Search Results for "APOE (isoform E4)" - 990 interactions found in 158 entries.

Entry-ID
Interactor1 (Subject) Interaction type Interactor2 (Object) additional information
PubMed-ID
Diseases
1,107
7243 APOE (isoform E4) increases_activity of Alzheimer disease
7344 APOE (isoform E4) increases_quantity of amyloid beta deposits
7345 APOE (isoform E4) increases_activity of astrocyte activation
20462385 Alzheimer disease
Dementia
1,441
10320 APOE (isoform E4) increases_activity of Alzheimer disease
19166904 Alzheimer disease
Hemochromatosis, type 1
1,893
14500 APOE (isoform E4) increases_activity of Alzheimer disease
14502 APOE (isoform E4) increases_activity of neurodegeneration
14513 APOE (isoform E4) increases_activity of Parkinson disease
14514 APOE (isoform E4) increases_activity of Multiple sclerosis
14519 APOE (isoform E4) affects_activity of synapse assembly
14521 APOE (isoform E4) decreases_activity of learning or memory compared to apo E3 knock-in mice
14529 APOE (isoform E4) increases_quantity of amyloid beta deposits
14558 APOE (isoform E4) interacts (colocalizes) with ABCA1
20170744 Alzheimer disease
1,957
15166 APOE (isoform E4) affects_activity of metabolic process
19076444 Alzheimer disease
2,072
16715 APOE (isoform E4) increases_activity of abnormal blood flow velocity in ApoE4 6-month and 12-month mice; compared to WT mouse
16716 APOE (isoform E4) increases_activity of CNS ischemia in ApoE4 6-month and 12-month mice; compared to WT mouse
16717 APOE (isoform E4) increases_activity of brain hypoperfusion in ApoE4 6-month and 12-month mice; compared to WT mouse
16719 APOE (isoform E4) increases_activity of Alzheimer disease in APOE4 mice
16751 APOE (isoform E4) increases_activity of response to stress in APOE4 mouse microvessels
16752 APOE (isoform E4) affects_activity of vascular endothelium in APOE4 mouse microvessels
38965 APOE (isoform E4) decreases_activity of learning or memory in APOE4 mice; if mice are fed with selective mitochondrial antioxidants acetyl-L-carnitine and R-alpha-lipoic acid
95892 APOE (isoform E4) increases_activity of decreased blood flow velocity in ApoE4 6-month and 12-month mice; compared to WT mouse
95893 APOE (isoform E4) increases_activity of cognitive impairment in APOE4 mice; improved cognitive impairment if mice are fed with selective mitochondrial antioxidants acetyl-L-carnitine and R-alpha-lipoic acid
95894 mitochondrial antioxidants decreases_activity of APOE (isoform E4) in APOE4 mice; improved cognitive impairment if mice are fed with selective mitochondrial antioxidants acetyl-L-carnitine and R-alpha-lipoic acid
95895 Acetylcarnitine decreases_activity of APOE (isoform E4) in APOE4 mice; improved cognitive impairment if mice are fed with selective mitochondrial antioxidants acetyl-L-carnitine and R-alpha-lipoic acid
95896 R-alpha-lipoic acid decreases_activity of APOE (isoform E4) in APOE4 mice; improved cognitive impairment if mice are fed with selective mitochondrial antioxidants acetyl-L-carnitine and R-alpha-lipoic acid
19342064 Alzheimer disease
2,533
23594 APOE (isoform E4) increases_activity of Alzheimer disease
21448224 Alzheimer disease
3,064
28099 APOE (isoform E4) increases_activity of Alzheimer disease
18401020 Diabetes mellitus, type II
Insulin resistance
3,081
28303 APOE (isoform E4) affects_activity of Amyloid beta peptide (40)
28308 Amyloid beta peptide (12-28) interacts (colocalizes) with APOE (isoform E4)
28341 APOE (isoform E4) increases_activity of response to nitrosative stress
22101739 Alzheimer disease
3,167
29109 APOE (isoform E4) increases_quantity of amyloid beta deposits
20598287 Alzheimer disease
3,191
118869 APOE (isoform E4) increases_expression of CASP6 in the temporal cortex of the APOE4 group; strongly upregulated
118870 APOE (isoform E4) decreases_expression of CASP6 in the primary somatosensory cortex of the APOE4 group; modestely downregulated
20479757 Alzheimer disease
3,699
35842 APOE (isoform E4) increases_activity of Alzheimer disease In the presence of type 2 DM the risk of developing AD is increased to more than five-fold, compared to individuals without those two conditions.
