Search Results for "FOXO3" - 91 interactions found in 39 entries.

Entry-ID
Interactor1 (Subject) Interaction type Interactor2 (Object) additional information
PubMed-ID
Diseases
1,057
6696 PS cDKO mouse decreases_expression of FOXO3 fold change -2.3
15345711 Alzheimer disease
3,185
29259 Alzheimer disease increases_expression of FOXO3 in hippocampus
19273754 Alzheimer disease
4,459
44975 Tryptamine increases_expression of FOXO3
44976 FICZ increases_expression of FOXO3
22865928 Metabolic
5,327
52078 FOXO3 increases_expression of CLOCK in liver
52080 Insulin affects_activity of FOXO3
24856209 Metabolic
Sleep disorders
5,328
52089 AKT1 increases_phosphorylation of FOXO3 in liver
52090 YWHAZ increases_expression of FOXO3 in liver
21621563 Metabolic
5,353
52322 FOXO3 affects_activity of gluconeogenesis in liver
24692138 Metabolic
5,354
52324 FOXO3 interacts (colocalizes) with PPARGC1A
19324885 Metabolic
5,424
52951 Streptozocin-induced diabetes decreases_phosphorylation of FOXO3
52958 ALDH2 affects_phosphorylation of FOXO3 in streptozocin-induced diabetes
22524197 Diabetes mellitus, type II
Diabetes mellitus, type I
Insulin resistance
Cardiomyopathy, diabetic
6,114
57182 FOXO3 increases_activity of autophagy
57183 Pulmonary fibrosis, idiopathic decreases_expression of FOXO3 in fibroblasts
57184 Pulmonary fibrosis, idiopathic decreases_quantity of FOXO3 in fibroblasts
57185 FOXO3 increases_expression of MAP1LC3B
26186945 Pulmonary fibrosis, idiopathic
Lung disease
6,540
63227 Amyloid beta peptide decreases_expression of FOXO3
63229 Amyloid beta peptide decreases_quantity of FOXO3
26515689 Alzheimer disease
Dementia, Lewy body
Metabolic
6,900
68015 AMPK decreases_acetylation of FOXO3
27127460 Diabetes mellitus, type II
Insulin resistance
7,359
72297 H2O2 decreases_phosphorylation of FOXO3
72298 H2O2 increases_transport of FOXO3 in nucleus
72302 phosphatidylinositol 3-kinase signaling affects_activity of FOXO3 in H9c2 cells; via AKT
72305 FOXO3 increases_expression of BNIP3L
28006775 Cardiovascular disease
7,360
72325 Diabetes mellitus, type II NOT affects_expression of FOXO3 in skeletal muscle; in basal state
72333 Insulin decreases_expression of FOXO3 in skeletal muscle
26048236 Diabetes mellitus, type II
Insulin resistance
8,836
92400 FOXO3 is_expressed_in ovary in rodents
92412 FOXO3 is_expressed_in theca cell
92426 FOXO3 NOT affects_activity of CDKN1B
92431 Follicle-stimulating hormone NOT affects_expression of FOXO3 in granulosa cells
92437 SGK1 increases_phosphorylation of FOXO3
92440 FOXO3 is_expressed_in corpus luteum
92466 FOXO3 NOT affects_expression of FASLG
92474 FOXO3 is localized in luteal cell in some follicles with distinct expression; concerning FOXO3 mRNA
92476 FOXO3 is localized in granulosa cell in some follicles with distinct expression; concerning FOXO3 mRNA
11875118 Metabolic
8,837
92501 AKT1 increases_phosphorylation of FOXO3 in all mouse models (high-fat-fed mice; ob/ob mice; mice with genetically impaired muscle glucose transport); with Akt hyperactivation
92564 FOXO3 is localized in brain and insulin via Akt phosphorylates and inhibits all brain FOXOs
92568 Insulin increases_phosphorylation of FOXO3 in brain; and inhibits all brain FOXOs
92572 Insulin decreases_activity of FOXO3 in brain; via phosphorylation
92577 high-fat–fed mouse decreases_expression of FOXO3 in all brain cortical regions in HFF mice
26895791 Alzheimer disease
Diabetes mellitus, type II
Metabolic
8,846
92399 APP (intracellular domain AICD) interacts (colocalizes) with FOXO3 in the cytoplasm in HEK 293T cells
92702 FOXO3 is_part_of APP(AICD)-FOXO3 complex in the cytoplasm in HEK 293T cells
92714 FOXO3 is localized in nucleus in human neuroblastoma SY-SH5Y cells.; without oxidative stress, together with AICD
