|
98
|
| 326 |
SOD1-p.G93A
|
|
increases_quantity of
|
IGF1
|
in microglia cultures
|
|
19672969
|
Amyotrophic lateral sclerosis
|
|
116
|
| 391 |
IGF1
|
|
increases_activity of
|
AKT1
|
|
| 394 |
IGF1
|
|
affects_phosphorylation of
|
AKT1
|
at Thr308 and Ser473
|
|
8978681
|
Alzheimer disease
|
|
122
|
| 678 |
IGF1
|
|
decreases_activity of
|
GSK3B
|
by increased Ser9 phosphorylation
|
| 12930 |
IGF1
|
|
increases_phosphorylation of
|
GSK3B
|
at Ser9
|
| 50125 |
IGF1
|
|
increases_phosphorylation of
|
GSK3B
|
at Ser9
|
|
11527574
|
Alzheimer disease
|
|
457
|
| 2062 |
IGF1
|
|
affects_activity of
|
oligodendrocyte development
|
|
|
19712582
|
Alzheimer disease
|
|
1,290
|
| 8819 |
SOD1-p.G93A
|
|
increases_expression of
|
IGF1
|
in spinal cord microglia
|
| 8823 |
IL4
|
|
increases_quantity of
|
IGF1
|
in spinal cord microglia
|
|
18997009
|
Amyotrophic lateral sclerosis
|
|
1,343
|
| 9165 |
SOD1-p.G93A
|
|
decreases_quantity of
|
IGF1
|
in microglia; with or without LPS stimulation
|
|
17555556
|
Amyotrophic lateral sclerosis
|
|
1,344
|
| 9167 |
SOD1-p.G93A
|
|
decreases_quantity of
|
IGF1
|
in microglia/motoneuron co-cultures
|
|
17555556
|
Amyotrophic lateral sclerosis
|
|
1,513
|
| 10710 |
Resveratrol
|
|
decreases_quantity of
|
IGF1
|
in mice on high-calorie diet
|
|
17086191
|
Diabetes mellitus, type II
Insulin resistance
|
|
1,654
|
| 12186 |
Tg2576 mouse
|
|
increases_expression of
|
IGF1
|
in hippocampus
|
|
12196559
|
Alzheimer disease
|
|
1,665
|
| 12279 |
MAPK8
|
|
affects_quantity of
|
IGF1
|
|
|
20231445
|
Diabetes mellitus, type II
Obesity
Insulin resistance
Fatty liver disease, nonalcoholic
|
|
2,809
|
| 25905 |
IGF1
|
|
affects_activity of
|
Diabetes mellitus, type II
|
|
|
21059863
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,810
|
| 25917 |
IGF1
|
|
increases_activity of
|
Insulin-like growth factor 1 receptor
|
in pancreas, in pancreatic beta cells
|
|
20947509
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,814
|
| 25952 |
increased circulating insulin level
|
|
increases_quantity of
|
IGF1
|
in liver
|
| 26006 |
IGF1
|
|
increases_activity of
|
Insulin-like growth factor 1 receptor
|
|
| 26057 |
increased circulating insulin level
|
|
increases_quantity of
|
IGF1
|
|
| 26058 |
Obesity
|
|
increases_quantity of
|
IGF1
|
|
| 26110 |
IGF1
|
|
increases_activity of
|
Insulin-like growth factor 1 receptor
|
|
| 26111 |
IGF1
|
|
increases_activity of
|
INSR-A - IGF1R hybrid complex
|
|
| 26112 |
IGF1
|
|
increases_activity of
|
INSR-B - IGF1R hybrid complex
|
|
|
21912508
|
Diabetes mellitus, type II
Cancer
Insulin resistance
Metabolic syndrome
|
|
2,889
|
| 26556 |
IGF1
|
|
increases_activity of
|
positive regulation of mitotic nuclear division
|
|
|
18172327
|
Colorectal cancer
Diabetes mellitus, type II
Insulin resistance
|
|
2,935
|
| 26814 |
IGF1
|
|
increases_expression of
|
HIF1A
|
|
| 26817 |
IGF1
|
|
affects_activity of
|
phosphatidylinositol 3-kinase signaling
|
|
|
22249478
|
Diabetes mellitus, type II
Insulin resistance
|
|
3,073
|
| 28248 |
N-Nitrosodiethylamine
|
|
decreases_expression of
|
IGF1
|
in temporal lobe
|
|
20387270
|
