Search Results for "IRS1" - 211 interactions found in 95 entries.

Entry-ID
Interactor1 (Subject) Interaction type Interactor2 (Object) additional information
PubMed-ID
Diseases
122
445 GSK3B increases_phosphorylation of IRS1
11527574 Alzheimer disease
368
1508 HSPA5 affects_activity of IRS1
1509 HSPA5 affects_expression of IRS1
19363290 Diabetes mellitus, type II
Obesity
Insulin resistance
Fatty liver disease, nonalcoholic
468
2245 Metformin NOT affects_phosphorylation of IRS1 in liver
2246 Metformin NOT affects_expression of IRS1 in liver
15561958 Diabetes mellitus, type II
Insulin resistance
598
3240 high-phytoestrogen soy-based diet decreases_phosphorylation of IRS1
3241 high-phytoestrogen soy-based diet affects_phosphorylation of IRS1 at Ser636/Ser639 of IRS1
18420492 Diabetes mellitus, type II
Obesity
Insulin resistance
654
3516 DGAT1 affects_activity of IRS1
15569818 Diabetes mellitus, type II
Obesity
Insulin resistance
Fatty liver disease, nonalcoholic
703
3898 Diabetes mellitus, type II decreases_phosphorylation of IRS1 in skeletal muscle, in adipose tissue; at Tyr residue
11597827 Diabetes mellitus, type II
Insulin resistance
964
5936 Insulin receptor increases_phosphorylation of IRS1
6038 IRS1 increases_quantity of GRB2-SOS complex
6058 Diabetes mellitus, type II decreases_phosphorylation of IRS1 in skeletal muscle
6081 Obesity decreases_phosphorylation of IRS1 in skeletal muscle
6107 Diabetes mellitus, type II decreases_phosphorylation of IRS1 in adipose tissue; at Tyr residues of IRS1
6113 MAPK8 increases_phosphorylation of IRS1 at Ser312 of IRS1
6116 IKBKB increases_phosphorylation of IRS1 at Ser312 of IRS1
6117 MTOR increases_phosphorylation of IRS1 at Ser312 of IRS1
6149 MTOR increases_phosphorylation of IRS1 at Ser636 of IRS1
6157 MAPK increases_phosphorylation of IRS1 at Ser636 of IRS1
6179 PRKCA increases_phosphorylation of IRS1 at Ser24 of IRS1
6185 PRKCA decreases_activity of IRS1 via phosphorylation at Ser24 of IRS1
6186 IRAK increases_phosphorylation of IRS1 at Ser24 of IRS1
6187 IRAK decreases_activity of IRS1 via phosphorylation at Ser24 of IRS1
6188 Protein kinase C increases_phosphorylation of IRS1 at Ser318 of IRS1
6189 Protein kinase C decreases_activity of IRS1 via phosphorylation at Ser318 of IRS1
6190 GSK3 increases_phosphorylation of IRS1 at Ser332 of IRS1
6191 GSK3 decreases_activity of IRS1 via phosphorylation at Ser332 of IRS1
6192 AKT1 increases_phosphorylation of IRS1 at Ser522 of IRS1
6193 AKT1 decreases_activity of IRS1 via phosphorylation at Ser522 of IRS1
6194 PRKCZ increases_phosphorylation of IRS1 at Ser570 of IRS1
6196 PRKCZ decreases_activity of IRS1 via phosphorylation at Ser570 of IRS1
6197 AKT1 increases_phosphorylation of IRS1 at Ser629 of IRS1
6198 AKT1 increases_activity of IRS1 via phosphorylation at Ser629 of IRS1
6199 Protein kinase C increases_phosphorylation of IRS1 at Ser1101 of IRS1
6200 Protein kinase C decreases_activity of IRS1 via phosphorylation at Ser1101 of IRS1
6202 Kinase increases_activity of IRS1 via phosphorylation at Ser302 of IRS1
6203 Kinase increases_activity of IRS1 via phosphorylation at Ser1223 of IRS1
6214 phosphorylation affects_activity of IRS1
6218 Diabetes mellitus, type II decreases_activity of IRS1 in muscle; in obese type 2 diabetic patients
