Search Results for "PDPK1" - 40 interactions found in 15 entries.

Entry-ID
Interactor1 (Subject) Interaction type Interactor2 (Object) additional information
PubMed-ID
Diseases
418
1890 AKT1 interacts (colocalizes) with PDPK1
1976 PDPK1 increases_phosphorylation of AKT1 at Thr308; phosphorylation at Ser473 is required for full Akt activity;
14040 Amyloid beta peptide interacts (colocalizes) with PDPK1
19144826 Alzheimer disease
427
1869 PDPK1 is_part_of AKT1-PDPK1 interaction
1883 AKT1 interacts (colocalizes) with PDPK1 via intraneuronal beta-amyloid
19144826 Alzheimer disease
964
5945 Phosphatidylinositol-3,4,5-trisphosphate increases_activity of PDPK1
5949 PDPK1 increases_phosphorylation of AKT1
5950 PDPK1 increases_activity of AKT1
5951 PDPK1 increases_phosphorylation of PRKCZ
5952 PDPK1 increases_activity of PRKCZ
5953 PDPK1 increases_phosphorylation of PRKCI
5955 PDPK1 increases_activity of PRKCI
6225 PDPK1 increases_activity of AKT1 via phosphorylation at Thr308 of AKT
6230 PDPK1 increases_phosphorylation of AKT1 at Thr308 of AKT
19041393 Diabetes mellitus, type II
Obesity
Insulin resistance
2,253
19245 Phosphatidylinositol-3,4,5-trisphosphate increases_activity of PDPK1
19246 PDPK1 increases_activity of AKT1
19258 PDPK1 increases_activity of RPS6KB1
19260 PDPK1 increases_activity of SGK3
19261 PDPK1 increases_activity of PRKCZ
12040186 Diabetes mellitus, type II
Insulin resistance
3,388
31864 carnitine supplementation affects_expression of PDPK1
22134503 Diabetes mellitus, type II
Carnitine deficiency, systemic primary
Insulin resistance
Status epilepticus
Cardiovascular disease
4,902
48313 Metformin increases_activity of PDPK1
16443786 Diabetes mellitus, type II
Insulin resistance
5,329
52097 PIK3CA increases_activity of PDPK1
23131847 Metabolic
5,335
52110 PDPK1 increases_quantity of PRKCA
52111 PDPK1 increases_quantity of PRKCB
52112 PDPK1 increases_quantity of PRKCG
52113 PDPK1 increases_quantity of PRKCE
17617409 Metabolic
5,339
52120 PDPK1 interacts (colocalizes) with AKT3
22525724 Melanoma, cutaneous malignant
6,195
57969 Phosphatidylinositol-3,4,5-trisphosphate increases_activity of PDPK1
57970 PDPK1 increases_activity of AKT1 via phosphorylation at Thr308
23625692 Glioblastoma
6,579
62755 Phosphatidylinositol 3-kinase increases_activity of PDPK1
62756 PDPK1 increases_phosphorylation of AKT1 at Thr-308, resulting in active AKT1
62765 Phosphatidylinositol-3,4,5-trisphosphate increases_activity of PDPK1
62862 PDPK1 increases_activity of AKT1 via phosphorylation at Thr-308
22363263 Metabolic
6,887
67248 Diabetes mellitus, type II decreases_activity of PDPK1 in brain
67251 PDPK1 increases_activity of protein O-linked glycosylation in brain
21598254 Diabetes mellitus, type II
Insulin resistance
7,173
70736 epidermal growth factor receptor signaling pathway affects_activity of PDPK1
Cancer
Nephronophthisis
Ciliopathy
7,340
72128 Phosphatidylinositol-3,4,5-trisphosphate interacts (colocalizes) with PDPK1
72130 Phosphatidylinositol-3,4-bisphosphate interacts (colocalizes) with PDPK1
72131 PDPK1 increases_activity of AKT1 via phosphorylation at Thr308
26862211 Diabetes mellitus, type II
Insulin resistance
12,362
121076 PDPK1 increases_activity of AKT1 if PIP3 is bound to AKT1
24450744 Diabetes mellitus, type II
Insulin resistance
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