Search Results for "NR1H4" - 227 interactions found in 16 entries.

Entry-ID
Interactor1 (Subject) Interaction type Interactor2 (Object) additional information
PubMed-ID
Diseases
1,415
9760 NR1H4 decreases_activity of NF-kappaB complex in liver
18972444 Schizophrenia
3,567
33327 NR1H4 decreases_activity of gallstones
33328 LIRKO mouse decreases_expression of NR1H4
33329 LIRKO mouse affects_activity of NR1H4
18587407 Diabetes mellitus, type II
Insulin resistance
Gallbladder disease 1
3,569
33366 NR1H4 NOT affects_expression of ABCG5 in liver
33367 NR1H4 NOT affects_expression of ABCG8 in liver
18587407 Diabetes mellitus, type II
Insulin resistance
3,571
33380 NR1H4 affects_quantity of adipose tissue
33384 NR1H4 affects_activity of decreased circulating leptin level in blood serum
33386 NR1H4 affects_activity of increased circulating free fatty acid level in blood plasma
33387 NR1H4 affects_activity of impaired glucose tolerance
33388 NR1H4 affects_activity of Insulin resistance
33389 NR1H4 affects_activity of insulin receptor signaling pathway in white adipose tissue, in skeletal muscle
33390 NR1H4 affects_phosphorylation of AKT1 in white adipose tissue, in skeletal muscle
33391 NR1H4 NOT is_expressed_in skeletal muscle
33392 NR1H4 is_expressed_in white adipose tissue
33393 fat cell differentiation increases_expression of NR1H4
33394 NR1H4 affects_activity of fat cell differentiation
33395 NR1H4 NOT affects_expression of PPARG in white adipose tissue
33403 NR1H4 NOT affects_expression of CEBPA in white adipose tissue
33404 NR1H4 NOT affects_expression of FABP4 in white adipose tissue
33405 NR1H4 affects_expression of CEBPB in white adipose tissue
33406 NR1H4 affects_expression of SREBF1c in white adipose tissue
33407 NR1H4 affects_expression of LEP in white adipose tissue
33408 NR1H4 NOT affects_expression of ADIPOQ in white adipose tissue
33409 NR1H4 NOT affects_expression of RETN in white adipose tissue
33410 NR1H4 NOT affects_expression of IL6 in white adipose tissue
33411 NR1H4 affects_expression of TNF in white adipose tissue
33412 NR1H4 NOT affects_expression of DGAT1 in white adipose tissue
33413 NR1H4 NOT affects_expression of FASN in white adipose tissue
33414 NR1H4 NOT affects_expression of PCK1 in white adipose tissue
33415 NR1H4 affects_expression of LIPE in white adipose tissue
33416 NR1H4 affects_expression of LPL in white adipose tissue
33417 NR1H4 affects_expression of SLC27A1 in white adipose tissue
33418 NR1H4 affects_expression of PPARA in skeletal muscle
33419 NR1H4 affects_expression of PPARD in skeletal muscle
33420 NR1H4 affects_expression of SLC27A1 in skeletal muscle
33421 NR1H4 affects_expression of LPL in skeletal muscle
33422 NR1H4 affects_expression of DGAT1 in skeletal muscle
33423 NR1H4 affects_expression of CPT1B in skeletal muscle
33424 NR1H4 affects_expression of UCP2 in skeletal muscle
33425 NR1H4 affects_expression of UCP3 in skeletal muscle
33426 NR1H4 affects_expression of ACO in skeletal muscle
16446356 Diabetes mellitus, type II
Insulin resistance
3,576
33528 NR1H4 is_expressed_in pancreatic beta cell
33529 NR1H4 increases_activity of insulin secretion involved in cellular response to glucose stimulus
33531 NR1H4 is_expressed_in intestine
33590 NR1H4 decreases_expression of SREBF1 in liver; via LXR
33592 NR1H4 decreases_activity of VLDL secretion in liver
33593 NR1H4 decreases_activity of ectopic lipid storage in liver
33595 NR1H4 increases_expression of APOC2 in liver
33596 NR1H4 decreases_expression of APOC3 in liver
33597 NR1H4 decreases_expression of CYP7A1 in liver
