Search Results for "BACE1" - 127 interactions found in 50 entries.

Entry-ID
Interactor1 (Subject) Interaction type Interactor2 (Object) additional information
PubMed-ID
Diseases
381
1552 BACE1 increases_processing of APP
21379 BACE1 affects_activity of beta-amyloid formation
12048259 Alzheimer disease
613
3296 Metformin increases_activity of BACE1 in brain frontal region; in wild-type C57B6 mice; in vivo
19237574 Diabetes mellitus, type II
Insulin resistance
952
5813 Insulin affects_activity of BACE1
5822 LEP affects_activity of BACE1
20385830 Alzheimer disease
1,008
6321 COL25A1 TG mouse increases_expression of BACE1 if COL25A1 is overexpressed
19548013 Alzheimer disease
1,281
8724 mir-107 decreases_expression of BACE1
8725 Alzheimer disease increases_quantity of BACE1
20413881 Alzheimer disease
1,377
9452 Oxidizing agent increases_expression of BACE1
9453 lipid oxidation increases_expression of BACE1
9551 response to oxidative stress increases_expression of BACE1
9552 Gamma-secretase complex increases_expression of BACE1 in a positive feedback loop
9706 hypoxia increases_expression of BACE1
9707 hypoxia increases_activity of BACE1
9740 HIF1A increases_expression of BACE1 in neuronal cells; if HIF1A is overexpressed, via binding to BACE1 promoter;
20552043 Alzheimer disease
1,520
10786 BACE1 affects_quantity of Amyloid beta peptide
10787 response to oxidative stress increases_expression of BACE1
10788 Alzheimer disease increases_expression of BACE1 in AD brain
10790 PSEN1 increases_expression of BACE1 Oxidative stress-induced BACE1 expression is reduced in presenilin-1 (gamma-secretase)-deficient cells.
10799 BACE1 increases_activity of Alzheimer disease in AD brain; Levels of beta-secretase activities were greater in brain tissue samples from AD patients compared to non-demented control subjects.
10803 Gamma-secretase complex affects_expression of BACE1 at the transcriptional level
18687504 Alzheimer disease
1,522
10800 Gamma-secretase complex increases_expression of BACE1 in brain; of 3xTgAD mouse
18687504 Alzheimer disease
1,576
11352 Alzheimer disease affects_quantity of BACE1
11353 Reactive oxygen species increases_expression of BACE1 if ROS is overexpressed
11355 Gamma-secretase complex increases_activity of BACE1
20442493 Alzheimer disease
1,831
13844 mir-29a affects_expression of BACE1
13851 mir-29b-1 affects_expression of BACE1
13852 mir-9 affects_expression of BACE1
13855 Alzheimer disease increases_expression of BACE1
18434550 Alzheimer disease
1,935
14887 BACE1 increases_processing of APP
14932 BACE1 increases_activity of beta-amyloid formation
16025111 Alzheimer disease
1,957
15248 2-Deoxy-D-glucose increases_quantity of BACE1 in Tg2576 transgenic mice
15249 Insulin increases_quantity of BACE1 in Tg2576 transgenic mice
15250 beta-Nitropropanoate increases_quantity of BACE1 in Tg2576 transgenic mice
15251 Kainic acid increases_quantity of BACE1 in Tg2576 transgenic mice
19076444 Alzheimer disease
2,130
17532 NOS3 decreases_quantity of BACE1
21127294 Alzheimer disease
2,136
17742 BACE1 increases_quantity of Amyloid beta peptide (15) experimentally concluded via treatment with alpha- and beta-secretase inhibitors.
17743 BACE1 increases_quantity of Amyloid beta peptide (14) experimentally concluded via treatment with alpha- and beta-secretase inhibitors.
