|
824
|
| 4843 |
PPARGC1A
|
|
affects_activity of
|
fatty acid beta-oxidation
|
in liver
|
| 4953 |
PPARGC1B
|
|
increases_activity of
|
triglyceride biosynthetic process
|
in liver
|
| 5104 |
PPARGC1A
|
|
affects_activity of
|
Insulin resistance
|
|
|
19770177
|
Diabetes mellitus, type II
Obesity
Insulin resistance
|
|
886
|
| 5219 |
PPARGC1A-p.T394T-G482S
|
|
increases_activity of
|
Diabetes mellitus, type II
|
|
|
12107756
|
Diabetes mellitus, type II
Insulin resistance
|
|
889
|
| 5289 |
PPARGC1B
|
|
increases_expression of
|
SLC2A4
|
|
| 5297 |
PPARGC1B
|
|
affects_activity of
|
lipid biosynthetic process
|
in liver; induced by fructose, if PPARGC1B expression is knocked down
|
|
19254570
|
Diabetes mellitus, type II
Insulin resistance
|
|
964
|
| 5941 |
IRS1-phosTyr
|
|
increases_activity of
|
Phosphatidylinositol 3-kinase
|
|
| 5950 |
PDPK1
|
|
increases_activity of
|
AKT1
|
|
| 5956 |
AKT1
|
|
increases_phosphorylation of
|
GSK3B
|
at Ser9 of GSK3
|
| 6038 |
IRS1
|
|
increases_quantity of
|
GRB2-SOS complex
|
|
| 73819 |
Insulin receptor
|
|
increases_activity of
|
insulin receptor signaling pathway
|
|
|
19041393
|
Diabetes mellitus, type II
Obesity
Insulin resistance
|
|
1,092
|
| 7072 |
ADIPOQ
|
|
affects_activity of
|
Insulin resistance
|
|
|
18053812
|
Diabetes mellitus, type II
Obesity
Insulin resistance
|
|
1,674
|
| 12408 |
hyperglycemia
|
|
increases_expression of
|
PRKCD
|
in adipose tissue
|
|
15536073
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,408
|
| 21492 |
KCNQ1 rs231362
|
|
increases_activity of
|
Diabetes mellitus, type II
|
the risk allele is G
|
|
20581827
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,539
|
| 23641 |
PPARGC1A
|
|
affects_activity of
|
insulin secretion
|
|
|
18270681
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,575
|
| 24219 |
ABCC8 rs757110
|
|
decreases_activity of
|
hyperglycemia
|
after fasting, after treatment with gliclazide, the effective allele is G
|
|
18599530
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,578
|
| 24268 |
ABCC8
|
|
is_part_of
|
ATP-sensitive potassium channel complex
|
in pancreas, in pancratic beta cells, in pancreatic alpha cells, in intestinal L-cells, in neurons
|
| 24269 |
KCNJ11
|
|
is_part_of
|
ATP-sensitive potassium channel complex
|
in pancreas, in pancratic beta cells, in pancreatic alpha cells, in intestinal L-cells, in neurons
|
| 24270 |
ATP-sensitive potassium channel complex
|
|
affects_activity of
|
insulin secretion
|
in pancreas, in pancreatic beta cells
|
| 24300 |
ABCC8
|
|
affects_activity of
|
Hyperinsulinemic hypoglycemia, familial, 1
|
|
| 24312 |
ABCC8 rs757110
|
|
increases_activity of
|
Diabetes mellitus, type II
|
the risk allele is G
|
|
21968738
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,580
|
| 24318 |
ABCC8 rs757110
|
|
decreases_activity of
|
insulin secretion
|
|
|
17259403
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,814
|
| 25952 |
increased circulating insulin level
|
|
increases_quantity of
|
IGF1
|
in liver
|
|
21912508
|
Diabetes mellitus, type II
Cancer
Insulin resistance
Metabolic syndrome
|
|
3,795
|
| 37669 |
TSC1-TSC2 complex
|
|
decreases_activity of
|
mTORC1 complex