33598 NR1H4 increases_expression of ABCB11 in liver
33599 NR1H4 decreases_expression of SLC10A1 in liver
33604 NR1H4 increases_expression of SLC51A in intestine
33607 NR1H4 increases_expression of SLC51B in intestine
33610 NR1H4 increases_expression of FABP6 in intestine
33612 NR1H4 increases_expression of FGF19 in intestine
33614 NR1H4 decreases_expression of APOA1 in liver
33618 NR1H4 decreases_expression of LDLR in liver
33619 NR1H4 increases_expression of ABCG5 in liver
33620 NR1H4 increases_expression of ABCG8 in liver
33621 NR1H4 increases_expression of SCARB1 in liver
33623 NR1H4 decreases_expression of PCSK9 in liver
21991404 Diabetes mellitus, type II
Cholestasis, progressive familial intrahepatic 2
Insulin resistance
3,609
34059 NR1H4 is_expressed_in pancreatic islet
34060 NR1H4 increases_activity of insulin secretion involved in cellular response to glucose stimulus
34061 NR1H4 affects_expression of INS
34062 NR1H4 increases_transport of SLC2A2 to the plasma membrane
34063 NR1H4 increases_activity of glucose import in pancreas, in pancreatic beta cells
34064 NR1H4 increases_phosphorylation of AKT1 in pancreas, in pancreatic beta cells
34065 NR1H4 increases_activity of protein kinase B signaling in pancreas, in pancreatic beta cells
34066 NR1H4 NOT affects_expression of SLC2A2 in pancreas, in pancreatic beta cells
34067 NR1H4 increases_expression of KLF11 in pancreas
20060466 Diabetes mellitus, type II
Insulin resistance
3,610
34068 NR1H4 affects_activity of Diabetes mellitus, type I
34069 NR1H4 increases_activity of insulin secretion involved in cellular response to glucose stimulus
34070 NR1H4 increases_expression of SLC2A4 in liver
20060466 Diabetes mellitus, type I
3,615
34141 Cholic acid NOT affects_expression of NR1H4 in brown adipose tissue
16400329 Diabetes mellitus, type II
Obesity
Insulin resistance
3,632
34412 Chenodeoxycholate increases_activity of NR1H4
34413 Lithocholic acid increases_activity of NR1H4
34414 Deoxycholic acid increases_activity of NR1H4
34415 Cholic acid increases_activity of NR1H4
34419 NR1H4 interacts (colocalizes) with RXR
34420 NR1H4 increases_expression of NR0B2
34421 NR1H4 increases_expression of FGF19 in intestine
34428 Diabetes mellitus, type II decreases_expression of NR1H4
34432 NR1H4 affects_expression of PKLR
34433 NR1H4 affects_expression of FASN
34434 NR1H4 affects_expression of ACACA
34435 NR1H4 decreases_activity of gluconeogenesis
34436 NR1H4 decreases_expression of PCK1
34438 NR1H4 decreases_expression of G6PC
34439 NR1H4 decreases_expression of FBP1
34441 NR1H4 affects_activity of Insulin resistance in peripheral tissues
34442 NR1H4 affects_activity of insulin secretion involved in cellular response to glucose stimulus
34445 NR1H4 affects_activity of hyperlipidemia
34456 NR1H4 affects_quantity of adipose tissue
34485 NR1H4 affects_activity of fat cell differentiation via PPARG and Wnt pathway
34486 NR1H4 increases_activity of PPARG
34487 NR1H4 decreases_activity of canonical Wnt signaling pathway
34488 NR1H4 affects_activity of lipid catabolic process
34489 NR1H4 affects_activity of lipid biosynthetic process
34490 NR1H4 increases_activity of glucose import
34517 NR1H4 increases_activity of LPL
34518 NR1H4 increases_expression of LDLR in vitro
34522 NR1H4 decreases_expression of PCSK9 in vitro
34526 NR1H4 decreases_expression of APOA1
34531 NR1H4 increases_expression of SCARB1 in liver
34535 NR1H4 increases_activity of decreased circulating HDL cholesterol level
34543 NR1H4 decreases_activity of liver fibrosis in liver; caused by inflammatory cell infiltration
34546 NR1H4 decreases_expression of TGFB1
