses-Werringloer U et al.: A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimers disease risk Cell 2008 133: 1149-1161
20619502 Liu W et al.: MicroRNA-16 targets amyloid precursor protein to potentially modulate Alzheimers-associated pathogenesis in SAMP8 mice Neurobiol. Aging 2012 33: 522-534
19090996 Block ML et al.: NADPH oxidase as a therapeutic target in Alzheimers disease BMC Neurosci 2008 9: S8
20442493 Young KJ et al.: The mitochondrial secret(ase) of Alzheimers disease J. Alzheimers Dis. 2010 20: S381-S400
16551656 Manczak M et al.: Mitochondria are a direct site of A beta accumulation in Alzheimers disease neurons: implications for free radical generation and oxidative damage in disease progression Hum. Mol. Genet. 2006 15: 1437-1449
20463396 Di Filippo M et al.: Mitochondria and the link between neuroinflammation and neurodegeneration J. Alzheimers Dis. 2010 20: S369-S379
20463408 Morais VA et al.: Mitochondria dysfunction and neurodegenerative disorders: cause or consequence J. Alzheimers Dis. 2010 20: S255-S263
15087549 Lustbader JW et al.: ABAD directly links Abeta to mitochondrial toxicity in Alzheimers disease Science 2004 304: 448-452
18757748 Hansson Petersen CA et al.: The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae Proc. Natl. Acad. Sci. U.S.A. 2008 105
15456764 Hansson CA et al.: Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria J. Biol. Chem. 2004 279
20655099 Ittner LM et al.: Dendritic function of tau mediates amyloid-beta toxicity in Alzheimers disease mouse models Cell 2010 142: 387-397
20691893 Haass C et al.: Fyn-tau-amyloid: a toxic triad Cell 2010 142: 356-358
17088888 Lin MT et al.: Alzheimers APP mangles mitochondria Nat. Med. 2006 12: 1241-1243
12196559 Stein TD et al.: Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activation of cell survival pathways J. Neurosci. 2002 22: 7380-7388
12196559 Stein TD et al.: Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activation of cell survival pathways J. Neurosci. 2002 22: 7380-7388
14675736 Cardoso SM et al.: Cytochrome c oxidase is decreased in Alzheimers disease platelets Neurobiol. Aging 2004 25: 105-110
12270688 Casley CS et al.: Beta-amyloid fragment 25-35 causes mitochondrial dysfunction in primary cortical neurons Neurobiol. Dis. 2002 10: 258-267
19605646 Wang X et al.: Impaired balance of mitochondrial fission and fusion in Alzheimers disease J. Neurosci. 2009 29: 9090-9103
15591653 Keil U et al.: Elevated nitric oxide production mediates beta-amyloid-induced mitochondria failure Pol J Pharmacol 2004 56: 631-634
20816785 Anekonda TS et al.: L-type voltage-gated calcium channel blockade with isradipine as a therapeutic strategy for Alzheimers disease. Neurobiol. Dis. 2011 41: 62-70
21134458 Rozkalne A et al.: Calcineurin inhibition with FK506 ameliorates dendritic spine density deficits in plaque-bearing Alzheimer model mice Neurobiol. Dis. 2011 41: 650-654
20887789 Batlevi Y et al.: Mitochondrial autophagy in neural function, neurodegenerative disease, neuron cell death, and aging Neurobiol. Dis. 2011 43: 46-51
20888417 Massone S et al.: 17A, a novel non-coding RNA, regulates GABA B alternative splicing and signaling in response to inflammatory stimuli and in Alzheimer disease Neurobiol. Dis. 2011 41: 308-317
21081164 Rohn TT et al.: Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimers disease brain Neurobiol. Dis. 2011 43: 68-78
20732422 Yamamoto A et al.: The elimination of accumulated and aggregated proteins: a role for aggrephagy in neurodegeneration Neurobiol. Dis. 2011 43: 17-28
12270682 Janciauskiene S et al.: Interactions of A beta with endogenous anti-inflammatory agents: a basis for chronic neuroinflammation in Alzheimers disease Neurobiol. Dis. 2002 10: 187-200
21270867 Ledford H et al.: Alzheimers-disease probe nears approval. Nature 2011 469: 458
20551690 Kaiser E et al.: Cerebrospinal fluid concentrations of functionally important amino acids and metabolic compounds in patients with mild cognitive impairment and Alzheimers disease. Neurodegener Dis 2010 7: 251-259
18037246 Padmashri R et al.: Glutamate transporter blockade affects Ca(2+) responses in astrocytes. Neuroscience 2008 151: 56-62
19897719 Rhein V et al.: Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimers disease mice. Proc. Natl. Acad. Sci. U.S.A. 2009 106
19035593 Frydman-Marom A et al.: Cognitive-performance recovery of Alzheimers disease model mice by modulation of early soluble amyloidal assemblies. Angew. Chem. Int. Ed. Engl. 2009 48: 1981-1986
20709030 Wang H et al.: miR-106b aberrantly expressed in a double transgenic mouse model for Alzheimers disease targets TGF-beta type II receptor. Brain Res. 2010 1357: 166-174
20937840 Cui JG et al.: Differential regulation of interleukin-1 receptor-associated kinase-1 (IRAK-1) and IRAK-2 by microRNA-146a and NF-kappaB in stressed human astroglial cells and in Alzheimer disease J. Biol. Chem. 2010 285
18838197 Vargas T et al.: Abeta accumulation in choroid plexus is associated with mitochondrial-induced apoptosis Neurobiol. Aging 2010 31: 1569-1581
21062284 Smith P et al.: In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs. J. Neurochem. 2011 116: 240-247
18434550 Hebert SS et al.: Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimers disease correlates with increased BACE1/beta-secretase expression Proc. Natl. Acad. Sci. U.S.A. 2008 105: 6415-6420
16599941 Wilhelmus MM et al.: Specific association of small heat shock proteins with the pathological hallmarks of Alzheimers disease brains Neuropathol. Appl. Neurobiol. 2006 32: 119-130
16611012 Gomez-Ramos A et al.: Inhibition of GSK3 dependent tau phosphorylation by metals. Curr Alzheimer Res 2006 3: 123-127
19795195 Pickrell AM et al.: The role of cytochrome c oxidase deficiency in ROS and amyloid plaque formation. J. Bioenerg. Biomembr. 2009 41: 453-456
19342591 Cho DH et al.: S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury. Science 2009 324: 102-105
19050078 Wang X et al.: Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins. Proc. Natl. Acad. Sci. U.S.A. 2008 105
17715058 Fukui H et al.: Cytochrome c oxidase deficiency in neurons decreases both oxidative stress and amyloid formation in a mouse model of Alzheimers disease Proc. Natl. Acad. Sci. U.S.A. 2007 104
19091971 Liu Y et al.: Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimers disease. J. Neurosci. 2008 28
19118186 Sato S et al.: Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1 J. Neurosci. 2008 28
19118186 Sato S et al.: Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1. J. Neurosci. 2008 28
21208686 van Beek AH et al.: Oscillations in cerebral blood flow and cortical oxygenation in Alzheimers disease Neurobiol. Aging 2012 33: 428
19063999 Kennelly SP et al.: Blood pressure and the risk for dementia: a double edged sword Ageing Res. Rev. 2009 8: 61-70
18692159 Chung HY et al.: Molecular inflammation: underpinnings of aging and age-related diseases. Ageing Res. Rev. 2009 8: 18-30
18313368 Chung JH et al.: Molecular mechanism of PPAR in the regulation of age-related inflammation Ageing Res. Rev. 2008 7: 126-136
20170744 Vance JE et al.: Formation and function of apolipoprotein E-containing lipoproteins in the nervous system Biochim. Biophys. Acta 2010 1801: 806-818
20228251 Lee M et al.: Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases. FASEB J. 2010 24: 2533-2545
16025111 Snyder EM et al.: Regulation of NMDA receptor trafficking by amyloid-beta. Nat. Neurosci. 2005 8: 1051-1058
18813209 Chiba T et al.: Amyloid-beta causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons. Mol. Psychiatry 2009 14: 206-222
20889807 Geldmacher DS et al.: Alzheimer disease prevention: focus on cardiovascular risk, not amyloid Cleve Clin J Med 2010 77: 689-704
19076444 Gibson GE et al.: Oxidant-induced changes in mitochondria and calcium dynamics in the pathophysiology of Alzheimers disease Ann. N. Y. Acad. Sci. 2008 1147: 221-232
16472763 Clementi ME et al.: Alzheimers amyloid beta-peptide (1-42) induces cell death in human neuroblastoma via bax/bcl-2 ratio increase: an intriguing role for methionine 35. Biochem. Biophys. Res. Commun. 2006 342: 206-213
20933077 Zhang H et al.: Puerarin protects Alzheimers disease neuronal cybrids from oxidant-stress induced apoptosis by inhibiting pro-death signaling pathways. Exp. Gerontol. 2011 46: 30-37
21461981 Bajic VP et al.: Mislocalization of CDK11/PITSLRE, a regulator of the G2/M phase of the cell cycle, in Alzheimer disease Cell. Mol. Biol. Lett. 2011 16: 359-372
21421841 Jin M et al.: Soluble amyloid {beta}-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration. Proc. Natl. Acad. Sci. U.S.A. 2011 108: 5819-5824
21349442 Bonda DJ et al.: The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations Lancet Neurol 2011 10: 275-279
21121893 Monteiro JP et al.: SIRT1 deacetylase activity and the maintenance of protein homeostasis in response to stress: an overview. Protein Pept. Lett. 2011 18: 167-173
16751189 Qin W et al.: Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. J. Biol. Chem. 2006 281
17517621 De Ferrari GV et al.: Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimers disease. Proc. Natl. Acad. Sci. U.S.A. 2007 104: 9434-9439
21383494 Sultana R et al.: Increased Protein and Lipid Oxidative Damage in Mitochondria Isolated from Lymphocytes from Patients with Alzheimers Disease: Insights into the Role of Oxidative Stress in Alzheimers Disease and Initial Investigations into a Potential Biomarker for this Dementing Disorder. J. Alzheimers Dis. 2011 24: 77-84
21187585 Schrag M et al.: Effect of cerebral amyloid angiopathy on brain iron, copper, and zinc in Alzheimers disease. J. Alzheimers Dis. 2011 24: 137-149
21187587 Zhou R et al.: Association between Bone Mineral Density and the Risk of Alzheimers Disease. J. Alzheimers Dis. 2011 24: 101-108
21376707 Li W et al.: Regulation of matrix metalloproteinase 2 by oligomeric amyloid beta protein. Brain Res. 2011 1387: 141-148
21148560 Jawhar S et al.: Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate A{beta} formation, induces behavioral deficits, and glutaminyl cyclase knock-out rescues the behavioral phenotype in 5XFAD mice. J. Biol. Chem. 2011 286: 4454-4460
19863057 Buchholz M et al.: Inhibitors for human glutaminyl cyclase by structure based design and bioisosteric replacement. J. Med. Chem. 2009 52: 7069-7080
20128815 Manthey D et al.: The selective beta1-adrenoceptor antagonist nebivolol is a potential oestrogen receptor agonist with neuroprotective abilities. Br. J. Pharmacol. 2010 159: 1264-1273
21288892 Huang KF et al.: Structures of Human Golgi-resident Glutaminyl Cyclase and Its Complexes with Inhibitors Reveal a Large Loop Movement upon Inhibitor Binding. J. Biol. Chem. 2011 286
18836460 Schilling S et al.: Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimers disease-like pathology. Nat. Med. 2008 14: 1106-1111
19342064 Shenk JC et al.: The effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimers disease J. Neurol. Sci. 2009 283: 199-206
20385883 Gu Y et al.: Food combination and Alzheimer disease risk: a protective diet Arch. Neurol. 2010 67: 699-706
20627092 Yamada K et al.: Effect of a centrally active angiotensin-converting enzyme inhibitor, perindopril, on cognitive performance in a mouse model of Alzheimers disease. Brain Res. 2010 1352: 176-186
20971085 Shi JQ et al.: Anti-TNF-alpha reduces amyloid plaques and tau phosphorylation and induces CD11c-positive dendritic-like cell in the APP/PS1 transgenic mouse brains. Brain Res. 2011 1368: 239-247
18926603 Julien C et al.: High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model. Neurobiol. Aging 2010 31: 1516-1531
19604602 DOnofrio M et al.: Early inflammation and immune response mRNAs in the brain of AD11 anti-NGF mice. Neurobiol. Aging 2011 32: 1007-1022
16813604 Akomolafe A et al.: Genetic association between endothelial nitric oxide synthase and Alzheimer disease Clin. Genet. 2006 70: 49-56
21127294 Austin SA et al.: Endothelial nitric oxide modulates expression and processing of amyloid precursor protein. Circ. Res. 2010 107: 1498-1502
19604603 Portelius E et al.: A novel pathway for amyloid precursor protein processing Neurobiol. Aging 2011 32: 1090-1098
19604604 Liu RM et al.: Knockout of plasminogen activator inhibitor 1 gene reduces amyloid beta peptide burden in a mouse model of Alzheimers disease. Neurobiol. Aging 2011 32: 1079-1089
19628305 Amadoro G et al.: Endogenous Abeta causes cell death via early tau hyperphosphorylation. Neurobiol. Aging 2011 32: 969-990
17534003 Gliebus G et al.: The influence of beta-blockers on delayed memory function in people with cognitive impairment. Am J Alzheimers Dis Other Demen 2007 22: 57-61
19805638 Takeda S et al.: Angiotensin receptor blocker prevented beta-amyloid-induced cognitive impairment associated with recovery of neurovascular coupling. Hypertension 2009 54: 1345-1352
21633502 Bigalke B et al.: Adipocytokines and CD34 Progenitor Cells in Alzheimers Disease. PLoS ONE 2011 6
21297254 Mateos L et al.: Upregulation of brain renin angiotensin system by 27-hydroxycholesterol in Alzheimers disease J. Alzheimers Dis. 2011 24: 669-679
21368380 Fiala M et al.: MGAT3 mRNA: a biomarker for prognosis and therapy of Alzheimers disease by vitamin D and curcuminoids J. Alzheimers Dis. 2011 25: 135-144
21157028 Gelber RP et al.: Coffee intake in midlife and risk of dementia and its neuropathologic correlates. J. Alzheimers Dis. 2011 23: 607-615
21321396 Carrasquillo MM et al.: Replication of BIN1 association with Alzheimers disease and evaluation of genetic interactions J. Alzheimers Dis. 2011 24: 751-758
21132329 Belbin O et al.: Investigation of 15 of the top candidate genes for late-onset Alzheimers disease. Hum. Genet. 2011 129: 273-282
21098976 Keller L et al.: The obesity related gene, FTO, interacts with APOE, and is associated with Alzheimers disease risk: a prospective cohort study J. Alzheimers Dis. 2011 23: 461-469
21321400 Tiribuzi R et al.: Lysosomal beta-galactosidase and beta-hexosaminidase activities correlate with clinical stages of dementia associated with Alzheimers disease and type 2 diabetes mellitus J. Alzheimers Dis. 2011 24: 785-797
21321389 Echeverria V et al.: Cotinine reduces amyloid-beta aggregation and improves memory in Alzheimers disease mice J. Alzheimers Dis. 2011 24: 817-835
20413858 Carlsson CM et al.: Type 2 diabetes mellitus, dyslipidemia, and Alzheimers disease. J. Alzheimers Dis. 2010 20: 711-722
18376061 Carlsson CM et al.: Effects of simvastatin on cerebrospinal fluid biomarkers and cognition in middle-aged adults at risk for Alzheimers disease. J. Alzheimers Dis. 2008 13: 187-197
21536132 Butterfield DA et al.: Cholesterol-independent neuroprotective and neurotoxic activities of statins: perspectives for statin use in Alzheimer disease and other age-related neurodegenerative disorders Pharmacol. Res. 2011 64: 180-186
20847439 Murphy MP et al.: Changes in cognition and amyloid-beta processing with long term cholesterol reduction using atorvastatin in aged dogs. J. Alzheimers Dis. 2010 22: 135-150
21345168 Heneka MT et al.: Molecular mechanisms and therapeutic application of NSAIDs and derived compounds in Alzheimers disease. Curr Alzheimer Res 2011 8: 115-131
20639188 Gulaj E et al.: Kynurenine and its metabolites in Alzheimers disease patients Adv Med Sci 2010 55: 204-211
17049675 Urbanelli L et al.: Cathepsin D expression is decreased in Alzheimers disease fibroblasts. Neurobiol. Aging 2008 29: 12-22
21416488 Green KN et al.: ST101 induces a novel 17 kDa APP cleavage that precludes Abeta generation in vivo. Ann. Neurol. 2011 69: 831-844
11786245 Sly LM et al.: Endogenous brain cytokine mRNA and inflammatory responses to lipopolysaccharide are elevated in the Tg2576 transgenic mouse model of Alzheimers disease. Brain Res. Bull. 2001 56: 581-588
21466683 Kok EH et al.: CLU, CR1 and PICALM genes associate with Alzheimers-related senile plaques. Alzheimers Res Ther 2011 3: 12
21391232 Chibnik LB et al.: CR1 is associated with amyloid plaque burden and age-related cognitive decline. Ann. Neurol. 2011 69: 560-569
16515786 Pedersen WA et al.: Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice Exp. Neurol. 2006 199: 265-273
21280074 Chu J et al.: 5-lipoxygenase as an endogenous modulator of amyloid beta formation in vivo. Ann. Neurol. 2011 69: 34-46
21280075 Reitz C et al.: SORCS1 alters amyloid precursor protein processing and variants may increase Alzheimers disease risk. Ann. Neurol. 2011 69: 47-64
21321391 Fragkouli A et al.: Matrix metalloproteinase-9 participates in NGF-induced alpha-secretase cleavage of amyloid-beta protein precursor in PC12 cells J. Alzheimers Dis. 2011 24: 705-719
21416485 Jayadev S et al.: Familial prion disease with Alzheimer disease-like tau pathology and clinical phenotype. Ann. Neurol. 2011 69: 712-720
21504563 Piette F et al.: Masitinib as an adjunct therapy for mild-to-moderate Alzheimers disease: a randomised, placebo-controlled phase 2 trial. Alzheimers Res Ther 2011 3: 16
21406112 Li B et al.: Stem cell factor and granulocyte colony-stimulating factor reduce beta-amyloid deposits in the brains of APP/PS1 transgenic mice. Alzheimers Res Ther 2011 3: 8
21193043 Barone E et al.: Long-term high-dose atorvastatin decreases brain oxidative and nitrosative stress in a preclinical model of Alzheimer disease: a novel mechanism of action Pharmacol. Res. 2011 63: 172-180
21335656 Perez-Gonzalez R et al.: Leptin induces proliferation of neuronal progenitors and neuroprotection in a mouse model of Alzheimers disease. J. Alzheimers Dis. 2011 24: 17-25
21633390 Garwood CJ et al.: Astrocytes are important mediators of Abeta-induced neurotoxicity and tau phosphorylation in primary culture. Cell Death Dis 2011 2: E167
21527912 Kumar S et al.: Extracellular phosphorylation of the amyloid beta-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimers disease. EMBO J. 2011 30: 2255-2265
21562267 Terwel D et al.: Critical role of astroglial apolipoprotein E and liver X receptor-alpha expression for microglial Abeta phagocytosis. J. Neurosci. 2011 31: 7049-7059
21817177 Yanagisawa K et al.: [Newly approved drugs for Alzheimer disease: effectiveness and limitation]. Brain Nerve 2011 63: 863-868
19694182 Wang B et al.: Schisandrin B protects rat cortical neurons against Abeta1-42-induced neurotoxicity. Pharmazie 2009 64: 450-454
21037121 Starkstein SE et al.: Anosognosia is a significant predictor of apathy in Alzheimers disease. J Neuropsychiatry Clin Neurosci 2010 22: 378-383
20808100 Orfei MD et al.: Anosognosia in mild cognitive impairment and mild Alzheimers disease: frequency and neuropsychological correlates. Am J Geriatr Psychiatry 2010 18: 1133-1140
20555149 Sedaghat F et al.: Brain SPECT findings of anosognosia in Alzheimers disease. J. Alzheimers Dis. 2010 21: 641-647
20188013 Leicht H et al.: Anosognosia in Alzheimers disease: the role of impairment levels in assessment of insight across domains. J Int Neuropsychol Soc 2010 16: 463-473
17361039 Jacob CP et al.: Alterations in expression of glutamatergic transporters and receptors in sporadic Alzheimers disease. J. Alzheimers Dis. 2007 11: 97-116
21211392 Lei JK et al.: [Change of serum ACTH and cortisol levels in Alzheimer disease and mild cognition impairment]. Zhonghua Yi Xue Za Zhi 2010 90: 2894-2896
20937084 Fleisher-Berkovich S et al.: Distinct modulation of microglial amyloid beta phagocytosis and migration by neuropeptides (i). J Neuroinflammation 2010 7: 61
21387370 Himeno E et al.: Apomorphine treatment in Alzheimer mice promoting amyloid-beta degradation. Ann. Neurol. 2011 69: 248-256
21448224 Di Paolo G et al.: Linking lipids to Alzheimers disease: cholesterol and beyond. Nat. Rev. Neurosci. 2011 12: 284-296
21147981 Oliveira TG et al.: Phospholipase d2 ablation ameliorates Alzheimers disease-linked synaptic dysfunction and cognitive deficits. J. Neurosci. 2010 30
21357679 Chapuis J et al.: Growth arrest-specific 1 binds to and controls the maturation and processing of the amyloid-beta precursor protein Hum. Mol. Genet. 2011 20: 2026-2036
19196476 Prinzen C et al.: Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice. BMC Genomics 2009 10: 66
21672962 Rolyan H et al.: Telomere shortening reduces Alzheimers disease amyloid pathology in mice. Brain 2011 134: 2044-2056
21389082 Casas-Tinto S et al.: The ER stress factor XBP1s prevents amyloid-beta neurotoxicity. Hum. Mol. Genet. 2011 20: 2144-2160
18276079 Clement AB et al.: Effects of neuron-specific ADAM10 modulation in an in vivo model of acute excitotoxic stress. Neuroscience 2008 152: 459-468
17722071 Shimmyo Y et al.: Multifunction of myricetin on A beta: neuroprotection via a conformational change of A beta and reduction of A beta via the interference of secretases. J. Neurosci. Res. 2008 86: 368-377
20592218 Mitterreiter S et al.: Bepridil and amiodarone simultaneously target the Alzheimers disease beta- and gamma-secretase via distinct mechanisms. J. Neurosci. 2010 30: 8974-8983
18391946 Berman DE et al.: Oligomeric amyloid-beta peptide disrupts phosphatidylinositol-4,5-bisphosphate metabolism Nat. Neurosci. 2008 11: 547-554
19109907 OConnor T et al.: Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis. Neuron 2008 60: 988-1009
20492361 Xu J et al.: Actin interaction and regulation of cyclin-dependent kinase 5/p35 complex activity J. Neurochem. 2011 116: 192-204
20348102 Lammich S et al.: Expression of the anti-amyloidogenic secretase ADAM10 is suppressed by its 5-untranslated region. J. Biol. Chem. 2010 285
20427278 Ullrich S et al.: The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein. J. Biol. Chem. 2010 285
21955788 Zhang L et al.: Identifying Tmem59 related gene regulatory network of mouse neural stem cell from a compendium of expression profiles. BMC Syst Biol 2011 5: 152
21413990 Lichtenthaler SF et al.: Regulated intramembrane proteolysis--lessons from amyloid precursor protein processing. J. Neurochem. 2011 117: 779-796
21695060 Hogl S et al.: Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and gamma-secretase. PLoS ONE 2011 6
20676056 Kuhn PH et al.: ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons. EMBO J. 2010 29: 3020-3032
21460840 Hollingworth P et al.: Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimers disease Nat. Genet. 2011 43: 429-435
19879754 Baumann S et al.: NSAID-derived gamma-secretase modulators. Part III: Membrane anchoring. Bioorg. Med. Chem. Lett. 2009 19: 6986-6990
21689411 Ferris SH et al.: Analyzing the impact of 23 mg/day donepezil on language dysfunction in moderate to severe Alzheimers disease. Alzheimers Res Ther 2011 3: 22
19552690 Lu P et al.: Silibinin prevents amyloid beta peptide-induced memory impairment and oxidative stress in mice Br. J. Pharmacol. 2009 157: 1270-1277
12714508 Hundhausen C et al.: The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion Blood 2003 102: 1186-1195
21881209 Krohn M et al.: Cerebral amyloid-beta proteostasis is regulated by the membrane transport protein ABCC1 in mice J. Clin. Invest. 2011 121: 3924-3931
21035623 Craig-Schapiro R et al.: YKL-40: a novel prognostic fluid biomarker for preclinical Alzheimers disease. Biol. Psychiatry 2010 68: 903-912
16371011 Glatz DC et al.: The alternative splicing of tau exon 10 and its regulatory proteins CLK2 and TRA2-BETA1 changes in sporadic Alzheimers disease. J. Neurochem. 2006 96: 635-644
21470964 Qian W et al.: Regulation of the alternative splicing of tau exon 10 by SC35 and Dyrk1A. Nucleic Acids Res. 2011 39: 6161-6171
21281635 Jung HJ et al.: Increased expression of three-repeat isoforms of tau contributes to tau pathology in a rat model of chronic type 2 diabetes. Exp. Neurol. 2011 228: 232-241
21367856 Shi J et al.: Cyclic AMP-dependent protein kinase regulates the alternative splicing of tau exon 10: a mechanism involved in tau pathology of Alzheimer disease. J. Biol. Chem. 2011 286
21807765 Smith PY et al.: MicroRNA-132 loss is associated with tau exon 10 inclusion in progressive supranuclear palsy. Hum. Mol. Genet. 2011 20: 4016-4024
20930824 author information missing article information missing
16943417 Wu JY et al.: SRp54 (SFRS11), a regulator for tau exon 10 alternative splicing identified by an expression cloning strategy. Mol. Cell. Biol. 2006 26: 6739-6747
15972296 Prinzen C et al.: Genomic structure and functional characterization of the human ADAM10 promoter. FASEB J. 2005 19: 1522-1524
19608551 Kim M et al. et al.: Potential late-onset Alzheimers disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity Hum. Mol. Genet. 2009 18: 3987-3996
19498037 Rodriguez-Martin T et al.: Correction of tau mis-splicing caused by FTDP-17 MAPT mutations by spliceosome-mediated RNA trans-splicing Hum. Mol. Genet. 2009 18: 3266-3273
2181826 Godfrey DG et al.: The distribution, relationships and identification of enzymic variants within the subgenus Trypanozoon. Adv. Parasitol. 1990 29: 1-74
16777844 Kar A et al.: RBM4 interacts with an intronic element and stimulates tau exon 10 inclusion. J. Biol. Chem. 2006 281
21333649 Qian W et al.: Splicing factor SC35 promotes tau expression through stabilization of its mRNA. FEBS Lett. 2011 585: 875-880
20615469 Chen KL et al.: Amyloid-beta peptide alteration of tau exon-10 splicing via the GSK3beta-SC35 pathway Neurobiol. Dis. 2010 40: 378-385
19502709 Kooistra J et al.: A new function of human HtrA2 as an amyloid-beta oligomerization inhibitor. J. Alzheimers Dis. 2009 17: 281-294
21365281 Gutierrez-Lopez MD et al.: The sheddase activity of ADAM17/TACE is regulated by the tetraspanin CD9. Cell. Mol. Life Sci. 2011 68: 3275-3292
20194618 Ohe K et al.: HMGA1a trapping of U1 snRNP at an authentic 5 splice site induces aberrant exon skipping in sporadic Alzheimers disease. Mol. Cell. Biol. 2010 30: 2220-2228
11193153 Fahrenholz F et al.: Alpha-secretase activity of the disintegrin metalloprotease ADAM 10. Influences of domain structure. Ann. N. Y. Acad. Sci. 2000 920: 215-222
21799908 Pietrzak M et al.: Epigenetic silencing of nucleolar rRNA genes in Alzheimers disease. PLoS ONE 2011 6
21835916 Wilkinson K et al.: A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36. J. Biol. Chem. 2011 286
15695522 Wang Y et al.: Tau exons 2 and 10, which are misregulated in neurodegenerative diseases, are partly regulated by silencers which bind a SRp30c.SRp55 complex that either recruits or antagonizes htra2beta1. J. Biol. Chem. 2005 280
22278060 Israel MA et al.: Probing sporadic and familial Alzheimers disease using induced pluripotent stem cells Nature 2012 482: 216-220
15615629 Andreadis A et al.: Tau gene alternative splicing: expression patterns, regulation and modulation of function in normal brain and neurodegenerative diseases. Biochim. Biophys. Acta 2005 1739: 91-103
21114897 Radenahmad N et al.: Young coconut juice, a potential therapeutic agent that could significantly reduce some pathologies associated with Alzheimers disease: novel findings. Br. J. Nutr. 2011 105: 738-746
21492498 Barak Y et al.: Escitalopram versus risperidone for the treatment of behavioral and psychotic symptoms associated with Alzheimers disease: a randomized double-blind pilot study Int Psychogeriatr 2011 23: 1515-1519
15890777 Zhou S et al.: CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimers disease amyloid beta-peptide production. Proc. Natl. Acad. Sci. U.S.A. 2005 102: 7499-7504
21343338 Kar A et al.: RNA helicase p68 (DDX5) regulates tau exon 10 splicing by modulating a stem-loop structure at the 5 splice site. Mol. Cell. Biol. 2011 31: 1812-1821
21902456 Hedskog L et al.: Strategic role for mitochondria in Alzheimers disease and cancer Antioxid. Redox Signal. 2012 16: 1476-1491
21707856 Kato K et al.: Protein kinase C stabilizes X-linked inhibitor of apoptosis protein (XIAP) through phosphorylation at Ser(87) to suppress apoptotic cell death. Psychogeriatrics 2011 11: 90-97
21054783 Hedskog L et al.: gamma-Secretase complexes containing caspase-cleaved presenilin-1 increase intracellular Abeta(42) /Abeta(40) ratio. J. Cell. Mol. Med. 2011 15: 2150-2163
19389700 Quintanilla RA et al.: Caspase-cleaved tau expression induces mitochondrial dysfunction in immortalized cortical neurons: implications for the pathogenesis of Alzheimer disease J. Biol. Chem. 2009 284
22079237 Alldred MJ et al.: Microarray analysis of CA1 pyramidal neurons in a mouse model of tauopathy reveals progressive synaptic dysfunction Neurobiol. Dis. 2012 45: 751-762
20570249 Yang H et al.: Amelioration of the Alzheimers disease phenotype by absence of 12/15-lipoxygenase Biol. Psychiatry 2010 68: 922-929
21900234 Bate C et al.: Amyloid-beta-induced synapse damage is mediated via cross-linkage of cellular prion proteins. J. Biol. Chem. 2011 286
21715329 Xue Y et al.: Crystal structure of the E2 domain of amyloid precursor protein-like protein 1 in complex with sucrose octasulfate. J. Biol. Chem. 2011 286
22101739 Samy AS et al.: Regulation of IL-1beta-induced cyclooxygenase-2 expression by interactions of Abeta peptide, apolipoprotein E and nitric oxide in human neuroglioma J. Mol. Neurosci. 2012 47: 533-545
21795680 Griffiths HH et al.: Prion protein interacts with BACE1 protein and differentially regulates its activity toward wild type and Swedish mutant amyloid precursor protein. J. Biol. Chem. 2011 286
19671904 Scarmeas N et al.: Physical activity, diet, and risk of Alzheimer disease. JAMA 2009 302: 627-637
20009056 Lieb W et al.: Association of plasma leptin levels with incident Alzheimer disease and MRI measures of brain aging. JAMA 2009 302: 2565-2572
19887909 Kellett KA et al.: Prion protein and Alzheimer disease. Prion 2009 3: 190-194
20819221 Bitel CL et al.: Increased expression and local accumulation of the prion protein, Alzheimer Abeta peptides, superoxide dismutase 1, and nitric oxide synthases 1 & 2 in muscle in a rabbit model of diabetes. BMC Physiol. 2010 10: 18
22072713 Murakami K et al.: SOD1 (copper/zinc superoxide dismutase) deficiency drives amyloid beta protein oligomerization and memory loss in mouse model of Alzheimer disease J. Biol. Chem. 2011 286
21694453 Novak P et al.: Tauons and prions: infamous cousins? J. Alzheimers Dis. 2011 26: 413-430
20473510 Reiniger L et al.: Tau, prions and Abeta: the triad of neurodegeneration Acta Neuropathol. 2011 121: 5-20
22100763 Kudo W et al.: Cellular prion protein is essential for oligomeric amyloid-beta-induced neuronal cell death. Hum. Mol. Genet. 2012 21: 1138-1144