|
|
| 37738 |
RHEB
|
|
increases_activity of
|
mTORC1 complex
|
|
|
18765678
|
Diabetes mellitus, type II
Insulin resistance
|
|
3,991
|
| 40913 |
Diabetes mellitus, type II
|
|
increases_expression of
|
FBP1
|
in liver; in diabetic db/db mouse
|
|
20567778
|
Diabetes mellitus, type II
Insulin resistance
|
|
3,992
|
| 40916 |
FBP1
|
|
affects_activity of
|
gluconeogenesis
|
in liver
|
|
20567778
|
Diabetes mellitus, type II
Insulin resistance
|
|
4,409
|
| 44928 |
GSK3B
|
|
increases_activity of
|
TSC2
|
|
|
22131415
|
Metabolic
|
|
4,486
|
| 45063 |
Diabetes mellitus, type II
|
|
increases_expression of
|
CACNA2D1
|
|
|
21216827
|
Diabetes mellitus, type II
Insulin resistance
|
|
4,500
|
| 45092 |
ABL1
|
|
interacts (colocalizes) with
|
EGFR
|
|
|
16273093
|
Metabolic
Circadian rhythm
|
|
4,520
|
| 45130 |
ABL1
|
|
affects_activity of
|
insulin receptor signaling pathway
|
|
|
19251035
|
Diabetes mellitus, type II
Diabetes mellitus
Insulin resistance
|
|
4,570
|
| 49191 |
Insulin
|
|
increases_activity of
|
AKT3
|
in 3T3-L1 fibroblasts and adipocytes
|
|
9480839
|
Obesity
|
|
4,585
|
| 45587 |
Diabetes mellitus, type II
|
|
increases_expression of
|
TRPC4
|
|
|
19393642
|
Diabetes mellitus, type II
Insulin resistance
|
|
5,296
|
| 51763 |
KCNJ6
|
|
affects_activity of
|
insulin secretion
|
|
|
7626127
|
Diabetes mellitus, type II
|
|
5,318
|
| 52049 |
insulin receptor signaling pathway
|
|
affects_activity of
|
AKT3
|
in lean muscles
|
|
12663464
|
Obesity
|
|
5,319
|
| 52050 |
AKT3
|
|
increases_phosphorylation of
|
TBC1D4
|
|
| 52051 |
TBC1D4
|
|
increases_transport of
|
SLC2A4
|
|
| 52052 |
SLC2A4
|
|
affects_activity of
|
glucose import
|
|
|
24611020
|
Diabetes mellitus, type II
Insulin resistance
|
|
5,320
|
| 52053 |
IRS1
|
|
interacts (colocalizes) with
|
AP3S1
|
|
|
9792713
|
Diabetes mellitus, type II
|
|
5,321
|
| 52055 |
AP3S1 (rs3756555)
|
|
increases_activity of
|
Diabetes mellitus, type II
|
in the Chinese Northern Han population, the risk allele is C
|
|
20512086
|
Diabetes mellitus, type II
|
|
5,322
|
| 52058 |
ATXN1-mut
|
|
affects_expression of
|
IGFBP5
|
|
| 52059 |
ATXN7-mut
|
|
affects_expression of
|
IGFBP5
|
|
|
18216249
|
Spinocerebellar ataxia 1
Spinocerebellar ataxia 7
|
|
5,323
|
| 52060 |
IGFBP5-mut
|
|
affects_activity of
|
glucose homeostasis
|
after high-fat diet
|
|
19897600
|
Diabetes mellitus, type II
Obesity
Insulin resistance
|
|
5,324
|
| 52061 |
Insulin
|
|
interacts (colocalizes) with
|
Insulin receptor
|
|
| 52062 |
INSR
|
|
interacts (colocalizes) with
|
SH2B2
|
|
| 52063 |
SH2B2
|
|
increases_activity of
|
CBL-SORBS1 complex
|
|
| 52064 |
CBL
|
|
interacts (colocalizes) with
|
CRKII-C3G complex
|
|
| 52065 |
RAPGEF1
|
|
is_part_of
|
CRKII-C3G complex
|
|
| 52067 |
RAPGEF1
|
|
increases_activity of
|
RHOQ
|
|
| 52070 |
RHOQ
|
|
interacts (colocalizes) with
|
EXOC7
|
|
| 52071 |
EXOC7
|
|
affects transport of
|
SLC2A4
|
|
| 52072 |
EXOC7
|
|
affects_activity of
|
synaptic vesicle targeting
|
|
|
22617471
|
Diabetes mellitus, type II
Insulin resistance
|
|
5,325
|
| 52074 |
FBP1
|
|
affects_activity of
|
insulin secretion
|
|
|
20719858
|
Diabetes mellitus, type II
Insulin resistance
|
CIDeR