|
1,057
|
| 6696 |
PS cDKO mouse
|
|
decreases_expression of
|
FOXO3
|
fold change -2.3
|
|
15345711
|
Alzheimer disease
|
|
3,185
|
| 29259 |
Alzheimer disease
|
|
increases_expression of
|
FOXO3
|
in hippocampus
|
|
19273754
|
Alzheimer disease
|
|
4,459
|
| 44975 |
Tryptamine
|
|
increases_expression of
|
FOXO3
|
|
| 44976 |
FICZ
|
|
increases_expression of
|
FOXO3
|
|
|
22865928
|
Metabolic
|
|
5,327
|
| 52078 |
FOXO3
|
|
increases_expression of
|
CLOCK
|
in liver
|
| 52080 |
Insulin
|
|
affects_activity of
|
FOXO3
|
|
|
24856209
|
Metabolic
Sleep disorders
|
|
5,328
|
| 52089 |
AKT1
|
|
increases_phosphorylation of
|
FOXO3
|
in liver
|
| 52090 |
YWHAZ
|
|
increases_expression of
|
FOXO3
|
in liver
|
|
21621563
|
Metabolic
|
|
5,353
|
| 52322 |
FOXO3
|
|
affects_activity of
|
gluconeogenesis
|
in liver
|
|
24692138
|
Metabolic
|
|
5,354
|
| 52324 |
FOXO3
|
|
interacts (colocalizes) with
|
PPARGC1A
|
|
|
19324885
|
Metabolic
|
|
5,424
|
| 52951 |
Streptozocin-induced diabetes
|
|
decreases_phosphorylation of
|
FOXO3
|
|
| 52958 |
ALDH2
|
|
affects_phosphorylation of
|
FOXO3
|
in streptozocin-induced diabetes
|
|
22524197
|
Diabetes mellitus, type II
Diabetes mellitus, type I
Insulin resistance
Cardiomyopathy, diabetic
|
|
6,114
|
| 57182 |
FOXO3
|
|
increases_activity of
|
autophagy
|
|
| 57183 |
Pulmonary fibrosis, idiopathic
|
|
decreases_expression of
|
FOXO3
|
in fibroblasts
|
| 57184 |
Pulmonary fibrosis, idiopathic
|
|
decreases_quantity of
|
FOXO3
|
in fibroblasts
|
| 57185 |
FOXO3
|
|
increases_expression of
|
MAP1LC3B
|
|
|
26186945
|
Pulmonary fibrosis, idiopathic
Lung disease
|
|
6,540
|
| 63227 |
Amyloid beta peptide
|
|
decreases_expression of
|
FOXO3
|
|
| 63229 |
Amyloid beta peptide
|
|
decreases_quantity of
|
FOXO3
|
|
|
26515689
|
Alzheimer disease
Dementia, Lewy body
Metabolic
|
|
6,900
|
| 68015 |
AMPK
|
|
decreases_acetylation of
|
FOXO3
|
|
|
27127460
|
Diabetes mellitus, type II
Insulin resistance
|
|
7,359
|
| 72297 |
H2O2
|
|
decreases_phosphorylation of
|
FOXO3
|
|
| 72298 |
H2O2
|
|
increases_transport of
|
FOXO3
|
in nucleus
|
| 72302 |
phosphatidylinositol 3-kinase signaling
|
|
affects_activity of
|
FOXO3
|
in H9c2 cells; via AKT
|
| 72305 |
FOXO3
|
|
increases_expression of
|
BNIP3L
|
|
|
28006775
|
Cardiovascular disease
|
|
7,360
|
| 72325 |
Diabetes mellitus, type II
|
NOT |
affects_expression of
|
FOXO3
|
in skeletal muscle; in basal state
|
| 72333 |
Insulin
|
|
decreases_expression of
|
FOXO3
|
in skeletal muscle
|
|
26048236
|
Diabetes mellitus, type II
Insulin resistance
|
|
8,836
|
| 92400 |
FOXO3
|
|
is_expressed_in
|
ovary
|
in rodents
|
| 92412 |
FOXO3
|
|
is_expressed_in
|
theca cell
|
|
| 92426 |
FOXO3
|
NOT |
affects_activity of
|
CDKN1B
|
|
| 92431 |
Follicle-stimulating hormone
|
NOT |
affects_expression of
|
FOXO3
|
in granulosa cells
|
| 92437 |
SGK1
|
|
increases_phosphorylation of
|
FOXO3
|
|
| 92440 |
FOXO3
|
|
is_expressed_in
|
corpus luteum