22028219 Jucker M et al.: Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders. Ann. Neurol. 2011 70: 532-540
22017494 Rosen RF et al.: Exogenous seeding of cerebral beta-amyloid deposition in betaAPP-transgenic rats J. Neurochem. 2012 120: 660-666
21699076 Szymanski P et al.: Design, synthesis and biological evaluation of new 2-benzoxazolinone derivatives as potential cholinesterase inhibitors for therapy of alzheimers disease Pharmazie 2011 66: 399-403
20598287 Grimmer T et al.: Progression of cerebral amyloid load is associated with the apolipoprotein E epsilon4 genotype in Alzheimers disease Biol. Psychiatry 2010 68: 879-884
20400860 Khalifa NB et al.: What is the role of amyloid precursor protein dimerization Cell Adh Migr 2010 4: 268-272
17050537 Kuan YH et al.: PAT1a modulates intracellular transport and processing of amyloid precursor protein (APP), APLP1, and APLP2 J. Biol. Chem. 2006 281
16230627 Rodriguez-Martin T et al.: Reprogramming of tau alternative splicing by spliceosome-mediated RNA trans-splicing: implications for tauopathies Proc. Natl. Acad. Sci. U.S.A. 2005 102
22077634 Sheng B et al.: Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimers disease J. Neurochem. 2012 120: 419-429
19273754 Qin W et al.: PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia Arch. Neurol. 2009 66: 352-361
21255795 Zhang Y et al.: The -1082G/A polymorphism in IL-10 gene is associated with risk of Alzheimers disease: a meta-analysis J. Neurol. Sci. 2011 303: 133-138
20479757 Conejero-Goldberg C et al.: Molecular signatures in post-mortem brain tissue of younger individuals at high risk for Alzheimers disease as based on APOE genotype Mol. Psychiatry 2011 16: 836-847
17998437 Li H et al.: Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease Arch. Neurol. 2008 65: 45-53
17684015 Huttunen HJ et al.: HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation J. Biol. Chem. 2007 282
18292081 Kotilinek LA et al.: Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity Brain 2008 131: 651-664
19943124 Rothman SM et al.: Adverse stress, hippocampal networks, and Alzheimers disease Neuromolecular Med. 2010 12: 56-70
22275252 Chu J et al.: Transcriptional regulation of beta-secretase-1 by 12/15-lipoxygenase results in enhanced amyloidogenesis and cognitive impairments Ann. Neurol. 2012 71: 57-67
18021299 Tachida Y et al.: Interleukin-1 beta up-regulates TACE to enhance alpha-cleavage of APP in neurons: resulting decrease in Abeta production J. Neurochem. 2008 104: 1387-1393
18587388 Yuzwa SA et al.: A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo Nat. Chem. Biol. 2008 4: 483-490
17940659 Dias WB et al.: O-GlcNAc modification in diabetes and Alzheimers disease Mol Biosyst 2007 3: 766-772
19122823 Bajic VP et al.: Is the time dimension of the cell cycle re-entry in AD regulated by centromere cohesion dynamics Biosci Hypotheses 2008 1: 156-161
15974909 Ringman JM et al.: A potential role of the curry spice curcumin in Alzheimers disease Curr Alzheimer Res 2005 2: 131-136
18815129 Ono K et al.: Effects of grape seed-derived polyphenols on amyloid beta-protein self-assembly and cytotoxicity J. Biol. Chem. 2008 283
18032783 Nixon RA et al.: Autophagy, amyloidogenesis and Alzheimer disease J. Cell. Sci. 2007 120: 4081-4091
21968187 Klug W et al.: Phosphorylation of LRP1 regulates the interaction with Fe65 FEBS Lett. 2011 585: 3229-3235
16195917 Mikol J et al.: Extensive cortico-subcortical lesions in Wilsons disease: clinico-pathological study of two cases Acta Neuropathol. 2005 110: 451-458
22264991 Chen R et al.: Elevation of serum TNF-alpha levels in mild and moderate Alzheimer patients with daytime sleepiness J. Neuroimmunol. 2012 244: 97-102
22349686 Spalletta G et al.: Anosognosia and neuropsychiatric symptoms and disorders in mild Alzheimer disease and mild cognitive impairment J. Alzheimers Dis. 2012 29: 761-772
21129451 Jardanhazi-Kurutz D et al.: Distinct adrenergic system changes and neuroinflammation in response to induced locus ceruleus degeneration in APP/PS1 transgenic mice Neuroscience 2011 176: 396-407
11470313 Strausak D et al.: Copper in disorders with neurological symptoms: Alzheimers, Menkes, and Wilson diseases Brain Res. Bull. 2001 55: 175-185
20493925 Song H et al.: Association between haplotype -88G/25G in A2M with Alzheimers disease Neurosci. Lett. 2010 479: 143-145
9697696 Blacker D et al.: Alpha-2 macroglobulin is genetically associated with Alzheimer disease Nat. Genet. 1998 19: 357-360
21216965 Chen WT et al.: Distinct effects of Zn2+, Cu2+, Fe3+, and Al3+ on amyloid-beta stability, oligomerization, and aggregation: amyloid-beta destabilization promotes annular protofibril formation J. Biol. Chem. 2011 286: 9646-9656
16236446 Deary IJ et al.: Polymorphisms in the gene encoding 11B-hydroxysteroid dehydrogenase type 1 (HSD11B1) and lifetime cognitive change Neurosci. Lett. 2006 393: 74-77
14583441 de Quervain DJ et al.: Glucocorticoid-related genetic susceptibility for Alzheimers disease Hum. Mol. Genet. 2004 13: 47-52
11257240 Rasmuson S et al.: Increased glucocorticoid production and altered cortisol metabolism in women with mild to moderate Alzheimers disease Biol. Psychiatry 2001 49: 547-552
20157240 Souza-Talarico JN et al.: Relationship between cortisol levels and memory performance may be modulated by the presence or absence of cognitive impairment: evidence from healthy elderly, mild cognitive impairment and Alzheimers disease subjects J. Alzheimers Dis. 2010 19: 839-848
22660329 Nussbaum JM et al.: Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-beta Nature 2012 485: 651-655
22654059 Barrett PJ et al.: The amyloid precursor protein has a flexible transmembrane domain and binds cholesterol Science 2012 336: 1168-1171
18482978 Tolia A et al.: Transmembrane domain 9 of presenilin determines the dynamic conformation of the catalytic site of gamma-secretase J. Biol. Chem. 2008 283
20871650 Shawkatova I et al.: No association between cytokine gene polymorphism and risk of Alzheimers disease in Slovaks Acta Neurobiol Exp (Wars) 2010 70: 303-307
22178568 Fang M et al.: The miR-124 regulates the expression of BACE1/beta-secretase correlated with cell death in Alzheimers disease Toxicol. Lett. 2012 209: 94-105
18096514 Lee MR et al.: Inhibition of APP intracellular domain (AICD) transcriptional activity via covalent conjugation with Nedd8 Biochem. Biophys. Res. Commun. 2008 366: 976-981
22506131 Borquez DA et al.: The amyloid precursor protein intracellular domain-fe65 multiprotein complexes: a challenge to the amyloid hypothesis for Alzheimers disease Int J Alzheimers Dis 2012 2012
19282473 Stante M et al.: Fe65 is required for Tip60-directed histone H4 acetylation at DNA strand breaks Proc. Natl. Acad. Sci. U.S.A. 2009 106: 5093-5098
15331662 von Rotz RC et al.: The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor J. Cell. Sci. 2004 117: 4435-4448
22122663 Pardossi-Piquard R et al.: The physiology of the beta-amyloid precursor protein intracellular domain AICD J. Neurochem. 2012 120: 109-124
17093061 Muller T et al.: Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD) Mol. Biol. Cell 2007 18: 201-210
15708439 Caccamo A et al.: Age- and region-dependent alterations in Abeta-degrading enzymes: implications for Abeta-induced disorders Neurobiol. Aging 2005 26: 645-654
22563077 Maesako M et al.: Exercise Is More Effective than Diet Control in Preventing High Fat Diet-induced beta-Amyloid Deposition and Memory Deficit in Amyloid Precursor Protein Transgenic Mice J. Biol. Chem. 2012 287
22303443 Westin K et al.: CCL2 is associated with a faster rate of cognitive decline during early stages of Alzheimers disease PLoS ONE 2012 7
22805778 Hoshi A et al.: Characteristics of aquaporin expression surrounding senile plaques and cerebral amyloid angiopathy in Alzheimer disease J. Neuropathol. Exp. Neurol. 2012 71: 750-759
22801501 Jonsson T et al.: A mutation in APP protects against Alzheimers disease and age-related cognitive decline Nature 2012 488: 96-99
10742146 Lu DC et al.: A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor Nat. Med. 2000 6: 397-404
14557245 Chen Y et al.: APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimers disease brain J. Cell Biol. 2003 163: 27-33
12533840 Dil Kuazi A et al.: NEDD8 protein is involved in ubiquitinated inclusion bodies J. Pathol. 2003 199: 259-266
18801622 Guldiken S et al.: Subclinical Cushings syndrome is a potential cause of metabolic dementia and rapidly progressive Alzheimer-type dementia Med. Hypotheses 2008 71: 703-705
16125145 Elgh E et al.: Cognitive dysfunction, hippocampal atrophy and glucocorticoid feedback in Alzheimers disease Biol. Psychiatry 2006 59: 155-161
10722740 Chen Y et al.: The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons J. Biol. Chem. 2000 275: 8929-8935
21880910 Li X et al.: Neuronal production of transthyretin in human and murine Alzheimers disease: is it protective J. Neurosci. 2011 31
15192323 Chen YZ et al.: APP induces neuronal apoptosis through APP-BP1-mediated downregulation of beta-catenin Apoptosis 2004 9: 415-422
12777371 Weggen S et al.: Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain J. Biol. Chem. 2003 278
20689579 Ghosal K et al.: APP intracellular domain impairs adult neurogenesis in transgenic mice by inducing neuroinflammation PLoS ONE 2010 5
21958873 Paris D et al.: Anatabine lowers Alzheimers Abeta production in vitro and in vivo Eur. J. Pharmacol. 2011 670: 384-391
16973241 Carter CJ et al.: Convergence of genes implicated in Alzheimers disease on the cerebral cholesterol shuttle: APP, cholesterol, lipoproteins, and atherosclerosis Neurochem. Int. 2007 50: 12-38
22464332 Nakamura K et al.: Proline isomer-specific antibodies reveal the early pathogenic tau conformation in Alzheimers disease Cell 2012 149: 232-244
18587408 Faghihi MA et al.: Expression of a noncoding RNA is elevated in Alzheimers disease and drives rapid feed-forward regulation of beta-secretase Nat. Med. 2008 14: 723-730
22915175 Singh-Manoux A et al.: Obesity phenotypes in midlife and cognition in early old age: the Whitehall II cohort study Neurology 2012 79: 755-762
22796576 Eyles DW et al.: Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease Front Neuroendocrinol 2013 34: 47-64
22591405 Qiao DL et al.: Is vitamin D beneficial to Alzheimer disease? A surprising dilemma CNS Neurosci Ther 2012 18: 601-603
21486290 Webster SJ et al.: The acute effects of dimebolin, a potential Alzheimers disease treatment, on working memory in rhesus monkeys Br. J. Pharmacol. 2011 164: 970-978
22942647 Sozio P et al.: Transdermal donepezil on the treatment of Alzheimers disease Neuropsychiatr Dis Treat 2012 8: 361-368
21502597 Rafii MS et al.: A phase II trial of huperzine A in mild to moderate Alzheimer disease Neurology 2011 76: 1389-1394
22227962 Kummer MP et al.: Nitric oxide decreases the enzymatic activity of insulin degrading enzyme in APP/PS1 mice J Neuroimmune Pharmacol 2012 7: 165-172
22766135 Martins LC et al.: Disease-specific expression of the serotonin-receptor 5-HT(2C) in natural killer cells in Alzheimers dementia J. Neuroimmunol. 2012 251: 73-79
19072283 Owen JB et al.: Proteomics-determined differences in the concanavalin-A-fractionated proteome of hippocampus and inferior parietal lobule in subjects with Alzheimers disease and mild cognitive impairment: implications for progression of AD J. Proteome Res. 2009 8: 471-482
22801742 Doecke JD et al.: Blood-based protein biomarkers for diagnosis of Alzheimer disease Arch. Neurol. 2012 69: 1318-1325
22329649 Cai H et al.: Metabolic dysfunction in Alzheimers disease and related neurodegenerative disorders Curr Alzheimer Res 2012 9: 5-17
16843497 Rentzos M et al.: Interleukin-12 is reduced in cerebrospinal fluid of patients with Alzheimers disease and frontotemporal dementia J. Neurol. Sci. 2006 249: 110-114
23178247 Vom Berg J et al.: Inhibition of IL-12/IL-23 signaling reduces Alzheimers disease-like pathology and cognitive decline Nat. Med. 2012 18: 1812-1819
11137576 Szczepanik AM et al.: IL-4, IL-10 and IL-13 modulate A beta(1--42)-induced cytokine and chemokine production in primary murine microglia and a human monocyte cell line J. Neuroimmunol. 2001 113: 49-62
23157339 Arlt S et al.: Genetic risk factors for depression in Alzheimer`s disease patients Curr Alzheimer Res 2013 10: 72-81
22970774 Azizi G et al.: The potential role of proinflammatory and antiinflammatory cytokines in Alzheimer disease pathogenesis Immunopharmacol Immunotoxicol 2012 34: 881-895
19776284 Reed-Geaghan EG et al.: CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation J. Neurosci. 2009 29
21071836 Murata N et al.: Silymarin attenuated the amyloid beta plaque burden and improved behavioral abnormalities in an Alzheimers disease mouse model Biosci. Biotechnol. Biochem. 2010 74: 2299-2306
21185897 Yin F et al.: Silibinin: a novel inhibitor of Abeta aggregation Neurochem. Int. 2011 58: 399-403
22610069 Lehmann SM et al.: An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration Nat. Neurosci. 2012 15: 827-835
19464758 Srikanth V et al.: Advanced glycation endproducts and their receptor RAGE in Alzheimers disease Neurobiol. Aging 2011 32: 763-777
23393093 Mori K et al.: The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS Science 2013 339: 1335-1338
23352322 Cacace R et al.: C9orf72 G4C2 repeat expansions in Alzheimers disease and mild cognitive impairment Neurobiol. Aging 2013 34: 1712
23150934 Guerreiro R et al.: TREM2 variants in Alzheimers disease N. Engl. J. Med. 2013 368: 117-127
19484711 Oulhaj A et al.: Homocysteine as a predictor of cognitive decline in Alzheimers disease Int J Geriatr Psychiatry 2010 25: 82-90
9823829 Clarke R et al.: Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease Arch. Neurol. 1998 55: 1449-1455
22964832 Xi Z et al.: Investigation of c9orf72 in 4 neurodegenerative disorders Arch. Neurol. 2012 69: 1583-1590
16688597 Rota E et al.: Increased intrathecal TGF-beta1, but not IL-12, IFN-gamma and IL-10 levels in Alzheimers disease patients Neurol. Sci. 2006 27: 33-39
9147373 Xu S et al.: Increased incidence of anti-beta-amyloid autoantibodies secreted by Epstein-Barr virus transformed B cell lines from patients with Alzheimers disease Mech. Ageing Dev. 1997 94: 213-222
21857683 Deng HX et al.: Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia Nature 2011 477: 211-215
20074050 Haapasalo A et al.: Emerging role of Alzheimers disease-associated ubiquilin-1 in protein aggregation Biochem. Soc. Trans. 2010 38: 150-155
21966562 Haapasalo A et al.: Involvement of ubiquilin-1 transcript variants in protein degradation and accumulation Commun Integr Biol 2011 4: 428-432
23162743 Ma QL et al.: PAK in Alzheimer disease, Huntington disease and X-linked mental retardation Cell Logist 2012 2: 117-125
21852239 Stieren ES et al.: Ubiquilin-1 is a molecular chaperone for the amyloid precursor protein J. Biol. Chem. 2011 286
23204143 Yarchoan M et al.: Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias Brain 2012 135: 3749-3756
22745485 Kook SY et al.: Abeta(1)(-)(4)(2)-RAGE interaction disrupts tight junctions of the blood-brain barrier via Ca(2)(+)-calcineurin signaling J. Neurosci. 2012 32: 8845-8854
23208281 Ashe KH et al.: Prions, prionoids and pathogenic proteins in Alzheimer disease Prion 2013 7: 55-59
21969301 Bakalash S et al.: Egr1 expression is induced following glatiramer acetate immunotherapy in rodent models of glaucoma and Alzheimers disease Invest. Ophthalmol. Vis. Sci. 2011 52: 9033-9046
23667698 Takasugi N et al.: FTY720/Fingolimod, a Sphingosine Analogue, Reduces Amyloid-beta Production in Neurons PLoS ONE 2013 8
15923191 Tamboli IY et al.: Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide J. Biol. Chem. 2005 280
20110603 Rojo LE et al.: Selective interaction of lansoprazole and astemizole with tau polymers: potential new clinical use in diagnosis of Alzheimers disease J. Alzheimers Dis. 2010 19: 573-589
10226937 Baran H et al.: Kynurenine metabolism in Alzheimers disease J Neural Transm 1999 106: 165-181
17017544 Nemeth H et al.: Kynurenines, Parkinsons disease and other neurodegenerative disorders: preclinical and clinical studies J. Neural Transm. Suppl. 2006 70: 285-304
21538537 De Deyn PP et al.: Tolerability of extended-release quetiapine fumarate compared with immediate-release quetiapine fumarate in older patients with Alzheimers disease with symptoms of psychosis and/or agitation: a randomised, double-blind, parallel-group study Int J Geriatr Psychiatry 2012 27: 296-304
15465626 Walter A et al.: Glycerophosphocholine is elevated in cerebrospinal fluid of Alzheimer patients Neurobiol. Aging 2004 25: 1299-1303
16227558 Serot JM et al.: Homocysteine and methylmalonic acid concentrations in cerebrospinal fluid: relation with age and Alzheimers disease J. Neurol. Neurosurg. Psychiatr. 2005 76: 1585-1587
23365075 Browne TC et al.: IFN-gamma Production by amyloid beta-specific Th1 cells promotes microglial activation and increases plaque burden in a mouse model of Alzheimers disease J. Immunol. 2013 190: 2241-2251
19199127 Leoni V et al.: Oxysterols as markers of neurological disease--a review Scand. J. Clin. Lab. Invest. 2009 69: 22-25
11027840 Bretillon L et al.: Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases Neurosci. Lett. 2000 293: 87-90
23666171 Leoni V et al.: Diagnostic power of 24S-hydroxycholesterol in cerebrospinal fluid: candidate marker of brain health J. Alzheimers Dis. 2013 36: 739-747
23285020 Hosokawa M et al.: Methylene blue reduced abnormal tau accumulation in P301L tau transgenic mice PLoS ONE 2012 7
23435411 Lira-De Leon KI et al.: Molecular mechanism of tau aggregation induced by anionic and cationic dyes J. Alzheimers Dis. 2013 35: 319-334
23443659 Crowe A et al.: Aminothienopyridazines and methylene blue affect Tau fibrillization via cysteine oxidation J. Biol. Chem. 2013 288
23653592 Xie L et al.: Methylene blue induces macroautophagy through 5 adenosine monophosphate-activated protein kinase pathway to protect neurons from serum deprivation Front Cell Neurosci 2013 7: 56
22377780 Hughes TM et al.: Markers of cholesterol metabolism in the brain show stronger associations with cerebrovascular disease than Alzheimers disease J. Alzheimers Dis. 2012 30: 53-61
20158567 Nilsson P et al.: Gene therapy in Alzheimers disease - potential for disease modification J. Cell. Mol. Med. 2010 14: 741-757
21383512 Mori K et al.: Effects of Hericium erinaceus on amyloid beta(25-35) peptide-induced learning and memory deficits in mice Biomed. Res. 2011 32: 67-72
18758067 Mori K et al.: Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells Biol. Pharm. Bull. 2008 31: 1727-1732
22078238 Costa A et al.: Galanin and alpha-MSH autoantibodies in cerebrospinal fluid of patients with Alzheimers disease J. Neuroimmunol. 2011 240-241: 114-120
21399480 Lauterbach EC et al.: Psychotropic drug effects on gene transcriptomics relevant to Alzheimer disease Alzheimer Dis Assoc Disord 2012 26: 1-7
23935582 Mariani S et al.: Effects of hemochromatosis and transferrin gene mutations on peripheral iron dyshomeostasis in mild cognitive impairment and Alzheimers and Parkinsons diseases Front Aging Neurosci 2013 5: 37
17234346 Salins P et al.: Lovastatin protects human neurons against Abeta-induced toxicity and causes activation of beta-catenin-TCF/LEF signaling Neurosci. Lett. 2007 412: 211-216
22654722 Heneka MT et al.: Impact and Therapeutic Potential of PPARs in Alzheimers Disease Curr Neuropharmacol 2011 9: 643-650
10078972 Pradier L et al.: Mapping the APP/presenilin (PS) binding domains: the hydrophilic N-terminus of PS2 is sufficient for interaction with APP and can displace APP/PS1 interaction Neurobiol. Dis. 1999 6: 43-55
24270855 Han J et al.: OCIAD2 activates gamma-secretase to enhance amyloid beta production by interacting with nicastrin Cell. Mol. Life Sci. 2014 71: 2561-2576
11740561 Kamal A et al.: Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP Nature 2001 414: 643-648
21298039 Gatta V et al.: Microarray analysis on human neuroblastoma cells exposed to aluminum, beta(1-42)-amyloid or the beta(1-42)-amyloid aluminum complex PLoS ONE 2011 6
24780254 Laurent C et al.: Beneficial effects of caffeine in a transgenic model of Alzheimers disease-like tau pathology Neurobiol. Aging 2014 35: 2079-2090
11278378 Kihara T et al.: alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity J. Biol. Chem. 2001 276
10681545 Wang HY et al.: beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimers disease pathology J. Biol. Chem. 2000 275: 5626-5632
24123152 Zhang L et al.: Tyrosine phosphatase STEP61 negatively regulates amyloid beta-mediated ERK/CREB signaling pathways via alpha7 nicotinic acetylcholine receptors J. Neurosci. Res. 2013 91: 1581-1590
23810791 Sokolov AN et al.: Chocolate and the brain: neurobiological impact of cocoa flavanols on cognition and behavior Neurosci Biobehav Rev 2013 37: 2445-2453
21982844 Williams RJ et al.: Flavonoids, cognition, and dementia: actions, mechanisms, and potential therapeutic utility for Alzheimer disease Free Radic. Biol. Med. 2012 52: 35-45
24511465 Robin NC et al.: Simvastatin Promotes Adult Hippocampal Neurogenesis by Enhancing Wnt/beta-Catenin Signaling Stem Cell Reports 2013 2: 9-17
16230462 Ryan KA et al.: Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain J. Cell Biol. 2005 171: 327-335
18070361 Chen Y et al.: Amyloid precursor protein modulates beta-catenin degradation J Neuroinflammation 2007 4: 29
18234671 Magdesian MH et al.: Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling J. Biol. Chem. 2008 283: 9359-9368
25878270 Kan MJ et al.: Arginine deprivation and immune suppression in a mouse model of Alzheimers disease J. Neurosci. 2015 15: 5969-5982
25502766 Sun Y et al.: Translational study of Alzheimers disease (AD) biomarkers from brain tissues in AbetaPP/PS1 mice and serum of AD patients J. Alzheimers Dis. 2015 45: 269-282
22406198 Kim YH et al.: Proteomic analysis of plasma from a Tau transgenic mouse Int. J. Dev. Neurosci. 2012 30: 277-283
21912965 Boda E et al.: Brain expression of Kv3 subunits during development, adulthood and aging and in a murine model of Alzheimers disease J. Mol. Neurosci. 2012 3: 606-615
15485486 Angulo E et al.: Up-regulation of the Kv3.4 potassium channel subunit in early stages of Alzheimers disease J. Neurochem. 2004 3: 547-557
18449908 Poduslo SE et al.: Genome screen of late-onset Alzheimers extended pedigrees identifies TRPC4AP by haplotype analysis Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009 1: 50-55
21116278 Furney SJ et al.: Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimers disease Mol. Psychiatry 2011 16: 1130-1138
26458046 Mainz A et al.: The chaperone alphaB-crystallin uses different interfaces to capture an amorphous and an amyloid client
26033219 Cecarini V et al.: Effects of Ghrelin on the Proteolytic Pathways of Alzheimers Disease Neuronal Cells
25998028 Folch J et al.: The role of leptin in the sporadic form of Alzheimers disease. Interactions with the adipokines amylin, ghrelin and the pituitary hormone prolactin Life Sci. 2015 140: 19-28
23595620 Hokama M et al.: Altered expression of diabetes-related genes in Alzheimers disease brains: the Hisayama study Cereb. Cortex 2014 24: 2476-2488
26515689 Lin CL et al.: Amyloid-beta suppresses AMP-activated protein kinase (AMPK) signaling and contributes to alpha-synuclein-induced cytotoxicity Exp. Neurol. 2016 275: 84-98
22367557 Cai Z et al.: Roles of AMP-activated protein kinase in Alzheimers disease Neuromolecular Med. 2012 14: 1-14
26250687 Goedert M et al.: NEURODEGENERATION. Alzheimers and Parkinsons diseases: The prion concept in relation to assembled Abeta, tau, and alpha-synuclein Science 2015 349
22746245 Nunes MA et al.: Microdose lithium treatment stabilized cognitive impairment in patients with Alzheimers disease Curr Alzheimer Res 2013 10: 104-107
23246577 Lee E et al.: Effect of conjugated linoleic acid, mu-calpain inhibitor, on pathogenesis of Alzheimers disease Biochim. Biophys. Acta 2013 1831: 709-718
9848094 Torp R et al.: GADD45 is induced in Alzheimers disease, and protects against apoptosis in vitro Neurobiol. Dis. 1998 5: 245-252
28035934 author information missing article information missing
28111074 Huang YA et al.: ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Abeta Secretion Cell 2017 168: 427-441.e21
25328986 Phillips MC et al.: Apolipoprotein E isoforms and lipoprotein metabolism IUBMB Life 2014 66: 616-623
11408727 Dupuy AM et al.: The relationship between apolipoprotein E4 and lipid metabolism is impaired in Alzheimers disease Gerontology 2001 47: 213-218
25280473 Ashbrook DG et al.: Joint genetic analysis of hippocampal size in mouse and human identifies a novel gene linked to neurodegenerative disease BMC Genomics 2014 15: 850
24456642 Couttas TA et al.: Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimers disease pathogenesis Acta Neuropathol Commun 2014 2: 9
10416513 Caramelli P et al.: Increased apolipoprotein B serum concentration in Alzheimers disease Acta Neurol. Scand. 1999 100: 61-63
24470773 Mielke MM et al.: Clinical epidemiology of Alzheimers disease: assessing sex and gender differences Clin Epidemiol 2014 6: 37-48
28240269 Suhre K et al. et al.: Connecting genetic risk to disease end points through the human blood plasma proteome Nat Commun 2017 8: 14357
21841246 Mosconi L et al.: Reduced mitochondria cytochrome oxidase activity in adult children of mothers with Alzheimers disease J. Alzheimers Dis. 2011 27: 483-490
25633671 Hull J et al.: Regional Increase in the Expression of the BCAT Proteins in Alzheimers Disease Brain: Implications in Glutamate Toxicity J. Alzheimers Dis. 2015 45: 891-905
26983404 Gallart-Palau X et al.: Gender differences in white matter pathology and mitochondrial dysfunction in Alzheimers disease with cerebrovascular disease Mol Brain 2016 9: 27
26969397 Riedel BC et al.: Age, APOE and sex: Triad of risk of Alzheimers disease J. Steroid Biochem. Mol. Biol. 2016 160: 134-147
28107809 Kitamura Y et al.: Plasma protein profiling for potential biomarkers in the early diagnosis of Alzheimers disease Neurol. Res. 2017 39: 231-238
17077142 Wang JM et al.: Activation of estrogen receptor alpha increases and estrogen receptor beta decreases apolipoprotein E expression in hippocampus in vitro and in vivo Proc. Natl. Acad. Sci. U.S.A. 2006 103
24444806 Panizzon MS et al.: Interaction of APOE genotype and testosterone on episodic memory in middle-aged men Neurobiol. Aging 2014 35: 1778
21423873 Elliott DA et al.: Apolipoproteins in the brain: implications for neurological and psychiatric disorders Clin Lipidol 2010 51: 555-573
14741101 DeMattos RB et al.: ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo Neuron 2004 41: 193-202
9547226 Stone DJ et al.: Increased synaptic sprouting in response to estrogen via an apolipoprotein E-dependent mechanism: implications for Alzheimers disease J. Neurosci. 1998 18: 3180-3185
22701550 Song F et al.: Plasma apolipoprotein levels are associated with cognitive status and decline in a community cohort of older individuals PLoS ONE 2012 7
18395206 Raber J et al.: AR, apoE, and cognitive function Horm Behav 2008 53: 706-715
0 author information missing article information missing
28248224 Martins IJ et al.: The Role of Clinical Proteomics, Lipidomics, and Genomics in the Diagnosis of Alzheimers Disease
7737971 Hamazaki H et al.: Ca(2+)-dependent binding of human serum amyloid P component to Alzheimers beta-amyloid peptide J. Biol. Chem. 1995 270
12214001 Kindy MS et al.: Apolipoprotein Serum Amyloid A in Alzheimers Disease J. Alzheimers Dis. 1999 1: 155-167
10329371 Chauhan VP et al.: Binding of gelsolin, a secretory protein, to amyloid beta-protein Biochem. Biophys. Res. Commun. 1999 258: 241-246
26980008 Ashby EL et al.: Altered Expression of Human Mitochondrial Branched Chain Aminotransferase in Dementia with Lewy Bodies and Vascular Dementia Neurochem. Res. 2017 42: 306-319
28261376 Griffin JW et al.: Amino Acid Catabolism in Alzheimers Disease Brain: Friend or Foe? }, authors { names std { { name ml Griffin JW, affil str Department of Biomedical Sciences, East Tennessee State University College of Medicine, Johnson City, TN 37614, USA Oxid Med Cell Longev 2017 2017
28298292 Chang TY et al.: Cellular cholesterol homeostasis and Alzheimers disease J. Lipid Res. 2017 58: 2239-2254
27634977 Pistollato F et al.: Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease Nutr. Rev. 2016 74: 624-634
18657226 Ryu JK et al.: A leaky blood-brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimers disease brain J. Cell. Mol. Med. 2009 13: 2911-2925
19863188 Roher AE et al.: Proteomics-derived cerebrospinal fluid markers of autopsy-confirmed Alzheimers disease Biomarkers 2009 14: 493-501
22883744 Cudaback E et al.: Apolipoprotein C-I is an APOE genotype-dependent suppressor of glial activation J Neuroinflammation 2012 9: 192
25938590 Fonteh AN et al.: Sphingolipid metabolism correlates with cerebrospinal fluid Beta amyloid levels in Alzheimers disease PLoS ONE 2015 10
28697566 Johansson P et al.: Reduced Cerebrospinal Fluid Concentration of Apolipoprotein A-I in Patients with Alzheimers Disease
24952994 Mielke MM et al.: Cerebrospinal fluid sphingolipids, beta-amyloid, and tau in adults at risk for Alzheimers disease Neurobiol. Aging 2014 35: 2486-2494
23868911 Fonteh AN et al.: Alterations in cerebrospinal fluid glycerophospholipids and phospholipase A2 activity in Alzheimers disease J. Lipid Res. 2013 54: 2884-2897
22521584 Kosicek M et al.: Elevated cerebrospinal fluid sphingomyelin levels in prodromal Alzheimers disease Neurosci. Lett. 2012 516: 302-305
22835784 van Echten-Deckert G et al.: Sphingolipids: critical players in Alzheimers disease Prog. Lipid Res. 2012 51: 378-393
20953867 Kosicek M et al.: Nano-HPLC-MS analysis of phospholipids in cerebrospinal fluid of Alzheimers disease patients--a pilot study Anal Bioanal Chem 2010 398: 2929-2937
20452460 Haughey NJ et al.: Roles for dysfunctional sphingolipid metabolism in Alzheimers disease neuropathogenesis Biochim. Biophys. Acta 2010 1801: 878-886
20110596 Martin V et al.: Lipid alterations in lipid rafts from Alzheimers disease human brain cortex J. Alzheimers Dis. 2010 19: 489-502
18547682 He X et al.: Deregulation of sphingolipid metabolism in Alzheimers disease Neurobiol. Aging 2010 31: 398-408
