Search Results for "PRNP" - 75 interactions found in 11 entries.

Entry-ID
Interactor1 (Subject) Interaction type Interactor2 (Object) additional information
PubMed-ID
Diseases
976
6024 Amyloid beta peptide (oligomer) interacts (colocalizes) with PRNP (within PrPC, amino acid residues 95–110 are crucial for Abeta binding)
6025 PRNP interacts (colocalizes) with membrane
6028 Alpha-secretase increases_processing of PRNP between residues 111 and 112
19242462 Alzheimer disease
Prion disease
1,361
9315 PRNP interacts (colocalizes) with Amyloid beta peptide
20739979 Alzheimer disease
Prion disease
2,352
64057 PRNP-p.Q160X decreases_activity of PRNP
21416485 Alzheimer disease
Prion disease
3,074
28183 synapse affects_expression of PRNP
28202 PRNP interacts (colocalizes) with Amyloid beta peptide (oligomer)
28291 Amyloid beta peptide (oligomer) interacts (colocalizes) with PRNP at cholesterol dense membranes (lipid rafts)
28296 PRNP is_part_of Amyloid beta peptide (oligomer)-PrPC complex in Prnp wild-type neurons
21900234 Alzheimer disease
Prion disease
3,093
28388 PRNP interacts (colocalizes) with BACE1 with the prodomain of the immature Golgi-localized form of BACE1
28432 PRNP affects_activity of BACE1 by binding to the prodomain of the immature Golgi-localized form of BACE1
21795680 Alzheimer disease
Prion disease
3,104
28485 PRNP interacts (colocalizes) with BACE1
28493 PRNP decreases_activity of BACE1 This decreases both Abeta and AICD (amyloid intracellular domain) production.
28494 PRNP interacts (colocalizes) with Amyloid beta peptide (oligomer) PRNP acts as a receptor and appears to be controlled by the amyloid intracellular domain (AICD). The AICD upregulates PrPC expression. In AD this interaction is increased.
28498 APP (intracellular domain AICD) increases_expression of PRNP
28522 APP (intracellular domain AICD) increases_expression of PRNP
28530 Alzheimer disease affects_activity of PRNP and prevents it from regulating BACE1 activity
19887909 Alzheimer disease
Prion disease
3,108
28581 hyperglycemia increases_quantity of PRNP in muscle from diabetic animals; via stress produced during the onset and progression of diabetes and hyperglycemia
28582 Diabetes mellitus increases_quantity of PRNP in muscle from diabetic animals; via stress produced during the onset and progression of diabetes and hyperglycemia
37480 response to stress increases_quantity of PRNP in muscle from diabetic animals; during the onset and progression of diabetes and hyperglycemia
20819221 Alzheimer disease
3,128
28881 PRNP-mod (infectious) affects_activity of PRNP conformational conversion of PrPC (wild-type) to PrPSc (infectious type)
28947 PRNP affects_quantity of Amyloid beta peptide
28948 PRNP increases_quantity of tau protein deposits
29011 PRNP increases_quantity of MAPT-phos in cerebellum
64058 PRNP-p.P102L decreases_activity of PRNP
64059 PRNP-p.A117V decreases_activity of PRNP
64060 PRNP-p.D178N decreases_activity of PRNP
64061 PRNP-p.E200K decreases_activity of PRNP
64062 PRNP-mut (96 octarepeat insert) decreases_activity of PRNP
64063 PRNP-mut (144 octarepeat insert) decreases_activity of PRNP
64071 PRNP-p.P105L decreases_activity of PRNP
20473510 Alzheimer disease
Prion disease
3,152
29018 PRNP increases_activity of neuron death Abeta oligomer-induced
29021 PRNP interacts (colocalizes) with Amyloid beta peptide
22100763 Alzheimer disease
Prion disease
4,266
43630 Olanzapine decreases_expression of PRNP
43639 Olanzapine decreases_expression of PRNP
21399480 Alzheimer disease
6,645
63873 PRNP-p.P84S decreases_activity of PRNP
63875 PRNP-p.P102L decreases_activity of PRNP
63883 PRNP-p.P105L decreases_activity of PRNP
63891 PRNP-p.P105S decreases_activity of PRNP
63895 PRNP-p.M129V affects_activity of PRNP
63898 PRNP-p.P105T decreases_activity of PRNP
63900 PRNP-p.G114V decreases_activity of PRNP
63903 PRNP-p.A117V decreases_activity of PRNP
63906 PRNP-p.G131V decreases_activity of PRNP
63922 PRNP-p.S132I decreases_activity of PRNP
63924 PRNP-p.A133V decreases_activity of PRNP
63926 PRNP-p.R136S decreases_activity of PRNP
63930 PRNP-p.Y145X decreases_activity of PRNP
63932 PRNP-p.R148H decreases_activity of PRNP
63935 PRNP-p.Q160X decreases_activity of PRNP
63938 PRNP-p.Y163X decreases_activity of PRNP
63941 PRNP-p.D178N decreases_activity of PRNP
63944 PRNP-p.V180I decreases_activity of PRNP
63947 PRNP-p.T183A decreases_activity of PRNP
63950 PRNP-p.H187R decreases_activity of PRNP
63952 PRNP-p.T188A decreases_activity of PRNP
63954 PRNP-p.T188K decreases_activity of PRNP
63956 PRNP-p.T188R decreases_activity of PRNP
63959 PRNP-p.M195X decreases_activity of PRNP
64025 PRNP-p.E196K decreases_activity of PRNP
64027 PRNP-p.F198S decreases_activity of PRNP
64029 PRNP-p.E200K decreases_activity of PRNP
64031 PRNP-p.D202N decreases_activity of PRNP
64033 PRNP-p.V203I decreases_activity of PRNP
64035 PRNP-p.R208H decreases_activity of PRNP
64037 PRNP-p.V210I decreases_activity of PRNP
64039 PRNP-p.E211Q decreases_activity of PRNP
64041 PRNP-p.Q212P decreases_activity of PRNP
64043 PRNP-p.I215V decreases_activity of PRNP
64045 PRNP-p.Q217R decreases_activity of PRNP
64047 PRNP-p.Y218N decreases_activity of PRNP
64049 PRNP-p.Y226X decreases_activity of PRNP
64051 PRNP-p.Q227X decreases_activity of PRNP
64053 PRNP-p.M232R decreases_activity of PRNP
64055 PRNP-p.M232T decreases_activity of PRNP
26250687 Alzheimer disease
Dementia, Lewy body
Frontotemporal dementia
Parkinson disease
Prion disease
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