Search Results for "APP" - 273 interactions found in 110 entries.

Entry-ID
Interactor1 (Subject) Interaction type Interactor2 (Object) additional information
PubMed-ID
Diseases
122
419 GSK3B increases_phosphorylation of APP
481 GSK3B increases_phosphorylation of APP at Thr743
482 GSK3B increases_processing of APP
11527574 Alzheimer disease
322
1269 NCSTN interacts (colocalizes) with APP
1290 protein processing increases_activity of APP by a two-step proteolytic pathway
10993067 Alzheimer disease
381
1552 BACE1 increases_processing of APP
1564 Gamma-secretase complex increases_processing of APP
12048259 Alzheimer disease
457
2181 Streptozocin increases_expression of APP
19712582 Alzheimer disease
485
2281 Amyloid beta peptide (25-35) increases_quantity of APP in cytoplasm of rat hippocampal neurons; via tau protein kinase I/glycogen synthase kinase-3beta (TPK1/GSK-3B) in hippocampal neurons
8592647 Alzheimer disease
505
14083 APP increases_quantity of Amyloid beta peptide
11943765 Alzheimer disease
569
2966 Glucose affects_quantity of APP in plasma
2967 Insulin affects_quantity of APP in plasma
2986 APOE decreases_quantity of APP in plasma
10670439 Alzheimer disease
574
3016 Gamma-secretase complex affects_processing of APP
17298085 Alzheimer disease
580
3103 Lithium affects_processing of APP
3140 GSK3A affects_processing of APP
3141 GSK3B affects_processing of APP
12761548 Alzheimer disease
613
3266 Metformin NOT affects_expression of APP
3268 Metformin affects_quantity of APP
19237574 Diabetes mellitus, type II
Insulin resistance
645
3424 GSK3B affects_processing of APP APP processed to amyloid beta peptide
3427 CDK5 affects_processing of APP APP processed to amyloid beta peptide
14651959 Alzheimer disease
667
3599 APP interacts (colocalizes) with TOM complex, mitochondrial in mitochondrion
3601 APP interacts (colocalizes) with TIM complex, mitochondrial in mitochondrion
19268425 Alzheimer disease
695
3828 LRRK2-p.G2019S NOT increases_activity of APP
20064389 Parkinson disease
717
4011 Lithium affects_processing of APP
4012 Valproic acid affects_processing of APP
15170327 Alzheimer disease
718
4013 Lithium affects_processing of APP
4014 Valproic acid affects_processing of APP
4023 GSK3B affects_processing of APP
15170327 Alzheimer disease
792
4623 HSPA5 interacts (colocalizes) with APP in endoplasmic reticulum
4628 STUB1 interacts (colocalizes) with APP
4681 HSF1 increases_expression of APP during stress
19449461 Alzheimer disease
924
5661 Epigallocatechin 3-gallate increases_processing of APP at alpha-C-terminal fragment of APP
16177050 Alzheimer disease
937
5675 ADAM10 affects_processing of APP if green tea (-)-epigallocatechin-3-gallate-induced
16624814 Alzheimer disease
952
5825 Insulin affects_processing of APP
5826 LEP affects_processing of APP
20385830 Alzheimer disease
976
6030 Alpha-secretase increases_processing of APP
19242462 Alzheimer disease
Prion disease
1,107
7349 increased cholesterol level increases_processing of APP
82834 increased cholesterol level decreases_quantity of APP via increased APP cleavage
20462385 Alzheimer disease
Dementia
1,169
7758 IL1B increases_expression of APP
15290893 Alzheimer disease
Down syndrome
1,321
9036 Gamma-secretase complex increases_processing of APP
16645044 Alzheimer disease
1,418
9793 APP increases_activity of ferroxidase activity
9795 zinc ion binding decreases_activity of APP zinc ion (2+) binding
9799 APP increases_activity of oxidoreductase activity, oxidizing metal ions APP catalytically oxidizes Fe2+
9807 APP increases_activity of iron ion binding Fe3+ binding; APP loads Fe3+ into transferrin
9811 APP interacts (colocalizes) with SLC40A1 in HEK293T cells and in human cortical tissue
9822 Zn2+ decreases_activity of APP
9833 APP increases_quantity of Fe3+ via oxidizing Fe2+ to Fe3+
9875 Alzheimer disease decreases_activity of APP cortical APP ferroxidase activity
104413 APP decreases_quantity of Fe2+ via oxidizing Fe2+ to Fe3+
20817278 Alzheimer disease
1,420
9854 APP decreases_activity of response to oxidative stress
12090 APP NOT increases_quantity of Iron
20817278 Alzheimer disease
1,422
9878 IL1B (active form) affects_expression of APP at translational level
9960 APP affects_activity of coagulation If APP is secreted
9963 APP interacts (colocalizes) with Factor IXa If APP is secreted
9967 response to interleukin-1 increases_expression of APP
9976 APP decreases_activity of response to oxidative stress
9979 APP increases_activity of neuroprotection
10036 astrocyte activation increases_quantity of APP
19021541 Alzheimer disease
1,441
10118 Metal affects_expression of APP
10385 Alpha-secretase increases_processing of APP
10386 Copper increases_expression of APP Up-regulation of APP transcription
19166904 Alzheimer disease
Hemochromatosis, type 1
1,534
10956 APP affects_activity of Alzheimer disease
10957 APP interacts (colocalizes) with TNFRSF21 compare Corum:6056
19225519 Alzheimer disease
1,556
11123 CALHM1 affects_processing of APP
18585350 Alzheimer disease
1,558
11125 SAMP8 mouse increases_quantity of APP in the hippocampus of aged SAMP8 mice
11172 mir-16 affects_expression of APP
11174 mir-16 decreases_expression of APP if mir-16 is overexpressed
20619502 Alzheimer disease
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