Search Results for "APP (intracellular domain AICD)" - 96 interactions found in 11 entries.

Entry-ID
Interactor1 (Subject) Interaction type Interactor2 (Object) additional information
PubMed-ID
Diseases
3,104
28498 APP (intracellular domain AICD) increases_expression of PRNP
28522 APP (intracellular domain AICD) increases_expression of PRNP
19887909 Alzheimer disease
Prion disease
3,380
31461 NEDD8 affects_activity of APP (intracellular domain AICD) via covalent NEDD8 conjugation (neddylation) of AICD (APP intracellular domain)
31462 APP (intracellular domain AICD) interacts (colocalizes) with APBB1 resulting in AICD-Fe65-Tip60 complex formation
31466 Gamma-secretase complex increases_quantity of APP (intracellular domain AICD) and generates the APP intracellular domain (AICD)
31467 APP increases_quantity of APP (intracellular domain AICD)
31468 APP (intracellular domain AICD) is_part_of AICD-APBB1-KAT5 complex
31469 APP (intracellular domain AICD) increases_activity of mRNA transcription for target gene activation following localization into the nucleus
31470 APP (intracellular domain AICD) is localized in nucleus
18096514 Alzheimer disease
3,382
31483 Alzheimer disease increases_quantity of APP (intracellular domain AICD) in brain of AD patients
31505 APP (intracellular domain AICD) interacts (colocalizes) with PIN1 AICD acts as a docking site
31506 APP (intracellular domain AICD) interacts (colocalizes) with APBA1 AICD acts as a docking site
31507 APP (intracellular domain AICD) interacts (colocalizes) with DAB1 AICD acts as a docking site
31508 APP (intracellular domain AICD) interacts (colocalizes) with SHC1 AICD acts as a docking site
31509 APP (intracellular domain AICD) interacts (colocalizes) with MAPK8IP1 AICD acts as a docking site
31510 APP (intracellular domain AICD) interacts (colocalizes) with APBB2 AICD acts as a docking site
31511 APP (intracellular domain AICD) interacts (colocalizes) with APBB3 AICD acts as a docking site
31514 beta-amyloid formation affects_quantity of APP (intracellular domain AICD)
31520 APP (intracellular domain AICD) interacts (colocalizes) with MME (promoter) cell type-dependent
22506131 Alzheimer disease
3,401
31581 APP affects_quantity of APP (intracellular domain AICD)
31582 APP (intracellular domain AICD) interacts (colocalizes) with APBB1
31592 MAPK8IP1 affects transport of APP (intracellular domain AICD) to nucleus
31593 MAPK8IP1 interacts (colocalizes) with APP (intracellular domain AICD)
31600 APBA1 interacts (colocalizes) with APP (intracellular domain AICD) in cytosol
31601 APP (intracellular domain AICD) affects_expression of APP
15331662 Alzheimer disease
3,414
31686 APP (CTF-C99) increases_quantity of APP (intracellular domain AICD)
31689 IDE decreases_activity of APP (intracellular domain AICD)
31694 IDE decreases_quantity of APP (intracellular domain AICD) by degradation of AICD
31702 APBA1 decreases_activity of APP (intracellular domain AICD) (AICD-induced transactivation)
31703 APBA2 decreases_activity of APP (intracellular domain AICD) (AICD-induced transactivation)
31704 APBA3 NOT affects_activity of APP (intracellular domain AICD) (AICD-induced transactivation)
31842 APP (intracellular domain AICD) increases_expression of CD82 via promoter-binding
31844 APP (intracellular domain AICD) increases_expression of GSK3B
31845 APP (intracellular domain AICD) increases_expression of APP
31846 APP (intracellular domain AICD) increases_expression of BACE1
31847 APP (intracellular domain AICD) increases_expression of KAT5
31851 APP (intracellular domain AICD) increases_expression of MME via promoter-binding; depending on cell type
31869 APP (intracellular domain AICD) increases_expression of PTCH1 via promoter-binding
31870 APP (intracellular domain AICD) increases_expression of TP53 via promoter-binding
31871 APP (intracellular domain AICD) increases_expression of TAGLN
31872 APP (intracellular domain AICD) increases_expression of IGFBP3
31873 APP (intracellular domain AICD) increases_expression of S100A9
31874 APP (intracellular domain AICD) increases_expression of AQP1
31875 APP (intracellular domain AICD) increases_expression of SLC17A6
31876 APP (intracellular domain AICD) increases_expression of CCNB1
31877 APP (intracellular domain AICD) increases_expression of CCND1
31878 APP (intracellular domain AICD) decreases_expression of EGFR via promoter-binding