6221 Diabetes mellitus, type II decreases_activity of IRS1 in myotubes; in obese type 2 diabetic patients
19041393 Diabetes mellitus, type II
Obesity
Insulin resistance
1,056
6598 PTPN1 decreases_phosphorylation of IRS1
6851 PTPN11 decreases_phosphorylation of IRS1
6852 PTPRF decreases_phosphorylation of IRS1
6853 PTPRA decreases_phosphorylation of IRS1
6860 PTPN1-IRS1 complex decreases_phosphorylation of IRS1
10660596 Diabetes mellitus, type II
Insulin resistance
1,092
6980 Insulin receptor increases_phosphorylation of IRS1 at Tyr residues of IRS1
6982 IKBKB increases_phosphorylation of IRS1 at Ser307 of IRS1
6983 MAPK8 increases_phosphorylation of IRS1 at Ser307 of IRS1
7001 SOCS1 increases_ubiquitination/sumoylation of IRS1
7003 SOCS3 increases_ubiquitination/sumoylation of IRS1
7004 SOCS1 decreases_quantity of IRS1 via increased degradation of IRS1
7005 SOCS3 decreases_quantity of IRS1 via increased degradation of IRS1
7087 IKBKB increases_phosphorylation of IRS1 at Ser residues of IRS1
7088 IKBKB decreases_activity of IRS1 via phosphorylation at Ser residues of IRS1
7090 TNF decreases_expression of IRS1 in adipose tissue
7189 MAPK8 affects_phosphorylation of IRS1 in liver; at Ser307 of IRS1
7244 NOS2 decreases_quantity of IRS1 via increased degradation of IRS1 if NPS2 activity is increased
18053812 Diabetes mellitus, type II
Obesity
Insulin resistance
1,135
7377 SOCS1 interacts (colocalizes) with IRS1
7379 SOCS3 interacts (colocalizes) with IRS1
7382 SOCS1 decreases_quantity of IRS1 via increased degradation of IRS1
7384 SOCS3 decreases_quantity of IRS1 via increased degradation of IRS1
12228220 Diabetes mellitus, type II
Insulin resistance
1,138
7391 SOCS1 increases_ubiquitination/sumoylation of IRS1 in liver
12228220 Diabetes mellitus, type II
Insulin resistance
1,139
7455 CAP1 NOT affects_phosphorylation of IRS1
11001060 Diabetes mellitus, type II
Insulin resistance
1,148
7494 SMPD decreases_activity of IRS1 via inhibition of Tyr phosphorylation
7496 Ceramide decreases_activity of IRS1 via inhibition of Tyr phosphorylation
13240 TNF decreases_phosphorylation of IRS1 if stimulated by insulin
13241 TNF NOT affects_quantity of IRS1
8662983 Diabetes mellitus, type II
Insulin resistance
1,153
7536 TNF decreases_expression of IRS1
7573 TNF NOT affects_phosphorylation of IRS1
8995390 Diabetes mellitus, type II
Insulin resistance
1,162
7686 IKBKB decreases_phosphorylation of IRS1 in muscle; in LIKK mice
15685173 Diabetes mellitus, type II
Insulin resistance
1,176
7772 S-nitrosoglutathione decreases_quantity of IRS1 in C2C12 myotubes
7778 S-nitrosoglutathione decreases_phosphorylation of IRS1 in C2C12 myotubes
7783 Insulin decreases_quantity of IRS1 in C2C12 myotubes
7787 S-nitrosoglutathione NOT affects_expression of IRS1 in C2C12 myotubes
7793 ob/ob mouse decreases_quantity of IRS1 in skeletal muscle
7796 iNOS-/- ob/ob mouse NOT affects_quantity of IRS1 in skeletal muscle
7798 NOS2 NOT affects_expression of IRS1 in skeletal muscle
13351 NOS2 affects_quantity of IRS1 in skeletal muscle
15805118 Diabetes mellitus, type II
Insulin resistance
1,188
7921 obesity, high-fat diet-induced decreases_phosphorylation of IRS1 in skeletal muscle; in wild-type mice
7924 obesity, high-fat diet-induced NOT decreases_phosphorylation of IRS1 in skeletal muscle; in NOS2-/- mice
11590438 Diabetes mellitus, type II
Insulin resistance