22329649 Alzheimer disease
4,947
48906 APOE (isoform E4) increases_quantity of PLA2G7 in Caucasians and African Americans
22632920 Cardiovascular disease
6,481
62475 APOE (isoform E4) increases_activity of leptin-mediated signaling pathway Accumulation of ApoE4 results in a transient enhancement of Lep signalling that might lead to Lep resistance over time.
62483 APOE (isoform E4) increases_activity of inflammatory response
62516 APOE (isoform E4) increases_activity of gliosis in the brain; in transgenic animal models overexpressing human form of apoE4 .
25998028 Alzheimer disease
6,894
67343 APOE (isoform E4) decreases_activity of amyloid-beta clearance
67344 APOE (isoform E4) decreases_activity of maintenance of permeability of blood-brain barrier
67345 APOE (isoform E4) increases_activity of amyloid beta deposits
67346 APOE (isoform E4) increases_activity of PPIA
67347 APOE (isoform E4) interacts (colocalizes) with VLDLR
67350 APOE (isoform E4) increases_activity of increased circulating LDL cholesterol level
67351 APOE (isoform E4) increases_activity of increased circulating triglyceride level
67352 APOE (isoform E4) increases_activity of Cardiovascular disease
67358 APOE (isoform E4) affects_activity of intranasal insulin
67365 APOE (isoform E4) affects_activity of lipid metabolic process
27470930 Diabetes mellitus, type II
Insulin resistance
7,238
71247 APOE (isoform E4) decreases_activity of Alzheimer disease in plasma; among women, in the Baltimore Longitudinal Study of Aging;
71259 sex affects_activity of APOE (isoform E4) in plasma; concerning the risk of AD in the Baltimore Longitudinal Study of Aging;
71262 APOE (isoform E4) NOT affects_activity of Ceramide in plasma ; concerning the risk of AD among men and women in the Baltimore Longitudinal Study of Aging;
71264 APOE (isoform E4) NOT affects_activity of Sphingomyelin in plasma; concerning the risk of AD among men in the Baltimore Longitudinal Study of Aging;
Alzheimer disease
7,250
71302 APOE (isoform E4) increases_expression of APP in human neurons; compared to ApoE3 and ApoE2
71312 APOE (isoform E4) increases_activity of Amyloid beta peptide (42) secretion in human neurons cultured on MEFs ; compared to ApoE3 and ApoE2
71315 APOE (isoform E4) increases_activity of Amyloid beta peptide (40) secretion in human neurons cultured on MEFs ; compared to ApoE3 and ApoE2
71334 APOE (isoform E4) increases_activity of MAP3K12 in human neurons; compared to ApoE3 and ApoE2; via binding to ApoE receptors
71364 APOE (isoform E4) increases_activity of Alzheimer disease if human neurons are cultured on mouse glia;
124911 APOE (isoform E4) increases_quantity of Amyloid beta peptide (42) compared to ApoE3 and ApoeE2; unrelated to alpha-or beta-secretase expression
124917 APOE (isoform E4) increases_quantity of Amyloid beta peptide (40) compared to ApoE3 and ApoeE2; unrelated to alpha-or beta-secretase expression
28111074 Alzheimer disease
7,255
71375 APOE (isoform E4) increases_activity of abnormal circulating lipid level
71388 APOE (isoform E4) affects_activity of low-density lipoprotein particle receptor binding Binding of APOE4 to the LDLR is unaffected.
71391 APOE (isoform E4) increases_activity of lipid binding The amino acid substitution affects the organization and stability of both the N-terminal helix bundle domain and separately folded C-terminal domain so that apoE4 has enhanced lipid binding ability.