34547 NR1H4 decreases_expression of TIMP1
21431855 Diabetes mellitus, type II
Obesity
Insulin resistance
Fatty liver disease, nonalcoholic
3,646
34559 Bile salt interacts (colocalizes) with NR1H4
34560 NR1H4 is_expressed_in liver
34595 NR1H4 is_expressed_in intestine
34596 NR1H4 is_expressed_in kidney
34599 NR1H4 is_expressed_in adrenal gland
34600 NR1H4 affects_activity of bile acid metabolic process
34609 NR1H4 affects_activity of abnormal intestinal barrier
34612 NR1H4 affects_activity of abnormal innate immunity
34613 NR1H4 affects_activity of tumorigenesis
34615 NR1H4 decreases_activity of increased bile salt level in liver
34617 NR1H4 decreases_activity of bile acid biosynthetic process in liver
34619 NR1H4 increases_activity of bile acid excretion
34621 NR1H4 decreases_expression of SREBF1c via NR0B2 activation
34625 NR1H4 decreases_activity of fatty acid biosynthetic process via SREBF1c repression
34626 NR1H4 decreases_activity of triglyceride biosynthetic process via SREBF1c repression
34628 NR1H4 increases_activity of very-low-density lipoprotein particle clearance via increased VLDLR expression
34630 NR1H4 increases_activity of chylomicron remnant clearance via increased VLDLR expression
34631 NR1H4 increases_expression of VLDLR
34632 NR1H4 affects_activity of very-low-density lipoprotein particle assembly via MTTP and APOB repression
34633 NR1H4 decreases_expression of MTTP
34635 NR1H4 decreases_expression of APOB
34636 NR1H4 increases_activity of SDC1
34637 NR1H4 increases_activity of LPL
34638 NR1H4 increases_activity of APOC2
34639 NR1H4 increases_activity of APOA4
34640 NR1H4 decreases_expression of APOC3
34641 NR1H4 decreases_expression of ANGPTL3
34643 NR1H4 increases_expression of PPARA
34645 NR1H4 decreases_activity of increased circulating triglyceride level
34646 NR1H4 decreases_activity of Fatty liver disease, nonalcoholic
34647 NR1H4 affects_activity of cholesterol metabolic process
34648 NR1H4 affects_activity of increased susceptibility to atherosclerosis
34649 NR1H4 affects_activity of glucose homeostasis
34651 NR1H4 decreases_activity of hyperglycemia
34652 NR1H4 decreases_activity of hyperlipidemia
34653 NR1H4 decreases_activity of I-kappaB kinase/NF-kappaB signaling in liver
34655 NR1H4 decreases_activity of inflammatory response in liver
34657 NR1H4 decreases_activity of liver fibrosis
34662 NR1H4 decreases_expression of TGFB1 in liver
34663 NR1H4 decreases_expression of TIMP1 in liver
34664 NR1H4 decreases_expression of COL1A1 in liver
34665 NR1H4 decreases_expression of ACTA2 in liver
34666 NR1H4 decreases_expression of MMP2 in liver
34668 NR1H4 decreases_expression of COL1A2 in liver
34669 NR1H4 decreases_expression of mir-29a in liver
22187656 Diabetes mellitus, type II
Insulin resistance
Fatty liver disease, nonalcoholic
4,598
45882 NR1H4 decreases_expression of CYP19A1 in breast cancer cells
45883 NR1H4 decreases_expression of UGT2B15 in prostate cancer cells
45884 NR1H4 decreases_expression of UGT2B17 in prostate cancer cells
45885 NR1H4 increases_activity of SULT2A1
19762543 Diabetes mellitus, type II
Insulin resistance
6,387
61646 SIRT1 affects_activity of NR1H4
25955819 Metabolic
6,606
63634 Bile salt increases_activity of NR1H4
63635 NR1H4 increases_activity of FGF19 in intestine
63678 Chenodeoxycholate interacts (colocalizes) with NR1H4
63679 Lithocholic acid interacts (colocalizes) with NR1H4
63680 Deoxycholic acid interacts (colocalizes) with NR1H4
63681 Cholic acid interacts (colocalizes) with NR1H4
63682 NR1H4 affects_activity of bile acid biosynthetic process