|
|
| 92466 |
FOXO3
|
NOT |
affects_expression of
|
FASLG
|
|
| 92474 |
FOXO3
|
|
is localized in
|
luteal cell
|
in some follicles with distinct expression; concerning FOXO3 mRNA
|
| 92476 |
FOXO3
|
|
is localized in
|
granulosa cell
|
in some follicles with distinct expression; concerning FOXO3 mRNA
|
|
11875118
|
Metabolic
|
|
8,837
|
| 92501 |
AKT1
|
|
increases_phosphorylation of
|
FOXO3
|
in all mouse models (high-fat-fed mice; ob/ob mice; mice with genetically impaired muscle glucose transport); with Akt hyperactivation
|
| 92564 |
FOXO3
|
|
is localized in
|
brain
|
and insulin via Akt phosphorylates and inhibits all brain FOXOs
|
| 92568 |
Insulin
|
|
increases_phosphorylation of
|
FOXO3
|
in brain; and inhibits all brain FOXOs
|
| 92572 |
Insulin
|
|
decreases_activity of
|
FOXO3
|
in brain; via phosphorylation
|
| 92577 |
high-fat–fed mouse
|
|
decreases_expression of
|
FOXO3
|
in all brain cortical regions in HFF mice
|
|
26895791
|
Alzheimer disease
Diabetes mellitus, type II
Metabolic
|
|
8,846
|
| 92399 |
APP (intracellular domain AICD)
|
|
interacts (colocalizes) with
|
FOXO3
|
in the cytoplasm in HEK 293T cells
|
| 92702 |
FOXO3
|
|
is_part_of
|
APP(AICD)-FOXO3 complex
|
in the cytoplasm in HEK 293T cells
|
| 92714 |
FOXO3
|
|
is localized in
|
nucleus
|
in human neuroblastoma SY-SH5Y cells.; without oxidative stress, together with AICD
|
| 92716 |
response to oxidative stress
|
|
increases_transport of
|
FOXO3
|
into nucleus in HEK 293T cells; together with AICD
|
| 92717 |
FOXO3
|
|
is localized in
|
cytoplasm
|
predominant localization
|
|
24832605
|
Alzheimer disease
|
|
8,848
|
| 92489 |
AKT1
|
|
increases_phosphorylation of
|
FOXO3
|
in brain of diet-dependent long-standing obesity/T2DM monkeys
|
|
26895791
|
Alzheimer disease
Metabolic
|
|
8,853
|
| 92764 |
FOXO3
|
|
is_expressed_in
|
neuron
|
|
| 92765 |
FOXO3
|
|
is_expressed_in
|
astrocyte
|
|
| 92766 |
FOXO3
|
|
is_expressed_in
|
oligodendrocyte
|
|
| 92768 |
FOXO3
|
|
is_expressed_in
|
forebrain
|
in subventricular zone of forebrain
|
| 92769 |
FOXO3
|
|
is_expressed_in
|
subventricular zone
|
in subventricular zone of forebrain
|
| 92771 |
FOXO3
|
|
is_expressed_in
|
hippocampus
|
in the subgranular zone in the hippocampus
|
| 92773 |
FOXO3
|
|
is_expressed_in
|
ventricular zone
|
in the embryonic brain
|
| 92775 |
FOXO3
|
|
is_expressed_in
|
brain
|
in NSC-rich regions of the developing and adult brain, and in cultured NSC-containing neurospheres from embryonic and adult brain
|
| 92852 |
FOXO3
|
|
decreases_activity of
|
canonical Wnt signaling pathway
|
in neural stem cells (NSC); enforced expression of constitutively active FoxO3
|
| 92857 |
FOXO3
|
|
increases_expression of
|
SFRP1
|
in FoxO null NSC; enforced expression of constitutively active FoxO3
|
| 92858 |
FOXO3
|
|
increases_expression of
|
SFRP2
|
in FoxO null NSC; enforced expression of constitutively active FoxO3
|
| 92860 |
FOXO3
|
|