1,217
8178 Estradiol increases_quantity of IRS1
19164473 Diabetes mellitus, type II
Insulin resistance
1,292
8786 PPARG affects_phosphorylation of IRS1 in liver, in skeletal muscle; after myeloid-specific PPARG deletion, at Tyr residues of IRS1
17525798 Diabetes mellitus, type II
Insulin resistance
1,293
8860 Insulin increases_phosphorylation of IRS1 in skeletal muscle
8862 Lipid increases_phosphorylation of IRS1 in skeletal muscle; at Ser307 of IRS1
13521 TLR4 affects_phosphorylation of IRS1 in skeletal muscle; at Ser307 of IRS1, if induced by lipid
17053832 Diabetes mellitus, type II
Insulin resistance
1,306
8923 MAPK8 increases_phosphorylation of IRS1 in liver; at Ser residues of IRS1
8924 MAPK8 decreases_activity of IRS1 in liver
15486293 Diabetes mellitus, type II
Insulin resistance
1,311
8966 Sodium phenylbutyrate decreases_phosphorylation of IRS1 in liver, in adipose tissue; at Ser307 of IRS1
8970 Sodium phenylbutyrate increases_activity of IRS1 in liver; via Tyr phosphorylation of IRS1
8985 Tauroursodeoxycholic acid decreases_phosphorylation of IRS1 in liver, in adipose tissue; at Ser307 of IRS1
16931765 Diabetes mellitus, type II
Insulin resistance
1,347
9206 SFRP5 affects_phosphorylation of IRS1 in adipose tissue; after high-fat high-sucrose diet, at Ser307 of IRS1
20558665 Diabetes mellitus, type II
Obesity
Insulin resistance
Fatty liver disease, nonalcoholic
1,445
10167 IL1B decreases_phosphorylation of IRS1 at Tyr residues of IRS1
10169 IL1B decreases_expression of IRS1
17038556 Diabetes mellitus, type II
Insulin resistance
1,448
10173 IL6 increases_phosphorylation of IRS1 in muscle; at Ser318 of IRS1
10175 IL6 NOT increases_phosphorylation of IRS1 in liver; at Ser318 of IRS1
10176 IRS1 interacts (colocalizes) with IL6 receptor in skeletal muscle; induced by IL6
10177 IL6 NOT affects_phosphorylation of IRS1 at Tyr residues
10179 IL6 increases_phosphorylation of IRS1 in liver; at Ser307 of IRS1
10180 IL6 NOT increases_phosphorylation of IRS1 in muscle; at Ser307 of IRS1
16418171 Diabetes mellitus, type II
Insulin resistance
1,486
10502 1 year postpartum after gestational diabetes mellitus NOT affects_expression of IRS1 in skeletal muscle
10513 1 year postpartum after gestational diabetes mellitus increases_phosphorylation of IRS1 in skeletal muscle; at Ser312 of IRS1
18083784 Diabetes mellitus, type II
Insulin resistance
Gestational diabetes mellitus
1,508
10671 Palmitic acid decreases_activity of IRS1 in pancreas, in pancreatic beta cells
10673 MAPK8 increases_phosphorylation of IRS1 in pancreas, in pancreatic beta cells
10675 MAPK8 decreases_activity of IRS1 in pancreas, in pancreatic beta cells
17050683 Diabetes mellitus, type II
Obesity
Insulin resistance
1,519
10779 Polyunsaturated fatty acid, omega-3 increases_expression of IRS1 in adipose tissue
19211925 Diabetes mellitus, type II
Obesity
Insulin resistance
Fatty liver disease, nonalcoholic
1,523
10830 Arachidonic acid increases_phosphorylation of IRS1 in liver; at Ser307 of IRS1
16210322 Diabetes mellitus, type II
Insulin resistance
1,530
10952 12(S)-HETE decreases_activity of IRS1 in adipose tissue; via increased phosphorylation at Ser residues and decreased phosphorylation at Tyr residues of IRS1
19521344 Diabetes mellitus, type II
Insulin resistance
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