17342407 Katsel P et al.: Gene expression alterations in the sphingolipid metabolism pathways during progression of dementia and Alzheimers disease: a shift toward ceramide accumulation at the earliest recognizable stages of Alzheimers disease? }, authors { names std { { name ml Katsel P, affil str Department of Psychiatry, The Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6575, USA. pavel.katsel@mssm.edu }, { name ml Li C }, { name ml Haroutunian V } } }, from journal { title { iso-jta Neurochem. Res Neurochem. Res. 2007 32: 845-856
7699335 Mucke L et al.: Protection against HIV-1 gp120-induced brain damage by neuronal expression of human amyloid precursor protein J. Exp. Med. 1995 181: 1551-1556
14970312 Cutler RG et al.: Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimers disease Proc. Natl. Acad. Sci. U.S.A. 2004 101: 2070-2075
14748735 Alessenko AV et al.: Connection of lipid peroxide oxidation with the sphingomyelin pathway in the development of Alzheimers disease Biochem. Soc. Trans. 2004 32: 144-146
12358786 Han X et al.: Substantial sulfatide deficiency and ceramide elevation in very early Alzheimers disease: potential role in disease pathogenesis J. Neurochem. 2002 82: 809-818
19036474 Barrier L et al.: Gender-dependent accumulation of ceramides in the cerebral cortex of the APP(SL)/PS1Ki mouse model of Alzheimers disease Neurobiol. Aging 2010 31: 1843-1853
28341160 Toledo JB et al.: Metabolic network failures in Alzheimers disease-A biochemical road map
17888544 Bandaru VV et al.: ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimers but not normal brain Neurobiol. Aging 2009 30: 591-599
24368217 Kunzler J et al.: APOE modulates the effect of estrogen therapy on Abeta accumulation EFAD-Tg mice Neurosci. Lett. 2014 560: 131-136
24486621 Panchal M et al.: Ceramides and sphingomyelinases in senile plaques Neurobiol. Dis. 2014 65: 193-201
17064658 Park JH et al.: Acid ceramidase and human disease Biochim. Biophys. Acta 2006 1758: 2133-2138
26708713 Moser VA et al.: Obesity and sex interact in the regulation of Alzheimers disease Neurosci Biobehav Rev 2016 67: 102-118
24468113 Ceccom J et al.: Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimers disease Acta Neuropathol Commun 2014 2: 12
15610181 Huang Y et al.: Elevation of the level and activity of acid ceramidase in Alzheimers disease brain Eur. J. Neurosci. 2004 20: 3489-3497
20409323 Lorenzen A et al.: Rapid and direct transport of cell surface APP to the lysosome defines a novel selective pathway Mol Brain 2010 3: 11
14709545 Lee JT et al.: Amyloid-beta peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway J. Cell Biol. 2004 164: 123-131
23779114 Hanson AJ et al.: Effect of apolipoprotein E genotype and diet on apolipoprotein E lipidation and amyloid peptides: randomized clinical trial JAMA Neurol 2013 70: 972-980
21125201 Doruk H et al.: The relationship between body mass index and incidental mild cognitive impairment, Alzheimers disease and vascular dementia in elderly J Nutr Health Aging 2010 14: 834-838
26198711 Grimm A et al.: Sex hormone-related neurosteroids differentially rescue bioenergetic deficits induced by amyloid-beta or hyperphosphorylated tau protein Cell. Mol. Life Sci. 2016 73: 201-215
18295935 Schaeffer V et al.: Dose-dependent and sequence-sensitive effects of amyloid-beta peptide on neurosteroidogenesis in human neuroblastoma cells Neurochem. Int. 2008 52: 948-955
27163830 Kantarci K et al.: Early Postmenopausal Transdermal 17beta-Estradiol Therapy and Amyloid-beta Deposition J. Alzheimers Dis. 2016 53: 547-556
25443293 Dionisio PA et al.: Amyloid-beta pathology is attenuated by tauroursodeoxycholic acid treatment in APP/PS1 mice after disease onset Neurobiol. Aging 2015 36: 228-240
20569235 Jazwinski SM et al.: HRAS1 and LASS1 with APOE are associated with human longevity and healthy aging Aging Cell 2010 9: 698-708
28035926 den Hoedt S et al.: Pleiotropic Effect of Human ApoE4 on Cerebral Ceramide and Saturated Fatty Acid Levels
22470521 Grimm MO et al.: Amyloid precursor protein (APP) mediated regulation of ganglioside homeostasis linking Alzheimers disease pathology with ganglioside metabolism PLoS ONE 2012 7
21543615 Takasugi N et al.: BACE1 activity is modulated by cell-associated sphingosine-1-phosphate J. Neurosci. 2011 31: 6850-6857
28301062 Enche Ady CNA et al.: Metabolomic-guided discovery of Alzheimers disease biomarkers from body fluid J. Neurosci. Res. 2017 95: 2005-2024
15084661 Kawarabayashi T et al.: Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimers disease J. Neurosci. 2004 24: 3801-3809
18096814 Williamson R et al.: Membrane-bound beta-amyloid oligomers are recruited into lipid rafts by a fyn-dependent mechanism FASEB J. 2008 22: 1552-1559
20739292 Lefterov I et al.: Apolipoprotein A-I deficiency increases cerebral amyloid angiopathy and cognitive deficits in APP/PS1DeltaE9 mice J. Biol. Chem. 2010 285
27033548 Hong S et al.: Complement and microglia mediate early synapse loss in Alzheimer mouse models Science 2016 352: 712-716
18048067 Walker DG et al.: Human postmortem brain-derived cerebrovascular smooth muscle cells express all genes of the classical complement pathway: a potential mechanism for vascular damage in cerebral amyloid angiopathy and Alzheimers disease Microvasc. Res. 2008 75: 411-419
7575468 Munger JS et al.: Lysosomal processing of amyloid precursor protein to A beta peptides: a distinct role for cathepsin S Biochem. J. 1995 311: 299-305
11004532 Oyama R et al.: Glutamine synthetase, hemoglobin alpha-chain, and macrophage migration inhibitory factor binding to amyloid beta-protein: their identification in rat brain by a novel affinity chromatography and in Alzheimers disease brain by immunoprecipitation Biochim. Biophys. Acta 2000 1479: 91-102
25206748 Zhou X et al.: Lipid rafts participate in aberrant degradative autophagic-lysosomal pathway of amyloid-beta peptide in Alzheimers disease Neural Regen Res 2014 9: 92-100
16480949 Chen TY et al.: The intracellular domain of amyloid precursor protein interacts with flotillin-1, a lipid raft protein Biochem. Biophys. Res. Commun. 2006 342: 266-272
27814578 Canerina-Amaro A et al.: Lipid raft ER signalosome malfunctions in menopause and Alzheimers disease Front Biosci (Schol Ed) 2017 9: 111-126
2207271 Colombo MF et al.: Hydration-dependent conformational states of hemoglobin. Equilibrium and kinetic behavior Biophys. Chem. 1990 36: 33-39
9354781 author information missing Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition Nat. Genet. 1997 17: 263-264
22737128 Hicks DA et al.: Lipid rafts and Alzheimers disease: protein-lipid interactions and perturbation of signaling Front Physiol 2012 3: 189
24625793 Tiwari V et al.: Pyruvate carboxylase and pentose phosphate fluxes are reduced in AbetaPP-PS1 mouse model of Alzheimers disease: a (1)(3)C NMR study J. Alzheimers Dis. 2014 41: 387-399
18539594 Osenkowski P et al.: Direct and potent regulation of gamma-secretase by its lipid microenvironment J. Biol. Chem. 2008 283
20798852 Bjerke M et al.: Confounding factors influencing amyloid Beta concentration in cerebrospinal fluid
20961856 Belyaev ND et al.: The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a {beta}-secretase-dependent pathway J. Biol. Chem. 2010 285
19028695 Cheng H et al.: S-palmitoylation of gamma-secretase subunits nicastrin and APH-1 J. Biol. Chem. 2009 284: 1373-1384
29211722 Sorrentino V et al.: Enhancing mitochondrial proteostasis reduces amyloid-beta proteotoxicity
26680489 Vankova M et al.: Reduced sulfotransferase SULT2A1 activity in patients with Alzheimers disease Physiol Res 2015 64: Suppl 2 S265-S273
26704533 Vankova M et al.: Preliminary evidence of altered steroidogenesis in women with Alzheimers disease: Have the patients OLDER adrenal zona reticularis? }, authors { names std { { name ml Vankova M, affil str Institute of Endocrinology, Narodni 8, Prague 116 94, Czech Republic. Electronic address: mvankova@endo.cz J. Steroid Biochem. Mol. Biol. 2016 158: 157-177
11427315 Schonknecht P et al.: Reduced cerebrospinal fluid estradiol levels are associated with increased beta-amyloid levels in female patients with Alzheimers disease Neurosci. Lett. 2001 307: 122-124
19186121 Davis CH et al.: Interaction between amyloid-beta (1-42) peptide and phospholipid bilayers: a molecular dynamics study Biophys. J. 2009 96: 785-797
16721824 Kim SI et al.: Amyloid beta oligomerization is induced by brain lipid rafts J. Cell. Biochem. 2006 99: 878-889
15718041 Pitto M et al.: Enhanced GM1 ganglioside catabolism in cultured fibroblasts from Alzheimer patients Neurobiol. Aging 2005 26: 833-838
22146133 Aly HF et al.: Neuroprotective effects of dehydroepiandrosterone (DHEA) in rat model of Alzheimers disease Acta Biochim. Pol. 2011 58: 513-520
28377712 Xia DY et al.: PGC-1alpha or FNDC5 Is Involved in Modulating the Effects of Abeta1-42 Oligomers on Suppressing the Expression of BDNF, a Beneficial Factor for Inhibiting Neuronal Apoptosis, Abeta Deposition and Cognitive Decline of APP/PS1 Tg Mice Front Aging Neurosci 2017 9: 65
26334640 Cieslik M et al.: The Molecular Mechanism of Amyloid beta42 Peptide Toxicity: The Role of Sphingosine Kinase-1 and Mitochondrial Sirtuins PLoS ONE 2015 10
29249916 Marksteiner J et al.: Bile acid quantification of 20 plasma metabolites identifies lithocholic acid as a putative biomarker in Alzheimers disease Metabolomics 2018 14: 1
11551970 Mathews PM et al.: Alzheimers disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Abeta secretion: role for altered lysosomal hydrolase distribution in beta-amyloidogenesis J. Biol. Chem. 2002 277: 5299-5307
16399207 Kar S et al.: Cellular distribution of insulin-like growth factor-II/mannose-6-phosphate receptor in normal human brain and its alteration in Alzheimers disease pathology Neurobiol. Aging 2006 27: 199-210
26993302 Wang Y et al.: Insulin-Like Growth Factor-II/Cation-Independent Mannose 6-Phosphate Receptor in Neurodegenerative Diseases Mol. Neurobiol. 2017 54: 2636-2658
20050287 Martins IJ et al.: Cholesterol metabolism and transport in the pathogenesis of Alzheimers disease J. Neurochem. 2009 111: 1275-1308
28941727 Fernandez-de Retana S et al.: Intravenous treatment with human recombinant ApoA-I Milano reduces beta amyloid cerebral deposition in the APP23-transgenic mouse model of Alzheimers disease Neurobiol. Aging 2017 60: 116-128
26923602 Ben Halima S et al.: Specific Inhibition of beta-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein Cell Rep 2016 14: 2127-2141
27333034 Letronne F et al.: ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimers Disease EBioMedicine 2016 9: 278-292
27396345 Becker-Pauly C et al.: Mice are not Men: ADAM30 Findings Emphasize a Broader Look Towards Murine Alzheimers Disease Models EBioMedicine 2016 9: 19-20
18177262 Schechter I et al.: Kinetic properties of cathepsin D and BACE 1 indicate the need to search for additional beta-secretase candidate(s) Biol. Chem. 2008 389: 313-320
11741391 Petit-Turcotte C et al.: Apolipoprotein C-I expression in the brain in Alzheimers disease Neurobiol. Dis. 2001 8: 953-963
10828089 Demeester N et al.: Characterization and functional studies of lipoproteins, lipid transfer proteins, and lecithin:cholesterol acyltransferase in CSF of normal individuals and patients with Alzheimers disease J. Lipid Res. 2000 41: 963-974
20413849 Kim WS et al.: Increased ATP-binding cassette transporter A1 expression in Alzheimers disease hippocampal neurons J. Alzheimers Dis. 2010 21: 193-205
17361034 Strum JC et al.: Rosiglitazone induces mitochondrial biogenesis in mouse brain J. Alzheimers Dis. 2007 11: 45-51
26117841 Abdullah MM et al.: Nutrigenetics of cholesterol metabolism: observational and dietary intervention studies in the postgenomic era Nutr. Rev. 2015 73: 523-543
29115990 Martiskainen H et al.: DHCR24 exerts neuroprotection upon inflammation-induced neuronal death J Neuroinflammation 2017 14: 215
26628388 Hernandez-Jimenez M et al.: Seladin-1/DHCR24 Is Neuroprotective by Associating EAAT2 Glutamate Transporter to Lipid Rafts in Experimental Stroke Stroke 2016 47: 206-213
22910610 Feher A et al.: Gender dependent effect of DHCR24 polymorphism on the risk for Alzheimers disease Neurosci. Lett. 2012 526: 20-23
15954227 Peri A et al.: Seladin-1 as a target of estrogen receptor activation in the brain: a new gene for a rather old story? }, authors { names std { { name ml Peri A, affil str Department of Clinical Physiopathology, Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies, University of Florence, Italy. a.peri@dfc.unifi.it }, { name ml Danza G }, { name ml Serio M } } }, from journal { title { iso-jta J. Endocrinol. Invest J. Endocrinol. Invest. 2005 28: 285-293
19597241 Drzewinska J et al.: [Seladin-1/DHCR24: a key protein of cell homeostasis and cholesterol biosynthesis] Postepy Hig Med Dosw (Online) 2009 63: 318-330
18194465 Cecchi C et al.: Seladin-1/DHCR24 protects neuroblastoma cells against Abeta toxicity by increasing membrane cholesterol content J. Cell. Mol. Med. 2008 12: 1990-2002
20061018 Alberdi E et al.: Amyloid beta oligomers induce Ca2+ dysregulation and neuronal death through activation of ionotropic glutamate receptors Cell Calcium 2010 47: 264-272
25339759 Shibuya Y et al.: Inhibiting ACAT1/SOAT1 in microglia stimulates autophagy-mediated lysosomal proteolysis and increases Abeta1-42 clearance J. Neurosci. 2014 34
29559883 Marin R et al.: Estrogen Interactions With Lipid Rafts Related to Neuroprotection. Impact of Brain Ageing and Menopause Front Neurosci 2018 12: 128
25168729 Fernandez-Echevarria C et al.: Abeta promotes VDAC1 channel dephosphorylation in neuronal lipid rafts. Relevance to the mechanisms of neurotoxicity in Alzheimers disease Neuroscience 2014 278: 354-366
28102888 Chen LH et al.: Genetic Polymorphisms in Estrogen Metabolic Pathway Associated with Risks of Alzheimers Disease: Evidence from a Southern Chinese Population J Am Geriatr Soc 2017 65: 332-339
27541017 Li Q et al.: miR-98-5p Acts as a Target for Alzheimers Disease by Regulating Abeta Production Through Modulating SNX6 Expression J. Mol. Neurosci. 2016 60: 413-420
23872114 Chua LM et al.: The Kunitz-protease inhibitor domain in amyloid precursor protein reduces cellular mitochondrial enzymes expression and function Biochem. Biophys. Res. Commun. 2013 437: 642-647
15882808 Thakur MK et al.: Estradiol regulates APP mRNA alternative splicing in the mice brain cortex Neurosci. Lett. 2005 381: 154-157
15357665 Feng Z et al.: Long-term effects of melatonin or 17 beta-estradiol on improving spatial memory performance in cognitively impaired, ovariectomized adult rats J. Pineal Res. 2004 37: 198-206
9223340 Xia W et al.: Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease Proc. Natl. Acad. Sci. U.S.A. 1997 94: 8208-8213
28731435 Hong H et al.: Identification of Circulating miR-125b as a Potential Biomarker of Alzheimers Disease in APP/PS1 Transgenic Mouse J. Alzheimers Dis. 2017 59: 1449-1458
26497032 Ren RJ et al.: Peripheral Blood MicroRNA Expression Profiles in Alzheimers Disease: Screening, Validation, Association with Clinical Phenotype and Implications for Molecular Mechanism Mol. Neurobiol. 2016 53: 5772-5781
8239286 Higgins LS et al.: Transgenic mice expressing human beta-APP751, but not mice expressing beta-APP695, display early Alzheimers disease-like histopathology Ann. N. Y. Acad. Sci. 1993 695: 224-227
20417581 Ishunina TA et al.: Decreased alternative splicing of estrogen receptor-alpha mRNA in the Alzheimers disease brain Neurobiol. Aging 2012 33: 286-296.e3
29869871 DelBove CE et al.: The Fate of Nascent APP in Hippocampal Neurons: A Live Cell Imaging Study
2111579 Johnson SA et al.: Relation of neuronal APP-751/APP-695 mRNA ratio and neuritic plaque density in Alzheimers disease Science 1990 248: 854-857
2881207 author information missing The precursor of Alzheimers disease amyloid A4 protein resembles a cell-surface receptor Nature 1987 325: 733-736
23684647 Nalivaeva NN et al.: The amyloid precursor protein: a biochemical enigma in brain development, function and disease FEBS Lett. 2013 587: 2046-2054
25695604 Shu R et al. et al.: APP intracellular domain acts as a transcriptional regulator of miR-663 suppressing neuronal differentiation Cell Death Dis 2015 6: e1651
21172309 Long JM et al.: MicroRNA-101 downregulates Alzheimers amyloid-beta precursor protein levels in human cell cultures and is differentially expressed Biochem. Biophys. Res. Commun. 2011 404: 889-895
22733824 Long JM et al.: MicroRNA-153 physiologically inhibits expression of amyloid-beta precursor protein in cultured human fetal brain cells and is dysregulated in a subset of Alzheimer disease patients J. Biol. Chem. 2012 287
11441186 Cao X et al.: A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60 Science 2001 293: 115-120
21293490 Xu X et al.: Mediator is a transducer of amyloid-precursor-protein-dependent nuclear signalling EMBO Rep. 2011 12: 216-222
10718932 Bowen RL et al.: An association of elevated serum gonadotropin concentrations and Alzheimer disease? J. Neuroendocrinol. 2000 12: 351-354
11560301 Short RA et al.: Elevated gonadotropin levels in patients with Alzheimer disease Mayo Clin. Proc. 2001 76: 906-909
12391612 Bowen RL et al.: Elevated luteinizing hormone expression colocalizes with neurons vulnerable to Alzheimers disease pathology J. Neurosci. Res. 2002 70: 514-518
21368841 Turner AJ et al.: Mediator: the missing link in amyloid precursor protein nuclear signalling EMBO Rep. 2011 12: 180-181
15886752 Tsolaki M et al.: Serum estradiol, progesterone, testosterone, FSH and LH levels in postmenopausal women with Alzheimers dementia Hell J Nucl Med 2005 8: 39-42
26895791 Sajan M et al.: Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1alpha and Increases in Abeta1-40/42 and Phospho-Tau May Abet Alzheimer Development Diabetes 2016 65: 1892-1903
24832605 Wang X et al.: FoxO mediates APP-induced AICD-dependent cell death Cell Death Dis 2014 5: e1233
19478482 Corbo RM et al.: Genetic variation of CYP19 (aromatase) gene influences age at onset of Alzheimers disease in women Dement Geriatr Cogn Disord 2009 27: 513-518
21297427 Erten-Lyons D et al.: Microcephaly genes and risk of late-onset Alzheimer disease Alzheimer Dis Assoc Disord 2011 25: 276-282
24567336 Akhter R et al.: The essential role of p53-up-regulated modulator of apoptosis (Puma) and its regulation by FoxO3a transcription factor in beta-amyloid-induced neuron death J. Biol. Chem. 2014 289
12600719 Ueberham U et al.: Cyclin C expression is involved in the pathogenesis of Alzheimers disease Neurobiol. Aging 2003 24: 427-435
26455863 Fluteau A et al.: The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain Neurosci. Lett. 2015 609: 11-17
21354436 Herrera JL et al.: Estradiol and tamoxifen differentially regulate a plasmalemmal voltage-dependent anion channel involved in amyloid-beta induced neurotoxicity Steroids 2011 76: 840-844
27507672 Oikonomidi A et al.: Homocysteine metabolism is associated with cerebrospinal fluid levels of soluble amyloid precursor protein and amyloid beta J. Neurochem. 2016 139: 324-332
8624099 Sandbrink R et al.: APP gene family. Alternative splicing generates functionally related isoforms Ann. N. Y. Acad. Sci. 1996 777: 281-287
21865747 Corbo RM et al.: Influence of variation in the follicle-stimulating hormone receptor gene (FSHR) and age at menopause on the development of Alzheimers disease in women Dement Geriatr Cogn Disord 2011 32: 63-69
28538088 Koenig AM et al.: Effects of the Insulin Sensitizer Metformin in Alzheimer Disease: Pilot Data From a Randomized Placebo-controlled Crossover Study Alzheimer Dis Assoc Disord 2017 31: 107-113
21839813 Yenkoyan K et al.: Neuroprotective action of proline-rich polypeptide-1 in beta-amyloid induced neurodegeneration in rats Brain Res. Bull. 2011 86: 262-271
9202320 Keller JN et al.: Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid beta-peptide: role of the lipid peroxidation product 4-hydroxynonenal J. Neurochem. 1997 69: 273-284
29055815 An Y et al. et al.: Evidence for brain glucose dysregulation in Alzheimers disease Alzheimers Dement 2018 14: 318-329
17023091 Hartai Z et al.: Decreased serum and red blood cell kynurenic acid levels in Alzheimers disease Neurochem. Int. 2007 50: 308-313
19595769 Ramirez CM et al.: VDAC and ERalpha interaction in caveolae from human cortex is altered in Alzheimers disease Mol. Cell. Neurosci. 2009 42: 172-183
20053478 Zhao L et al.: 17beta-Estradiol regulates insulin-degrading enzyme expression via an ERbeta/PI3-K pathway in hippocampus: relevance to Alzheimers prevention Neurobiol. Aging 2011 32: 1949-1963
10213152 Kamboh MI et al.: A novel mutation in the apolipoprotein E gene (APOE*4 Pittsburgh) is associated with the risk of late-onset Alzheimers disease Neurosci. Lett. 1999 263: 129-132
20547867 Chen Y et al.: ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling Proc. Natl. Acad. Sci. U.S.A. 2010 107
27103636 Sweet RA et al. et al.: Apolipoprotein E*4 (APOE*4) Genotype Is Associated with Altered Levels of Glutamate Signaling Proteins and Synaptic Coexpression Networks in the Prefrontal Cortex in Mild to Moderate Alzheimer Disease Mol. Cell Proteomics 2016 15: 2252-2262
10801051 Trioche P et al.: Apolipoprotein E polymorphism and serum concentrations in patients with glycogen storage disease type Ia J. Inherit. Metab. Dis. 2000 23: 107-112
2935594 author information missing Loss of endoplasmic reticulum-associated enzymes in affected brain regions in Huntingtons disease and Alzheimer-type dementia J. Neurol. Sci. 1985 71: 137-143
27392855 Bangen KJ et al.: Interaction Between Midlife Blood Glucose and APOE Genotype Predicts Later Alzheimers Disease Pathology J. Alzheimers Dis. 2016 53: 1553-1562
27328687 Yamazaki Y et al.: Apolipoprotein E as a Therapeutic Target in Alzheimers Disease: A Review of Basic Research and Clinical Evidence CNS Drugs 2016 30: 773-789
29946028 Prasad H et al.: Amyloid clearance defect in ApoE4 astrocytes is reversed by epigenetic correction of endosomal pH Proc. Natl. Acad. Sci. U.S.A. 2018 115
25561733 Prasad H et al.: The Na+/H+ exchanger NHE6 modulates endosomal pH to control processing of amyloid precursor protein in a cell culture model of Alzheimer disease J. Biol. Chem. 2015 290: 5311-5327
30337151 MahmoudianDehkordi S et al. et al.: Altered bile acid profile associates with cognitive impairment in Alzheimers disease-An emerging role for gut microbiome
23340677 Schousboe A et al.: Glutamate metabolism in the brain focusing on astrocytes Adv Neurobiol 2014 11: 13-30
29476033 Ekblad LL et al.: Midlife insulin resistance, APOE genotype, and late-life brain amyloid accumulation Neurology 2018 90
20452985 Munter LM et al.: Aberrant amyloid precursor protein (APP) processing in hereditary forms of Alzheimer disease caused by APP familial Alzheimer disease mutations can be rescued by mutations in the APP GxxxG motif J. Biol. Chem. 2010 285
26402005 Keeney JT et al.: Human ApoE Isoforms Differentially Modulate Glucose and Amyloid Metabolic Pathways in Female Brain: Evidence of the Mechanism of Neuroprotection by ApoE2 and Implications for Alzheimers Disease Prevention and Early Intervention J. Alzheimers Dis. 2015 48: 411-424
30032423 Uddin MS et al.: APOE and Alzheimers Disease: Evidence Mounts that Targeting APOE4 may Combat Alzheimers Pathogenesis Mol. Neurobiol. 2019 56: 2450-2465
30134963 Yi D et al.: Synergistic interaction between APOE and family history of Alzheimers disease on cerebral amyloid deposition and glucose metabolism Alzheimers Res Ther 2018 10: 84
28934977 Chhibber A et al.: ERbeta and ApoE isoforms interact to regulate BDNF-5-HT2A signaling and synaptic function in the female brain Alzheimers Res Ther 2017 9: 79
28272510 Johnson LA et al.: Apolipoprotein E4 and Insulin Resistance Interact to Impair Cognition and Alter the Epigenome and Metabolome Sci Rep 2017 7: 43701
28434655 Zhao N et al.: Apolipoprotein E, Receptors, and Modulation of Alzheimers Disease Biol. Psychiatry 2018 83: 347-357
29967007 Wu L et al.: Human ApoE Isoforms Differentially Modulate Brain Glucose and Ketone Body Metabolism: Implications for Alzheimers Disease Risk Reduction and Early Intervention J. Neurosci. 2018 38: 6665-6681
14966149 Mosconi L et al.: Brain metabolic decreases related to the dose of the ApoE e4 allele in Alzheimers disease J. Neurol. Neurosurg. Psychiatry 2004 75: 370-376
30337152 Nho K et al. et al.: Altered bile acid profile in mild cognitive impairment and Alzheimers disease: Relationship to neuroimaging and CSF biomarkers
30441866 Giau VV et al.: Gut Microbiota and Their Neuroinflammatory Implications in Alzheimers Disease
30182854 Junges VM et al.: Crosstalk between Gut Microbiota and Central Nervous System: A Focus on Alzheimers Disease Curr Alzheimer Res 2018 15: 1179-1190
27604604 Kohler CA et al.: The Gut-Brain Axis, Including the Microbiome, Leaky Gut and Bacterial Translocation: Mechanisms and Pathophysiological Role in Alzheimers Disease Curr. Pharm. Des. 2016 22: 6152-6166
28937600 Del Rio D et al.: The Gut Microbial Metabolite Trimethylamine-N-Oxide Is Present in Human Cerebrospinal Fluid
30138667 de J R De-Paula V et al.: Relevance of gutmicrobiota in cognition, behaviour and Alzheimers disease Pharmacol. Res. 2018 136: 29-34
27255810 Ciavardelli D et al.: Medium-chain plasma acylcarnitines, ketone levels, cognition, and gray matter volumes in healthy elderly, mildly cognitively impaired, or Alzheimers disease subjects Neurobiol. Aging 2016 43: 1-12
27566465 Hu X et al.: Alzheimers disease and gut microbiota Sci China Life Sci 2016 59: 1006-1023
22392034 Wang CC et al.: The role of PGC-1 and Apoepsilon4 in insomnia Psychiatr. Genet. 2012 22: 82-87
19749434 Cimini A et al.: Early biochemical and morphological modifications in the brain of a transgenic mouse model of Alzheimers disease: a role for peroxisomes J. Alzheimers Dis. 2009 18: 935-952
29758946 Zhuang ZQ et al. et al.: Gut Microbiota is Altered in Patients with Alzheimers Disease J. Alzheimers Dis. 2018 63: 1337-1346
28461186 Fan YY et al.: APOE epsilon4 allele elevates the expressions of inflammatory factors and promotes Alzheimers disease progression: A comparative study based on Han and She populations in the Wenzhou area Brain Res. Bull. 2017 132: 39-43
24990149 Guedes JR et al.: Early miR-155 upregulation contributes to neuroinflammation in Alzheimers disease triple transgenic mouse model Hum. Mol. Genet. 2014 23: 6286-6301
21377451 Zhou J et al.: Paeonol increases levels of cortical cytochrome oxidase and vascular actin and improves behavior in a rat model of Alzheimers disease Brain Res. 2011 1388: 141-147
29627302 Zhao H et al.: Inhibitive Effect of Resveratrol on the Inflammation in Cultured Astrocytes and Microglia Induced by Abeta1-42 Neuroscience 2018 379: 390-404
24145446 Theendakara V et al. et al.: Neuroprotective Sirtuin ratio reversed by ApoE4 Proc. Natl. Acad. Sci. U.S.A. 2013 110
29575030 Bauerl C et al.: Shifts in gut microbiota composition in an APP/PSS1 transgenic mouse model of Alzheimers disease during lifespan Lett. Appl. Microbiol. 2018 66: 464-471
29051531 Vogt NM et al.: Gut microbiome alterations in Alzheimers disease Sci Rep 2017 7: 13537
19631758 Reiman EM et al.: Higher serum total cholesterol levels in late middle age are associated with glucose hypometabolism in brain regions affected by Alzheimers disease and normal aging Neuroimage 2010 49: 169-176
28982335 Metaxas A et al.: Reduced Serotonin Transporter Levels and Inflammation in the Midbrain Raphe of 12 Month Old APPswe/PSEN1dE9 Mice Curr Alzheimer Res 2018 15: 420-428
18322398 Counts SE et al.: Galanin hyperinnervation upregulates choline acetyltransferase expression in cholinergic basal forebrain neurons in Alzheimers disease Neurodegener Dis 2008 5: 228-231
26592823 Zhang B et al.: MiR-16 regulates cell death in Alzheimers disease by targeting amyloid precursor protein Eur Rev Med Pharmacol Sci 2015 19: 4020-4027
26449188 Yun HM et al.: Serotonin 6 receptor controls Alzheimers disease and depression Oncotarget 2015 6
29703883 Kitzlerova E et al.: Interactions Among Polymorphisms of Susceptibility Loci for Alzheimers Disease or Depressive Disorder Med. Sci. Monit. 2018 24: 2599-2619
21926624 Enache D et al.: Depression in dementia: epidemiology, mechanisms, and treatment Curr Opin Psychiatry 2011 24: 461-472
12052537 Emilsson L et al.: Increased monoamine oxidase messenger RNA expression levels in frontal cortex of Alzheimers disease patients Neurosci. Lett. 2002 326: 56-60
12098640 Takehashi M et al.: Association of monoamine oxidase A gene polymorphism with Alzheimers disease and Lewy body variant Neurosci. Lett. 2002 327: 79-82
17692293 Wu YH et al.: A promoter polymorphism in the monoamine oxidase A gene is associated with the pineal MAOA activity in Alzheimers disease patients Brain Res. 2007 1167: 13-19
30692905 Forny-Germano L et al.: The Role of Leptin and Adiponectin in Obesity-Associated Cognitive Decline and Alzheimers Disease Front Neurosci 2019 12: 1027
29929471 Chang YS et al.: Higher levels of thyroxine may predict a favorable response to donepezil treatment in patients with Alzheimer disease: a prospective, case-control study BMC Neurosci 2018 19: 36
11155096 Kalmijn S et al.: Subclinical hyperthyroidism and the risk of dementia. The Rotterdam study Clin. Endocrinol. (Oxf) 2000 53: 733-737
28124751 Farbood Y et al.: Peripheral and central administration of T3 improved the histological changes, memory and the dentate gyrus electrophysiological activity in an animal model of Alzheimers disease Metab Brain Dis 2017 32: 693-701
29481662 McAninch EA et al.: A Common DIO2 Polymorphism and Alzheimer Disease Dementia in African and European Americans J. Clin. Endocrinol. Metab. 2018 103: 1818-1826
17105838 de Jong FJ et al.: The association of polymorphisms in the type 1 and 2 deiodinase genes with circulating thyroid hormone parameters and atrophy of the medial temporal lobe J. Clin. Endocrinol. Metab. 2007 92: 636-640
25735998 Wang T et al.: TNF-alpha G308A polymorphism and the susceptibility to Alzheimers disease: an updated meta-analysis Arch. Med. Res. 2015 46: 24-30.e1
28294066 Shukla M et al.: Mechanisms of Melatonin in Alleviating Alzheimers Disease Curr Neuropharmacol 2017 15: 1010-1031
29774516 Fu X et al.: Periodic Variation of AAK1 in an Abeta1-42-Induced Mouse Model of Alzheimers Disease J. Mol. Neurosci. 2018 65: 179-189
29376091 Kjeldsen EW et al.: ABCA7 and risk of dementia and vascular disease in the Danish population Ann Clin Transl Neurol 2017 5: 41-51
