Search Results for "LRRK2" - 249 interactions found in 71 entries.

Entry-ID
Interactor1 (Subject) Interaction type Interactor2 (Object) additional information
PubMed-ID
Diseases
8
16 LRRK2 is localized in cytoplasm
20 LRRK2 interacts (colocalizes) with PARK2
21 LRRK2 NOT interacts (colocalizes) with SNCA
22 LRRK2 NOT interacts (colocalizes) with PARK7
23 LRRK2 NOT interacts (colocalizes) with MAPT
16352719 Parkinson disease
10
28 LRRK2 NOT increases_activity of neuron death
16352719 Parkinson disease
11
33 LRRK2 NOT increases_activity of neuron death
16352719 Parkinson disease
169
657 LRRK2 is localized in cytoplasm
658 LRRK2 is localized in mitochondrial outer membrane
659 LRRK2 increases_phosphorylation of MBP
662 LRRK2 increases_phosphorylation of LRRK2
16269541 Parkinson disease
170
665 LRRK2 interacts (colocalizes) with LRRK2
666 LRRK2-p.I2020T interacts (colocalizes) with LRRK2
667 LRRK2 interacts (colocalizes) with HSP90
668 LRRK2 interacts (colocalizes) with CDC37
669 LRRK2 increases_phosphorylation of LRRK2
1118 LRRK2 is localized in cytoplasm
16321986 Parkinson disease
214
849 LRRK2 NOT increases_quantity of CYCS in cytoplasm
1430 LRRK2 is localized in cytoplasm
13591 LRRK2 NOT increases_activity of release of cytochrome c from mitochondria
17409193 Parkinson disease
245
1026 LRRK2 NOT decreases_activity of neuron projection development
1040 LRRK2 increases_phosphorylation of EZR in filopodia
1042 LRRK2 increases_phosphorylation of RDX in filopodia
1043 LRRK2 increases_phosphorylation of MSN in filopodia
19890007 Parkinson disease
268
1090 LRRK2 interacts (colocalizes) with STUB1
1094 STUB1 increases_ubiquitination/sumoylation of LRRK2
1095 STUB1 decreases_quantity of LRRK2 via ubiquitin-mediated proteasomal degradation
19196961 Parkinson disease
269
1093 LRRK2 interacts (colocalizes) with STUB1
19196961 Parkinson disease
270
1098 STUB1 decreases_quantity of LRRK2
19196961 Parkinson disease
271
1107 STUB1 interacts (colocalizes) with LRRK2
1109 HSP90 interacts (colocalizes) with LRRK2
3746 17AAD decreases_quantity of LRRK2
19196961 Parkinson disease
279
1126 LRRK2 increases_phosphorylation of MAP2K3
1128 LRRK2 increases_phosphorylation of MAP2K6 at its N-terminal lobe
1140 LRRK2 increases_phosphorylation of MAP2K4 at the canonical activation site
1141 LRRK2 increases_phosphorylation of MAP2K7 at the canonical activation site
19302196 Parkinson disease
284
1144 LRRK2 increases_phosphorylation of MBP
1153 LRRK2-p.G2019S increases_phosphorylation of LRRK2 with 3-fold higher rate than wildtype
1154 LRRK2 increases_phosphorylation of LRRK2
1160 LRRK2 increases_phosphorylation of EZR
1161 LRRK2 increases_phosphorylation of RDX
17447891 Parkinson disease
290
1156 LRRK2 increases_phosphorylation of DPYSL2
1157 LRRK2 increases_phosphorylation of CKB
1158 LRRK2 increases_phosphorylation of MSN at Thr558 of moesin
17447891 Parkinson disease
298
1189 LRRK2 interacts (colocalizes) with MBP
1193 LRRK2 increases_phosphorylation of MBP
1201 LRRK2 NOT decreases_activity of neuron projection development
1205 LRRK2 NOT increases_quantity of tau protein deposits
17114044 Parkinson disease
309