17749 BACE1 increases_quantity of sAPP-alpha
17750 BACE1 decreases_quantity of Amyloid beta peptide (42) compared with vehicle or untreated cells.
17751 BACE1 decreases_quantity of Amyloid beta peptide (40) compared with vehicle or untreated cells.
17752 BACE1 decreases_quantity of Amyloid beta peptide (38) compared with vehicle or untreated cells.
17753 BACE1 decreases_quantity of Amyloid beta peptide (14) compared with vehicle or untreated cells.
17812 BACE1 decreases_quantity of Amyloid beta peptide (15) compared with vehicle or untreated cells.
17813 BACE1 decreases_quantity of Amyloid beta peptide (16) compared with vehicle or untreated cells.
19604603 Alzheimer disease
2,249
19236 Atorvastatin decreases_quantity of BACE1
21536132 Alzheimer disease
Dementia
2,269
19403 Cholesterol affects_activity of BACE1
19404 Cholesterol affects_activity of BACE1
20847439 Alzheimer disease
2,278
19542 Pioglitazone decreases_expression of BACE1 in APP transgenic mice
28111 BACE1 affects_processing of APP
28112 BACE1 increases_quantity of sAPP-beta
21345168 Alzheimer disease
2,309
19935 ST101 NOT affects_quantity of BACE1
21416488 Alzheimer disease
2,351
20578 NGF decreases_expression of BACE1 through binding to the NGF high affinity receptor TrkA
21321391 Alzheimer disease
2,533
23825 Cholesterol increases_activity of BACE1
24060 BACE1 interacts (colocalizes) with membrane raft Cholesterol depletion decreases the association of BACE1 with lipid rafts.
24086 BACE1 interacts (colocalizes) with APP in lipid raft domains; promoted by cholesterol
24130 Sphingolipid affects_activity of BACE1
21448224 Alzheimer disease
2,587
24431 Myricetin decreases_activity of BACE1 by direct binding and inhibition
82427 Myricetin interacts (colocalizes) with BACE1
17722071 Alzheimer disease
2,593
24465 Bepridil decreases_activity of BACE1
24466 Amiodarone decreases_activity of BACE1
24472 intracellular pH elevation decreases_activity of BACE1
24473 BACE1 increases_processing of APP in the acidic endosomes
82428 response to acidic pH increases_activity of BACE1 in the acidic endosomes
82429 BACE1 decreases_quantity of APP in the acidic endosomes; via cleaving APP
20592218 Alzheimer disease
2,600
24593 EIF2A-P increases_expression of BACE1 EIF2A-P is activated form of EIF2A
24607 Salubrinal increases_quantity of BACE1
19109907 Alzheimer disease
2,673
25115 BACE1 increases_processing of APLP2
82430 BACE1 decreases_quantity of APLP2
21695060 Alzheimer disease
3,079
28298 Heparan sulfate decreases_activity of BACE1
21715329 Alzheimer disease
3,093
28388 PRNP interacts (colocalizes) with BACE1 with the prodomain of the immature Golgi-localized form of BACE1
28391 BACE1 interacts (colocalizes) with cell surface
28428 BACE1 interacts (colocalizes) with endosome
28429 BACE1 increases_processing of APP at cell surface, in endosomes, and Golgi; depending on the interaction of PrPC and BACE1
28430 BACE1 is localized in trans-Golgi network
28432 PRNP affects_activity of BACE1 by binding to the prodomain of the immature Golgi-localized form of BACE1
21795680 Alzheimer disease
Prion disease
3,104
28485 PRNP interacts (colocalizes) with BACE1
28493 PRNP decreases_activity of BACE1 This decreases both Abeta and AICD (amyloid intracellular domain) production.
29033 Alzheimer disease affects_activity of BACE1
19887909 Alzheimer disease
Prion disease
3,212
29666 12/15-Lipoxygenase affects_expression of BACE1 BACE1 mRNA expression level is regulated via the activation of the transcription factor Sp1
29667 SP1 affects_expression of BACE1 BACE1 mRNA expression level is regulated via the activation of the transcription factor Sp1.
29669 BACE1 affects_quantity of Amyloid beta peptide transcriptionally regulated by by 12/15-lipoxygenase
29670 BACE1 affects_activity of cognitive impairment transcriptionally regulated by 12/15-lipoxygenase.
22275252 Alzheimer disease
3,374
31373 mir-124 affects_expression of BACE1
22178568 Alzheimer disease
3,382
31475 BACE1 affects_activity of regulation of proteolysis of APP
31482 BACE1 affects_activity of membrane protein ectodomain proteolysis of APP
22506131 Alzheimer disease
-->