25594074 Rohn TT et al.: Is Apolipoprotein E4 an Important Risk Factor for Dementia in Persons with Down Syndrome?
20946940 Patel A et al.: Association of variants within APOE, SORL1, RUNX1, BACE1 and ALDH18A1 with dementia in Alzheimers disease in subjects with Down syndrome Neurosci. Lett. 2011 487: 144-148
21098978 Sherva R et al.: Identification of novel candidate genes for Alzheimers disease by autozygosity mapping using genome wide SNP data J Alzheimers Dis 2011 23: 349-359
30898171 Smith AR et al.: Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimers disease Clin Epigenetics 2019 11: 52
17687027 Romito-DiGiacomo RR et al.: Effects of Alzheimers disease on different cortical layers: the role of intrinsic differences in Abeta susceptibility J. Neurosci. 2007 27: 8496-8504
31618972 Psemeneckiene G et al.: Polymorphisms of Proinflammatory Cytokines in Relation to APOE Epsilon 4 and Risk of Alzheimers Disease in the Lithuanian Population
24671632 Chin D et al.: Adenosine triphosphate concentrations are higher in the brain of APOE3- compared to APOE4-targeted replacement mice and can be modulated by curcumin Genes Nutr 2014 9: 397
26564908 Tambini MD et al.: ApoE4 upregulates the activity of mitochondria-associated ER membranes EMBO Rep. 2016 17: 27-36
22730380 Cash JG et al.: Apolipoprotein E4 impairs macrophage efferocytosis and potentiates apoptosis by accelerating endoplasmic reticulum stress J. Biol. Chem. 2012 287
28333036 Abdullah L et al.: APOE epsilon4 specific imbalance of arachidonic acid and docosahexaenoic acid in serum phospholipids identifies individuals with preclinical Mild Cognitive Impairment/Alzheimers Disease Aging (Albany NY) 2017 9: 964-985
30804776 Fernandez CG et al.: The Role of APOE4 in Disrupting the Homeostatic Functions of Astrocytes and Microglia in Aging and Alzheimers Disease Front Aging Neurosci 2019 11: 14
26993346 Schott JM et al. et al.: Genetic risk factors for the posterior cortical atrophy variant of Alzheimers disease Alzheimers Dement 2016 12: 862-871
26374899 Atagi Y et al. et al.: Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) J. Biol. Chem. 2015 290
24386905 Tai LM et al.: Soluble apoE/Abeta complex: mechanism and therapeutic target for APOE4-induced AD risk Mol Neurodegener 2014 9: 2
30127720 Konishi H et al.: Microglial TREM2/DAP12 Signaling: A Double-Edged Sword in Neural Diseases Front Cell Neurosci 2018 12: 206
28164773 Shackleton B et al.: Apolipoprotein E-mediated Modulation of ADAM10 in Alzheimers Disease Curr Alzheimer Res 2017 14: 578-585
30836275 Manzine PR et al.: ADAM10 in Alzheimers disease: Pharmacological modulation by natural compounds and its role as a peripheral marker Biomed. Pharmacother. 2019 113
31980586 Meilandt WJ et al. et al.: Trem2 deletion reduces late-stage amyloid plaque accumulation, elevates the Abeta42:Abeta40 ratio, and exacerbates axonal dystrophy and dendritic spine loss in the PS2APP Alzheimers mouse model
28930663 Krasemann S et al. et al.: The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases Immunity 2017 47: 566-581.e9
31130847 Muth C et al.: Phagocytosis of Apoptotic Cells Is Specifically Upregulated in ApoE4 Expressing Microglia in vitro Front Cell Neurosci 2019 13: 181
30038567 Zhou Y et al.: TREM2-Dependent Effects on Microglia in Alzheimers Disease Front Aging Neurosci 2018 10: 202
27239545 Guedes JR et al.: MicroRNA deregulation and chemotaxis and phagocytosis impairment in Alzheimers disease Alzheimers Dement (Amst) 2015 3: 7-17
25593125 Li X et al.: Different mechanisms of apolipoprotein E isoform-dependent modulation of prostaglandin E2 production and triggering receptor expressed on myeloid cells 2 (TREM2) expression after innate immune activation of microglia FASEB J. 2015 29: 1754-1762
27636840 Musunuri S et al.: Increased Levels of Extracellular Microvesicle Markers and Decreased Levels of Endocytic/Exocytic Proteins in the Alzheimers Disease Brain J. Alzheimers Dis. 2016 54: 1671-1686
31640095 Wong MWK et al.: APOE Genotype Differentially Modulates Plasma Lipids in Healthy Older Individuals, with Relevance to Brain Health J. Alzheimers Dis. 2019 72: 703-716
27087442 Zhou M et al. et al.: APOE4 Induces Site-Specific Tau Phosphorylation Through Calpain-CDK5 Signaling Pathway in EFAD-Tg Mice Curr Alzheimer Res 2016 13: 1048-1055
28959956 Shi Y et al. et al.: ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy Nature 2017 549: 523-527
30314521 Sierksma A et al.: Deregulation of neuronal miRNAs induced by amyloid-beta or TAU pathology Mol Neurodegener 2018 13: 54
32123170 Arnold M et al. et al.: Sex and APOE epsilon4 genotype modify the Alzheimers disease serum metabolome Nat Commun 2020 11: 1148
27457486 Dose J et al.: APOE genotype and stress response - a mini review Lipids Health Dis 2016 15: 121
29340569 Apostolova LG et al. et al.: Associations of the Top 20 Alzheimer Disease Risk Variants With Brain Amyloidosis JAMA Neurol 2018 75: 328-341
31848472 Luo J et al.: Mechanisms and regulation of cholesterol homeostasis
30590907 Lee S et al.: The Interface Between ER and Mitochondria: Molecular Compositions and Functions Mol. Cells 2018 41: 1000-1007
27235807 Area-Gomez E et al.: Mitochondria-associated ER membranes and Alzheimer disease Curr. Opin. Genet. Dev. 2016 38: 90-96
26639975 Malishkevich A et al.: Blood-Borne Activity-Dependent Neuroprotective Protein (ADNP) is Correlated with Premorbid Intelligence, Clinical Stage, and Alzheimers Disease Biomarkers J. Alzheimers Dis. 2016 50: 249-260
22832961 Kamboh MI et al. et al.: Genome-wide association study of Alzheimers disease Transl Psychiatry 2012 2: e117
21786198 Chakroborty S et al.: Early calcium dysregulation in Alzheimers disease: setting the stage for synaptic dysfunction Sci China Life Sci 2011 54: 752-762
30883359 Orr AL et al.: Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function J. Alzheimers Dis. 2019 68: 991-1011
31052389 Suidan GL et al.: Targeting Apolipoprotein E for Alzheimers Disease: An Industry Perspective
11447277 Huang Y et al.: Apolipoprotein E fragments present in Alzheimers disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons Proc. Natl. Acad. Sci. U.S.A. 2001 98: 8838-8843
16344479 Chang S et al.: Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity Proc. Natl. Acad. Sci. U.S.A. 2005 102
23867607 Rohn TT et al.: Proteolytic cleavage of apolipoprotein E4 as the keystone for the heightened risk associated with Alzheimers disease Int J Mol Sci 2013 14
19695092 Nakamura T et al.: Apolipoprotein E4 (1-272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells Mol Neurodegener 2009 4: 35
12939405 Harris FM et al. et al.: Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimers disease-like neurodegeneration and behavioral deficits in transgenic mice Proc. Natl. Acad. Sci. U.S.A. 2003 100
30028014 Chernick D et al.: High-density lipoprotein mimetic peptide 4F mitigates amyloid-beta-induced inhibition of apolipoprotein E secretion and lipidation in primary astrocytes and microglia J. Neurochem. 2018 147: 647-662
30444064 Stopnicki B et al.: Helper CD4 T cells expressing granzyme B cause glial fibrillary acidic protein fragmentation in astrocytes in an MHCII-independent manner Glia 2019 67: 582-593
8819138 Haug LS et al.: Decreased inositol (1,4,5)-trisphosphate receptor levels in Alzheimers disease cerebral cortex: selectivity of changes and possible correlation to pathological severity Neurodegeneration 1996 5: 169-176
29253316 Egorova PA et al.: Inositol 1,4,5-trisphosphate receptors and neurodegenerative disorders FEBS J. 2018 285: 3547-3565
18478527 Wojda U et al.: Calcium ions in neuronal degeneration IUBMB Life 2008 60: 575-590
26372964 Zhu L et al.: Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimers disease pathogenesis Proc. Natl. Acad. Sci. U.S.A. 2015 112
27277824 Mahley RW et al.: Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders J. Mol. Med. 2016 94: 739-746
31306119 Simonovitch S et al.: The Effects of APOE4 on Mitochondrial Dynamics and Proteins in vivo J. Alzheimers Dis. 2019 70: 861-875
1663746 Mattson MP et al.: Effects of elevated intracellular calcium levels on the cytoskeleton and tau in cultured human cortical neurons Mol. Chem. Neuropathol. 1991 15: 117-142
26213471 Giau VV et al.: Role of apolipoprotein E in neurodegenerative diseases Neuropsychiatr Dis Treat 2015 11: 1723-1737
28424375 Ventura-Clapier R et al.: Mitochondria: a central target for sex differences in pathologies Clin. Sci. 2017 131: 803-822
19075583 Muller T et al.: Disease state, age, sex, and post-mortem time-dependent expression of proteins in AD vs. control frontal cortex brain samples Curr Alzheimer Res 2008 5: 562-571
20157261 Mueller C et al.: The heme degradation pathway is a promising serum biomarker source for the early detection of Alzheimers disease J. Alzheimers Dis. 2010 19: 1081-1091
30890171 Safieh M et al.: ApoE4: an emerging therapeutic target for Alzheimers disease BMC Med 2019 17: 64
16369530 Rovelet-Lecrux A et al. et al.: APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy Nat. Genet. 2006 38: 24-26
30507579 Reed MJ et al.: Increased Hyaluronan and TSG-6 in Association with Neuropathologic Changes of Alzheimers Disease J. Alzheimers Dis. 2019 67: 91-102
11053967 Savaskan E et al.: Alterations in trk A, trk B and trk C receptor immunoreactivities in parietal cortex and cerebellum in Alzheimers disease Eur. Neurol. 2000 44: 172-180
17564960 Liu F et al. et al.: A genomewide screen for late-onset Alzheimer disease in a genetically isolated Dutch population Am. J. Hum. Genet. 2007 81: 17-31
20858966 Gahete MD et al.: Expression of the ghrelin and neurotensin systems is altered in the temporal lobe of Alzheimers disease patients J. Alzheimers Dis. 2010 22: 819-828
21681798 Hata S et al. et al.: Alternative processing of gamma-secretase substrates in common forms of mild cognitive impairment and Alzheimers disease: evidence for gamma-secretase dysfunction Ann. Neurol. 2011 69: 1026-1031
26384575 Feher A et al.: Genetic analysis of the RELN gene: Gender specific association with Alzheimers disease Psychiatry Res 2015 230: 716-718
28821390 Ramakrishnan V et al.: PSEN1 gene polymorphisms in Caucasian Alzheimers disease: A meta-analysis Clin. Chim. Acta 2017 473: 65-70
29885764 Wachinger C et al.: A Longitudinal Imaging Genetics Study of Neuroanatomical Asymmetry in Alzheimers Disease Biol. Psychiatry 2018 84: 522-530
31068785 Brooks LRK et al.: Data-Driven Analysis of Age, Sex, and Tissue Effects on Gene Expression Variability in Alzheimers Disease Front Neurosci 2019 13: 392
32160551 Yasukawa T et al.: NRBP1-Containing CRL2/CRL4A Regulates Amyloid beta Production by Targeting BRI2 and BRI3 for Degradation Cell Rep 2020 30: 3478-3491.e6
30480246 Dolfe L et al. et al.: The Bri2 and Bri3 BRICHOS Domains Interact Differently with Abeta42 and Alzheimer Amyloid Plaques J Alzheimers Dis Rep 2018 2: 27-39
19874264 Zhong N et al.: Understanding the basis for the association of apoE4 with Alzheimers disease: opening the door for therapeutic approaches Curr Alzheimer Res 2009 6: 415-418
15312168 Irizarry MC et al.: Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein J. Neurochem. 2004 90: 1132-1143
9067471 Ishii K et al. et al.: Abeta1-40 but not Abeta1-42 levels in cortex correlate with apolipoprotein E epsilon4 allele dosage in sporadic Alzheimers disease Brain Res. 1997 748: 250-252
8602762 Gearing M et al.: Abeta-peptide length and apolipoprotein E genotype in Alzheimers disease Ann. Neurol. 1996 39: 395-399
27884212 Kehoe PG et al.: Angiotensin-converting enzyme 2 is reduced in Alzheimers disease in association with increasing amyloid-beta and tau pathology Alzheimers Res Ther 2016 8: 50
29196815 Mroczko B et al.: Amyloid beta oligomers (AbetaOs) in Alzheimers disease J Neural Transm (Vienna) 2018 125: 177-191
30541599 Kant S et al.: Choroid plexus genes for CSF production and brain homeostasis are altered in Alzheimers disease Fluids Barriers CNS 2018 15: 34
29755342 Lejri I et al.: Mitochondria, Estrogen and Female Brain Aging Front Aging Neurosci 2018 10: 124
25720398 Le Page A et al.: NK Cells are Activated in Amnestic Mild Cognitive Impairment but not in Mild Alzheimers Disease Patients J. Alzheimers Dis. 2015 46: 93-107
15225622 Yamamoto N et al.: Accelerated Abeta aggregation in the presence of GM1-ganglioside-accumulated synaptosomes of aged apoE4-knock-in mouse brain FEBS Lett. 2004 569: 135-139
29272008 Xu D et al.: Apolipoprotein E 4 triggers multiple pathway-mediated Ca2+ overload, causes CaMK II phosphorylation abnormity and aggravates oxidative stress caused cerebral cortical neuron damage Eur Rev Med Pharmacol Sci 2017 21: 5717-5728
27358062 Ayers KL et al.: A loss of function variant in CASP7 protects against Alzheimers disease in homozygous APOE epsilon4 allele carriers BMC Genomics 2016 17: Suppl 2 445
28985224 Rehker J et al. et al.: Caspase-8, association with Alzheimers Disease and functional analysis of rare variants PLoS ONE 2017 12
30850702 Mouchard A et al.: ApoE-fragment/Abeta heteromers in the brain of patients with Alzheimers disease Sci Rep 2019 9: 3989
18845536 Roychaudhuri R et al.: Amyloid beta-protein assembly and Alzheimer disease J. Biol. Chem. 2009 284: 4749-4753
23620513 Verghese PB et al.: ApoE influences amyloid-beta (Abeta) clearance despite minimal apoE/Abeta association in physiological conditions Proc. Natl. Acad. Sci. U.S.A. 2013 110
27470930 Salameh TS et al.: Insulin resistance, dyslipidemia, and apolipoprotein E interactions as mechanisms in cognitive impairment and Alzheimers disease Exp. Biol. Med. (Maywood) 2016 241: 1676-1683
30814349 Smith CJ et al.: Putative Survival Advantages in Young Apolipoprotein varepsilon4 Carriers are Associated with Increased Neural Stress J. Alzheimers Dis. 2019 68: 885-923
15220465 Corbo RM et al.: Apolipoprotein E polymorphism and fertility: a study in pre-industrial populations Mol. Hum. Reprod. 2004 10: 617-620
8698352 Gerdes LU et al.: Are men carrying the apolipoprotein epsilon 4- or epsilon 2 allele less fertile than epsilon 3 epsilon 3 genotypes? Hum. Genet. 1996 98: 239-242
28683096 van Exel E et al.: Effect of APOE epsilon4 allele on survival and fertility in an adverse environment PLoS ONE 2017 12
25282659 Gaynor JW et al. et al.: Validation of association of the apolipoprotein E epsilon2 allele with neurodevelopmental dysfunction after cardiac surgery in neonates and infants J. Thorac. Cardiovasc. Surg. 2014 148: 2560-2566
28335828 Yassine HN et al.: DHA brain uptake and APOE4 status: a PET study with [1-(11)C]-DHA Alzheimers Res Ther 2017 9: 23
21659554 Huebbe P et al.: APOE epsilon4 is associated with higher vitamin D levels in targeted replacement mice and humans FASEB J. 2011 25: 3262-3270
28284953 Stening E et al.: Specific patterns of whole-brain structural covariance of the anterior and posterior hippocampus in young APOE epsilon4 carriers Behav. Brain Res. 2017 326: 256-264
21606569 Alexopoulos P et al.: Hippocampal volume differences between healthy young apolipoprotein E epsilon2 and epsilon4 carriers J. Alzheimers Dis. 2011 26: 207-210
21215387 Taylor AE et al.: IQ, educational attainment, memory and plasma lipids: associations with apolipoprotein E genotype in 5995 children Biol. Psychiatry 2011 70: 152-158
8475230 Keltikangas-Jarvinen L et al.: Dependence between apolipoprotein E phenotypes and temperament in children, adolescents, and young adults Psychosom Med 1993 55: 155-163
19605830 Caselli RJ et al. et al.: Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect N. Engl. J. Med. 2009 361: 255-263
17395708 Brown CM et al.: Androgen-mediated immune function is altered by the apolipoprotein E gene Endocrinology 2007 148: 3383-3390
24444806 Panizzon MS et al. et al.: Interaction of APOE genotype and testosterone on episodic memory in middle-aged men Neurobiol. Aging 2014 35: 1778.e1-1778.e8
26791201 Theendakara V et al.: Direct Transcriptional Effects of Apolipoprotein E J. Neurosci. 2016 36: 685-700
12077215 Raber J et al.: Androgens protect against apolipoprotein E4-induced cognitive deficits J. Neurosci. 2002 22: 5204-5209
28533891 Love JE et al.: Nuclear uptake of an amino-terminal fragment of apolipoprotein E4 promotes cell death and localizes within microglia of the Alzheimers disease brain Int J Physiol Pathophysiol Pharmacol 2017 9: 40-57
29264400 Rohn TT et al.: Nuclear Localization of Apolipoprotein E4: A New Trick for an Old Protein
11305869 Cho HS et al.: Quantitation of apoE domains in Alzheimer disease brain suggests a role for apoE in Abeta aggregation J. Neuropathol. Exp. Neurol. 2001 60: 342-349
7715296 Wisniewski T et al.: Is Alzheimers disease an apolipoprotein E amyloidosis? Lancet 1995 345: 956-958
21368138 Bien-Ly N et al.: C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-beta (Abeta) and acts in concert with Abeta to elicit neuronal and behavioral deficits in mice Proc. Natl. Acad. Sci. U.S.A. 2011 108: 4236-4241
26402072 Duits FH et al.: Matrix Metalloproteinases in Alzheimers Disease and Concurrent Cerebral Microbleeds J. Alzheimers Dis. 2015 48: 711-720
25050378 Wang XX et al.: Matrix metalloproteinases and their multiple roles in Alzheimers disease Biomed Res Int 2014 2014
22445724 Dafnis I et al.: An apolipoprotein E4 fragment affects matrix metalloproteinase 9, tissue inhibitor of metalloproteinase 1 and cytokine levels in brain cell lines Neuroscience 2012 210: 21-32
16787929 Yan P et al. et al.: Matrix metalloproteinase-9 degrades amyloid-beta fibrils in vitro and compact plaques in situ J. Biol. Chem. 2006 281
20847401 Subramanian S et al.: CCR6: a biomarker for Alzheimers-like disease in a triple transgenic mouse model J. Alzheimers Dis. 2010 22: 619-629
12689599 Lorenzl S et al.: Increased plasma levels of matrix metalloproteinase-9 in patients with Alzheimers disease Neurochem. Int. 2003 43: 191-196
19235898 Hernandez-Guillamon M et al.: Neuronal TIMP-1 release accompanies astrocytic MMP-9 secretion and enhances astrocyte proliferation induced by beta-amyloid 25-35 fragment J. Neurosci. Res. 2009 87: 2115-2125
28094792 Urfer-Buchwalder A et al.: Identification of a Nuclear Respiratory Factor 1 Recognition Motif in the Apolipoprotein E Variant APOE4 linked to Alzheimers Disease Sci Rep 2017 7: 40668
22077634 Sheng B et al.: Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimers disease J. Neurochem. 2012 120: 419-429
28720530 Theendakara V et al.: Downregulation of protein phosphatase 2A by apolipoprotein E: Implications for Alzheimers disease Mol. Cell. Neurosci. 2017 83: 83-91
11796747 Casley CS et al.: Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities J. Neurochem. 2002 80: 91-100
32152337 Area-Gomez E et al. et al.: APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice Sci Rep 2020 10: 4277
29311783 Nuriel T et al.: The Endosomal-Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo Front Neurosci 2017 11: 702
10822435 Yaffe K et al.: Estrogen use, APOE, and cognitive decline: evidence of gene-environment interaction Neurology 2000 54: 1949-1954
9278514 Paech K et al.: Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites Science 1997 277: 1508-1510
22962256 Jayaraman A et al.: 17beta-estradiol and progesterone regulate expression of beta-amyloid clearance factors in primary neuron cultures and female rat brain Endocrinology 2012 153: 5467-5479
15590928 Zhao L et al.: Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimers disease intervention J. Neurosci. 2004 24
25745640 Gottschalk WK et al.: The Broad Impact of TOM40 on Neurodegenerative Diseases in Aging
22514691 Cha MY et al.: Mitochondria-specific accumulation of amyloid beta induces mitochondrial dysfunction leading to apoptotic cell death PLoS ONE 2012 7
27636849 Sainaghi PP et al.: Growth Arrest Specific 6 Concentration is Increased in the Cerebrospinal Fluid of Patients with Alzheimers Disease J. Alzheimers Dis. 2017 55: 59-65
29433734 Santo EE et al.: FOXO in Neural Cells and Diseases of the Nervous System Curr. Top. Dev. Biol. 2018 127: 105-118
31808750 Yin J et al.: Apolipoprotein E regulates mitochondrial function through the PGC-1alpha-sirtuin 3 pathway Aging (Albany NY) 2019 11
19076441 Mosconi L et al.: Brain glucose hypometabolism and oxidative stress in preclinical Alzheimers disease Ann. N. Y. Acad. Sci. 2008 1147: 180-195
9596412 Montine KS et al.: Distribution of reducible 4-hydroxynonenal adduct immunoreactivity in Alzheimer disease is associated with APOE genotype J. Neuropathol. Exp. Neurol. 1998 57: 415-425
27583919 Zheng J et al.: The CYP19A1 rs3751592 variant confers susceptibility to Alzheimer disease in the Chinese Han population Medicine (Baltimore) 2016 95: e4742
20819998 Panizzon MS et al. et al.: Testosterone modifies the effect of APOE genotype on hippocampal volume in middle-aged men Neurology 2010 75: 874-880
18439297 Haasl RJ et al.: A luteinizing hormone receptor intronic variant is significantly associated with decreased risk of Alzheimers disease in males carrying an apolipoprotein E epsilon4 allele BMC Med. Genet. 2008 9: 37
19339974 Bu G et al.: Apolipoprotein E and its receptors in Alzheimers disease: pathways, pathogenesis and therapy Nat. Rev. Neurosci. 2009 10: 333-344
32521573 Han C et al.: New mechanism of nerve injury in Alzheimers disease: beta-amyloid-induced neuronal pyroptosis
29028155 Brinkmalm G et al.: A Parallel Reaction Monitoring Mass Spectrometric Method for Analysis of Potential CSF Biomarkers for Alzheimers Disease
32460813 Konijnenberg E et al. et al.: APOE epsilon4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimers disease Alzheimers Res Ther 2020 12: 65
27128370 Perkins M et al. et al.: Altered Energy Metabolism Pathways in the Posterior Cingulate in Young Adult Apolipoprotein E varepsilon4 Carriers J. Alzheimers Dis. 2016 53: 95-106
20847408 Valla J et al.: Reduced posterior cingulate mitochondrial activity in expired young adult carriers of the APOE epsilon4 allele, the major late-onset Alzheimers susceptibility gene J. Alzheimers Dis. 2010 22: 307-313
23639788 Djogo N et al.: Adhesion molecule L1 binds to amyloid beta and reduces Alzheimers disease pathology in mice Neurobiol. Dis. 2013 56: 104-115
10571241 Hiesberger T et al.: Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation Neuron 1999 24: 481-489
15014128 Brecht WJ et al.: Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice J. Neurosci. 2004 24: 2527-2534
32587511 Yassine HN et al.: APOE Alleles and Diet in Brain Aging and Alzheimers Disease Front Aging Neurosci 2020 12: 150
31738402 Seo DO et al.: Gut Microbiota: From the Forgotten Organ to a Potential Key Player in the Pathology of Alzheimers Disease J Gerontol A Biol Sci Med Sci 2020 75: 1232-1241
30958695 Tran TTT et al.: APOE genotype influences the gut microbiome structure and function in humans and mice: relevance for Alzheimers disease pathophysiology FASEB J 2019 33: 8221-8231
30336580 Griffin BA et al.: APOE4 Genotype Exerts Greater Benefit in Lowering Plasma Cholesterol and Apolipoprotein B than Wild Type (E3/E3), after Replacement of Dietary Saturated Fats with Low Glycaemic Index Carbohydrates
19176370 Catalano A et al.: The plexin-A1 receptor activates vascular endothelial growth factor-receptor 2 and nuclear factor-kappaB to mediate survival and anchorage-independent growth of malignant mesothelioma cells Cancer Res. 2009 69: 1485-1493
19176370 Catalano A et al.: The plexin-A1 receptor activates vascular endothelial growth factor-receptor 2 and nuclear factor-kappaB to mediate survival and anchorage-independent growth of malignant mesothelioma cells. Cancer Res. 2009 69: 1485-1493
19176370 Catalano A et al.: The plexin-A1 receptor activates vascular endothelial growth factor-receptor 2 and nuclear factor-kappaB to mediate survival and anchorage-independent growth of malignant mesothelioma cells Cancer Res. 2009 69: 1485-1493
19325129 Schwarz Q et al.: Neuropilin 1 signaling guides neural crest cells to coordinate pathway choice with cell specification. Proc. Natl. Acad. Sci. U.S.A. 2009 106: 6164-6169
9331345 Taniguchi M et al.: Disruption of semaphorin III/D gene causes severe abnormality in peripheral nerve projection Neuron 1997 19: 519-530
18708346 Bae D et al.: Metabolic stress induces the lysosomal degradation of neuropilin-1 but not neuropilin-2 J. Biol. Chem. 2008 283
18708346 Bae D et al.: Metabolic stress induces the lysosomal degradation of neuropilin-1 but not neuropilin-2. J. Biol. Chem. 2008 283
18664627 Kawamura H et al.: Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization. Blood 2008 112: 3638-3649
16966330 Lamalice L et al.: Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF. J. Biol. Chem. 2006 281
14724572 Lamalice L et al.: Phosphorylation of tyrosine 1214 on VEGFR2 is required for VEGF-induced activation of Cdc42 upstream of SAPK2/p38. Oncogene 2004 23: 434-445
17569671 Guttmann-Raviv N et al.: Semaphorin-3A and semaphorin-3F work together to repel endothelial cells and to inhibit their survival by induction of apoptosis. J. Biol. Chem. 2007 282
18056484 Moretti S et al.: Semaphorin3A signaling controls Fas (CD95)-mediated apoptosis by promoting Fas translocation into lipid rafts. Blood 2008 111: 2290-2299
9215629 Yang X et al.: Daxx, a novel Fas-binding protein that activates JNK and apoptosis Cell 1997 89: 1067-1076
16330548 Kurschat P et al.: Neuron restrictive silencer factor NRSF/REST is a transcriptional repressor of neuropilin-1 and diminishes the ability of semaphorin 3A to inhibit keratinocyte migration. J. Biol. Chem. 2006 281: 2721-2729
17369826 Semenova MM et al.: Rho mediates calcium-dependent activation of p38alpha and subsequent excitotoxic cell death Nat. Neurosci. 2007 10: 436-443
19251628 Vance C et al. et al.: Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6 Science 2009 323: 1208-1211
18309045 Sreedharan J et al.: TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis. Science 2008 319: 1668-1672
17023659 Neumann M et al. et al.: Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis Science 2006 314: 130-133
17469116 Mackenzie IR et al. et al.: Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations Ann. Neurol. 2007 61: 427-434
8446170 Rosen DR et al.: Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 1993 362: 59-62
10196546 Takahashi T et al.: Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors. Nat. Neurosci. 1998 1: 487-493
10520994 Takahashi T et al.: Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors Cell 1999 99: 59-69
16495486 Chadborn NH et al.: PTEN couples Sema3A signalling to growth cone collapse J. Cell. Sci. 2006 119: 951-957
16495486 Chadborn NH et al.: PTEN couples Sema3A signalling to growth cone collapse. J. Cell. Sci. 2006 119: 951-957
11956225 Eickholt BJ et al.: An inactive pool of GSK-3 at the leading edge of growth cones is implicated in Semaphorin 3A signaling. J. Cell Biol. 2002 157: 211-217
18180379 Acevedo LM et al.: Semaphorin 3A suppresses VEGF-mediated angiogenesis yet acts as a vascular permeability factor. Blood 2008 111: 2674-2680
18180379 Acevedo LM et al.: Semaphorin 3A suppresses VEGF-mediated angiogenesis yet acts as a vascular permeability factor Blood 2008 111: 2674-2680
18327764 Gallo G et al.: Semaphorin 3A inhibits ERM protein phosphorylation in growth cone filopodia through inactivation of PI3K Dev Neurobiol 2008 68: 926-933
9236236 Jin Z et al.: Rac1 mediates collapsin-1-induced growth cone collapse. J. Neurosci. 1997 17: 6256-6263
18272814 Narazaki M et al.: Sulfated polysaccharides identified as inducers of neuropilin-1 internalization and functional inhibition of VEGF165 and semaphorin3A Blood 2008 111: 4126-4136
15378658 Weydt P et al.: Increased cytotoxic potential of microglia from ALS-transgenic mice Glia 2004 48: 179-182
19672969 Zhao W et al.: Extracellular mutant SOD1 induces microglial-mediated motoneuron injury Glia 2010 58: 231-243
18519638 Nishitoh H et al.: ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1 Genes Dev. 2008 22: 1451-1464
12847526 Lambrechts D et al.: VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death. Nat. Genet. 2003 34: 383-394
11381259 Oosthuyse B et al.: Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nat. Genet. 2001 28: 131-138
18519638 Nishitoh H et al.: ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1 Genes Dev. 2008 22: 1451-1464
19762508 Hetz C et al.: XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy Genes Dev. 2009 23: 2294-2306
19762508 Hetz C et al.: XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy. Genes Dev. 2009 23: 2294-2306
15568021 Storkebaum E et al.: Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS. Nat. Neurosci. 2005 8: 85-92
19183264 Suzuki H et al.: ALS-linked P56S-VAPB, an aggregated loss-of-function mutant of VAPB, predisposes motor neurons to ER stress-related death by inducing aggregation of co-expressed wild-type VAPB J. Neurochem. 2009 108: 973-985
18233996 Oh YK et al.: Superoxide dismutase 1 mutants related to amyotrophic lateral sclerosis induce endoplasmic stress in neuro2a cells J. Neurochem. 2008 104: 993-1005
19330001 Saxena S et al.: A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice Nat. Neurosci. 2009 12: 627-636
19330001 Saxena S et al.: A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice. Nat. Neurosci. 2009 12: 627-636
18077368 Kieran D et al.: Deletion of the BH3-only protein puma protects motoneurons from ER stress-induced apoptosis and delays motoneuron loss in ALS mice. Proc. Natl. Acad. Sci. U.S.A. 2007 104
18077368 Kieran D et al.: Deletion of the BH3-only protein puma protects motoneurons from ER stress-induced apoptosis and delays motoneuron loss in ALS mice Proc. Natl. Acad. Sci. U.S.A. 2007 104
18413601 Taoufik E et al.: TNF receptor I sensitizes neurons to erythropoietin- and VEGF-mediated neuroprotection after ischemic and excitotoxic injury. Proc. Natl. Acad. Sci. U.S.A. 2008 105: 6185-6190
18413601 Taoufik E et al.: TNF receptor I sensitizes neurons to erythropoietin- and VEGF-mediated neuroprotection after ischemic and excitotoxic injury Proc. Natl. Acad. Sci. U.S.A. 2008 105: 6185-6190
7507336 Cheng B et al.: Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis Neuron 1994 12: 139-153
11029549 Jin KL et al.: Induction of vascular endothelial growth factor and hypoxia-inducible factor-1alpha by global ischemia in rat brain. Neuroscience 2000 99: 577-585
16847061 Atkin JD et al.: Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1 J. Biol. Chem. 2006 281
16847061 Atkin JD et al.: Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1 J. Biol. Chem. 2006 281
16847061 Atkin JD et al.: Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1. J. Biol. Chem. 2006 281
19661182 Ying Z et al.: Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation. Hum. Mol. Genet. 2009 18: 4268-4281
19661182 Ying Z et al.: Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation Hum. Mol. Genet. 2009 18: 4268-4281
9618543 Rosenstein JM et al.: Patterns of brain angiogenesis after vascular endothelial growth factor administration in vitro and in vivo. Proc. Natl. Acad. Sci. U.S.A. 1998 95: 7086-7091
19661182 Ying Z et al.: Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation Hum. Mol. Genet. 2009 18: 4268-4281
9618543 Rosenstein JM et al.: Patterns of brain angiogenesis after vascular endothelial growth factor administration in vitro and in vivo Proc. Natl. Acad. Sci. U.S.A. 1998 95: 7086-7091
18566591 Jeyabalan A et al.: Cigarette smoke exposure and angiogenic factors in pregnancy and preeclampsia Am. J. Hypertens. 2008 21: 943-947
19889996 Yang YS et al.: Reticulon-4A (Nogo-A) redistributes protein disulfide isomerase to protect mice from SOD1-dependent amyotrophic lateral sclerosis. J. Neurosci. 2009 29
17360578 Warner-Schmidt JL et al.: VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressants Proc. Natl. Acad. Sci. U.S.A. 2007 104: 4647-4652
17360578 Warner-Schmidt JL et al.: VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressants. Proc. Natl. Acad. Sci. U.S.A. 2007 104: 4647-4652
18263603 Gkogkas C et al.: VAPB interacts with and modulates the activity of ATF6 Hum. Mol. Genet. 2008 17: 1517-1526
18263603 Gkogkas C et al.: VAPB interacts with and modulates the activity of ATF6 Hum. Mol. Genet. 2008 17: 1517-1526
16891305 Kanekura K et al.: Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8) J. Biol. Chem. 2006 281