Diabetes mellitus, type II
Insulin resistance
Fatty liver disease, nonalcoholic
|
|
3,131
|
| 28873 |
LEP
|
NOT |
affects_quantity of
|
IGF1
|
|
| 28903 |
fasting
|
|
decreases_quantity of
|
IGF1
|
|
|
16714386
|
Diabetes mellitus, type II
Insulin resistance
|
|
3,388
|
| 31862 |
carnitine supplementation
|
|
increases_expression of
|
IGF1
|
in liver
|
| 31865 |
Carnitine
|
|
increases_quantity of
|
IGF1
|
in blood plasma
|
|
22134503
|
Diabetes mellitus, type II
Carnitine deficiency, systemic primary
Insulin resistance
Status epilepticus
Cardiovascular disease
|
|
3,512
|
| 32658 |
Obesity
|
|
decreases_quantity of
|
IGF1
|
in blood serum
|
|
19356713
|
Diabetes mellitus, type II
Obesity
Insulin resistance
|
|
3,651
|
| 34718 |
IGF1
|
|
affects_quantity of
|
Glycine
|
|
| 34719 |
IGF1
|
|
affects_quantity of
|
LysoPC(18:2)
|
|
|
23010998
|
Diabetes mellitus, type II
Insulin resistance
|
|
3,686
|
| 35455 |
prenatal caffeine ingestion
|
|
decreases_expression of
|
IGF1
|
in fetal liver
|
|
22583948
|
Diabetes mellitus, type II
Insulin resistance
|
|
3,794
|
| 37579 |
obese Zucker rat
|
|
decreases_expression of
|
IGF1
|
in skeletal muscle
|
|
20959535
|
Diabetes mellitus, type II
Insulin resistance
|
|
3,977
|
| 40440 |
prenatal growth retardation
|
|
decreases_quantity of
|
IGF1
|
in fetus
|
|
11788666
|
Diabetes mellitus, type II
Insulin resistance
|
|
4,595
|
| 45716 |
aging
|
|
decreases_quantity of
|
IGF1
|
|
|
9215295
|
Diabetes mellitus, type II
Insulin resistance
|
|
5,275
|
| 51579 |
NT-PPARGC1A-a
|
|
increases_expression of
|
IGF1
|
|
|
25136584
|
Diabetes mellitus, type II
Insulin resistance
|
|
5,300
|
| 51939 |
NT-PPARGC1A-b
|
|
increases_expression of
|
IGF1
|
in skeletal muscle
|
| 51940 |
PPARGC1A-a
|
NOT |
affects_expression of
|
IGF1
|
in skeletal muscle
|
| 51953 |
resistance exercise
|
NOT |
affects_expression of
|
IGF1
|
in skeletal muscle
|
| 51954 |
endurance exercise
|
NOT |
affects_expression of
|
IGF1
|
in skeletal muscle
|
|
23217713
|
Diabetes mellitus, type II
Insulin resistance
|
|
5,350
|
| 52315 |
IGF1
|
|
interacts (colocalizes) with
|
IGF1R
|
|
| 52316 |
IGF1
|
|
interacts (colocalizes) with
|
Insulin
|
|
|
17315038
|
Metabolic
|
|
5,441
|
| 53113 |
LRP5
|
|
affects_expression of
|
IGF1
|
in pancreas, in pancreatic islets
|
|
12509515
|
Diabetes mellitus, type II
Insulin resistance
|
|
5,448
|
| 53175 |
IGF1
|
NOT |
increases_activity of
|
DNA biosynthetic process
|
in pancreas, in pancreatic islets
|
| 53186 |
IGF1
|
|
increases_expression of
|
INS
|
in pancreas, in pancreatic islets; via GSK3B
|
| 53187 |
IGF1
|
|
increases_expression of
|
PDX1
|
in pancreas, in pancreatic islets; via GSK3B
|
| 53188 |
IGF1
|
|
increases_expression of
|
NKX6-1
|
in pancreas, in pancreatic islets; via GSK3B
|
| 53189 |
IGF1
|
|
increases_expression of
|
NKX2-2
|
in pancreas, in pancreatic islets; via GSK3B
|
|
23650507
|
Diabetes mellitus, type II
Insulin resistance
|
|
5,740
|
| 54360 |
PDX1 rs193922360
|
|
decreases_quantity of
|
IGF1
|
in homozygous mutation carriers
|
|
20009086
|
Diabetes mellitus, type II
Diabetes mellitus, permanent neonatal
Insulin resistance
|
CIDeR