31879 APP (intracellular domain AICD) decreases_expression of LRP1 via promoter-binding
31880 APP (intracellular domain AICD) decreases_expression of CLU
31881 APP (intracellular domain AICD) increases_expression of DDIT3 via promoter-binding
31883 APP (intracellular domain AICD) increases_expression of ACTA2
52848 PSEN1 affects_quantity of APP (intracellular domain AICD)
52849 PSEN2 affects_quantity of APP (intracellular domain AICD)
52853 APP (CTF-C99) increases_quantity of APP (intracellular domain AICD)
52854 APP (CTF-C83) increases_quantity of APP (intracellular domain AICD)
52856 APP (intracellular domain AICD) cooccurs with Alzheimer disease in sporadic AD-affected brains
52861 GRB2 interacts (colocalizes) with APP (intracellular domain AICD)
52862 ABL1 interacts (colocalizes) with APP (intracellular domain AICD)
52863 NUMB interacts (colocalizes) with APP (intracellular domain AICD)
52864 DAB1 interacts (colocalizes) with APP (intracellular domain AICD)
52865 SHC1 interacts (colocalizes) with APP (intracellular domain AICD)
52866 SHC2 interacts (colocalizes) with APP (intracellular domain AICD)
52867 APP (intracellular domain AICD) is localized in nucleus
52868 APP (intracellular domain AICD) interacts (colocalizes) with APBB1
52869 APP (intracellular domain AICD) interacts (colocalizes) with NOTCH (intracellular domain NICD)
52870 APP (intracellular domain AICD) affects_activity of calcium ion homeostasis
52871 APP (intracellular domain AICD) increases_activity of cell death in Jurkat cells; FADD (Fas domain associated protein)-induced cell death;
52872 APP (intracellular domain AICD) interacts (colocalizes) with TP53 (promoter)
67185 APP (intracellular domain AICD) increases_quantity of APP (cytotoxic fragment C31)
22122663 Alzheimer disease
3,429
31906 APP (intracellular domain AICD) affects_expression of IGFBP3
31909 APP (intracellular domain AICD) affects_expression of TAGLN
31910 APP (intracellular domain AICD) affects_expression of ACTA2
31911 APP (intracellular domain AICD) affects_expression of FN1
31912 APP (intracellular domain AICD) affects_expression of RAB3B
31913 APP (intracellular domain AICD) affects_expression of TPM1
31914 APP (intracellular domain AICD) affects_expression of SLC7A5
31915 APP (intracellular domain AICD) affects_expression of MICAL2
17093061 Alzheimer disease
3,540
32937 Ibuprofen NOT decreases_quantity of APP (intracellular domain AICD)
32990 Sulindac sulfide NOT decreases_quantity of APP (intracellular domain AICD)
32991 Dimethyl sulfoxide decreases_quantity of APP (intracellular domain AICD)
32993 NSAID NOT decreases_quantity of APP (intracellular domain AICD)
12777371 Alzheimer disease
3,552
32996 APP (intracellular domain AICD) decreases_activity of memory in AD by impairing adult neurogenesis
32997 APP (intracellular domain AICD) decreases_activity of neurogenesis in AD
20689579 Alzheimer disease
4,308
44132 canonical Wnt signaling pathway increases_quantity of APP (intracellular domain AICD) due to the increased protein stability by Wnt/beta-catenin
44133 CTNNB1 interacts (colocalizes) with APP (intracellular domain AICD)
44134 CTNNB1 increases_activity of APP (intracellular domain AICD)
44135 APBB1 NOT affects_activity of APP (intracellular domain AICD) concerning the regulation of AICD mediated transcriptional activity by Wnt/beta-catenin
44139 canonical Wnt signaling pathway increases_activity of APP (intracellular domain AICD) concerning the transcriptional activity of AICD
21798242 Metabolic
5,414
52882 APP (intracellular domain AICD) decreases_activity of canonical Wnt signaling pathway if induced by LRP6, Dishevelled1/2/3 and beta-catenin wild-type (wt);
52883 APP (intracellular domain AICD) interacts (colocalizes) with GSK3B
52884 APP (intracellular domain AICD) increases_activity of neuron projection development in N2a mouse neuroblastoma cells, rat pheochromocytoma PC12 cells and primary neurons
52885 APP (intracellular domain AICD) decreases_expression of MYC by suppressing Wnt/beta-catenin signalling in a GSK3B kinase-dependent manner;
52886 APP (intracellular domain AICD) increases_activity of GSK3B
52887 APP (intracellular domain AICD) decreases_activity of cell proliferation
52889 APP (intracellular domain AICD) decreases_activity of MYC (promoter)
22613765 Metabolic
5,432
53013 APP (intracellular domain AICD) increases_activity of GSK3B in brain
16230462 Alzheimer disease
Metabolic
-->