1222 GTP increases_activity of LRRK2 via the intrinsic GTPase Roc domain of LRRK2
16980962 Neurological
311
1231 LRRK2 interacts (colocalizes) with HSP90
1233 LRRK2 interacts (colocalizes) with STUB1
19536328 Parkinson disease
313
1235 STUB1 decreases_quantity of LRRK2
1243 STUB1 increases_ubiquitination/sumoylation of LRRK2
1244 STUB1 decreases_quantity of LRRK2 via ubiquitin-mediated proteasomal degradation
1291 HSP90 increases_quantity of LRRK2 by inhibiting proteasomal degradation
19536328 Parkinson disease
336
1323 LRRK2 interacts (colocalizes) with HSPA8 after treatment with geldanamycin
1324 Geldanamycin decreases_quantity of LRRK2
4364 LRRK2 interacts (colocalizes) with HSPA8 after treatment with geldanamycin
18367605 Parkinson disease
338
1325 Geldanamycin decreases_quantity of LRRK2
1327 PU-H71 decreases_quantity of LRRK2
1329 PU-DZ8 decreases_quantity of LRRK2
1336 HSP90 increases_quantity of LRRK2 by inhibiting proteasomal degradation
3022 LRRK2 NOT interacts (colocalizes) with STIP1
3023 LRRK2 interacts (colocalizes) with HSP90
3024 LRRK2 interacts (colocalizes) with CDC37
3025 proteasome-mediated ubiquitin-dependent protein catabolic process decreases_quantity of LRRK2
3026 autophagy NOT decreases_quantity of LRRK2
18367605 Parkinson disease
340
1353 LRRK2 interacts (colocalizes) with FADD
1354 LRRK2 interacts (colocalizes) with TRADD
1355 LRRK2 interacts (colocalizes) with RIPK1
1361 LRRK2 NOT interacts (colocalizes) with CRADD
1362 LRRK2 NOT interacts (colocalizes) with LTBR
1363 LRRK2 NOT interacts (colocalizes) with FAS
1365 LRRK2 NOT interacts (colocalizes) with TNFRSF10A
1366 LRRK2 NOT interacts (colocalizes) with TNFRSF10B
19176810 Parkinson disease
348
1382 LRRK2 interacts (colocalizes) with FADD
19176810 Parkinson disease
358
1444 Goe6976 decreases_activity of LRRK2
1446 K252a decreases_activity of LRRK2
1448 K252b decreases_activity of LRRK2
1449 Staurosporine decreases_activity of LRRK2
1454 LRRK2 increases_phosphorylation of LRRK2
1455 LRRK2 increases_phosphorylation of MBP
19027715 Parkinson disease
363
1462 LRRK2 increases_phosphorylation of LRRK2 at amino acid position T1343
19733152 Parkinson disease
366
1473 LRRK2 increases_phosphorylation of SNCA at amino acid position 129
19576176 Parkinson disease
382
1566 LRRK2 interacts (colocalizes) with TUBB
1570 LRRK2 increases_phosphorylation of TUBB at position Thr-107
19545277 Parkinson disease
383
1574 LRRK2 interacts (colocalizes) with TUBB
1577 LRRK2 interacts (colocalizes) with microtubule cytoskeleton
1958 LRRK2 increases_activity of neuron projection development if LRRK2 is bound to beta-tubulin
19545277 Parkinson disease
384
1576 LRRK2 increases_phosphorylation of MAPT although MAPT is not directly phosphorylated by LRRK2
19545277 Parkinson disease
389
1590 LRRK2 interacts (colocalizes) with TUBA
1591 LRRK2 interacts (colocalizes) with TUBB
1593 LRRK2 interacts (colocalizes) with RPS8
1594 LRRK2 interacts (colocalizes) with RPL23
18214993 Parkinson disease
390
1601 LRRK2 interacts (colocalizes) with TUBB
1602 LRRK2 interacts (colocalizes) with TUBA
1604 LRRK2 interacts (colocalizes) with microtubule
18214993 Parkinson disease
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