16192378 McCloskey DP et al.: Depression of synaptic transmission by vascular endothelial growth factor in adult rat hippocampus and evidence for increased efficacy after chronic seizures J. Neurosci. 2005 25: 8889-8897
19109488 Kieran D et al.: Control of motoneuron survival by angiogenin J. Neurosci. 2008 28
19109488 Kieran D et al.: Control of motoneuron survival by angiogenin J. Neurosci. 2008 28
18065154 Nicoletti JN et al.: Vascular endothelial growth factor is up-regulated after status epilepticus and protects against seizure-induced neuronal loss in hippocampus Neuroscience 2008 151: 232-241
18065154 Nicoletti JN et al.: Vascular endothelial growth factor is up-regulated after status epilepticus and protects against seizure-induced neuronal loss in hippocampus. Neuroscience 2008 151: 232-241
19444281 Sebastia J et al.: Angiogenin protects motoneurons against hypoxic injury. Cell Death Differ. 2009 16: 1238-1247
19444281 Sebastia J et al.: Angiogenin protects motoneurons against hypoxic injury Cell Death Differ. 2009 16: 1238-1247
19444281 Sebastia J et al.: Angiogenin protects motoneurons against hypoxic injury Cell Death Differ. 2009 16: 1238-1247
15258583 Cao L et al.: VEGF links hippocampal activity with neurogenesis, learning and memory Nat. Genet. 2004 36: 827-835
15258583 Cao L et al.: VEGF links hippocampal activity with neurogenesis, learning and memory. Nat. Genet. 2004 36: 827-835
16581901 Raoul C et al.: Chronic activation in presymptomatic amyotrophic lateral sclerosis (ALS) mice of a feedback loop involving Fas, Daxx, and FasL Proc. Natl. Acad. Sci. U.S.A. 2006 103: 6007-6012
16964394 Yoshino Y et al.: Activation of p38 MAPK and/or JNK contributes to increased levels of VEGF secretion in human malignant glioma cells. Int. J. Oncol. 2006 29: 981-987
12354397 Raoul C et al.: Motoneuron death triggered by a specific pathway downstream of Fas. potentiation by ALS-linked SOD1 mutations. Neuron 2002 35: 1067-1083
15207859 Ackerley S et al.: p38alpha stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis Mol. Cell. Neurosci. 2004 26: 354-364
15207859 Ackerley S et al.: p38alpha stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis. Mol. Cell. Neurosci. 2004 26: 354-364
15207859 Ackerley S et al.: p38alpha stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis Mol. Cell. Neurosci. 2004 26: 354-364
16000635 Martin LJ et al.: Adult motor neuron apoptosis is mediated by nitric oxide and Fas death receptor linked by DNA damage and p53 activation J. Neurosci. 2005 25: 6449-6459
16000635 Martin LJ et al.: Adult motor neuron apoptosis is mediated by nitric oxide and Fas death receptor linked by DNA damage and p53 activation J. Neurosci. 2005 25: 6449-6459
12812752 Tortarolo M et al.: Persistent activation of p38 mitogen-activated protein kinase in a mouse model of familial amyotrophic lateral sclerosis correlates with disease progression Mol. Cell. Neurosci. 2003 23: 180-192
17630988 Petri S et al.: The lipophilic metal chelators DP-109 and DP-460 are neuroprotective in a transgenic mouse model of amyotrophic lateral sclerosis J. Neurochem. 2007 102: 991-1000
19091752 Liu Y et al.: Expression of amyotrophic lateral sclerosis-linked SOD1 mutant increases the neurotoxic potential of microglia via TLR2 J. Biol. Chem. 2009 284: 3691-3699
16510725 Kiaei M et al.: Thalidomide and lenalidomide extend survival in a transgenic mouse model of amyotrophic lateral sclerosis J. Neurosci. 2006 26: 2467-2473
16510725 Kiaei M et al.: Thalidomide and lenalidomide extend survival in a transgenic mouse model of amyotrophic lateral sclerosis. J. Neurosci. 2006 26: 2467-2473
19734218 D'Ambrosi N et al.: The proinflammatory action of microglial P2 receptors is enhanced in SOD1 models for amyotrophic lateral sclerosis J. Immunol. 2009 183: 4648-4656
16512913 Yiangou Y et al.: COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord. BMC Neurol 2006 6: 12
16619237 Almer G et al.: Is prostaglandin E(2) a pathogenic factor in amyotrophic lateral sclerosis Ann. Neurol. 2006 59: 980-983
19477238 Mir M et al.: Tumor necrosis factor alpha and interferon gamma cooperatively induce oxidative stress and motoneuron death in rat spinal cord embryonic explants Neuroscience 2009 162: 959-971
18219391 Harraz MM et al.: SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model J. Clin. Invest. 2008 118: 659-670
18219391 Harraz MM et al.: SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model J. Clin. Invest. 2008 118: 659-670
17853944 Marden JJ et al.: Redox modifier genes in amyotrophic lateral sclerosis in mice J. Clin. Invest. 2007 117: 2913-2919
17389365 Son M et al.: Overexpression of CCS in G93A-SOD1 mice leads to accelerated neurological deficits with severe mitochondrial pathology Proc. Natl. Acad. Sci. U.S.A. 2007 104: 6072-6077
19765191 Gal J et al.: Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism J. Neurochem. 2009 111: 1062-1073
19765191 Gal J et al.: Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism J. Neurochem. 2009 111: 1062-1073
19793721 Ferguson CJ et al.: Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2. Hum. Mol. Genet. 2009 18: 4868-4878
19793721 Ferguson CJ et al.: Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2 Hum. Mol. Genet. 2009 18: 4868-4878
19944744 Wang X et al.: Degradation of TDP-43 and its pathogenic form by autophagy and the ubiquitin-proteasome system Neurosci. Lett. 2010 469: 112-116
18250315 Fornai F et al.: Lithium delays progression of amyotrophic lateral sclerosis Proc. Natl. Acad. Sci. U.S.A. 2008 105: 2052-2057
18250315 Fornai F et al.: Lithium delays progression of amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. U.S.A. 2008 105: 2052-2057
18337307 Proescher JB et al.: Biological effects of CCS in the absence of SOD1 enzyme activation: implications for disease in a mouse model for ALS Hum. Mol. Genet. 2008 17: 1728-1737
19656261 Tokuda E et al.: Dysregulation of intracellular copper trafficking pathway in a mouse model of mutant copper/zinc superoxide dismutase-linked familial amyotrophic lateral sclerosis J. Neurochem. 2009 111: 181-191
19765193 Boylan K et al.: Immunoreactivity of the phosphorylated axonal neurofilament H subunit (pNF-H) in blood of ALS model rodents and ALS patients: evaluation of blood pNF-H as a potential ALS biomarker J. Neurochem. 2009 111: 1182-1191
19765193 Boylan K et al.: Immunoreactivity of the phosphorylated axonal neurofilament H subunit (pNF-H) in blood of ALS model rodents and ALS patients: evaluation of blood pNF-H as a potential ALS biomarker. J. Neurochem. 2009 111: 1182-1191
18003833 Yamashita N et al.: Regulation of spine development by semaphorin3A through cyclin-dependent kinase 5 phosphorylation of collapsin response mediator protein 1. J. Neurosci. 2007 27
14762105 Shea TB et al.: Cdk5 regulates axonal transport and phosphorylation of neurofilaments in cultured neurons J. Cell. Sci. 2004 117: 933-941
18519042 Manser C et al.: Deregulation of PKN1 activity disrupts neurofilament organisation and axonal transport. FEBS Lett. 2008 582: 2303-2308
18519042 Manser C et al.: Deregulation of PKN1 activity disrupts neurofilament organisation and axonal transport FEBS Lett. 2008 582: 2303-2308
19717447 Zhu X et al.: MSC p43 required for axonal development in motor neurons. Proc. Natl. Acad. Sci. U.S.A. 2009 106
10893265 Ackerley S et al.: Glutamate slows axonal transport of neurofilaments in transfected neurons. J. Cell Biol. 2000 150: 165-176
11082065 El-Husseini AE et al.: PSD-95 involvement in maturation of excitatory synapses. Science 2000 290: 1364-1368
17344389 Su KY et al.: Mice deficient in collapsin response mediator protein-1 exhibit impaired long-term potentiation and impaired spatial learning and memory J. Neurosci. 2007 27: 2513-2524
17344389 Su KY et al.: Mice deficient in collapsin response mediator protein-1 exhibit impaired long-term potentiation and impaired spatial learning and memory. J. Neurosci. 2007 27: 2513-2524
15372378 Nishimura AL et al.: A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis Am. J. Hum. Genet. 2004 75: 822-831
20008544 Fasana E et al.: A VAPB mutant linked to amyotrophic lateral sclerosis generates a novel form of organized smooth endoplasmic reticulum FASEB J. 2010 24: 1419-1430
16945901 Ferri A et al.: Familial ALS-superoxide dismutases associate with mitochondria and shift their redox potentials Proc. Natl. Acad. Sci. U.S.A. 2006 103
9853749 Migaud M et al.: Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein Nature 1998 396: 433-439
19344252 Cozzolino M et al.: Oligomerization of mutant SOD1 in mitochondria of motoneuronal cells drives mitochondrial damage and cell toxicity. Antioxid. Redox Signal. 2009 11: 1547-1558
20007902 Williams AH et al.: MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice Science 2009 326: 1549-1554
18715867 Kawamata H et al.: Lysyl-tRNA synthetase is a target for mutant SOD1 toxicity in mitochondria J. Biol. Chem. 2008 283
20007902 Williams AH et al.: MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice. Science 2009 326: 1549-1554
17099709 Kaneko S et al.: A selective Sema3A inhibitor enhances regenerative responses and functional recovery of the injured spinal cord. Nat. Med. 2006 12: 1380-1389
16478527 Damiano M et al.: Neural mitochondrial Ca2+ capacity impairment precedes the onset of motor symptoms in G93A Cu/Zn-superoxide dismutase mutant mice J. Neurochem. 2006 96: 1349-1361
9705358 Giraudo E et al.: Tumor necrosis factor-alpha regulates expression of vascular endothelial growth factor receptor-2 and of its co-receptor neuropilin-1 in human vascular endothelial cells. J. Biol. Chem. 1998 273
12649282 Duval M et al.: Vascular endothelial growth factor-dependent down-regulation of Flk-1/KDR involves Cbl-mediated ubiquitination. Consequences on nitric oxide production from endothelial cells. J. Biol. Chem. 2003 278
19041930 Tolosa L et al.: Vascular endothelial growth factor protects motoneurons from serum deprivation-induced cell death through phosphatidylinositol 3-kinase-mediated p38 mitogen-activated protein kinase inhibition. Neuroscience 2009 158: 1348-1355
18182045 Tolosa L et al.: Vascular endothelial growth factor protects spinal cord motoneurons against glutamate-induced excitotoxicity via phosphatidylinositol 3-kinase. J. Neurochem. 2008 105: 1080-1090
15233914 Pasinelli P et al.: Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria. Neuron 2004 43: 19-30
17855507 Duval M et al.: Src-mediated phosphorylation of Hsp90 in response to vascular endothelial growth factor (VEGF) is required for VEGF receptor-2 signaling to endothelial NO synthase. Mol. Biol. Cell 2007 18: 4659-4668
15233914 Pasinelli P et al.: Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria Neuron 2004 43: 19-30
16710367 Crosio C et al.: Bcl2a1 serves as a switch in death of motor neurons in amyotrophic lateral sclerosis Cell Death Differ. 2006 13: 2150-2153
16710367 Crosio C et al.: Bcl2a1 serves as a switch in death of motor neurons in amyotrophic lateral sclerosis Cell Death Differ. 2006 13: 2150-2153
19545440 Jaiswal MK et al.: Impairment of mitochondrial calcium handling in a mtSOD1 cell culture model of motoneuron disease. BMC Neurosci 2009 10: 64
16928866 Gould TW et al.: Complete dissociation of motor neuron death from motor dysfunction by Bax deletion in a mouse model of ALS. J. Neurosci. 2006 26: 8774-8786
19046404 Soo KY et al.: Recruitment of mitochondria into apoptotic signaling correlates with the presence of inclusions formed by amyotrophic lateral sclerosis-associated SOD1 mutations J. Neurochem. 2009 108: 578-590
17394546 Ezzi SA et al.: Wild-type superoxide dismutase acquires binding and toxic properties of ALS-linked mutant forms through oxidation J. Neurochem. 2007 102: 170-178
17394546 Ezzi SA et al.: Wild-type superoxide dismutase acquires binding and toxic properties of ALS-linked mutant forms through oxidation J. Neurochem. 2007 102: 170-178
17394546 Ezzi SA et al.: Wild-type superoxide dismutase acquires binding and toxic properties of ALS-linked mutant forms through oxidation. J. Neurochem. 2007 102: 170-178
19638399 Kupershmidt L et al.: Neuroprotective and neuritogenic activities of novel multimodal iron-chelating drugs in motor-neuron-like NSC-34 cells and transgenic mouse model of amyotrophic lateral sclerosis FASEB J. 2009 23: 3766-3779
19523650 Fang L et al.: Linking neuron and skin: matrix metalloproteinases in amyotrophic lateral sclerosis (ALS). J. Neurol. Sci. 2009 285: 62-66
17362932 Kiaei M et al.: Matrix metalloproteinase-9 regulates TNF-alpha and FasL expression in neuronal, glial cells and its absence extends life in a transgenic mouse model of amyotrophic lateral sclerosis Exp. Neurol. 2007 205: 74-81
20097566 Soon CP et al.: Serum matrix metalloproteinase-9 activity is dysregulated with disease progression in the mutant SOD1 transgenic mice Neuromuscul. Disord. 2010 20: 260-266
15358145 Choi JS et al.: Co-chaperone CHIP associates with mutant Cu/Zn-superoxide dismutase proteins linked to familial amyotrophic lateral sclerosis and promotes their degradation by proteasomes Biochem. Biophys. Res. Commun. 2004 321: 574-583
15358145 Choi JS et al.: Co-chaperone CHIP associates with mutant Cu/Zn-superoxide dismutase proteins linked to familial amyotrophic lateral sclerosis and promotes their degradation by proteasomes Biochem. Biophys. Res. Commun. 2004 321: 574-583
15198682 Urushitani M et al.: CHIP promotes proteasomal degradation of familial ALS-linked mutant SOD1 by ubiquitinating Hsp/Hsc70 J. Neurochem. 2004 90: 231-244
19610091 Sone J et al.: Dorfin ameliorates phenotypes in a transgenic mouse model of amyotrophic lateral sclerosis J. Neurosci. Res. 2010 88: 123-135
15201339 Nguyen DT et al.: Nck-dependent activation of extracellular signal-regulated kinase-1 and regulation of cell survival during endoplasmic reticulum stress Mol. Biol. Cell 2004 15: 4248-4260
15201339 Nguyen DT et al.: Nck-dependent activation of extracellular signal-regulated kinase-1 and regulation of cell survival during endoplasmic reticulum stress. Mol. Biol. Cell 2004 15: 4248-4260
12145308 Niwa J et al.: Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity J. Biol. Chem. 2002 277
12145308 Niwa J et al.: Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity. J. Biol. Chem. 2002 277
17666395 Niwa J et al.: Disulfide bond mediates aggregation, toxicity, and ubiquitylation of familial amyotrophic lateral sclerosis-linked mutant SOD1. J. Biol. Chem. 2007 282
14684739 Miyazaki K et al.: NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1 J. Biol. Chem. 2004 279
14684739 Miyazaki K et al.: NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1. J. Biol. Chem. 2004 279
19179380 Lee J et al.: Activation of Ets-2 by oxidative stress induces Bcl-xL expression and accounts for glial survival in amyotrophic lateral sclerosis FASEB J. 2009 23: 1739-1749
17925878 Yamagishi S et al.: An in vitro model for Lewy body-like hyaline inclusion/astrocytic hyaline inclusion: induction by ER stress with an ALS-linked SOD1 mutation PLoS ONE 2007 2: E1030
20223753 Wong M et al.: Skeletal muscle-restricted expression of human SOD1 causes motor neuron degeneration in transgenic mice Hum. Mol. Genet. 2010 19: 2284-2302
18706911 Pierce A et al.: GAPDH is conformationally and functionally altered in association with oxidative stress in mouse models of amyotrophic lateral sclerosis J. Mol. Biol. 2008 382: 1195-1210
16043017 Poon HF et al.: Redox proteomics analysis of oxidatively modified proteins in G93A-SOD1 transgenic mice--a model of familial amyotrophic lateral sclerosis Free Radic. Biol. Med. 2005 39: 453-462
17584954 Muller FL et al.: Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2007 293
17584954 Muller FL et al.: Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production Am. J. Physiol. Regul. Integr. Comp. Physiol. 2007 293
20007371 Gros-Louis F et al.: Chromogranin B P413L variant as risk factor and modifier of disease onset for amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. U.S.A. 2009 106
20007371 Gros-Louis F et al.: Chromogranin B P413L variant as risk factor and modifier of disease onset for amyotrophic lateral sclerosis Proc. Natl. Acad. Sci. U.S.A. 2009 106
20198480 Kraemer BC et al.: Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis. Acta Neuropathol. 2010 119: 409-419
19379745 Feiguin F et al.: Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behavior. FEBS Lett. 2009 583: 1586-1592
19816510 Wang M et al.: Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis Cell Death Differ. 2010 17: 488-498
20188146 Tudor EL et al.: Amyotrophic lateral sclerosis mutant vesicle-associated membrane protein-associated protein-B transgenic mice develop TAR-DNA-binding protein-43 pathology Neuroscience 2010 167: 774-785
16835242 Latreille M et al.: Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress J. Biol. Chem. 2006 281
16835242 Latreille M et al.: Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress J. Biol. Chem. 2006 281
16835242 Latreille M et al.: Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress. J. Biol. Chem. 2006 281
19383787 Zhang YJ et al.: Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity. Proc. Natl. Acad. Sci. U.S.A. 2009 106: 7607-7612
19805353 Iwawaki T et al.: Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability. Proc. Natl. Acad. Sci. U.S.A. 2009 106
19805353 Iwawaki T et al.: Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability Proc. Natl. Acad. Sci. U.S.A. 2009 106
20379728 Braak H et al.: Amyotrophic lateral sclerosis: dash-like accumulation of phosphorylated TDP-43 in somatodendritic and axonal compartments of somatomotor neurons of the lower brainstem and spinal cord Acta Neuropathol. 2010 120: 67-74
20043239 Shiina Y et al.: TDP-43 dimerizes in human cells in culture Cell. Mol. Neurobiol. 2010 30: 641-652
20071528 Barmada SJ et al.: Cytoplasmic mislocalization of TDP-43 is toxic to neurons and enhanced by a mutation associated with familial amyotrophic lateral sclerosis J. Neurosci. 2010 30: 639-649
19251627 Kwiatkowski TJ Jr et al.: Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. Science 2009 323: 1205-1208
18923022 Poesen K et al.: Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration. J. Neurosci. 2008 28
18923022 Poesen K et al.: Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration J. Neurosci. 2008 28
18923022 Poesen K et al.: Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration J. Neurosci. 2008 28
17652584 Lu L et al.: Mutant Cu/Zn-superoxide dismutase associated with amyotrophic lateral sclerosis destabilizes vascular endothelial growth factor mRNA and downregulates its expression J. Neurosci. 2007 27: 7929-7938
17652584 Lu L et al.: Mutant Cu/Zn-superoxide dismutase associated with amyotrophic lateral sclerosis destabilizes vascular endothelial growth factor mRNA and downregulates its expression. J. Neurosci. 2007 27: 7929-7938
19196430 Li X et al.: Mutant copper-zinc superoxide dismutase associated with amyotrophic lateral sclerosis binds to adenine/uridine-rich stability elements in the vascular endothelial growth factor 3-untranslated region. J. Neurochem. 2009 108: 1032-1044
19622636 Uemura A et al.: Unconventional splicing of XBP1 mRNA occurs in the cytoplasm during the mammalian unfolded protein response. J. Cell. Sci. 2009 122: 2877-2886
17403682 Zhang F et al.: Interaction between familial amyotrophic lateral sclerosis (ALS)-linked SOD1 mutants and the dynein complex. J. Biol. Chem. 2007 282
17403682 Zhang F et al.: Interaction between familial amyotrophic lateral sclerosis (ALS)-linked SOD1 mutants and the dynein complex J. Biol. Chem. 2007 282
18515363 Strom AL et al.: Interaction of amyotrophic lateral sclerosis (ALS)-related mutant copper-zinc superoxide dismutase with the dynein-dynactin complex contributes to inclusion formation J. Biol. Chem. 2008 283
18719118 Ilieva HS et al.: Mutant dynein (Loa) triggers proprioceptive axon loss that extends survival only in the SOD1 ALS model with highest motor neuron death Proc. Natl. Acad. Sci. U.S.A. 2008 105
18719118 Ilieva HS et al.: Mutant dynein (Loa) triggers proprioceptive axon loss that extends survival only in the SOD1 ALS model with highest motor neuron death Proc. Natl. Acad. Sci. U.S.A. 2008 105
18178312 Gomes E et al.: p38 MAPK as a negative regulator of VEGF/VEGFR2 signaling pathway in serum deprived human SK-N-SH neuroblastoma cells Neurosci. Lett. 2008 431: 95-100
11445557 Chen R et al.: Regulation of Akt/PKB activation by tyrosine phosphorylation. J. Biol. Chem. 2001 276
20020442 Price J et al.: Akt-1 mediates survival of chondrocytes from endoplasmic reticulum-induced stress. J. Cell. Physiol. 2010 222: 502-508
15911875 Kieran D et al.: A mutation in dynein rescues axonal transport defects and extends the life span of ALS mice J. Cell Biol. 2005 169: 561-567
12730604 Hafezparast M et al.: Mutations in dynein link motor neuron degeneration to defects in retrograde transport Science 2003 300: 808-812
20428114 Maruyama H et al. et al.: Mutations of optineurin in amyotrophic lateral sclerosis Nature 2010 465: 223-226
20428114 Maruyama H et al.: Mutations of optineurin in amyotrophic lateral sclerosis. Nature 2010 465: 223-226
19657041 Perlson E et al.: A switch in retrograde signaling from survival to stress in rapid-onset neurodegeneration J. Neurosci. 2009 29: 9903-9917
15339911 Hu P et al.: Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death J. Biol. Chem. 2004 279
15339911 Hu P et al.: Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death. J. Biol. Chem. 2004 279
12654515 Li B et al.: VEGF-induced activation of the PI3-K/Akt pathway reduces mutant SOD1-mediated motor neuron cell death Brain Res. Mol. Brain Res. 2003 111: 155-164
17991856 Lin JH et al.: IRE1 signaling affects cell fate during the unfolded protein response. Science 2007 318: 944-949
18305234 Laird FM et al.: Motor neuron disease occurring in a mutant dynactin mouse model is characterized by defects in vesicular trafficking J. Neurosci. 2008 28: 1997-2005
18094236 Lai C et al.: The G59S mutation in p150(glued) causes dysfunction of dynactin in mice J. Neurosci. 2007 27
18701194 Anagnostou G et al.: Vesicle associated membrane protein B (VAPB) is decreased in ALS spinal cord. Neurobiol. Aging 2010 31: 969-985
18555774 Tsuda H et al.: The amyotrophic lateral sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors. Cell 2008 133: 963-977
18344992 Zhong Z et al.: ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration Nat. Neurosci. 2008 11: 420-422
18030339 Garbuzova-Davis S et al.: Evidence of compromised blood-spinal cord barrier in early and late symptomatic SOD1 mice modeling ALS PLoS ONE 2007 2: E1205
19841542 Zhong Z et al.: Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells J. Clin. Invest. 2009 119: 3437-3449
19841542 Zhong Z et al.: Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells J. Clin. Invest. 2009 119: 3437-3449
18250315 Fornai F et al. et al.: Lithium delays progression of amyotrophic lateral sclerosis Proc. Natl. Acad. Sci. U.S.A. 2008 105: 2052-2057
16236328 Shao L et al.: Mood stabilizing drug lithium increases expression of endoplasmic reticulum stress proteins in primary cultured rat cerebral cortical cells. Life Sci. 2006 78: 1317-1323
15980862 Ravikumar B et al.: Dynein mutations impair autophagic clearance of aggregate-prone proteins. Nat. Genet. 2005 37: 771-776
14960605 Nguyen MD et al.: Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis J. Neurosci. 2004 24: 1340-1349
15056289 Pehar M et al.: Astrocytic production of nerve growth factor in motor neuron apoptosis: implications for amyotrophic lateral sclerosis J. Neurochem. 2004 89: 464-473
20138122 Milane A et al.: P-glycoprotein expression and function are increased in an animal model of amyotrophic lateral sclerosis Neurosci. Lett. 2010 472: 166-170
11754077 Cassina P et al.: Peroxynitrite triggers a phenotypic transformation in spinal cord astrocytes that induces motor neuron apoptosis J. Neurosci. Res. 2002 67: 21-29
19733563 Neymotin A et al.: Lenalidomide (Revlimid) administration at symptom onset is neuroprotective in a mouse model of amyotrophic lateral sclerosis Exp. Neurol. 2009 220: 191-197
20616880 Huang C et al.: Sustained expression of TDP-43 and FUS in motor neurons in rodents lifetime Int. J. Biol. Sci. 2010 6: 396-406
20606625 Dormann D et al.: ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import EMBO J. 2010 29: 2841-2857
20606625 Dormann D et al.: ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import EMBO J. 2010 29: 2841-2857
17481916 Strong MJ et al.: TDP43 is a human low molecular weight neurofilament (hNFL) mRNA-binding protein Mol. Cell. Neurosci. 2007 35: 320-327
17481916 Strong MJ et al.: TDP43 is a human low molecular weight neurofilament (hNFL) mRNA-binding protein Mol. Cell. Neurosci. 2007 35: 320-327
20517935 Deng HX et al.: FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis Ann. Neurol. 2010 67: 739-748
18305110 Winton MJ et al.: Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation J. Biol. Chem. 2008 283
20570967 Crippa V et al.: The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS) Hum. Mol. Genet. 2010 19: 3440-3456
20570967 Crippa V et al. et al.: The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS) Hum. Mol. Genet. 2010 19: 3440-3456
20624952 Ling SC et al.: ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS Proc. Natl. Acad. Sci. U.S.A. 2010 107
19815002 Volkening K et al.: Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS) Brain Res. 2009 1305: 168-182
20138212 Caragounis A et al.: Zinc induces depletion and aggregation of endogenous TDP-43 Free Radic. Biol. Med. 2010 48: 1152-1161
16877542 Wu DC et al.: The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice Proc. Natl. Acad. Sci. U.S.A. 2006 103
20219021 Rentzos M et al.: Interleukin-17 and interleukin-23 are elevated in serum and cerebrospinal fluid of patients with ALS: a reflection of Th17 cells activation Acta Neurol. Scand. 2010 122: 425-429
19752764 Sargsyan SA et al.: Mutant SOD1 G93A microglia have an inflammatory phenotype and elevated production of MCP-1 Neuroreport 2009 20: 1450-1455
17852013 Rentzos M et al.: RANTES levels are elevated in serum and cerebrospinal fluid in patients with amyotrophic lateral sclerosis Amyotroph Lateral Scler 2007 8: 283-287
18997009 Chiu IM et al.: T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS Proc. Natl. Acad. Sci. U.S.A. 2008 105
20071543 Duplan L et al.: Collapsin response mediator protein 4a (CRMP4a) is upregulated in motoneurons of mutant SOD1 mice and can trigger motoneuron axonal degeneration and cell death J. Neurosci. 2010 30: 785-796
20071543 Duplan L et al.: Collapsin response mediator protein 4a (CRMP4a) is upregulated in motoneurons of mutant SOD1 mice and can trigger motoneuron axonal degeneration and cell death J. Neurosci. 2010 30: 785-796
19323997 Yang Y et al.: Presynaptic regulation of astroglial excitatory neurotransmitter transporter GLT1 Neuron 2009 61: 880-894
19323997 Yang Y et al.: Presynaptic regulation of astroglial excitatory neurotransmitter transporter GLT1 Neuron 2009 61: 880-894
11818550 Howland DS et al.: Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS) Proc. Natl. Acad. Sci. U.S.A. 2002 99: 1604-1609
19074031 Vargas MR et al.: Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis J. Neurosci. 2008 28
14755726 Henkel JS et al.: Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue Ann. Neurol. 2004 55: 221-235
19429692 D'Ambrogio A et al.: Functional mapping of the interaction between TDP-43 and hnRNP A2 in vivo Nucleic Acids Res. 2009 37: 4116-4126
19910924 Fiesel FC et al.: Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6 EMBO J. 2010 29: 209-221
19910924 Fiesel FC et al.: Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6 EMBO J. 2010 29: 209-221
20361056 Zhou H et al.: Transgenic rat model of neurodegeneration caused by mutation in the TDP gene PLoS Genet. 2010 6
17555556 Xiao Q et al.: Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microglia J. Neurochem. 2007 102: 2008-2019
19888600 Chen K et al.: Inducible nitric oxide synthase is present in motor neuron mitochondria and Schwann cells and contributes to disease mechanisms in ALS mice Brain Struct Funct 2010 214: 219-234
19236470 Kuhle J et al.: Increased levels of inflammatory chemokines in amyotrophic lateral sclerosis Eur. J. Neurol. 2009 16: 771-774
19236470 Kuhle J et al.: Increased levels of inflammatory chemokines in amyotrophic lateral sclerosis Eur. J. Neurol. 2009 16: 771-774
19005069 Cheret C et al.: Neurotoxic activation of microglia is promoted by a nox1-dependent NADPH oxidase. J. Neurosci. 2008 28
18598679 Li B et al.: The NADPH oxidase is involved in lipopolysaccharide-mediated motor neuron injury. Brain Res. 2008 1226: 199-208
19307024 Mantovani S et al.: Immune system alterations in sporadic amyotrophic lateral sclerosis patients suggest an ongoing neuroinflammatory process J. Neuroimmunol. 2009 210: 73-79
20544912 Mitchell RM et al.: Plasma biomarkers associated with ALS and their relationship to iron homeostasis Muscle Nerve 2010 42: 95-103
18825663 Liang X et al.: The prostaglandin E2 EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis Ann. Neurol. 2008 64: 304-314
18825663 Liang X et al.: The prostaglandin E2 EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis Ann. Neurol. 2008 64: 304-314
19539030 Casafont I et al.: TDP-43 localizes in mRNA transcription and processing sites in mammalian neurons J. Struct. Biol. 2009 167: 235-241
20740007 Elden AC et al. et al.: Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS Nature 2010 466: 1069-1075
20579074 Huang EJ et al.: Extensive FUS-immunoreactive pathology in juvenile amyotrophic lateral sclerosis with basophilic inclusions Brain Pathol. 2010 20: 1069-1076
20544928 Rademakers R et al.: Fus gene mutations in familial and sporadic amyotrophic lateral sclerosis Muscle Nerve 2010 42: 170-176
20154090 Hanson KA et al.: Ubiquilin modifies TDP-43 toxicity in a Drosophila model of amyotrophic lateral sclerosis (ALS) J. Biol. Chem. 2010 285
19112176 Kim SH et al.: Potentiation of amyotrophic lateral sclerosis (ALS)-associated TDP-43 aggregation by the proteasome-targeting factor, ubiquilin 1 J. Biol. Chem. 2009 284: 8083-8092
19887443 Nishimoto Y et al.: Characterization of alternative isoforms and inclusion body of the TAR DNA-binding protein-43. J. Biol. Chem. 2010 285: 608-619
17898224 Zhang YJ et al.: Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43 J. Neurosci. 2007 27
20600671 Duan W et al.: Mutant TAR DNA-binding protein-43 induces oxidative injury in motor neuron-like cell Neuroscience 2010 169: 1621-1629
20133711 Wils H et al.: TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration Proc. Natl. Acad. Sci. U.S.A. 2010 107: 3858-3863
18546284 Hasegawa M et al.: Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis Ann. Neurol. 2008 64: 60-70
18546284 Hasegawa M et al.: Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis Ann. Neurol. 2008 64: 60-70
20303959 Guo Y et al.: Decreased GLT-1 and increased SOD1 and HO-1 expression in astrocytes contribute to lumbar spinal cord vulnerability of SOD1-G93A transgenic mice FEBS Lett. 2010 584: 1615-1622
19223871 Tatom JB et al.: Mimicking aspects of frontotemporal lobar degeneration and Lou Gehrigs disease in rats via TDP-43 overexpression Mol. Ther. 2009 17: 607-613
19833869 Wegorzewska I et al.: TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration Proc. Natl. Acad. Sci. U.S.A. 2009 106
20660762 Chiang PM et al.: Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism Proc. Natl. Acad. Sci. U.S.A. 2010 107
16369483 Urushitani M et al.: Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis Nat. Neurosci. 2006 9: 108-118
16369483 Urushitani M et al.: Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis Nat. Neurosci. 2006 9: 108-118
20829229 Ferri A et al.: Glutaredoxin 2 prevents aggregation of mutant SOD1 in mitochondria and abolishes its toxicity Hum. Mol. Genet. 2010 19: 4529-4542
20202083 Yamashita S et al.: DJ-1 forms complexes with mutant SOD1 and ameliorates its toxicity J. Neurochem. 2010 113: 860-870
20202083 Yamashita S et al.: DJ-1 forms complexes with mutant SOD1 and ameliorates its toxicity J. Neurochem. 2010 113: 860-870
