Search Results for "PSEN1" - 87 interactions found in 39 entries.

Entry-ID
Interactor1 (Subject) Interaction type Interactor2 (Object) additional information
PubMed-ID
Diseases
122
907 PSEN1 increases_activity of protein localization of GSK3B and MAPT/TAU
908 PSEN1 interacts (colocalizes) with GSK3B
909 PSEN1 affects_activity of AKT1
11527574 Alzheimer disease
230
932 abnormal astrocyte physiology increases_expression of PSEN1
17515952 Epilepsy, temporal lobe
247
1105 APH1A interacts (colocalizes) with PSEN1
1264 NCSTN interacts (colocalizes) with PSEN1
16944319 Alzheimer disease
255
1055 FBXW7 interacts (colocalizes) with PSEN1
12354302 Metabolic
Epilepsy, temporal lobe
259
1060 PSEN1 affects_processing of CD44
12223485 Epilepsy, temporal lobe
322
1281 NCSTN interacts (colocalizes) with PSEN1
1289 CANX NOT interacts (colocalizes) with PSEN1
10993067 Alzheimer disease
331
1282 NCSTN interacts (colocalizes) with PSEN1
10993067 Alzheimer disease
344
1345 PSENEN affects_activity of PSEN1
1350 APH1A increases_activity of PSEN1 APH-1 stabilizes the presenilin holoprotein.
25279 PSENEN affects_processing of PSEN1
12660785 Alzheimer disease
355
1445 PSEN1 interacts (colocalizes) with NCSTN
12032140 Alzheimer disease
376
1530 NCSTN-p150-NCT interacts (colocalizes) with PSEN1
12044882 Alzheimer disease
381
1588 PSEN1 affects_activity of NCSTN
1589 NCSTN affects_activity of PSEN1
1610 PSEN1 interacts (colocalizes) with NCSTN
14072 PSEN1 affects_quantity of Amyloid beta peptide
14076 PSEN1 is_part_of Gamma-secretase complex
12048259 Alzheimer disease
505
2509 PSEN1 increases_quantity of Amyloid beta peptide
2511 PSEN1 affects_processing of NCSTN PSEN1 acts as member of gamma-secretase complex (CorumID: 466)
2517 PSEN1 affects_glycosylation of NCSTN
2519 PSEN1 interacts (colocalizes) with NCSTN
11943765 Alzheimer disease
512
2540 PSEN1 NOT affects_expression of HSPA5
2565 PSEN1 NOT affects_expression of DDIT3
11146649 Alzheimer disease
574
3047 GSK3B interacts (colocalizes) with PSEN1
3048 MAPT interacts (colocalizes) with PSEN1
3049 GSK3B affects_activity of PSEN1
17298085 Alzheimer disease
580
3125 PSEN1 interacts (colocalizes) with CTNNB1
3135 PSEN1 affects_quantity of CTNNB1
12761548 Alzheimer disease
608
3210 PSEN1 interacts (colocalizes) with CTNNB1
3246 PSEN1 decreases_quantity of CTNNB1
10341227 Alzheimer disease
613
3257 Metformin NOT affects_quantity of PSEN1
19237574 Diabetes mellitus, type II
Insulin resistance
614
3248 PSEN1 decreases_activity of canonical Wnt signaling pathway
3288 PSEN1 affects_phosphorylation of CTNNB1
3309 PSEN1 increases_quantity of CTNNB1-phosSer33Ser37Thr41
12297048 Alzheimer disease
681
3672 PSEN1 is localized in endoplasmic reticulum
9051814 Alzheimer disease
792
4682 PSEN1 increases_activity of aggresome assembly in endoplasmic reticulum; as response to heat shock stress (GO:0009408 )
19449461 Alzheimer disease
1,033
6496 NCSTN interacts (colocalizes) with PSEN1
12603837 Alzheimer disease
1,333
9185 PSEN1 affects_activity of PI3K/AKT cell survival signaling stimulation
9187 PSEN1 affects_activity of MEK/ERK cell survival signaling stimulation
9188 PSEN1 affects_activity of GSK3B
9189 PSEN1 affects_activity of calcium ion homeostasis
20594619 Alzheimer disease
1,348
9200 PSEN1 affects_activity of neurotransmitter secretion
9209 PSEN1 affects_activity of calcium ion-dependent exocytosis of neurotransmitter
9210 PSEN1 affects_activity of calcium ion homeostasis
9211 PSEN1 affects_activity of regulation of short-term neuronal synaptic plasticity
9212 PSEN1 affects_activity of regulation of long-term neuronal synaptic plasticity
9213 PSEN1 affects_activity of regulation of synaptic plasticity
9218 PSEN1-mut affects_activity of PSEN1
19641596 Alzheimer disease
1,349
9220 PSEN1 increases_activity of phosphatidylinositol 3-kinase signaling
9254 PSEN1 decreases_activity of neurodegeneration
9256 PSEN1 affects_activity of neurodegeneration
9297 PSEN1 affects_activity of CASP3
18184791 Alzheimer disease
1,520
10790 PSEN1 increases_expression of BACE1 Oxidative stress-induced BACE1 expression is reduced in presenilin-1 (gamma-secretase)-deficient cells.
10792 PSEN1 increases_activity of Gamma-secretase complex Oxidative stress-induced BACE1 expression is reduced in presenilin-1 (gamma-secretase)-deficient cells.
18687504 Alzheimer disease
1,576
11354 Reactive oxygen species increases_expression of PSEN1 if ROS is overexpressed; mediated through the activation of the JNK pathway;
20442493 Alzheimer disease
1,633
11974 PSEN1 is_part_of Gamma-secretase complex
11979 PSEN1 is localized in mitochondrion
15456764 Alzheimer disease
2,533
24087 PSEN1 is localized in membrane raft
24157 PLD1 interacts (colocalizes) with PSEN1
21448224 Alzheimer disease
2,989
27334 CASP increases_processing of PSEN1
27350 PSEN1-proc affects_activity of PSEN1
27360 PSEN1 affects_activity of regulation of gene expression of P53
27368 PSEN1 affects_activity of regulation of proteolysis (lysosomal proteolysis)
27369 PSEN1 affects_activity of regulation of autophagy
27385 CASP3 increases_processing of PSEN1 in AD brain
27386 CASP6 increases_processing of PSEN1 in AD brain
72211 CASP3 decreases_quantity of PSEN1 in AD brain; by cleaving PSEN1
72212 CASP6 decreases_quantity of PSEN1 in AD brain; by cleaving PSEN1
21902456 Alzheimer disease
3,009
27435 CASP affects_processing of PSEN1
21054783 Alzheimer disease
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