92716 response to oxidative stress increases_transport of FOXO3 into nucleus in HEK 293T cells; together with AICD
92717 FOXO3 is localized in cytoplasm predominant localization
24832605 Alzheimer disease
8,848
92489 AKT1 increases_phosphorylation of FOXO3 in brain of diet-dependent long-standing obesity/T2DM monkeys
26895791 Alzheimer disease
Metabolic
8,853
92764 FOXO3 is_expressed_in neuron
92765 FOXO3 is_expressed_in astrocyte
92766 FOXO3 is_expressed_in oligodendrocyte
92768 FOXO3 is_expressed_in forebrain in subventricular zone of forebrain
92769 FOXO3 is_expressed_in subventricular zone in subventricular zone of forebrain
92771 FOXO3 is_expressed_in hippocampus in the subgranular zone in the hippocampus
92773 FOXO3 is_expressed_in ventricular zone in the embryonic brain
92775 FOXO3 is_expressed_in brain in NSC-rich regions of the developing and adult brain, and in cultured NSC-containing neurospheres from embryonic and adult brain
92852 FOXO3 decreases_activity of canonical Wnt signaling pathway in neural stem cells (NSC); enforced expression of constitutively active FoxO3
92857 FOXO3 increases_expression of SFRP1 in FoxO null NSC; enforced expression of constitutively active FoxO3
92858 FOXO3 increases_expression of SFRP2 in FoxO null NSC; enforced expression of constitutively active FoxO3
92860 FOXO3 increases_expression of SOST in FoxO null NSC; enforced expression of constitutively active FoxO3
93185 FOXO3 decreases_expression of ASPM in the regulation of NSC proliferation, via occupying the ASPM promoter
93186 FOXO3 interacts (colocalizes) with ASPM (promoter) in neural stem cells (NSC)
19896444 Metabolic
8,896
93138 FOXO3 interacts (colocalizes) with BBC3 when PI3K/Akt signaling is inhibited
93139 FOXO3 interacts (colocalizes) with BBC3 upon exposure of neurons to oligomeric Abeta42; concerning the Puma gene, hereby inducing its expression; when PI3K/Akt signaling is inhibited
93140 FOXO3 increases_expression of BBC3 upon exposure of neurons to oligomeric Abeta42; via binding the Puma gene, hereby inducing its expression; when PI3K/Akt signaling is inhibited
24567336 Alzheimer disease
8,901
92987 FOXO3 increases_activity of response to oxidative stress by regulating the expression of genes involved in DNA repair and glutamine metabolism
93145 FOXO3 increases_expression of GLUL as response to oxidative stress
26455863 Alzheimer disease
8,992
94422 response to ischemia increases_activity of FOXO3
94424 Estradiol decreases_phosphorylation of FOXO3 as response to ischemia
94425 Estradiol decreases_activity of FOXO3 as response to ischemia
20114038 Metabolic
9,452
100628 SIRT1 decreases_acetylation of FOXO3
22086720 Metabolic
9,576
101392 FOXO3 affects_activity of mTORC1 complex
25625517 Metabolic
9,577
101393 Estradiol decreases_activity of FOXO3 in breast cancer cells
26470790 Metabolic
9,590
101564 Cardiomyopathy, hypertrophic increases_phosphorylation of FOXO3 in heart
101566 Cardiomyopathy, hypertrophic decreases_activity of FOXO3 in heart
101596 AKT1 decreases_activity of FOXO3 in heart
25168380 Cardiomyopathy, hypertrophic
9,619
101588 FOXO3 increases_expression of STK4 in cardiomyocytes
25168380 Cardiovascular
9,621
101628 FOXO3 increases_activity of extended life span
101651 FOXO3 decreases_activity of aging
18765803 Metabolic
9,622
101633 FOXO3 decreases_expression of CSRP1 in vascular cells (hVECs, hVSMCs, and hMSCs); by recruiting SIRT1 to the promoter
101637 FOXO3 increases_activity of SIRT1 in vascular cells (hVECs, hVSMCs, and hMSCs); by recruiting SIRT1 to the promoter of target genes
30661960 Cardiovascular
9,624
101654 PARP1 increases_activity of FOXO3
101656 FOXO3 increases_activity of autophagy
30323296 Cardiovascular disease
9,625
101657 Myocardial infarction increases_expression of FOXO3
29049183 Myocardial infarction
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