19889637 Zhou J et al.: Hyperactive intracellular calcium signaling associated with localized mitochondrial defects in skeletal muscle of an animal model of amyotrophic lateral sclerosis J. Biol. Chem. 2010 285: 705-712
20460269 Pedrini S et al.: ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2 Hum. Mol. Genet. 2010 19: 2974-2986
20460269 Pedrini S et al.: ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2 Hum. Mol. Genet. 2010 19: 2974-2986
17510659 Hetz C et al.: The proapoptotic BCL-2 family member BIM mediates motoneuron loss in a model of amyotrophic lateral sclerosis Cell Death Differ. 2007 14: 1386-1389
17510659 Hetz C et al.: The proapoptotic BCL-2 family member BIM mediates motoneuron loss in a model of amyotrophic lateral sclerosis Cell Death Differ. 2007 14: 1386-1389
19100675 Abutin RM et al.: Erythropoietin-induced phosphorylation/degradation of BIM contributes to survival of erythroid cells Exp. Hematol. 2009 37: 151-158
20456006 Tovar-Y-Romo LB et al.: VEGF protects spinal motor neurons against chronic excitotoxic degeneration in vivo by activation of PI3-K pathway and inhibition of p38MAPK J. Neurochem. 2010 115: 1090-1101
19741096 Yonashiro R et al.: Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced reactive oxygen species generation Mol. Biol. Cell 2009 20: 4524-4530
10650002 Urano F et al.: Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1 Science 2000 287: 664-666
17178835 Jiang SX et al.: Neuropilin-1 is a direct target of the transcription factor E2F1 during cerebral ischemia-induced neuronal death in vivo Mol. Cell. Biol. 2007 27: 1696-1705
20890041 Reyes NA et al.: Blocking the mitochondrial apoptotic pathway preserves motor neuron viability and function in a mouse model of amyotrophic lateral sclerosis J. Clin. Invest. 2010 120: 3673-3679
18160256 Nawa M et al.: A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB Cell. Signal. 2008 20: 493-505
18086918 Kang J et al.: MyD88-deficient bone marrow cells accelerate onset and reduce survival in a mouse model of amyotrophic lateral sclerosis J. Cell Biol. 2007 179: 1219-1230
17725983 De Vos KJ et al.: Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content Hum. Mol. Genet. 2007 16: 2720-2728
12390515 Jung C et al.: Mitochondrial electron transport chain complex dysfunction in a transgenic mouse model for amyotrophic lateral sclerosis J. Neurochem. 2002 83: 535-545
15634778 Kirkinezos IG et al.: Cytochrome c association with the inner mitochondrial membrane is impaired in the CNS of G93A-SOD1 mice J. Neurosci. 2005 25: 164-172
19240958 Lin J et al.: Specific electron transport chain abnormalities in amyotrophic lateral sclerosis J. Neurol. 2009 256: 774-782
12050154 Mattiazzi M et al.: Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice J. Biol. Chem. 2002 277
16903849 Raimondi A et al.: Cell culture models to investigate the selective vulnerability of motoneuronal mitochondria to familial ALS-linked G93ASOD1 Eur. J. Neurosci. 2006 24: 387-399
15758154 Vijayvergiya C et al.: Mutant superoxide dismutase 1 forms aggregates in the brain mitochondrial matrix of amyotrophic lateral sclerosis mice J. Neurosci. 2005 25: 2463-2470
18703498 Kawamata H et al.: Different regulation of wild-type and mutant Cu,Zn superoxide dismutase localization in mammalian mitochondria Hum. Mol. Genet. 2008 17: 3303-3317
19320055 Son M et al.: Redox susceptibility of SOD1 mutants is associated with the differential response to CCS over-expression in vivo Neurobiol. Dis. 2009 34: 155-162
17620987 Jiang YM et al.: Gene expressions specifically detected in motor neurons (dynactin 1, early growth response 3, acetyl-CoA transporter, death receptor 5, and cyclin C) differentially correlate to pathologic markers in sporadic amyotrophic lateral sclerosis J. Neuropathol. Exp. Neurol. 2007 66: 617-627
21078990 Li Q et al.: ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import Proc. Natl. Acad. Sci. U.S.A. 2010 107
21078990 Li Q et al.: ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import Proc. Natl. Acad. Sci. U.S.A. 2010 107
20797535 Israelson A et al.: Misfolded mutant SOD1 directly inhibits VDAC1 conductance in a mouse model of inherited ALS Neuron 2010 67: 575-587
20797535 Israelson A et al.: Misfolded mutant SOD1 directly inhibits VDAC1 conductance in a mouse model of inherited ALS Neuron 2010 67: 575-587
18296640 Vande Velde C et al.: Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria Proc. Natl. Acad. Sci. U.S.A. 2008 105: 4022-4027
19779023 Magrane J et al.: Mutant SOD1 in neuronal mitochondria causes toxicity and mitochondrial dynamics abnormalities Hum. Mol. Genet. 2009 18: 4552-4564
19272377 Martin LJ et al.: The mitochondrial permeability transition pore in motor neurons: involvement in the pathobiology of ALS mice Exp. Neurol. 2009 218: 333-346
19174508 Nguyen KT et al.: The Psi(m) depolarization that accompanies mitochondrial Ca2+ uptake is greater in mutant SOD1 than in wild-type mouse motor terminals Proc. Natl. Acad. Sci. U.S.A. 2009 106: 2007-2011
19404401 Dupuis L et al.: Muscle mitochondrial uncoupling dismantles neuromuscular junction and triggers distal degeneration of motor neurons PLoS ONE 2009 4: E5390
19158288 Jeong SY et al.: Dysregulation of iron homeostasis in the CNS contributes to disease progression in a mouse model of amyotrophic lateral sclerosis J. Neurosci. 2009 29: 610-619
17394531 Zimmerman MC et al.: Mutant SOD1-induced neuronal toxicity is mediated by increased mitochondrial superoxide levels J. Neurochem. 2007 102: 609-618
16702190 Wood-Allum CA et al.: Impairment of mitochondrial anti-oxidant defence in SOD1-related motor neuron injury and amelioration by ebselen Brain 2006 129: 1693-1709
20127819 Morimoto N et al.: Induction of parkinsonism-related proteins in the spinal motor neurons of transgenic mouse carrying a mutant SOD1 gene J. Neurosci. Res. 2010 88: 1804-1811
18712292 Lev N et al.: DJ-1 changes in G93A-SOD1 transgenic mice: implications for oxidative stress in ALS. J. Mol. Neurosci. 2009 38: 94-102
17434459 Eve DJ et al.: Transcription factor p53 in degenerating spinal cords. Brain Res. 2007 1150: 174-181
17099894 Martin LJ et al.: Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: mechanisms of mitochondriopathy and cell death. J. Comp. Neurol. 2007 500: 20-46
19805546 Lu L et al.: Amyotrophic lateral sclerosis-linked mutant SOD1 sequesters Hu antigen R (HuR) and TIA-1-related protein (TIAR): implications for impaired post-transcriptional regulation of vascular endothelial growth factor. J. Biol. Chem. 2009 284
17434152 Murakami T et al.: Early decrease of mitochondrial DNA repair enzymes in spinal motor neurons of presymptomatic transgenic mice carrying a mutant SOD1 gene. Brain Res. 2007 1150: 182-189
19900586 Loizzo S et al.: Dynamic NAD(P)H post-synaptic autofluorescence signals for the assessment of mitochondrial function in a neurodegenerative disease: monitoring the primary motor cortex of G93A mice, an amyotrophic lateral sclerosis model. Mitochondrion 2010 10: 108-114
19379740 Bradley LJ et al.: Increased sensitivity of myoblasts to oxidative stress in amyotrophic lateral sclerosis peripheral tissues. Exp. Neurol. 2009 218: 92-97
18417691 Cassina P et al.: Mitochondrial dysfunction in SOD1G93A-bearing astrocytes promotes motor neuron degeneration: prevention by mitochondrial-targeted antioxidants. J. Neurosci. 2008 28: 4115-4122
21059924 Bilsland LG et al.: Deficits in axonal transport precede ALS symptoms in vivo. Proc. Natl. Acad. Sci. U.S.A. 2010 107
20606625 Dormann D et al.: ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import. EMBO J. 2010 29: 2841-2857
25374358 Smith BN et al.: Exome-wide rare variant analysis identifies TUBA4A mutations associated with familial ALS Neuron 2014 84: 324-331
28989002 Sanfilippo C et al.: CHI3L1 and CHI3L2 overexpression in motor cortex and spinal cord of sALS patients Mol. Cell. Neurosci. 2017 85: 162-169
20079427 Halter B et al.: Oxidative stress in skeletal muscle stimulates early expression of Rad in a mouse model of amyotrophic lateral sclerosis Free Radic. Biol. Med. 2010 48: 915-923
23300739 Figueroa-Romero C et al.: Identification of epigenetically altered genes in sporadic amyotrophic lateral sclerosis PLoS ONE 2012 7
31784536 Yuva-Aydemir Y et al.: Transcription elongation factor AFF2/FMR2 regulates expression of expanded GGGGCC repeat-containing C9ORF72 allele in ALS/FTD Nat Commun 2019 10: 5466
17244347 Lederer CW et al.: Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis BMC Genomics 2007 8: 26
17671248 Dunckley T et al. et al.: Whole-genome analysis of sporadic amyotrophic lateral sclerosis N. Engl. J. Med. 2007 357: 775-788
24918638 Venkova K et al.: Semaphorin 3A signaling through neuropilin-1 is an early trigger for distal axonopathy in the SOD1G93A mouse model of amyotrophic lateral sclerosis J. Neuropathol. Exp. Neurol. 2014 73: 702-713
26704906 Figueroa-Romero C et al.: Expression of microRNAs in human post-mortem amyotrophic lateral sclerosis spinal cords provides insight into disease mechanisms Mol. Cell. Neurosci. 2016 71: 34-45
28283675 Andres-Benito P et al.: Amyotrophic lateral sclerosis, gene deregulation in the anterior horn of the spinal cord and frontal cortex area 8: implications in frontotemporal lobar degeneration Aging (Albany NY) 2017 9: 823-851
22922411 Van Hoecke A et al. et al.: EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans Nat. Med. 2012 18: 1418-1422
26687981 Lewandowski SA et al.: Presymptomatic activation of the PDGF-CC pathway accelerates onset of ALS neurodegeneration Acta Neuropathol. 2016 131: 453-464
27812125 Won YH et al.: Elucidation of Relevant Neuroinflammation Mechanisms Using Gene Expression Profiling in Patients with Amyotrophic Lateral Sclerosis PLoS ONE 2016 11
16807408 Parkinson N et al.: ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B) Neurology 2006 67: 1074-1077
11803234 Croonenberghs J et al.: Activation of the inflammatory response system in autism. Neuropsychobiology 2002 45: 1-6
19157572 Li X et al.: Elevated immune response in the brain of autistic patients. J. Neuroimmunol. 2009 207: 111-116
10693155 Croonenberghs J et al.: Peripheral markers of serotonergic and noradrenergic function in post-pubertal, caucasian males with autistic disorder Neuropsychopharmacology 2000 22: 275-283
10693155 Croonenberghs J et al.: Peripheral markers of serotonergic and noradrenergic function in post-pubertal, caucasian males with autistic disorder. Neuropsychopharmacology 2000 22: 275-283
21573053 Naik US et al.: A study of nuclear transcription factor-kappa B in childhood autism. PLoS ONE 2011 6
21521652 Al-ayadhi LY et al.: Increased serum osteopontin levels in autistic children: relation to the disease severity Brain Behav. Immun. 2011 25: 1393-1398
20705131 Ashwood P et al.: Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome Brain Behav. Immun. 2011 25: 40-45
12039413 Torres AR et al.: The transmission disequilibrium test suggests that HLA-DR4 and DR13 are linked to autism spectrum disorder Hum. Immunol. 2002 63: 311-316
21346746 Penzes P et al.: Dendritic spine pathology in neuropsychiatric disorders Nat. Neurosci. 2011 14: 285-293
23596459 Gilling M et al.: Dysfunction of the Heteromeric KV7.3/KV7.5 Potassium Channel is Associated with Autism Spectrum Disorders Front Genet 2013 4: 54
19289393 Ben-Shachar S et al.: Microdeletion 15q13.3: a locus with incomplete penetrance for autism, mental retardation, and psychiatric disorders J. Med. Genet. 2009 46: 382-388
24776741 McCarthy SE et al.: De novo mutations in schizophrenia implicate chromatin remodeling and support a genetic overlap with autism and intellectual disability
24752249 Breitenkamp AF et al.: Rare mutations of CACNB2 found in autism spectrum disease-affected families alter calcium channel function PLoS ONE 2014 9
25707359 Chen N et al.: Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes Biochim. Biophys. Acta 2015 7: 827-833
25271084 Mullegama SV et al.: MBD5 haploinsufficiency is associated with sleep disturbance and disrupts circadian pathways common to Smith-Magenis and fragile X syndromes Eur. J. Hum. Genet. 2015 23: 781-789
28720891 Al-Mubarak B et al. et al.: Whole exome sequencing reveals inherited and de novo variants in autism spectrum disorder: a trio study from Saudi families Sci Rep 2017 7: 5679
26749308 Turner TN et al. et al.: Genome Sequencing of Autism-Affected Families Reveals Disruption of Putative Noncoding Regulatory DNA Am. J. Hum. Genet. 2016 98: 58-74
25774383 Cartier E et al. et al.: Rare autism-associated variants implicate syntaxin 1 (STX1 R26Q) phosphorylation and the dopamine transporter (hDAT R51W) in dopamine neurotransmission and behaviors EBioMedicine 2015 2: 135-146
18593506 Nakamura K et al. et al.: Genetic and expression analyses reveal elevated expression of syntaxin 1A ( STX1A) in high functioning autism Int. J. Neuropsychopharmacol. 2008 11: 1073-1084
22495309 O'Roak BJ et al. et al.: Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations Nature 2012 485: 246-250
30873608 Castronovo P et al.: Phenotypic spectrum of NRXN1 mono- and bi-allelic deficiency: A systematic review
23995680 King IF et al. et al.: Topoisomerases facilitate transcription of long genes linked to autism Nature 2013 501: 58-62
23495017 Dabell MP et al. et al.: Investigation of NRXN1 deletions: clinical and molecular characterization Am. J. Med. Genet. A 2013 161A: 717-731
27965028 Sajid U et al.: Two De Novo Mutations in an Autistic Child Who Had Previously Undergone Transplantation for Dilated Cardiomyopathy: The Importance of Keeping an Open Mind Can J Cardiol 2017 33: 292.e5-292.e7
18057082 et al.: A patient with vertebral, cognitive and behavioural abnormalities and a de novo deletion of NRXN1alpha J. Med. Genet. 2008 45: 239-243
24360806 He Z et al. et al.: Rare-variant extensions of the transmission disequilibrium test: application to autism exome sequence data Am. J. Hum. Genet. 2014 94: 33-46
25363760 De Rubeis S et al. et al.: Synaptic, transcriptional and chromatin genes disrupted in autism Nature 2014 515: 209-215
28263302 C Yuen RK et al. et al.: Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder Nat. Neurosci. 2017 20: 602-611
22542183 Iossifov I et al. et al.: De novo gene disruptions in children on the autistic spectrum Neuron 2012 74: 285-299
25363768 Iossifov I et al. et al.: The contribution of de novo coding mutations to autism spectrum disorder Nature 2014 515: 216-221
29021403 Hamilton MJ et al. et al.: Heterozygous mutations affecting the protein kinase domain of CDK13 cause a syndromic form of developmental delay and intellectual disability J. Med. Genet. 2018 55: 28-38
23275889 Prasad A et al. et al.: A discovery resource of rare copy number variations in individuals with autism spectrum disorder G3 (Bethesda) 3 (B 2: 1665-1685
22495311 Neale BM et al. et al.: Patterns and rates of exonic de novo mutations in autism spectrum disorders Nature 2012 485: 242-245
28584692 Shroff G et al.: Human Embryonic Stem Cells in the Treatment of Autism: A Case Series Innov Clin Neurosci 2017 14: 12-16
22843504 Anney R et al. et al.: Individual common variants exert weak effects on the risk for autism spectrum disorders Hum. Mol. Genet. 2012 21: 4781-4792
29346770 Takata A et al. et al.: Integrative Analyses of De Novo Mutations Provide Deeper Biological Insights into Autism Spectrum Disorder Cell Rep 2018 22: 734-747
22965006 Skafidas E et al.: Predicting the diagnosis of autism spectrum disorder using gene pathway analysis Mol. Psychiatry 2014 19: 504-510
18252227 Marshall CR et al. et al.: Structural variation of chromosomes in autism spectrum disorder Am. J. Hum. Genet. 2008 82: 477-488
11706102 Purcell AE et al.: Postmortem brain abnormalities of the glutamate neurotransmitter system in autism Neurology 2001 57: 1618-1628
21614001 Voineagu I et al.: Transcriptomic analysis of autistic brain reveals convergent molecular pathology Nature 2011 474: 380-384
26783092 Feng J et al.: Clinical improvement following vitamin D3 supplementation in Autism Spectrum Disorder Nutr Neurosci 2017 20: 284-290
29505902 O'Connell KS et al.: The genetic architecture of schizophrenia, bipolar disorder, obsessive-compulsive disorder and autism spectrum disorder Mol. Cell. Neurosci. 2018 88: 300-307
11357950 Nelson KB et al.: Neuropeptides and neurotrophins in neonatal blood of children with autism or mental retardation Ann. Neurol. 2001 49: 597-606
21358714 Gai X et al. et al.: Rare structural variation of synapse and neurotransmission genes in autism Mol. Psychiatry 2012 17: 402-411
24007566 Stamova BS et al.: Evidence for differential alternative splicing in blood of young boys with autism spectrum disorders Mol Autism 2013 4: 30
31277925 Nakagawa N et al. et al.: Memo1-Mediated Tiling of Radial Glial Cells Facilitates Cerebral Cortical Development Neuron 2019 103: 836-852.e5
31327155 Miryounesi M et al.: ELMO Domain Containing 1 (ELMOD1) Gene Mutation Is Associated with Mental Retardation and Autism Spectrum Disorder J. Mol. Neurosci. 2019 69: 312-315
29428674 Quartier A et al.: Genes and Pathways Regulated by Androgens in Human Neural Cells, Potential Candidates for the Male Excess in Autism Spectrum Disorder Biol. Psychiatry 2018 84: 239-252
23279911 Boudry-Labis E et al. et al.: A novel microdeletion syndrome at 9q21.13 characterised by mental retardation, speech delay, epilepsy and characteristic facial features Eur J Med Genet 2013 56: 163-170
28251352 Zhang J et al. et al.: Haploinsufficiency of the E3 ubiquitin-protein ligase gene TRIP12 causes intellectual disability with or without autism spectrum disorders, speech delay, and dysmorphic features Hum. Genet. 2017 136: 377-386
23838881 Talebizadeh Z et al.: A proof-of-concept study: exon-level expression profiling and alternative splicing in autism using lymphoblastoid cell lines Psychiatr. Genet. 2014 24: 1-9
20308993 Vorstman JA et al. et al.: A double hit implicates DIAPH3 as an autism risk gene Mol. Psychiatry 2011 16: 442-451
26398136 Kuo PH et al. et al.: Genome-Wide Association Study for Autism Spectrum Disorder in Taiwanese Han Population PLoS ONE 2015 10
23756379 Poelmans G et al.: AKAPs integrate genetic findings for autism spectrum disorders Transl Psychiatry 2013 3: e270
27479844 Krishnan A et al.: Genome-wide prediction and functional characterization of the genetic basis of autism spectrum disorder Nat. Neurosci. 2016 19: 1454-1462
28628100 Geisheker MR et al. et al.: Hotspots of missense mutation identify neurodevelopmental disorder genes and functional domains Nat. Neurosci. 2017 20: 1043-1051
29147782 Chiocchetti AG et al. et al.: Common functional variants of the glutamatergic system in Autism spectrum disorder with high and low intellectual abilities J Neural Transm (Vienna) 2018 125: 259-271
27545675 Bain JM et al. et al.: Variants in HNRNPH2 on the X Chromosome Are Associated with a Neurodevelopmental Disorder in Females Am. J. Hum. Genet. 2016 99: 728-734
20452682 Mostafa GA et al.: The link of C4B null allele to autism and to a family history of autoimmunity in Egyptian autistic children J. Neuroimmunol. 2010 223: 115-119
22589251 Harper KM et al.: Alterations of social interaction through genetic and environmental manipulation of the 22q11.2 gene Sept5 in the mouse brain Hum. Mol. Genet. 2012 21: 3489-3499
31923461 Loomis C et al.: Identification of MAGUK scaffold proteins as intracellular binding partners of synaptic adhesion protein Slitrk2 Mol. Cell. Neurosci. 2020 103
20479760 Piton A et al. et al.: Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia Mol. Psychiatry 2011 16: 867-880
25360606 Jones RM et al.: MACROD2 gene associated with autistic-like traits in a general population sample Psychiatr. Genet. 2014 24: 241-248
21981781 Talkowski ME et al. et al.: Assessment of 2q23.1 microdeletion syndrome implicates MBD5 as a single causal locus of intellectual disability, epilepsy, and autism spectrum disorder Am. J. Hum. Genet. 2011 89: 551-563
27428651 Shemesh Y et al. et al.: Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics Nat. Neurosci. 2016 19: 1489-1496
26314684 Liu X et al. et al.: Genome-wide Association Study of Autism Spectrum Disorder in the East Asian Populations Autism Res 2016 9: 340-349
31094488 Torrico B et al.: Truncating variant burden in high-functioning autism and pleiotropic effects of LRP1 across psychiatric phenotypes }, authors { names std { { name ml Torrico B, affil str From the Departament de Genetica, Microbiologia i Estadistica, Universitat de Barcelona, Spain (Torrico, Vivo-Luque, Fernandez-Castillo, Cormand, Toma); the Institute of Biomedicine, University of Barcelona, Barcelona, Spain (Torrico, Fernandez-Castillo, Cormand, Toma); the Centro de Investigacion Biomedica en Red de Enfermedades Raras (CIBERER), Barcelona, Spain (Torrico, Fernandez-Castillo, Cormand, Toma); the Institut de Recerca Hospital Sant Joan de Deu, Esplugues de Llobregat, Barcelona, Spain (Torrico, Fernandez-Castillo, Cormand); the Neuroscience Research Australia, Sydney, NSW, Australia (Shaw, Fullerton, Toma); the School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia (Shaw, Fullerton, Toma); the Institute for Research in Biomedicine (IRB Barcelona) and the Barcelona Institute of Science and Technology, Barcelona, Spain (Mosca, Aloy); the Child and Adolescent Mental Health Unit, Hospital Universitari Mutua de Terrassa, Spain (Hervas); the Institucio Catalana de Recerca i Estudis Avancats (ICREA), Barcelona, Spain (Aloy); and the Centro Nacional de Analisis Genomico (CNAG), Barcelona, Spain (Bayes) J Psychiatry Neurosci 2019 44: 350-359
31018497 Carrasco M et al.: Alterations of Mitochondrial Biology in the Oral Mucosa of Chilean Children with Autism Spectrum Disorder (ASD)
25418537 O'Roak BJ et al. et al.: Recurrent de novo mutations implicate novel genes underlying simplex autism risk Nat Commun 2014 5: 5595
30394313 Wang M et al.: Alteration of gut microbiota-associated epitopes in children with autism spectrum disorders Brain Behav. Immun. 2019 75: 192-199
29114925 Ishizuka K et al. et al.: Possible involvement of a cell adhesion molecule, Migfilin, in brain development and pathogenesis of autism spectrum disorders J. Neurosci. Res. 2018 96: 789-802
28262759 Goto M et al.: Role of a circadian-relevant gene NR1D1 in brain development: possible involvement in the pathophysiology of autism spectrum disorders Sci Rep 2017 7: 43945
24520327 Choi J et al.: Autism associated gene, engrailed2, and flanking gene levels are altered in post-mortem cerebellum PLoS ONE 2014 9
11074872 Guidotti A et al.: Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study Arch. Gen. Psychiatry 2000 57: 1061-1069
17270400 Veldic M et al.: Epigenetic mechanisms expressed in basal ganglia GABAergic neurons differentiate schizophrenia from bipolar disorder Schizophr. Res. 2007 91: 51-61
19059449 Torres KC et al.: The leukocytes expressing DARPP-32 are reduced in patients with schizophrenia and bipolar disorder. Prog. Neuropsychopharmacol. Biol. Psychiatry 2009 33: 214-219
20368704 Williams HJ et al.: Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder Mol. Psychiatry 2011 16: 429-441
16924267 Severinsen JE et al.: Evidence implicating BRD1 with brain development and susceptibility to both schizophrenia and bipolar affective disorder. Mol. Psychiatry 2006 11: 1126-1138
16484223 Assmann EM et al.: FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region J. Biol. Chem. 2006 281: 9869-9881
20569643 Hope S et al.: Osteoprotegerin levels in patients with severe mental disorders J Psychiatry Neurosci 2010 35: 304-310
19754466 OBrien WT et al.: Validating GSK3 as an in vivo target of lithium action. Biochem. Soc. Trans. 2009 37: 1133-1138
21176028 Beech RD et al.: Increased peripheral blood expression of electron transport chain genes in bipolar depression. Bipolar Disord 2010 12: 813-824
20566748 Cataldo AM et al.: Abnormalities in mitochondrial structure in cells from patients with bipolar disorder. Am. J. Pathol. 2010 177: 575-585
17485607 Naydenov AV et al.: Differences in lymphocyte electron transport gene expression levels between subjects with bipolar disorder and normal controls in response to glucose deprivation stress. Arch. Gen. Psychiatry 2007 64: 555-564
20368511 Andreazza AC et al.: Mitochondrial complex I activity and oxidative damage to mitochondrial proteins in the prefrontal cortex of patients with bipolar disorder Arch. Gen. Psychiatry 2010 67: 360-368
1728159 Dubovsky SL et al.: Abnormal intracellular calcium ion concentration in platelets and lymphocytes of bipolar patients. Am J Psychiatry 1992 149: 118-120
15737668 Munakata K et al.: Mitochondrial DNA 3243A>G mutation and increased expression of LARS2 gene in the brains of patients with bipolar disorder and schizophrenia. Biol. Psychiatry 2005 57: 525-532
14993118 Konradi C et al.: Molecular evidence for mitochondrial dysfunction in bipolar disorder Arch. Gen. Psychiatry 2004 61: 300-308
16696827 MacDonald ML et al.: Decrease in creatine kinase messenger RNA expression in the hippocampus and dorsolateral prefrontal cortex in bipolar disorder. Bipolar Disord 2006 8: 255-264
18191109 Shao L et al.: Shared gene expression alterations in schizophrenia and bipolar disorder Biol. Psychiatry 2008 64: 89-97
19350560 Kahler AK et al.: Association study of PDE4B gene variants in Scandinavian schizophrenia and bipolar disorder multicenter case-control samples. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010 153B: 86-96
22428012 Li J et al.: Lithium impacts on the amplitude and period of the molecular circadian clockwork PLoS ONE 2012 7
22384149 McCarthy MJ et al.: A survey of genomic studies supports association of circadian clock genes with bipolar disorder spectrum illnesses and lithium response PLoS ONE 2012 7
11723175 Bezchlibnyk YB et al.: Gene expression differences in bipolar disorder revealed by cDNA array analysis of post-mortem frontal cortex J. Neurochem. 2001 79: 826-834
23231880 Manu P et al.: Insulin secretion in patients receiving clozapine, olanzapine, quetiapine and risperidone Schizophr. Res. 2013 143: 358-362
20591414 Mukherjee S et al.: Knockdown of Clock in the ventral tegmental area through RNA interference results in a mixed state of mania and depression-like behavior Biol. Psychiatry 2010 68: 503-511
17259569 Varma MK et al.: Life-threatening hyperglycemia and acidosis related to olanzapine: a case report and review of the literature J Intensive Care Med 2007 22: 52-55
11673795 Kirov G et al.: Screening ABCG1, the human homologue of the Drosophila white gene, for polymorphisms and association with bipolar affective disorder Mol. Psychiatry 2001 6: 671-677
21961650 Squassina A et al.: Evidence for association of an ACCN1 gene variant with response to lithium treatment in Sardinian patients with bipolar disorder Pharmacogenomics 2011 12: 1559-1569
20679588 Erk S et al.: Brain function in carriers of a genome-wide supported bipolar disorder variant Arch. Gen. Psychiatry 2010 67: 803-811
22831755 Meier S et al.: Neuregulin 3 is associated with attention deficits in schizophrenia and bipolar disorder Int. J. Neuropsychopharmacol. 2013 16: 549-556
21927946 Yamada K et al.: Association study of the KCNJ3 gene as a susceptibility candidate for schizophrenia in the Chinese population Hum. Genet. 2012 131: 443-451
22017219 Backlund L et al.: Cognitive manic symptoms associated with the P2RX7 gene in bipolar disorder Bipolar Disord 2011 13: 500-508
21738484 Smith EN et al.: Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes PLoS Genet. 2011 7
23437964 Gonzalez S et al.: Suggestive evidence for association between L-type voltage-gated calcium channel (CACNA1C) gene haplotypes and bipolar disorder in Latinos: a family-based association study Bipolar Disord 2013 15: 206-214
24114586 Weston-Green K et al.: Second generation antipsychotic-induced type 2 diabetes: a role for the muscarinic M3 receptor CNS Drugs 2013 27: 1069-1080
22472876 Ripke S et al.: A mega-analysis of genome-wide association studies for major depressive disorder Mol. Psychiatry 2013 18: 497-511
24461634 Finseth PI et al.: Association analysis between suicidal behaviour and candidate genes of bipolar disorder and schizophrenia J Affect Disord 2014 163: 110-114
23974872 Ripke S et al.: Genome-wide association analysis identifies 13 new risk loci for schizophrenia Nat. Genet. 2013 45: 1150-1159
23880959 Wolf C et al.: CACNA1C genotype explains interindividual differences in amygdala volume among patients with schizophrenia Eur Arch Psychiatry Clin Neurosci 2014 264: 93-102
15563509 Iwamoto K et al.: Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis Hum. Mol. Genet. 2005 14: 241-253
23070075 Green EK et al.: Replication of bipolar disorder susceptibility alleles and identification of two novel genome-wide significant associations in a new bipolar disorder case-control sample Mol. Psychiatry 2013 18: 1302-1307
17486107 Baum AE et al.: A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder Mol. Psychiatry 2008 13: 197-207
15722956 Pickard BS et al.: Candidate psychiatric illness genes identified in patients with pericentric inversions of chromosome 18 Psychiatr. Genet. 2005 15: 37-44
16733521 Borsotto M et al.: PP2A-Bgamma subunit and KCNQ2 K+ channels in bipolar disorder Pharmacogenomics J. 2007 7: 123-132
17678634 Cannon DM et al.: Elevated serotonin transporter binding in major depressive disorder assessed using positron emission tomography and [11C]DASB; comparison with bipolar disorder Biol. Psychiatry 2007 62: 870-877
31170425 Noroozi R et al.: Glutamate receptor metabotropic 7 (GRM7) gene polymorphisms in mood disorders and attention deficit hyperactive disorder Neurochem. Int. 2019 129
24348429 Kerner B et al.: Rare Genomic Variants Link Bipolar Disorder with Anxiety Disorders to CREB-Regulated Intracellular Signaling Pathways Front Psychiatry 2013 4: 154
12140780 Vawter MP et al.: Reduction of synapsin in the hippocampus of patients with bipolar disorder and schizophrenia Mol. Psychiatry 2002 7: 571-578
19166596 Kripke DF et al.: Circadian polymorphisms associated with affective disorders J Circadian Rhythms 2009 7: 2
24039173 McGrath LM et al.: Genetic predictors of risk and resilience in psychiatric disorders: a cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia Am. J. Med. Genet. B Neuropsychiatr. Genet. 2013 162B: 779-788
26848839 Davis KN et al.: GAD2 Alternative Transcripts in the Human Prefrontal Cortex, and in Schizophrenia and Affective Disorders PLoS ONE 2016 11
27350034 Pacifico R et al.: Transcriptome sequencing implicates dorsal striatum-specific gene network, immune response and energy metabolism pathways in bipolar disorder Mol. Psychiatry 2017 22: 441-449
24718920 Nurnberger JI Jr et al.: Identification of pathways for bipolar disorder: a meta-analysis JAMA Psychiatry 2014 71: 657-664
29628500 Lee SE et al.: nArgBP2-SAPAP-SHANK, the core postsynaptic triad associated with psychiatric disorders Exp. Mol. Med. 2018 50: 2
27890468 van Hulzen KJE et al. et al.: Genetic Overlap Between Attention-Deficit/Hyperactivity Disorder and Bipolar Disorder: Evidence From Genome-wide Association Study Meta-analysis Biol. Psychiatry 2017 82: 634-641
21382426 Iwamoto K et al.: Survey of the effect of genetic variations on gene expression in human prefrontal cortex and its application to genetics of psychiatric disorders Neurosci. Res. 2011 70: 238-242
20357757 Polter A et al.: Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances Neuropsychopharmacology 2010 35: 1761-1774
30149091 Corponi F et al.: Genetic basis of psychopathological dimensions shared between schizophrenia and bipolar disorder Prog. Neuropsychopharmacol. Biol. Psychiatry 2019 89: 23-29
30905121 Oral E et al.: Evaluation of Endothelial Dysfunction in Bipolar Affective Disorders: Serum Endocan and Urotensin-II Levels Clin Psychopharmacol Neurosci 2019 17: 211-221
21621268 Magno LA et al.: Genetic variations in FOXO3A are associated with Bipolar Disorder without confering vulnerability for suicidal behavior J Affect Disord 2011 133: 633-637
28463235 Scaini G et al.: Perturbations in the apoptotic pathway and mitochondrial network dynamics in peripheral blood mononuclear cells from bipolar disorder patients Transl Psychiatry 2017 7: e1111
32754070 Reponen EJ et al. et al.: Atherogenic Lipid Ratios Related to Myeloperoxidase and C-Reactive Protein Levels in Psychotic Disorders Front Psychiatry 2020 11: 672