increases_expression of
|
SOST
|
in FoxO null NSC; enforced expression of constitutively active FoxO3
|
| 93185 |
FOXO3
|
|
decreases_expression of
|
ASPM
|
in the regulation of NSC proliferation, via occupying the ASPM promoter
|
| 93186 |
FOXO3
|
|
interacts (colocalizes) with
|
ASPM (promoter)
|
in neural stem cells (NSC)
|
|
19896444
|
Metabolic
|
|
8,896
|
| 93138 |
FOXO3
|
|
interacts (colocalizes) with
|
BBC3
|
when PI3K/Akt signaling is inhibited
|
| 93139 |
FOXO3
|
|
interacts (colocalizes) with
|
BBC3
|
upon exposure of neurons to oligomeric Abeta42; concerning the Puma gene, hereby inducing its expression; when PI3K/Akt signaling is inhibited
|
| 93140 |
FOXO3
|
|
increases_expression of
|
BBC3
|
upon exposure of neurons to oligomeric Abeta42; via binding the Puma gene, hereby inducing its expression; when PI3K/Akt signaling is inhibited
|
|
24567336
|
Alzheimer disease
|
|
8,901
|
| 92987 |
FOXO3
|
|
increases_activity of
|
response to oxidative stress
|
by regulating the expression of genes involved in DNA repair and glutamine metabolism
|
| 93145 |
FOXO3
|
|
increases_expression of
|
GLUL
|
as response to oxidative stress
|
|
26455863
|
Alzheimer disease
|
|
8,992
|
| 94422 |
response to ischemia
|
|
increases_activity of
|
FOXO3
|
|
| 94424 |
Estradiol
|
|
decreases_phosphorylation of
|
FOXO3
|
as response to ischemia
|
| 94425 |
Estradiol
|
|
decreases_activity of
|
FOXO3
|
as response to ischemia
|
|
20114038
|
Metabolic
|
|
9,452
|
| 100628 |
SIRT1
|
|
decreases_acetylation of
|
FOXO3
|
|
|
22086720
|
Metabolic
|
|
9,576
|
| 101392 |
FOXO3
|
|
affects_activity of
|
mTORC1 complex
|
|
|
25625517
|
Metabolic
|
|
9,577
|
| 101393 |
Estradiol
|
|
decreases_activity of
|
FOXO3
|
in breast cancer cells
|
|
26470790
|
Metabolic
|
|
9,590
|
| 101564 |
Cardiomyopathy, hypertrophic
|
|
increases_phosphorylation of
|
FOXO3
|
in heart
|
| 101566 |
Cardiomyopathy, hypertrophic
|
|
decreases_activity of
|
FOXO3
|
in heart
|
| 101596 |
AKT1
|
|
decreases_activity of
|
FOXO3
|
in heart
|
|
25168380
|
Cardiomyopathy, hypertrophic
|
|
9,619
|
| 101588 |
FOXO3
|
|
increases_expression of
|
STK4
|
in cardiomyocytes
|
|
25168380
|
Cardiovascular
|
|
9,621
|
| 101628 |
FOXO3
|
|
increases_activity of
|
extended life span
|
|
| 101651 |
FOXO3
|
|
decreases_activity of
|
aging
|
|
|
18765803
|
Metabolic
|
|
9,622
|
| 101633 |
FOXO3
|
|
decreases_expression of
|
CSRP1
|
in vascular cells (hVECs, hVSMCs, and hMSCs); by recruiting SIRT1 to the promoter
|
| 101637 |
FOXO3
|
|
increases_activity of
|
SIRT1
|
in vascular cells (hVECs, hVSMCs, and hMSCs); by recruiting SIRT1 to the promoter of target genes
|
|
30661960
|
Cardiovascular
|
|
9,624
|
| 101654 |
PARP1
|
|
increases_activity of
|
FOXO3
|
|
| 101656 |
FOXO3
|
|
increases_activity of
|
autophagy
|
|
|
30323296
|
Cardiovascular disease
|
|
9,625
|
| 101657 |
Myocardial infarction
|
|
increases_expression of
|
FOXO3
|
|
|
29049183
|
Myocardial infarction
|
CIDeR