63683 NR1H4 affects_activity of enterohepatic circulation
63684 NR1H4 affects_activity of glucose metabolic process
63685 NR1H4 affects_activity of lipoprotein metabolic process
63686 NR1H4 affects_activity of lipid metabolic process
63687 NR1H4 affects_activity of inflammatory response
63688 NR1H4 affects_activity of defense response to tumor cell
26579434 Colorectal cancer
Diabetes mellitus, type II
Insulin resistance
6,607
63738 Bile salt increases_activity of NR1H4
63739 NR1H4 increases_activity of FGF19
63743 NR1H4 affects_expression of ABCB11 in liver
63772 NR1H4 affects_expression of SLC51A in liver
63773 NR1H4 affects_expression of SLC51B in liver
63774 NR1H4 affects_expression of SLC10A1 in liver
63777 NR1H4 affects_expression of NR0B2 in liver
63779 Cholic acid increases_activity of NR1H4 in liver
63780 NR1H4 decreases_activity of SREBF1c in liver
63781 NR1H4 decreases_activity of lipid biosynthetic process in liver; via SREBF1c
63782 NR1H4 decreases_quantity of Triacylglycerol in liver; via SREBF1c
63783 NR1H4 increases_expression of PPARA in liver
63784 NR1H4 increases_activity of lipid catabolic process in liver
63785 NR1H4 increases_activity of fatty acid beta-oxidation in liver
63786 NR1H4 affects_activity of lipoprotein metabolic process in liver
63787 NR1H4 affects_activity of lipid transport in liver
63788 NR1H4 decreases_expression of APOA1 in liver
63789 NR1H4 decreases_expression of APOC2 in liver
63790 NR1H4 increases_expression of APOC3 in liver
63791 NR1H4 increases_expression of VLDLR in liver
63793 NR1H4 decreases_expression of HNF4A in liver; via NR0B2 activation
63794 NR1H4 decreases_expression of G6PC in liver; via NR0B2 activation and HNF4A inhibition
63795 NR1H4 decreases_expression of PCK1 in liver; via NR0B2 activation and HNF4A inhibition
63796 NR1H4 decreases_activity of gluconeogenesis in liver; via NR0B2 activation and HNF4A inhibition
63797 NR1H4 affects_activity of PPARGC1A in liver
63798 NR1H4 increases_expression of PDK in liver
63800 NR1H4 increases_activity of AKT1 in liver
63801 NR1H4 affects_activity of insulin secretion
63802 NR1H4 affects_activity of insulin receptor signaling pathway
63803 NR1H4 affects_expression of SLC10A2 in ileum
63804 NR1H4 affects_expression of SLC51A in ileum
63805 NR1H4 affects_expression of SLC51B in ileum
63806 NR1H4 affects_expression of FABP6 in ileum
63807 NR1H4 affects_expression of FGF19 in ileum
26579438 Diabetes mellitus, type II
Insulin resistance
6,612
62983 AMPK decreases_activity of NR1H4
63034 Metformin decreases_activity of NR1H4 via AMPK activation
63042 NR1H4 interacts (colocalizes) with MED1
63045 NR1H4 interacts (colocalizes) with MED13
63047 NR1H4 interacts (colocalizes) with MED14
63048 NR1H4 interacts (colocalizes) with MED24
63049 NR1H4 interacts (colocalizes) with MED17
63050 NR1H4 interacts (colocalizes) with HELZ2
63051 NR1H4 interacts (colocalizes) with CREBBP
63052 NR1H4 interacts (colocalizes) with NCOA3
63053 NR1H4 interacts (colocalizes) with PPARGC1A
63054 NR1H4 interacts (colocalizes) with EP300
63056 NR1H4 interacts (colocalizes) with ARID1A
63057 NR1H4 interacts (colocalizes) with BAF60
63058 NR1H4 interacts (colocalizes) with MTA1
63059 NR1H4 interacts (colocalizes) with NRIP1
63060 NR1H4 interacts (colocalizes) with PRKAG2
63061 NR1H4 interacts (colocalizes) with PARP1
63062 NR1H4 interacts (colocalizes) with TOP2
Diabetes mellitus, type II
Insulin resistance
6,617
63035 Metformin decreases_activity of NR1H4 via phosphorylation
Diabetes mellitus, type II
Insulin resistance
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