18357389 Lee SJ et al.: Activation of matrix metalloproteinase-9 by TNF-alpha in human urinary bladder cancer HT1376 cells: the role of MAP kinase signaling pathways Oncol. Rep. 2008 19: 1007-1013
21601006 Yoganathan TN et al.: Integrin-linked kinase (ILK): a hot therapeutic target Biochem. Pharmacol. 2000 60: 1115-1119
30121007 Chakravarthi BVSK et al. et al.: A Role for De Novo Purine Metabolic Enzyme PAICS in Bladder Cancer Progression Neoplasia 2018 20: 894-904
27189278 Kim WT et al. et al.: Metabolic Pathway Signatures Associated with Urinary Metabolite Biomarkers Differentiate Bladder Cancer Patients from Healthy Controls Yonsei Med. J. 2016 57: 865-871
32094233 Lokeshwar VB et al. et al.: A Novel Splice Variant of HYAL-4 Drives Malignant Transformation and Predicts Outcome in Patients with Bladder Cancer
23866964 Dong LH et al.: Histone deacetylase inhibitor potentiated the ability of MTOR inhibitor to induce autophagic cell death in Burkitt leukemia/lymphoma J Hematol Oncol 2013 6: 53
20028864 Brown KA et al.: Obesity and breast cancer: progress to understanding the relationship Cancer Res. 2010 70: 4-7
19509226 Brown KA et al.: Subcellular localization of cyclic AMP-responsive element binding protein-regulated transcription coactivator 2 provides a link between obesity and breast cancer in postmenopausal women Cancer Res. 2009 69: 5392-5399
15766664 Kim RH et al.: DJ-1, a novel regulator of the tumor suppressor PTEN. Cancer Cell 2005 7: 263-273
11705844 Le Naour F et al.: Proteomics-based identification of RS/DJ-1 as a novel circulating tumor antigen in breast cancer. Clin. Cancer Res. 2001 7: 3328-3335
20971498 Berthier A et al.: PINK1 displays tissue-specific subcellular location and regulates apoptosis and cell growth in breast cancer cells Hum. Pathol. 2011 42: 75-87
16850246 Greenlee H et al.: Variants in estrogen metabolism and biosynthesis genes and urinary estrogen metabolites in women with a family history of breast cancer Breast Cancer Res. Treat. 2007 102: 111-117
1935184 Lessner MW et al.: A student nurses experience in an ICU. Crit Care Nurse 1991 11: 12
16361546 Cobleigh MA et al.: Tumor gene expression and prognosis in breast cancer patients with 10 or more positive lymph nodes Clin. Cancer Res. 2005 11: 8623-8631
11410592 Castro-Rivera E et al.: Estrogen regulation of cyclin D1 gene expression in ZR-75 breast cancer cells involves multiple enhancer elements. J. Biol. Chem. 2001 276
15870704 Lewandowski SA et al.: Opposite effects of estrogen receptors alpha and beta on MCF-7 sensitivity to the cytotoxic action of TNF and p53 activity. Oncogene 2005 24: 4789-4798
16328059 Li SY et al.: Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in human breast cancer. Oncol. Rep. 2006 15: 221-225
17519015 De Luca A et al.: Important roles of multiple Sp1 binding sites and epigenetic modifications in the regulation of the methionine sulfoxide reductase B1 (MsrB1) promoter. BMC Mol. Biol. 2007 8: 39
17510434 Lin Z et al.: Novel estrogen receptor-alpha binding sites and estradiol target genes identified by chromatin immunoprecipitation cloning in breast cancer. Cancer Res. 2007 67: 5017-5024
8195246 Krishnan V et al.: Estrogen receptor-Sp1 complexes mediate estrogen-induced cathepsin D gene expression in MCF-7 human breast cancer cells. J. Biol. Chem. 1994 269
9626663 Sun G et al.: Estrogen-induced retinoic acid receptor alpha 1 gene expression: role of estrogen receptor-Sp1 complex. Mol. Endocrinol. 1998 12: 882-890
12432273 Weinstein-Oppenheimer CR et al.: The effects of beta-estradiol on Raf activity, cell cycle progression and growth factor synthesis in the MCF-7 breast cancer cell line. Cancer Biol. Ther. 2002 1: 256-262
10733592 Perillo B et al.: 17beta-estradiol inhibits apoptosis in MCF-7 cells, inducing bcl-2 expression via two estrogen-responsive elements present in the coding sequence. Mol. Cell. Biol. 2000 20: 2890-2901
24495551 Mehta D et al.: Early predictive biomarkers for postpartum depression point to a role for estrogen receptor signaling
21655990 Hadad S et al.: Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial. Breast Cancer Res. Treat. 2011 128: 783-794
18714348 Martin KJ et al.: Prognostic breast cancer signature identified from 3D culture model accurately predicts clinical outcome across independent datasets. PLoS ONE 2008 3: E2994
21120602 Paruthiyil S et al.: Estrogen receptor beta causes a G2 cell cycle arrest by inhibiting CDK1 activity through the regulation of cyclin B1, GADD45A, and BTG2 Breast Cancer Res. Treat. 2011 129: 777-784
17268063 Iso T et al.: Modulation of the expression of bloom helicase by estrogenic agents. Biol. Pharm. Bull. 2007 30: 266-271
19477925 Pedram A et al.: Estrogen inhibits ATR signaling to cell cycle checkpoints and DNA repair. Mol. Biol. Cell 2009 20: 3374-3389
17942748 Boverhof DR et al.: Inhibition of estrogen-mediated uterine gene expression responses by dioxin Mol. Pharmacol. 2008 73: 82-93
18949048 Wang C et al.: Two estrogen response element sequences near the PCNA gene are not responsible for its estrogen-enhanced expression in MCF7 cells. PLoS ONE 2008 3: E3523
16010982 Vani G et al.: Effect of histone H1 on estrogen receptor status of human breast cancer MCF 7 cells. Mol. Cell. Biochem. 2005 272: 151-155
19221498 Alimova IN et al.: Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro. Cell Cycle 2009 8: 909-915
14506733 Kawai H et al.: Overexpression of histone deacetylase HDAC1 modulates breast cancer progression by negative regulation of estrogen receptor alpha Int. J. Cancer 2003 107: 353-358
17062558 Zakikhani M et al.: Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. Cancer Res. 2006 66
21185374 Englert NA et al.: Persistent and non-persistent changes in gene expression result from long-term estrogen exposure of MCF-7 breast cancer cells. J. Steroid Biochem. Mol. Biol. 2011 123: 140-150
12612058 Hodges LC et al.: Tamoxifen functions as a molecular agonist inducing cell cycle-associated genes in breast cancer cells. Mol. Cancer Res. 2003 1: 300-311
14605097 Wang DY et al.: Identification of estrogen-responsive genes by complementary deoxyribonucleic acid microarray and characterization of a novel early estrogen-induced gene: EEIG1. Mol. Endocrinol. 2004 18: 402-411
16962797 Lee SU et al.: Protein profiling and transcript expression levels of heat shock proteins in 17beta-estradiol-treated human MCF-7 breast cancer cells. Cell Biol. Int. 2006 30: 983-991
17392432 Eakin CM et al.: Estrogen receptor alpha is a putative substrate for the BRCA1 ubiquitin ligase. Proc. Natl. Acad. Sci. U.S.A. 2007 104: 5794-5799
19887602 Ueki T et al.: Ubiquitination and downregulation of BRCA1 by ubiquitin-conjugating enzyme E2T overexpression in human breast cancer cells. Cancer Res. 2009 69: 8752-8760
20501845 Zhao C et al.: Genome-wide mapping of estrogen receptor-beta-binding regions reveals extensive cross-talk with transcription factor activator protein-1. Cancer Res. 2010 70: 5174-5183
19434490 Treeck O et al.: Estrogen receptor beta exerts growth-inhibitory effects on human mammary epithelial cells. Breast Cancer Res. Treat. 2010 120: 557-565
17428314 Lin CY et al.: Inhibitory effects of estrogen receptor beta on specific hormone-responsive gene expression and association with disease outcome in primary breast cancer Breast Cancer Res. 2007 9: R25
10766163 Liu G et al.: Estrogen receptor protects p53 from deactivation by human double minute-2. Cancer Res. 2000 60: 1810-1814
15328371 Wang W et al.: TAFII70 isoform-specific growth suppression correlates with its ability to complex with the GADD45a protein Mol. Cancer Res. 2004 2: 442-452
17407970 Su T et al.: Dip1 inhibits growth and gene transcription in MCF-7 breast cancer cells J. Exp. Ther. Oncol. 2007 6: 117-127
10220405 Yarden RI et al.: BRCA1 interacts with components of the histone deacetylase complex Proc. Natl. Acad. Sci. U.S.A. 1999 96: 4983-4988
23288347 Yamada A et al.: High expression of ATP-binding cassette transporter ABCC11 in breast tumors is associated with aggressive subtypes and low disease-free survival Breast Cancer Res. Treat. 2013 137: 773-782
12878187 Gauthier ML et al.: Protein kinase Calpha negatively regulates cell spreading and motility in MDA-MB-231 human breast cancer cells downstream of epidermal growth factor receptor Biochem. Biophys. Res. Commun. 2003 307: 839-846
22279420 Mohibi S et al.: Mouse models of estrogen receptor-positive breast cancer J Carcinog 2011 10: 35
19754359 van der Veeken J et al.: Crosstalk between epidermal growth factor receptor- and insulin-like growth factor-1 receptor signaling: implications for cancer therapy Curr Cancer Drug Targets 2009 9: 748-760
18996184 Gaikwad NW et al.: Evidence for NQO2-mediated reduction of the carcinogenic estrogen ortho-quinones Free Radic. Biol. Med. 2009 46: 253-262
22386952 Pruthi S et al.: Evaluation of serum estrogen-DNA adducts as potential biomarkers for breast cancer risk J. Steroid Biochem. Mol. Biol. 2012 132: 73-79
16675129 Cavalieri E et al.: Catechol estrogen quinones as initiators of breast and other human cancers: implications for biomarkers of susceptibility and cancer prevention Biochim. Biophys. Acta 2006 1766: 63-78
25110054 Do MT et al.: Metformin suppresses CYP1A1 and CYP1B1 expression in breast cancer cells by down-regulating aryl hydrocarbon receptor expression Toxicol. Appl. Pharmacol. 2014 280: 138-148
19995559 Vinothini G et al.: Correlation of xenobiotic-metabolizing enzymes, oxidative stress and NFkappaB signaling with histological grade and menopausal status in patients with adenocarcinoma of the breast Clin. Chim. Acta 2010 411: 368-374
23576571 Rodriguez M et al.: CYP1A1 regulates breast cancer proliferation and survival Mol. Cancer Res. 2013 11: 780-792
23733406 Goode GD et al.: Knockdown of aberrantly upregulated aryl hydrocarbon receptor reduces tumor growth and metastasis of MDA-MB-231 human breast cancer cell line Int. J. Cancer 2013 133: 2769-2780
14647449 Stoner M et al.: Estrogen regulation of vascular endothelial growth factor gene expression in ZR-75 breast cancer cells through interaction of estrogen receptor alpha and SP proteins Oncogene 2004 5: 1052-1063
23172368 Sotgia F et al.: Mitochondria fuel breast cancer metabolism: fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells Cell Cycle 2012 11: 4390-4401
24212942 Gupta N et al.: beta-Catenin Is a Positive Regulator of Estrogen Receptor-alpha Function in Breast Cancer Cells Cancers (Basel) 2011 3: 2990-3001
20838384 Kalra J et al.: Suppression of Her2/neu expression through ILK inhibition is regulated by a pathway involving TWIST and YB-1 Oncogene 2010 29: 6343-6356
16785428 Bose R et al.: Phosphoproteomic analysis of Her2/neu signaling and inhibition Proc. Natl. Acad. Sci. U.S.A. 2006 103: 9773-9778
21402692 Mitra R et al.: CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (+/-)-14,15-epoxyeicosatrienoic acid (EET) J. Biol. Chem. 2011 286
21054339 Kim HG et al.: Metformin inhibits P-glycoprotein expression via the NF-kappaB pathway and CRE transcriptional activity through AMPK activation Br. J. Pharmacol. 2011 162: 1096-1108
21925487 Rudd LP et al.: Enhanced glutathione depletion, protein adduct formation, and cytotoxicity following exposure to 4-hydroxy-2-nonenal (HNE) in cells expressing human multidrug resistance protein-1 (MRP1) together with human glutathione S-transferase-M1 (GSTM1) Chem. Biol. Interact. 2011 194: 113-119
24667650 Sengupta D et al.: ERRbeta signalling through FST and BCAS2 inhibits cellular proliferation in breast cancer cells Br. J. Cancer 2014 110: 2144-2158
10608854 Li Z et al.: IQGAP1 and calmodulin modulate E-cadherin function J. Biol. Chem. 1999 274
25801958 Citro S et al.: PI3K/mTOR mediate mitogen-dependent HDAC1 phosphorylation in breast cancer: a novel regulation of estrogen receptor expression J Mol Cell Biol 2015 7: 132-142
21737670 Nakagawa M et al.: Expression of p53, Ki-67, E-cadherin, N-cadherin and TOP2A in triple-negative breast cancer Anticancer Res. 2011 31: 2389-2393
17875716 Miao ZH et al.: Nonclassic functions of human topoisomerase I: genome-wide and pharmacologic analyses Cancer Res. 2007 67: 8752-8761
20615467 Maeda T et al.: Uptake transporter organic anion transporting polypeptide 1B3 contributes to the growth of estrogen-dependent breast cancer J. Steroid Biochem. Mol. Biol. 2010 122: 180-185
24754247 Gozalpour E et al.: Interaction of digitalis-like compounds with liver uptake transporters NTCP, OATP1B1, and OATP1B3 Mol. Pharm. 2014 11: 1844-1855
19682730 Gupta PB et al.: Identification of selective inhibitors of cancer stem cells by high-throughput screening Cell 2009 138: 645-659
23730416 Hayman TJ et al.: Competitive but Not Allosteric mTOR Kinase Inhibition Enhances Tumor Cell Radiosensitivity Transl Oncol 2013 3: 355-362
24831777 Banerjee N et al.: Expression of membrane transporters and metabolic enzymes involved in estrone-3-sulphate disposition in human breast tumour tissues Breast Cancer Res. Treat. 2014 145: 647-661
26378621 Zhang W et al.: Tris(2-chloroethyl)phosphate-induced cell growth arrest via attenuation of SIRT1-independent PI3K/Akt/mTOR pathway J Appl Toxicol 2016 36: 914-924
21339306 Tiraby C et al.: Estrogen-related receptor gamma promotes mesenchymal-to-epithelial transition and suppresses breast tumor growth Cancer Res. 2011 71: 2518-2528
21566910 Vandewalle B et al.: Effect of calcium on e-cadherin expression in breast-tumor cells Int. J. Oncol. 1994 4: 181-185
18521741 Lanzino M et al.: Insulin receptor substrate 1 modulates the transcriptional activity and the stability of androgen receptor in breast cancer cells Breast Cancer Res. Treat. 2009 115: 297-306
22025613 Dong C et al.: Regulation of alpha(2B)-adrenergic receptor-mediated extracellular signal-regulated kinase 1/2 (ERK1/2) activation by ADP-ribosylation factor 1 J. Biol. Chem. 2011 286
11072781 Jeng MH et al.: Role of MAP kinase in the enhanced cell proliferation of long term estrogen deprived human breast cancer cells Breast Cancer Res. Treat. 2000 62: 167-175
20353938 Ingermann AR et al.: Identification of a novel cell death receptor mediating IGFBP-3-induced anti-tumor effects in breast and prostate cancer J. Biol. Chem. 2010 285
24304688 McGuirk S et al.: PGC-1alpha supports glutamine metabolism in breast cancer Cancer Metab 2013 1: 22
14500345 Oesterreich S et al.: Estrogen-mediated down-regulation of E-cadherin in breast cancer cells Cancer Res. 2003 63: 5203-5208
19943104 Jin W et al.: UHRF1 is associated with epigenetic silencing of BRCA1 in sporadic breast cancer Breast Cancer Res. Treat. 2010 123: 359-373
26621032 Holt SH et al.: Activation of apoptosis in NAF-1-deficient human epithelial breast cancer cells J. Cell. Sci. 2016 129: 155-165
23959881 Sohn YS et al.: NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth Proc. Natl. Acad. Sci. U.S.A. 2013 110
11525591 et al.:
23233354 Buffa L et al.: Molecular mechanism of WW-domain binding protein-2 coactivation function in estrogen receptor signaling IUBMB Life 2013 65: 76-84
21429623 Ordonez C et al.: Gender differences in apolipoprotein D expression during aging and in Alzheimer disease Neurobiol. Aging 2012 33: 433.e11-433.e20
28219369 McKinnon CM et al.: The tumor suppressor RhoBTB1 controls Golgi integrity and breast cancer cell invasion through METTL7B BMC Cancer 2017 17: 145
26887652 Gruel N et al.: LIN7A is a major determinant of cell-polarity defects in breast carcinomas Breast Cancer Res. 2016 18: 23
19901966 El-Tanani MK et al.: Interferon-induced transmembrane 3 binds osteopontin in vitro: expressed in vivo IFITM3 reduced OPN expression Oncogene 2010 29: 752-762
20696928 Clendening JW et al.: Dysregulation of the mevalonate pathway promotes transformation Proc. Natl. Acad. Sci. U.S.A. 2010 107
29655782 Miko E et al. et al.: Lithocholic acid, a bacterial metabolite reduces breast cancer cell proliferation and aggressiveness Biochim Biophys Acta Bioenerg 2018 1859: 958-974
23505378 Di Leva G et al. et al.: Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status PLoS Genet. 2013 9
30038517 Xia E et al.: Synaptopodin-2 plays an important role in the metastasis of breast cancer via PI3K/Akt/mTOR pathway Cancer Manag Res 2018 10: 1575-1583
12734209 Lam DD et al. et al.: Leptin does not directly affect CNS serotonin neurons to influence appetite Cell Metab. 2011 13: 584-591
28830874 O'Brien KM et al.: Single-Nucleotide Polymorphisms in Vitamin D-Related Genes May Modify Vitamin D-Breast Cancer Associations Cancer Epidemiol. Biomarkers Prev. 2017 26: 1761-1771
24008983 Xu X et al.: Differential 12-O-Tetradecanoylphorbol-13-acetate-induced activation of rat mammary carcinoma susceptibility Fbxo10 variant promoters via a PKC-AP1 pathway Mol. Carcinog. 2015 54: 134-147
28989055 Shu T et al.: Down-regulation of HECTD3 by HER2 inhibition makes serous ovarian cancer cells sensitive to platinum treatment Cancer Lett. 2017 411: 65-73
26795347 Bacci M et al.: miR-155 Drives Metabolic Reprogramming of ER+ Breast Cancer Cells Following Long-Term Estrogen Deprivation and Predicts Clinical Response to Aromatase Inhibitors Cancer Res. 2016 76: 1615-1626
24374807 Marastoni S et al.: EMILIN2 down-modulates the Wnt signalling pathway and suppresses breast cancer cell growth and migration J. Pathol. 2014 232: 391-404
29968965 Li K et al.: Upregulated IQUB promotes cell proliferation and migration via activating Akt/GSK3beta/beta-catenin signaling pathway in breast cancer Cancer Med 2018 7: 3875-3888
25436706 author information missing Expression of thyroid-stimulating hormone receptor, octamer-binding transcription factor 4, and intracisternal A particle-promoted polypeptide in human breast cancer tissues Horm Mol Biol Clin Investig 2012 9: 173-178
30335891 Kia V et al.: Evaluation of exosomal miR-9 and miR-155 targeting PTEN and DUSP14 in highly metastatic breast cancer and their effect on low metastatic cells J. Cell. Biochem. 2019 120: 5666-5676
28235484 Zhang L et al.: Branched-chain amino acid transaminase 1 (BCAT1) promotes the growth of breast cancer cells through improving mTOR-mediated mitochondrial biogenesis and function Biochem. Biophys. Res. Commun. 2017 486: 224-231
23001506 Godoy P et al.: Interferon-inducible guanylate binding protein (GBP2) is associated with better prognosis in breast cancer and indicates an efficient T cell response Breast Cancer 2014 21: 491-499
26640146 Park UH et al.: ASXL2 promotes proliferation of breast cancer cells by linking ERalpha to histone methylation Oncogene 2016 35: 3742-3752
23776679 Hwang MS et al.: miR-221/222 targets adiponectin receptor 1 to promote the epithelial-to-mesenchymal transition in breast cancer PLoS ONE 2013 8
31313837 Kang GJ et al.: SARNP, a participant in mRNA splicing and export, negatively regulates E-cadherin expression via interaction with pinin J. Cell. Physiol. 2020 235: 1543-1555
19946270 Veeriah S et al.: Somatic mutations of the Parkinsons disease-associated gene PARK2 in glioblastoma and other human malignancies Nat. Genet. 2010 42: 77-82
9842892 Piguet PF et al.: TNF-induced enterocyte apoptosis in mice is mediated by the TNF receptor 1 and does not require p53 Eur. J. Immunol. 1998 28: 3499-3505
21602532 Cheng I et al.: Type 2 diabetes risk variants and colorectal cancer risk: the Multiethnic Cohort and PAGE studies. Gut 2011 60: 1703-1711
18172327 Gunter MJ et al.: Insulin, insulin-like growth factor-I, endogenous estradiol, and risk of colorectal cancer in postmenopausal women. Cancer Res. 2008 68: 329-337
21674030 Okyar A et al.: Strain- and sex-dependent circadian changes in abcc2 transporter expression: implications for irinotecan chronotolerance in mouse ileum PLoS ONE 2011 6
21931543 Ballesta A et al.: A combined experimental and mathematical approach for molecular-based optimization of irinotecan circadian delivery PLoS Comput. Biol. 2011 7
17591803 Koda M et al.: Expression of the obesity hormone leptin and its receptor correlates with hypoxia-inducible factor-1 alpha in human colorectal cancer Ann. Oncol. 2007 18: VI116-VI119
26124005 Wang Z et al.: Resveratrol induces AMPK-dependent MDR1 inhibition in colorectal cancer HCT116/L-OHP cells by preventing activation of NF-kappaB signaling and suppressing cAMP-responsive element transcriptional activity
25165391 Zhu X et al.: Calcium intake and ion transporter genetic polymorphisms interact in human colorectal neoplasia risk in a 2-phase study J. Nutr. 2014 144: 1734-1741
11470825 Palmer HG et al.: Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling J. Cell Biol. 2001 154: 369-387
21514270 Kouchi Z et al.: Phosphatidylinositol 5-phosphate 4-kinase type II beta is required for vitamin D receptor-dependent E-cadherin expression in SW480 cells Biochem. Biophys. Res. Commun. 2011 408: 523-529
25559195 Takeda H et al.: Transposon mutagenesis identifies genes and evolutionary forces driving gastrointestinal tract tumor progression Nat. Genet. 2015 47: 142-150
25427913 Singh S et al.: Acetaldehyde and retinaldehyde-metabolizing enzymes in colon and pancreatic cancers Adv. Exp. Med. Biol. 2015 815: 281-294
26579434 Ridlon JM et al.: The human gut sterolbiome: bile acid-microbiome endocrine aspects and therapeutics Acta Pharm Sin B 2015 5: 99-105
19051325 Shaffer JM et al.: Promoter methylation blocks FES protein-tyrosine kinase gene expression in colorectal cancer Genes Chromosomes Cancer 2009 48: 272-284
23945926 Setaffy L et al.: Large serrated polyp with KRAS mutation in inflammatory bowel disease: a nondysplastic dysplasia-associated lesion or mass (DALM)? }, authors { names std { { name ml Setaffy L, affil str Institute of Pathology, Medical University, Graz, Austria Endoscopy 2013 45: E235-E236
22921465 Gillespie E et al.: Plasminogen activator inhibitor-1 is increased in colonic epithelial cells from patients with colitis-associated cancer J Crohns Colitis 2013 7: 403-411
28454420 Yu B et al.: Study of the expression and function of ACY1 in patients with colorectal cancer Oncol Lett 2017 13: 2459-2464
25907800 Deng Z et al.: Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis Nat Commun 2015 6: 6956
10906131 Hinoi T et al.: Complex formation of adenomatous polyposis coli gene product and axin facilitates glycogen synthase kinase-3 beta-dependent phosphorylation of beta-catenin and down-regulates beta-catenin J. Biol. Chem. 2000 275
28051067 Jiao S et al.: VGLL4 targets a TCF4-TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer Nat Commun 2017 8: 14058
28098873 Hu CE et al.: TRIM37 promotes epithelialmesenchymal transition in colorectal cancer Mol Med Rep 2017 15: 1057-1062
30252597 Chen C et al.: FOXD4 induces tumor progression in colorectal cancer by regulation of the SNAI3/CDH1 axis
31802911 Dong W et al.: CARF, As An Oncogene, Promotes Colorectal Cancer Stemness By Activating ERBB Signaling Pathway Onco Targets Ther 2019 12: 9041-9051
18216263 Wunderlich FT et al.: Hepatic NF-kappa B essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis Proc. Natl. Acad. Sci. U.S.A. 2008 105: 1297-1302
18932288 Lee CF et al.: Distinct expression patterns in hepatitis B virus- and hepatitis C virus-infected hepatocellular carcinoma World J. Gastroenterol. 2008 14: 6072-6077
12764143 Mottet D et al.: Regulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells J. Biol. Chem. 2003 278
9442036 Cha HH et al.: Glucocorticoids stimulate p21 gene expression by targeting multiple transcriptional elements within a steroid responsive region of the p21waf1/cip1 promoter in rat hepatoma cells J. Biol. Chem. 1998 273: 1998-2007
11741912 Adilakshmi T et al.: Ribosomal protein S25 mRNA partners with MTF-1 and La to provide a p53-mediated mechanism for survival or death J. Biol. Chem. 2002 277: 4147-4151
15611046 McMahon S et al.: Hypoxia-enhanced expression of the proprotein convertase furin is mediated by hypoxia-inducible factor-1: impact on the bioactivation of proproteins J. Biol. Chem. 2005 280: 6561-6569
25796501 Wang W et al.: Overexpression of AGGF1 is correlated with angiogenesis and poor prognosis of hepatocellular carcinoma Med. Oncol. 2015 32: 131
24448241 Noh JH et al.: HDAC2 provides a critical support to malignant progression of hepatocellular carcinoma through feedback control of mTORC1 and AKT Cancer Res. 2014 74: 1728-1738
20099302 Soll C et al.: Serotonin promotes tumor growth in human hepatocellular cancer Hepatology 2010 51: 1244-1254
26052399 Ampuero J et al.: Prevention of hepatocellular carcinoma by correction of metabolic abnormalities: Role of statins and metformin World J Hepatol 2015 7: 1105-1111
20351271 Suzuki S et al.: Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species Proc. Natl. Acad. Sci. U.S.A. 2010 107: 7461-7466
24797434 Liu J et al.: Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinoma Oncotarget 2014 5: 2635-2647
25915584 author information missing Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis J. Clin. Invest. 2015 125: 2293-2306
25844758 author information missing article information missing
29246230 Li M et al.: Bifunctional enzyme ATIC promotes propagation of hepatocellular carcinoma by regulating AMPK-mTOR-S6 K1 signaling Cell Commun. Signal 2017 15: 52
29088718 Liu P et al.: Central role of mTORC1 downstream of YAP/TAZ in hepatoblastoma development Oncotarget 2017 8
26311740 He C et al.: MiR-21 mediates sorafenib resistance of hepatocellular carcinoma cells by inhibiting autophagy via the PTEN/Akt pathway Oncotarget 2015 6
30836988 Peng R et al. et al.: Overexpression of RNF38 facilitates TGF-beta signaling by Ubiquitinating and degrading AHNAK in hepatocellular carcinoma J. Exp. Clin. Cancer Res. 2019 38: 113
31105839 Kong D et al.: EYA1 promotes cell migration and tumor metastasis in hepatocellular carcinoma Am J Transl Res 2019 11: 2328-2338
29151969 Huang XQ et al.: Overexpression of SMOC2 Attenuates the Tumorigenicity of Hepatocellular Carcinoma Cells and Is Associated With a Positive Postoperative Prognosis in Human Hepatocellular Carcinoma J Cancer 2017 8: 3812-3827
30332648 Chan LH et al. et al.: PRMT6 Regulates RAS/RAF Binding and MEK/ERK-Mediated Cancer Stemness Activities in Hepatocellular Carcinoma through CRAF Methylation Cell Rep 2018 25: 690-701.e8
27608898 Cao F et al.: PHACTR4 regulates proliferation, migration and invasion of human hepatocellular carcinoma by inhibiting IL-6/Stat3 pathway Eur Rev Med Pharmacol Sci 2016 20: 3392-3399
20176206 Mauchley D et al.: Modulation of growth in human esophageal adenocarcinoma cells by group IIa secretory phospholipase A(2) J. Thorac. Cardiovasc. Surg. 2010 139: 591-599
29909415 Iguchi T et al. et al.: Identification of UHRF2 as a Negative Regulator of Epithelial-Mesenchymal Transition and Its Clinical Significance in Esophageal Squamous Cell Carcinoma Oncology 2018 95: 179-187
19946270 Veeriah S et al.: Somatic mutations of the Parkinsons disease-associated gene PARK2 in glioblastoma and other human malignancies. Nat. Genet. 2010 42: 77-82
23408368 Fan S et al.: Overexpression of SLC7A7 predicts poor progression-free and overall survival in patients with glioblastoma Med. Oncol. 2013 30: 384
12584187 Berdiev BK et al.: Acid-sensing ion channels in malignant gliomas J. Biol. Chem. 2003 278
20368557 Liu Y et al.: Polymorphisms of LIG4, BTBD2, HMGA2, and RTEL1 genes involved in the double-strand break repair pathway predict glioblastoma survival J. Clin. Oncol. 2010 28: 2467-2474
24582898 Li W et al.: MUC4 modulates human glioblastoma cell proliferation and invasion by upregulating EGFR expression Neurosci. Lett. 2014 566: 82-87
25898313 Daniele S et al.: Combined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells Sci Rep 2015 5: 9956
25867026 Sesen J et al.: Metformin inhibits growth of human glioblastoma cells and enhances therapeutic response PLoS ONE 2015 10
25222834 Cuperlovic-Culf M et al.: Metabolic Effects of Known and Novel HDAC and SIRT Inhibitors in Glioblastomas Independently or Combined with Temozolomide Metabolites 2014 4: 807-830
23625692 Sami A et al.: Targeting the PI3K/AKT/mTOR signaling pathway in glioblastoma: novel therapeutic agents and advances in understanding Tumour Biol. 2013 34: 1991-2002
15578701 Camphausen K et al.: Enhancement of in vitro and in vivo tumor cell radiosensitivity by valproic acid Int. J. Cancer 2005 114: 380-386
21362133 Shabason JE et al.: Grand rounds at the National Institutes of Health: HDAC inhibitors as radiation modifiers, from bench to clinic J. Cell. Mol. Med. 2011 15: 2735-2744
24418474 Choi EJ et al.: Enhanced cytotoxic effect of radiation and temozolomide in malignant glioma cells: targeting PI3K-AKT-mTOR signaling, HSP90 and histone deacetylases BMC Cancer 2014 14: 17
20372862 Zhao N et al.: Akt-mTOR signaling is involved in Notch-1-mediated glioma cell survival and proliferation Oncol. Rep. 2010 23: 1443-1447
19827268 Jiang H et al.: Resveratrol downregulates PI3K/Akt/mTOR signaling pathways in human U251 glioma cells J. Exp. Ther. Oncol. 2009 8: 25-33
18772890 author information missing Comprehensive genomic characterization defines human glioblastoma genes and core pathways Nature 2008 455: 1061-1068
15143086 Chakravarti A et al.: The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomas J. Clin. Oncol. 2004 22: 1926-1933
24096582 Szeliga M et al.: Silencing of GLS and overexpression of GLS2 genes cooperate in decreasing the proliferation and viability of glioblastoma cells Tumour Biol. 2014 35: 1855-1862
24276018 Martin-Rufian M et al.: Both GLS silencing and GLS2 overexpression synergize with oxidative stress against proliferation of glioma cells J. Mol. Med. 2014 92: 277-290
25284789 Takai H et al.: 5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex Cell Rep 2014 9: 48-60
28534507 Zhu C et al.: CECR1-mediated cross talk between macrophages and vascular mural cells promotes neovascularization in malignant glioma Oncogene 2017 36: 5356-5368
22992974 Zadran S et al.: ENTPD5-mediated modulation of ATP results in altered metabolism and decreased survival in gliomablastoma multiforme Tumour Biol. 2012 33: 2411-2421
30552850 Wang Y et al.: Myosin Heavy Chain 10 (MYH10) Gene Silencing Reduces Cell Migration and Invasion in the Glioma Cell Lines U251, T98G, and SHG44 by Inhibiting the Wnt/beta-Catenin Pathway Med. Sci. Monit. 2018 24: 9110-9119
22740028 Anic GM et al.: An exploratory analysis of common genetic variants in the vitamin D pathway including genome-wide associated variants in relation to glioma risk and outcome Cancer Causes Control 2012 23: 1443-1449
26152360 Seong MW et al.: Deleterious c-Cbl Exon Skipping Contributes to Human Glioma Neoplasia 2015 17: 518-524
19519315 Chien J et al.: HtrA serine proteases as potential therapeutic targets in cancer Curr Cancer Drug Targets 2009 9: 451-468
15341671 Cangul H et al.: Hypoxia upregulates the expression of the NDRG1 gene leading to its overexpression in various human cancers BMC Genet. 2004 5: 27
23661552 Hollstein PE et al.: Identifying the Ubiquitin Ligase complex that regulates the NF1 tumor suppressor and Ras Cancer Discov 2013 3: 880-893
25088200 Gurgis FM et al.: The p38-MK2-HuR pathway potentiates EGFRvIII-IL-1beta-driven IL-6 secretion in glioblastoma cells Oncogene 2015 34: 2934-2942
26677976 Ohtsu N et al.: Eva1 Maintains the Stem-like Character of Glioblastoma-Initiating Cells by Activating the Noncanonical NF-kappaB Signaling Pathway Cancer Res. 2016 76: 171-181
29937354 Pavlyukov MS et al. et al.: Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors Cancer Cell 2018 34: 119-135.e10
27329597 Mao XG et al. et al.: Hypoxia upregulates HIG2 expression and contributes to bevacizumab resistance in glioblastoma Oncotarget 2016 7
29977365 Chen X et al.: Knockdown of RWD domain containing 3 inhibits the malignant phenotypes of glioblastoma cells via inhibition of phosphoinositide 3-kinase/protein kinase B signaling Exp Ther Med 2018 16: 384-393
18398573 Scrideli CA et al.: Gene expression profile analysis of primary glioblastomas and non-neoplastic brain tissue: identification of potential target genes by oligonucleotide microarray and real-time quantitative PCR J. Neurooncol. 2008 88: 281-291
26993504 D'Asti E et al.: Extracellular Vesicles in Brain Tumor Progression Cell. Mol. Neurobiol. 2016 36: 383-407
22843679 author information missing article information missing
