|
418
|
| 1890 |
AKT1
|
|
interacts (colocalizes) with
|
PDPK1
|
|
| 1976 |
PDPK1
|
|
increases_phosphorylation of
|
AKT1
|
at Thr308; phosphorylation at Ser473 is required for full Akt activity;
|
| 14040 |
Amyloid beta peptide
|
|
interacts (colocalizes) with
|
PDPK1
|
|
|
19144826
|
Alzheimer disease
|
|
427
|
| 1869 |
PDPK1
|
|
is_part_of
|
AKT1-PDPK1 interaction
|
|
| 1883 |
AKT1
|
|
interacts (colocalizes) with
|
PDPK1
|
via intraneuronal beta-amyloid
|
|
19144826
|
Alzheimer disease
|
|
964
|
| 5945 |
Phosphatidylinositol-3,4,5-trisphosphate
|
|
increases_activity of
|
PDPK1
|
|
| 5949 |
PDPK1
|
|
increases_phosphorylation of
|
AKT1
|
|
| 5950 |
PDPK1
|
|
increases_activity of
|
AKT1
|
|
| 5951 |
PDPK1
|
|
increases_phosphorylation of
|
PRKCZ
|
|
| 5952 |
PDPK1
|
|
increases_activity of
|
PRKCZ
|
|
| 5953 |
PDPK1
|
|
increases_phosphorylation of
|
PRKCI
|
|
| 5955 |
PDPK1
|
|
increases_activity of
|
PRKCI
|
|
| 6225 |
PDPK1
|
|
increases_activity of
|
AKT1
|
via phosphorylation at Thr308 of AKT
|
| 6230 |
PDPK1
|
|
increases_phosphorylation of
|
AKT1
|
at Thr308 of AKT
|
|
19041393
|
Diabetes mellitus, type II
Obesity
Insulin resistance
|
|
2,253
|
| 19245 |
Phosphatidylinositol-3,4,5-trisphosphate
|
|
increases_activity of
|
PDPK1
|
|
| 19246 |
PDPK1
|
|
increases_activity of
|
AKT1
|
|
| 19258 |
PDPK1
|
|
increases_activity of
|
RPS6KB1
|
|
| 19260 |
PDPK1
|
|
increases_activity of
|
SGK3
|
|
| 19261 |
PDPK1
|
|
increases_activity of
|
PRKCZ
|
|
|
12040186
|
Diabetes mellitus, type II
Insulin resistance
|
|
3,388
|
| 31864 |
carnitine supplementation
|
|
affects_expression of
|
PDPK1
|
|
|
22134503
|
Diabetes mellitus, type II
Carnitine deficiency, systemic primary
Insulin resistance
Status epilepticus
Cardiovascular disease
|
|
4,902
|
| 48313 |
Metformin
|
|
increases_activity of
|
PDPK1
|
|
|
16443786
|
Diabetes mellitus, type II
Insulin resistance
|
|
5,329
|
| 52097 |
PIK3CA
|
|
increases_activity of
|
PDPK1
|
|
|
23131847
|
Metabolic
|
|
5,335
|
| 52110 |
PDPK1
|
|
increases_quantity of
|
PRKCA
|
|
| 52111 |
PDPK1
|
|
increases_quantity of
|
PRKCB
|
|
| 52112 |
PDPK1
|
|
increases_quantity of
|
PRKCG
|
|
| 52113 |
PDPK1
|
|
increases_quantity of
|
PRKCE
|
|
|
17617409
|
Metabolic
|
|
5,339
|
| 52120 |
PDPK1
|
|
interacts (colocalizes) with
|
AKT3
|
|
|
22525724
|
Melanoma, cutaneous malignant
|
|
6,195
|
| 57969 |
Phosphatidylinositol-3,4,5-trisphosphate
|
|
increases_activity of
|
PDPK1
|
|
| 57970 |
PDPK1
|
|
increases_activity of
|
AKT1
|
via phosphorylation at Thr308
|
|
23625692
|
Glioblastoma
|
|
6,579
|
| 62755 |
Phosphatidylinositol 3-kinase
|
|
increases_activity of
|
PDPK1
|
|
| 62756 |
PDPK1
|
|
increases_phosphorylation of
|
AKT1
|
at Thr-308, resulting in active AKT1
|
| 62765 |
Phosphatidylinositol-3,4,5-trisphosphate
|
|
increases_activity of
|
PDPK1
|
|
| 62862 |
PDPK1
|
|
increases_activity of
|
AKT1
|
via phosphorylation at Thr-308
|
|
22363263
|
Metabolic
|
|
6,887
|
| 67248 |
Diabetes mellitus, type II
|
|
decreases_activity of
|
PDPK1
|
in brain
|
| 67251 |
PDPK1
|
|
increases_activity of
|
protein O-linked glycosylation
|
in brain
|
|
21598254
|
Diabetes mellitus, type II
Insulin resistance
|
|
7,173
|
| 70736 |
epidermal growth factor receptor signaling pathway
|
|
affects_activity of
|
PDPK1
|
|
|
|
Cancer
Nephronophthisis
Ciliopathy
|
|
7,340
|
| 72128 |
Phosphatidylinositol-3,4,5-trisphosphate
|
|
interacts (colocalizes) with
|
PDPK1
|
|
| 72130 |
Phosphatidylinositol-3,4-bisphosphate
|
|
interacts (colocalizes) with
|
PDPK1
|
|
| 72131 |
PDPK1
|
|
increases_activity of
|
AKT1
|
via phosphorylation at Thr308
|
|
26862211
|
Diabetes mellitus, type II
Insulin resistance
|
|
12,362
|
| 121076 |
PDPK1
|
|
increases_activity of
|
AKT1
|
if PIP3 is bound to AKT1
|
|
24450744
|
Diabetes mellitus, type II
Insulin resistance
|
CIDeR