24606203 Blank AE et al.: Tumour necrosis factor receptor superfamily member 9 (TNFRSF9) is up-regulated in reactive astrocytes in human gliomas Neuropathol. Appl. Neurobiol. 2015 41: e56-e67
30863117 Wu R et al.: Downregulation of KLF13 through DNMT1-mediated hypermethylation promotes glioma cell proliferation and invasion Onco Targets Ther 2019 12: 1509-1520
28551850 Zhang J et al.: MicroRNA-211 expression is down-regulated and associated with poor prognosis in human glioma J. Neurooncol. 2017 133: 553-559
28116547 Seo SB et al.: 14-3-3beta Depletion Drives a Senescence Program in Glioblastoma Cells Through the ERK/SKP2/p27 Pathway Mol. Neurobiol. 2018 55: 1259-1270
24065186 Gong F et al.: 14-3-3beta regulates the proliferation of glioma cells through the GSK3beta/beta-catenin signaling pathway Oncol. Rep. 2013 30: 2976-2982
26976975 Kolodziej MA et al.: NDRG2 and NDRG4 Expression Is Altered in Glioblastoma and Influences Survival in Patients with MGMT-methylated Tumors Anticancer Res. 2016 36: 887-897
30514230 Li L et al.: EGF/EGFR upregulates and cooperates with Netrin-4 to protect glioblastoma cells from DNA damage-induced senescence BMC Cancer 2018 18: 1215
27572852 Li Y et al.: Identification of hub genes and regulatory factors of glioblastoma multiforme subgroups by RNA-seq data analysis Int. J. Mol. Med. 2016 38: 1170-1178
24612214 Clara CA et al.: Angiogenesis and expression of PDGF-C, VEGF, CD105 and HIF-1alpha in human glioblastoma Neuropathology 2014 34: 343-352
31605013 Ji J et al. et al.: PMEPA1 isoform a drives progression of glioblastoma by promoting protein degradation of the Hippo pathway kinase LATS1 Oncogene 2020 39: 1125-1139
29966699 Panagopoulos AT et al.: The prostanoid pathway contains potential prognostic markers for glioblastoma Prostaglandins Other Lipid Mediat. 2018 137: 52-62
30590814 Zhi T et al.: ECT2/PSMD14/PTTG1 axis promotes the proliferation of glioma through stabilizing E2F1 Neuro-oncology 2019 21: 462-473
16685397 Genkai N et al.: Increased expression of pituitary tumor-transforming gene (PTTG)-1 is correlated with poor prognosis in glioma patients Oncol. Rep. 2006 15: 1569-1574
28244851 et al.: GGNBP2 Suppresses the Proliferation, Invasion, and Migration of Human Glioma Cells Oncol Res 2017 25: 831-842
31277942 Yu H et al.: RCC2 promotes proliferation and radio-resistance in glioblastoma via activating transcription of DNMT1 Biochem. Biophys. Res. Commun. 2019 516: 999-1006
32594352 Bhawe K et al.: Nuclear Respiratory Factor 1 (NRF1) Transcriptional Activity-Driven Gene Signature Association with Severity of Astrocytoma and Poor Prognosis of Glioblastoma Mol. Neurobiol. 2020 57: 3827-3845
25982477 Cao L et al.: Down-regulation of 14-3-3beta exerts anti-cancer effects through inducing ER stress in human glioma U87 cells: Involvement of CHOP-Wnt pathway Biochem. Biophys. Res. Commun. 2015 462: 389-395
27491149 author information missing [EXPRESSION OF PFKFB, HK2, NAMPT, TSPAN13 AND HSPB8 GENES IN PEDIATRIC GLIOMA]
30628650 Yang H et al.: A thirteengene set efficiently predicts the prognosis of glioblastoma Mol Med Rep 2019 19: 1613-1621
29655792 He Z et al.: Long non-coding RNA UCA1/miR-182/PFKFB2 axis modulates glioblastoma-associated stromal cells-mediated glycolysis and invasion of glioma cells Biochem. Biophys. Res. Commun. 2018 500: 569-576
32436804 Liu Z et al.: Abnormally high expression of HOXA2 as an independent factor for poor prognosis in glioma patients Cell Cycle 2020 19: 1632-1640
31807002 Chang M et al.: MicroRNA-769-5p Promotes The Growth Of Glioma Cells By Targeting Lysine Methyltransferase 2A Onco Targets Ther 2019 12: 9177-9187
31938310 Li H et al.: LOXL1 regulates cell apoptosis and migration in human neuroglioma U87 and U251 cells via Wnt/beta-catenin signaling Int J Clin Exp Pathol 2018 11: 2032-2037
26164207 Roy A et al.: Glioma-derived plasminogen activator inhibitor-1 (PAI-1) regulates the recruitment of LRP1 positive mast cells Oncotarget 2015 6
28297667 Cui Q et al. et al.: m(6)A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells Cell Rep 2017 18: 2622-2634
31494931 Li Y et al.: N-acetylglucosaminyltransferase I promotes glioma cell proliferation and migration through increasing the stability of the glucose transporter GLUT1 FEBS Lett. 2020 594: 358-366
15517309 Knobbe CB et al.: Mutation analysis of the Ras pathway genes NRAS, HRAS, KRAS and BRAF in glioblastomas Acta Neuropathol. 2004 108: 467-470
24861879 Shi Z et al. et al.: MiR-124 governs glioma growth and angiogenesis and enhances chemosensitivity by targeting R-Ras and N-Ras Neuro-oncology 2014 16: 1341-1353
26632666 Duan S et al. et al.: PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype Nat Commun 2015 6: 10068
31433208 Hu G et al.: Prognostic Markers Identification in Glioma by Gene Expression Profile Analysis J. Comput. Biol. 2020 27: 81-90
32518375 Yu S et al.: GBP2 enhances glioblastoma invasion through Stat3/fibronectin pathway Oncogene 2020 39: 5042-5055
30887657 author information missing article information missing
31636512 Wang R et al.: Histone methyltransferase SUV39H2 regulates cell growth and chemosensitivity in glioma via regulation of hedgehog signaling Cancer Cell Int 2019 19: 269
10917203 Mohr L et al.: Rabbit cytochrome P450 4B1: A novel prodrug activating gene for pharmacogene therapy of hepatocellular carcinoma Cancer Gene Ther 2000 7: 1008-1014
26119730 LaGory EL et al.: Suppression of PGC-1alpha Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma Cell Rep 2015 12: 116-127
25344677 Guo Z et al.: KCNJ1 inhibits tumor proliferation and metastasis and is a prognostic factor in clear cell renal cell carcinoma Tumour Biol. 2015 36: 1251-1259
25945836 Lucarelli G et al.: Metabolomic profile of glycolysis and the pentose phosphate pathway identifies the central role of glucose-6-phosphate dehydrogenase in clear cell-renal cell carcinoma Oncotarget 2015 6
31788053 Kotulak-Chrzaszcz A et al.: Expression of the Sonic Hedgehog pathway components in clear cell renal cell carcinoma Oncol Lett 2019 18: 5801-5810
25473003 Shou Y et al.: A Five-Gene Hedgehog Signature Developed as a Patient Preselection Tool for Hedgehog Inhibitor Therapy in Medulloblastoma
23900540 Holtz AM et al.: Essential role for ligand-dependent feedback antagonism of vertebrate hedgehog signaling by PTCH1, PTCH2 and HHIP1 during neural patterning Development 2013 140: 3423-3434
9931336 Smyth I et al.: Isolation and characterization of human patched 2 (PTCH2), a putative tumour suppressor gene inbasal cell carcinoma and medulloblastoma on chromosome 1p32 Hum. Mol. Genet. 1999 8: 291-297
19833601 Brugieres L et al.: Incomplete penetrance of the predisposition to medulloblastoma associated with germ-line SUFU mutations J. Med. Genet. 2010 47: 142-144
28276480 Coni S et al. et al.: Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma Sci Rep 2017 7: 44079
19584924 Lu Y et al.: Amplification and overexpression of Hsa-miR-30b, Hsa-miR-30d and KHDRBS3 at 8q24.22-q24.23 in medulloblastoma PLoS ONE 2009 4: e6159
31541170 Robinson MH et al.: Upregulation of the chromatin remodeler HELLS is mediated by YAP1 in Sonic Hedgehog Medulloblastoma Sci Rep 2019 9: 13611
26446920 Malhotra A et al.: Sonic Hedgehog Signaling Drives Mitochondrial Fragmentation by Suppressing Mitofusins in Cerebellar Granule Neuron Precursors and Medulloblastoma Mol. Cancer Res. 2016 14: 114-124
30810905 Vriend J et al.: Differential Expression of Genes for Ubiquitin Ligases in Medulloblastoma Subtypes Cerebellum 2019 18: 469-488
30227871 Callegari K et al.: Pharmacological inhibition of LSD1 activity blocks REST-dependent medulloblastoma cell migration Cell Commun. Signal 2018 16: 60
22525724 Li W et al.: SBF-1, a synthetic steroidal glycoside, inhibits melanoma growth and metastasis through blocking interaction between PDK1 and AKT3 Biochem. Pharmacol. 2012 84: 172-181
16778180 Furuta J et al.: Silencing of Peroxiredoxin 2 and aberrant methylation of 33 CpG islands in putative promoter regions in human malignant melanomas Cancer Res. 2006 66: 6080-6086
23537197 Pena-Chilet M et al.: Genetic variants in PARP1 (rs3219090) and IRF4 (rs12203592) genes associated with melanoma susceptibility in a Spanish population BMC Cancer 2013 13: 160
23431193 Posch C et al. et al.: Combined targeting of MEK and PI3K/mTOR effector pathways is necessary to effectively inhibit NRAS mutant melanoma in vitro and in vivo Proc. Natl. Acad. Sci. U.S.A. 2013 110: 4015-4020
21537389 author information missing A polymorphism in the glucokinase gene that raises plasma fasting glucose, rs1799884, is associated with diabetes mellitus and prostate cancer: findings from a population-based, case-control study (the ProtecT study) Int J Mol Epidemiol Genet 2010 1: 175-183
17603485 Gudmundsson J et al.: Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes Nat. Genet. 2007 39: 977-983
20203524 Pierce BL et al.: Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk. Hum. Hered. 2010 69: 193-201
18835745 Ma J et al.: Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: a long-term survival analysis. Lancet Oncol. 2008 9: 1039-1047
15059908 Chesire DR et al.: Identification of aryl hydrocarbon receptor as a putative Wnt/beta-catenin pathway target gene in prostate cancer cells Cancer Res. 2004 64: 2523-2533
20807808 Zhu ML et al.: Tubulin-targeting chemotherapy impairs androgen receptor activity in prostate cancer Cancer Res. 2010 70: 7992-8002
15598662 Hodgson MC et al.: The androgen receptor recruits nuclear receptor CoRepressor (N-CoR) in the presence of mifepristone via its N and C termini revealing a novel molecular mechanism for androgen receptor antagonists J. Biol. Chem. 2005 280: 6511-6519
19021144 Mamaeva OA et al.: Calcium/calmodulin-dependent kinase II regulates notch-1 signaling in prostate cancer cells J. Cell. Biochem. 2009 106: 25-32
18519708 Montgomery RB et al.: Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth Cancer Res. 2008 68: 4447-4454
18384941 Ummanni R et al.: Prohibitin identified by proteomic analysis of prostate biopsies distinguishes hyperplasia and cancer Cancer Lett. 2008 266: 171-185
18519708 Montgomery RB et al.: Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth Cancer Res. 2008 11: 4447-4454
24717169 Carter RC et al.: Effects of prenatal alcohol exposure on testosterone and pubertal development Alcohol. Clin. Exp. Res. 2014 38: 1671-1679
24779401 Makarevic J et al.: Cross-communication between histone H3 and H4 acetylation and Akt-mTOR signalling in prostate cancer cells J. Cell. Mol. Med. 2014 18: 1460-1466
23687346 Fendt SM et al.: Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism Cancer Res. 2013 73: 4429-4438
26002551 Loubiere C et al.: Metformin-induced energy deficiency leads to the inhibition of lipogenesis in prostate cancer cells Oncotarget 2015 6
26847995 author information missing article information missing
22842514 Hafiz S et al.: Expression of melanocortin receptors in human prostate cancer cell lines: MC2R activation by ACTH increases prostate cancer cell proliferation Int. J. Oncol. 2012 41: 1373-1380
29669796 Liu H et al. et al.: PRDM4 mediates YAP-induced cell invasion by activating leukocyte-specific integrin beta2 expression
19906297 Filleur S et al.: INTS6/DICE1 inhibits growth of human androgen-independent prostate cancer cells by altering the cell cycle profile and Wnt signaling Cancer Cell Int. 2009 9: 28
23272133 Lin X et al. et al.: MiR-155 Enhances Insulin Sensitivity by Coordinated Regulation of Multiple Genes in Mice PLoS Genet. 2016 12
30774776 Trujillo-Caceres SJ et al.: Contribution of MSMB promoter region gene polymorphism to early-onset prostate cancer risk in Mexican males Oncotarget 2019 10: 738-748
22531786 Chng KR et al.: A transcriptional repressor co-regulatory network governing androgen response in prostate cancers EMBO J. 2012 31: 2810-2823
14766760 Curtin JF et al.: JNK regulates HIPK3 expression and promotes resistance to Fas-mediated apoptosis in DU 145 prostate carcinoma cells J. Biol. Chem. 2004 279
14583493 MacKeigan JP et al.: Proteomic profiling drug-induced apoptosis in non-small cell lung carcinoma: identification of RS/DJ-1 and RhoGDIalpha. Cancer Res. 2003 63: 6928-6934
15976810 Shinbo Y et al.: Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities. Cell Death Differ. 2006 13: 96-108
17237272 Oguri T et al.: MRP8/ABCC11 directly confers resistance to 5-fluorouracil Mol. Cancer Ther. 2007 6: 122-127
22544838 Ware JJ et al.: From men to mice: CHRNA5/CHRNA3, smoking behavior and disease Nicotine Tob. Res. 2012 14: 1291-1299
18978787 Wang Y et al.: Common 5p15.33 and 6p21.33 variants influence lung cancer risk Nat. Genet. 2008 40: 1407-1409
21559498 Wang Y et al.: Chromosome 15q25 (CHRNA3-CHRNA5) variation impacts indirectly on lung cancer risk PLoS ONE 2011 6
19654303 Broderick P et al.: Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study Cancer Res. 2009 69: 6633-6641
23872218 Flora AV et al.: Functional characterization of SNPs in CHRNA3/B4 intergenic region associated with drug behaviors Brain Res. 2013 1529: 1-15
25884493 Etokebe GE et al.: Association of the FAM46A gene VNTRs and BAG6 rs3117582 SNP with non small cell lung cancer (NSCLC) in Croatian and Norwegian populations PLoS ONE 2015 10
20081861 Houghton AM et al.: Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth Nat. Med. 2010 16: 219-223
23420440 Chou CH et al.: SCUBE3 regulation of early lung cancer angiogenesis and metastatic progression Clin. Exp. Metastasis 2013 30: 741-752
21441952 Wu YY et al.: SCUBE3 is an endogenous TGF-beta receptor ligand and regulates the epithelial-mesenchymal transition in lung cancer Oncogene 2011 30: 3682-3693
23318453 Tsai HY et al.: Endoplasmic reticulum ribosome-binding protein 1 (RRBP1) overexpression is frequently found in lung cancer patients and alleviates intracellular stress-induced apoptosis through the enhancement of GRP78 Oncogene 2013 32: 4921-4931
26140362 Goswami MT et al.: Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer Oncotarget 2015 6
24452750 Haigl B et al.: Expression of microRNA-21 in non-small cell lung cancer tissue increases with disease progression and is likely caused by growth conditional changes during malignant transformation Int. J. Oncol. 2014 44: 1325-1334
30210621 Jin C et al.: Loss of UHRF2 Is Associated With Non-small Cell Lung Carcinoma Progression J Cancer 2018 9: 2994-3005
26622902 Li S et al.: Sequencing study on familial lung squamous cancer Oncol Lett 2015 10: 2634-2638
31278886 Wu Y et al.: Uridine-cytidine kinase 2 (UCK2): A potential diagnostic and prognostic biomarker for lung cancer Cancer Sci. 2019 110: 2734-2747
20473924 Schulte JH et al.: Accurate prediction of neuroblastoma outcome based on miRNA expression profiles Int. J. Cancer 2010 127: 2374-2385
10803465 Eggert A et al.: Molecular dissection of TrkA signal transduction pathways mediating differentiation in human neuroblastoma cells Oncogene 2000 19: 2043-2051
15322108 Bryan B et al.: GEFT, a Rho family guanine nucleotide exchange factor, regulates neurite outgrowth and dendritic spine formation J. Biol. Chem. 2004 279
18413728 Molenaar JJ et al.: Cyclin D1 and CDK4 activity contribute to the undifferentiated phenotype in neuroblastoma Cancer Res. 2008 68: 2599-2609
24912852 De Antonellis P et al.: Early targets of miR-34a in neuroblastoma Mol. Cell Proteomics 2014 13: 2114-2131
22331471 Virden RA et al.: Characterization of critical domains within the tumor suppressor CASZ1 required for transcriptional regulation and growth suppression Mol. Cell. Biol. 2012 32: 1518-1528
23939472 Wang JL et al.: Novel genes FAM134C, C3orf10 and ENOX1 are regulated by NRF-1 and differentially regulate neurite outgrowth in neuroblastoma cells and hippocampal neurons Gene 2013 529: 7-15
16631738 Shim KS et al.: Bach2 is involved in neuronal differentiation of N1E-115 neuroblastoma cells Exp. Cell Res. 2006 312: 2264-2278
22906418 Sung PJ et al.: Identification and characterisation of STMN4 and ROBO2 gene involvement in neuroblastoma cell differentiation Cancer Lett. 2013 328: 168-175
28115010 Haile Y et al.: Rab32 connects ER stress to mitochondrial defects in multiple sclerosis J Neuroinflammation 2017 14: 19
28605984 Gil-Ibanez P et al.: Is the Intrinsic Genomic Activity of Thyroxine Relevant In Vivo? Effects on Gene Expression in Primary Cerebrocortical and Neuroblastoma Cells Thyroid 2017 27: 1092-1098
19651775 Mascarenhas JB et al.: PAX6 is expressed in pancreatic cancer and actively participates in cancer progression through activation of the MET tyrosine kinase receptor gene J. Biol. Chem. 2009 284
19375425 Li D et al.: Antidiabetic therapies affect risk of pancreatic cancer. Gastroenterology 2009 137: 482-488
22590527 Hou J et al.: FKBP5 as a selection biomarker for gemcitabine and Akt inhibitors in treatment of pancreatic cancer PLoS ONE 2012 7
23803693 Nair V et al.: Metformin inhibits pancreatic cancer cell and tumor growth and downregulates Sp transcription factors Carcinogenesis 2013 12: 2870-2879
26164081 Cohen R et al.: Targeting cancer cell metabolism in pancreatic adenocarcinoma Oncotarget 2015 19
21448452 Vareed SK et al. et al.: Metabolites of purine nucleoside phosphorylase (NP) in serum have the potential to delineate pancreatic adenocarcinoma PLoS ONE 2011 6
26797144 Lachaud C et al.: Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability Science 2016 351: 846-849
18784743 Nishioka C et al.: Blockade of mTOR signaling potentiates the ability of histone deacetylase inhibitor to induce growth arrest and differentiation of acute myelogenous leukemia cells Leukemia 2008 22: 2159-2168
22932805 Khandanpour C et al.: The human GFI136N variant induces epigenetic changes at the Hoxa9 locus and accelerates K-RAS driven myeloproliferative disorder in mice Blood 2012 120: 4006-4017
16330448 author information missing The prognostic value of cN-II and cN-III enzymes in adult acute myeloid leukemia Haematologica 2005 90: 1699-1701
24973361 Micol JB et al. et al.: Frequent ASXL2 mutations in acute myeloid leukemia patients with t(8;21)/RUNX1-RUNX1T1 chromosomal translocations Blood 2014 124: 1445-1449
25306901 Inoue D et al. et al.: SETBP1 mutations drive leukemic transformation in ASXL1-mutated MDS Leukemia 2015 29: 847-857
30367089 Saika M et al.: ASXL1 and SETBP1 mutations promote leukaemogenesis by repressing TGFbeta pathway genes through histone deacetylation Sci Rep 2018 8: 15873
19996286 Lin LF et al.: ZBRK1 acts as a metastatic suppressor by directly regulating MMP9 in cervical cancer. Cancer Res. 2010 70: 192-201
29627439 Wang F et al.: MiR-155-5p inhibits PDK1 and promotes autophagy via the mTOR pathway in cervical cancer Int. J. Biochem. Cell Biol. 2018 99: 91-99
31897153 Han B et al.: FNDC3B is associated with ER stress and poor prognosis in cervical cancer Oncol Lett 2020 19: 406-414
14985505 Shaw RJ et al.: The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc. Natl. Acad. Sci. U.S.A. 2004 101: 3329-3335
12771025 Li J et al.: AMPK-beta1 subunit is a p53-independent stress responsive protein that inhibits tumor cell growth upon forced expression Carcinogenesis 2003 24: 827-834
19885556 Kim YC et al.: Oxidation of DJ-1-dependent cell transformation through direct binding of DJ-1 to PTEN. Int. J. Oncol. 2009 35: 1331-1341
20510502 Ren H et al.: DJ-1, a cancer and Parkinsons disease associated protein, regulates autophagy through JNK pathway in cancer cells Cancer Lett. 2010 297: 101-108
21912508 Braun S et al.: The link between the metabolic syndrome and cancer Int. J. Biol. Sci. 2011 7: 1003-1015
19564453 Libby G et al.: New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes. Diabetes Care 2009 32: 1620-1625
20947488 Decensi A et al.: Metformin and cancer risk in diabetic patients: a systematic review and meta-analysis. Cancer Prev Res (Phila) 2010 3: 1451-1461
19918015 Landman GW et al.: Metformin associated with lower cancer mortality in type 2 diabetes: ZODIAC-16. Diabetes Care 2010 33: 322-326
19082520 Monami M et al.: Sulphonylureas and cancer: a case-control study. Acta Diabetol 2009 46: 279-284
16443869 Bowker SL et al.: Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin. Diabetes Care 2006 29: 254-258
18006825 Dowling RJ et al.: Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. Cancer Res. 2007 67
22132214 Jung JW et al.: Metformin Represses Self-Renewal of the Human Breast Carcinoma Stem Cells via Inhibition of Estrogen Receptor-Mediated OCT4 Expression. PLoS ONE 2011 6
18212742 Ben Sahra I et al.: The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level. Oncogene 2008 27: 3576-3586
19822355 Cantrell LA et al.: Metformin is a potent inhibitor of endometrial cancer cell proliferation--implications for a novel treatment strategy. Gynecol. Oncol. 2010 116: 92-98
17447005 Isakovic A et al.: Dual antiglioma action of metformin: cell cycle arrest and mitochondria-dependent apoptosis. Cell. Mol. Life Sci. 2007 64: 1290-1302
19440038 Liu B et al.: Metformin induces unique biological and molecular responses in triple negative breast cancer cells. Cell Cycle 2009 8: 2031-2040
19491931 Chen W et al.: Phenotypes and genotypes of insulin-like growth factor 1, IGF-binding protein-3 and cancer risk: evidence from 96 studies. Eur. J. Hum. Genet. 2009 17: 1668-1675
18497064 Hontz AE et al.: Expression of selected Aurora A kinase substrates in solely estrogen-induced ectopic uterine stem cell tumors in the Syrian hamster kidney. Adv. Exp. Med. Biol. 2008 617: 411-418
22266860 Chuang JY et al.: Sp1 phosphorylation by cyclin-dependent kinase 1/cyclin B1 represses its DNA-binding activity during mitosis in cancer cells Oncogene 2012 31: 4946-4959
20679220 Ueda T et al.: Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development Proc. Natl. Acad. Sci. U.S.A. 2010 107
11463832 Knauf U et al.: Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2 Mol. Cell. Biol. 2001 21: 5500-5511
22392765 Hou J et al.: Targeting Mnks for cancer therapy Oncotarget 2012 3: 118-131
15345718 Legembre P et al.: Identification of SNF1/AMP kinase-related kinase as an NF-kappaB-regulated anti-apoptotic kinase involved in CD95-induced motility and invasiveness J. Biol. Chem. 2004 279
20458141 van de Sluis B et al.: COMMD1 disrupts HIF-1alpha/beta dimerization and inhibits human tumor cell invasion J. Clin. Invest. 2010 120: 2119-2130
20482850 Wu G et al.: A human functional protein interaction network and its application to cancer data analysis Genome Biol. 2010 11: R53
22259062 Peverelli E et al.: Filamin-A is essential for dopamine d2 receptor expression and signaling in tumorous lactotrophs J. Clin. Endocrinol. Metab. 2012 97: 967-977
12469206 Katoh M et al.: Expression and regulation of WNT1 in human cancer: up-regulation of WNT1 by beta-estradiol in MCF-7 cells Int. J. Oncol. 2003 22: 209-212
10572067 Fernandes AM et al.: Dominance of ErbB-1 heterodimers in lung epithelial cells overexpressing ErbB-2. Both ErbB-1 and ErbB-2 contribute significantly to tumorigenicity Am. J. Respir. Cell Mol. Biol. 1999 21: 701-709
10862525 Li DN et al.: Polymorphisms in P450 CYP1B1 affect the conversion of estradiol to the potentially carcinogenic metabolite 4-hydroxyestradiol Pharmacogenetics 2000 10: 343-353
15304487 Kouzmenko AP et al.: Wnt/beta-catenin and estrogen signaling converge in vivo J. Biol. Chem. 2004 279
21388974 author information missing article information missing
17138652 Lehnes K et al.: The effect of estradiol on in vivo tumorigenesis is modulated by the human epidermal growth factor receptor 2/phosphatidylinositol 3-kinase/Akt1 pathway Endocrinology 2007 148: 1171-1180
17410209 Li J et al.: CBP/p300 are bimodal regulators of Wnt signaling EMBO J. 2007 26: 2284-2294
14749120 Clevers H et al.: Wnt breakers in colon cancer Cancer Cell 2004 5: 5-6
18172554 Zudaire E et al.: The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers J. Clin. Invest. 2008 118: 640-650
21976023 Opitz CA et al.: An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor Nature 2011 478: 197-203
10329476 Kolla V et al.: Upregulation of mineralocorticoid- and glucocorticoid-receptor gene expression by Sp-I Mol. Cell Biol. Res. Commun. 1999 1: 44-47
19376845 Beedanagari SR et al.: Resveratrol inhibits dioxin-induced expression of human CYP1A1 and CYP1B1 by inhibiting recruitment of the aryl hydrocarbon receptor complex and RNA polymerase II to the regulatory regions of the corresponding genes Toxicol. Sci. 2009 110: 61-67
19018768 Choi H et al.: Curcumin attenuates cytochrome P450 induction in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin by ROS-dependently degrading AhR and ARNT Cancer Sci. 2008 99: 2518-2524
21878739 Terashima J et al.: Induction of CYP1 family members under low-glucose conditions requires AhR expression and occurs through the nuclear translocation of AhR Drug Metab. Pharmacokinet. 2011 26: 577-583
11279538 Lee YS et al.: Role of NAD(P)H oxidase in the tamoxifen-induced generation of reactive oxygen species and apoptosis in HepG2 human hepatoblastoma cells Cell Death Differ. 2000 7: 925-932
24049067 Garcia-Jimenez C et al.: A new link between diabetes and cancer: enhanced WNT/beta-catenin signaling by high glucose J Mol Endocrinol 2013 52: R51-R66
23500545 de Weille J et al.: Oxysterols in cancer cell proliferation and death Biochem. Pharmacol. 2013 86: 154-160
21239045 Feng Z et al.: Mammalian target of rapamycin regulates expression of beta-catenin in hepatocellular carcinoma Hum. Pathol. 2011 42: 659-668
23657817 Boscher C et al.: Galectin-3- and phospho-caveolin-1-dependent outside-in integrin signaling mediates the EGF motogenic response in mammary cancer cells Mol. Biol. Cell 2013 24: 2134-2145
21719054 Taylor CJ et al.: Integrin-linked kinase regulates phosphatase and tensin homologue activity to promote tumorigenesis in neuroblastoma cells Surgery 2011 150: 162-168
23796563 Antico Arciuch VG et al.: Inhibition of AMPK and Krebs cycle gene expression drives metabolic remodeling of Pten-deficient preneoplastic thyroid cells Cancer Res. 2013 73: 5459-5472
18339839 McDonald PC et al.: Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival Cancer Res. 2008 68: 1618-1624
24072782 Lamming DW et al.: Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2) FASEB J. 2014 28: 300-315
11719506 Yoon JW et al.: Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation J. Biol. Chem. 2002 277: 5548-5555
19706761 Lo HW et al.: A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion Cancer Res. 2009 69: 6790-6798
15737636 Hu H et al.: Alpha-actinin-2, a cytoskeletal protein, binds to angiogenin Biochem. Biophys. Res. Commun. 2005 329: 661-667
24947164 Bavarva JH et al.: Nicotine and oxidative stress induced exomic variations are concordant and overrepresented in cancer-associated genes Oncotarget 2014 5: 4788-4798
25281745 Cole SP et al.: Multidrug resistance protein 1 (MRP1, ABCC1), a multitasking ATP-binding cassette (ABC) transporter J. Biol. Chem. 2014 289
26180030 Ho CH et al.: Repurposing of phentolamine as a potential anticancer agent against human castration-resistant prostate cancer: A central role on microtubule stabilization and mitochondrial apoptosis pathway
24345474 author information missing Integrative DNA methylation and gene expression analysis in high-grade soft tissue sarcomas Genome Biol. 2013 14: R137
25367630 Kiehl S et al.: ABCB4 is frequently epigenetically silenced in human cancers and inhibits tumor growth Sci Rep 2014 4: 6899
23147569 Kurundkar D et al.: Vorinostat, an HDAC inhibitor attenuates epidermoid squamous cell carcinoma growth by dampening mTOR signaling pathway in a human xenograft murine model Toxicol. Appl. Pharmacol. 2013 266: 233-244
25060902 Kowshik J et al.: Ellagic acid inhibits VEGF/VEGFR2, PI3K/Akt and MAPK signaling cascades in the hamster cheek pouch carcinogenesis model Anticancer Agents Med Chem 2014 14: 1249-1260
23965899 Dai W et al.: Promoter CpG island methylation of genes in key cancer pathways associates with clinical outcome in high-grade serous ovarian cancer Clin. Cancer Res. 2013 19: 5788-5797
14578676 Kraus LA et al.: The mechanism of action of docetaxel (Taxotere) in xenograft models is not limited to bcl-2 phosphorylation Invest New Drugs 2003 21: 259-268
23608536 Aschauer L et al.: Delineation of the key aspects in the regulation of epithelial monolayer formation Mol. Cell. Biol. 2013 33: 2535-2550
25945730 Mariani A et al.: Differential Targeting of Human Topoisomerase II Isoforms with Small Molecules J. Med. Chem. 2015 58: 4851-4856
24186357 de Souza WF et al.: Ouabain-induced alterations of the apical junctional complex involve alpha1 and beta1 Na,K-ATPase downregulation and ERK1/2 activation independent of caveolae in colorectal cancer cells J. Membr. Biol. 2014 247: 23-33
20610891 Yamaguchi H et al.: Transport of estrone 3-sulfate mediated by organic anion transporter OATP4C1: estrone 3-sulfate binds to the different recognition site for digoxin in OATP4C1 Drug Metab. Pharmacokinet. 2010 25: 314-317
14993604 Mikkaichi T et al.: Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney Proc. Natl. Acad. Sci. U.S.A. 2004 101: 3569-3574
15050519 Geyer J et al.: Molecular cloning and functional characterization of the bovine (Bos taurus) organic anion transporting polypeptide Oatp1a2 (Slco1a2) Comp. Biochem. Physiol. B 2004 137: 317-329
12351693 Pizzagalli F et al.: Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter Mol. Endocrinol. 2002 16: 2283-2296
19775282 Tammam J et al.: Down-regulation of the Notch pathway mediated by a gamma-secretase inhibitor induces anti-tumour effects in mouse models of T-cell leukaemia Br. J. Pharmacol. 2009 158: 1183-1195
20332460 Okuhashi Y et al.: Effects of gamma-secretase inhibitors on the growth of leukemia cells Anticancer Res. 2010 30: 495-498
15448035 Dutcher JP et al.: Mammalian target of rapamycin inhibition Clin. Cancer Res. 2004 10: 6382
21652061 Kiewisz J et al.: Gene expression of WNTs, beta-catenin and E-cadherin during the periimplantation period of pregnancy in pigs--involvement of steroid hormones Theriogenology 2011 76: 687-699
18000824 Peng D et al.: Alterations in Barretts-related adenocarcinomas: a proteomic approach Int. J. Cancer 2008 122: 1303-1310
24382387 author information missing New and emerging HDAC inhibitors for cancer treatment J. Clin. Invest. 2014 124: 30-39
25247487 Erdem M et al.: herg1b expression as a potential specific marker in pediatric acute myeloid leukemia patients with HERG 897K/K genotype Pediatr Hematol Oncol 2015 32: 182-192
25098424 Prada J et al.: Significant decreases of interleukin-1alpha gene expression after application of the serotonin receptor antagonist ondansetron are found to correlate with antiproliferative properties in the acute lymphoblastic leukemia cell line REH Leuk. Lymphoma 2015 56: 1157-1159
25674239 Quesada AE et al.: Morphoproteomics identifies constitutive activation of the mTORC2/Akt and NF-kappaB pathways and expressions of IGF-1R, Sirt1, COX-2, and FASN in peripheral T-cell lymphomas: pathogenetic implications and therapeutic options Int J Clin Exp Pathol 2014 7: 8732-8739
12431979 Crociani O et al.: Cell cycle-dependent expression of HERG1 and HERG1B isoforms in tumor cells J. Biol. Chem. 2003 278: 2947-2955
24570000 Tanaka T et al.: Neuroendocrine signaling via the serotonin transporter regulates clearance of apoptotic cells J. Biol. Chem. 2014 289
9029730 Labrie F et al.: The key role of 17 beta-hydroxysteroid dehydrogenases in sex steroid biology Steroids 1997 62: 148-158
20435002 Juntti SA et al.: The androgen receptor governs the execution, but not programming, of male sexual and territorial behaviors Neuron 2010 66: 260-272
23591044 Chuffa LG et al.: Melatonin and ethanol intake exert opposite effects on circulating estradiol and progesterone and differentially regulate sex steroid receptors in the ovaries, oviducts, and uteri of adult rats Reprod. Toxicol. 2013 39: 40-49
22375794 Kirpich I et al.: Binge alcohol-induced microvesicular liver steatosis and injury are associated with down-regulation of hepatic Hdac 1, 7, 9, 10, 11 and up-regulation of Hdac 3 Alcohol. Clin. Exp. Res. 2012 36: 1578-1586
7424707 et al.: Acetaldehyde directly inhibits the conversion of androstenedione to testosterone in the testes Adv. Exp. Med. Biol. 1980 132: 211-217
14534309 Ali MK et al.: Elevated intracellular calcium