71392 APOE (isoform E4) increases_activity of very-low-density lipoprotein particle binding The strong lipid binding ability of apoE4 is the basis for the preferential binding of this isoform to VLDL particles, the surfaces of which are about 60% PL-covered. ApoE4 binds much better than apoE3 to VLDL but somewhat less well than apoE3 to HDL.
71394 APOE (isoform E4) increases_activity of alatered VLDL lipolytic processing ApoE4 binds better than apoE3 to the surface of very low density lipoprotein (VLDL) particles and impairs their lipolytic processing in the circulation.
71403 APOE (isoform E4) increases_activity of increased pro-atherogenic lipoprotein-cholesterol distribution
71423 APOE (isoform E4) increases_activity of increased circulating VLDL cholesterol level in transgenic mouse, in plasma
71430 APOE (isoform E4) increases_activity of increased susceptibility to atherosclerosis in transgenic mouse, in plasma
71431 APOE (isoform E4) increases_activity of increased circulating cholesterol level
71436 APOE (isoform E4) decreases_activity of high-density lipoprotein particle binding compared to apoE3; ApoE4 binds much better than apoE3 to VLDL but somewhat less well than apoE3 to HDL
71448 APOE (isoform E4) decreases_activity of lipid catabolic process ApoE4 binds more to VLDL because of its higher lipid affinity leading to inhibition of lipolysis
111429 APOE (isoform E4) interacts (colocalizes) with VLDL ApoE4 binds more to VLDL because of its higher lipid affinity leading to inhibition of lipolysis
113458 APOE (isoform E4) decreases_activity of cholesterol homeostasis resulting in Hypercholesterolemia
114524 APOE (isoform E4) decreases_activity of VLDL lipid catabolic process ApoE4 binds more to VLDL because of its higher lipid affinity leading to inhibition of lipolysis
25328986 Alzheimer disease
Metabolic
7,288
71590 APOE (isoform E4) increases_quantity of APOB with no gender effect
73921 APOE (isoform E4) increases_activity of Alzheimer disease only below age 80
73922 aging increases_activity of APOE (isoform E4) only below age 80
73923 APOE (isoform E4) increases_quantity of Cholesterol in men
11408727 Alzheimer disease
7,308
71708 APOE (isoform E4) increases_activity of Alzheimer disease
71716 APOE (isoform E4) decreases_activity of S1P/sphingosine ratio in hippocampus
24456642 Alzheimer disease
Metabolic
7,322
71967 APOE (isoform E4) increases_activity of Alzheimer disease
71968 sex, female increases_activity of APOE (isoform E4) concerning AD in women
71969 APOE (isoform E4) decreases_activity of hippocampus depending on sex: worse in women compared with men at different stages of AD.
71970 APOE (isoform E4) affects_activity of brain
71971 APOE (isoform E4) decreases_activity of memory depending on sex: worse in women compared with men at different stages of AD.
71972 APOE (isoform E4) increases_quantity of amyloid beta deposits especially in women who were E4 carriers.
71973 APOE (isoform E4) increases_quantity of neurofibrillary tangles especially in women who were E4 carriers.
72092 APOE (isoform E4) increases_activity of Alzheimer disease concerning AD in women.
124712 sex, male decreases_activity of APOE (isoform E4) in men; concerning AD, compared to women
24470773 Alzheimer disease
7,412
72681 APOE (isoform E4) increases_activity of Alzheimer disease
26969397 Alzheimer disease
7,430
73241 APOE (isoform E4) increases_activity of increased circulating LDL cholesterol level compared to APOE (isoform E3)
27112212 Coronary heart disease
7,455
73398 Estradiol NOT affects_expression of APOE (isoform E4) in cultured adult mouse cortical neurons
15033916 Metabolic
7,515
74144 APOE (isoform E4) decreases_quantity of APOE in plasma; in a group of APOE4 alelle carrier from Australia
74145 APOE (isoform E4) decreases_quantity of APOC3 in plasma; in a group of APOE4 alelle carrier from Australia
74146 APOE (isoform E4) decreases_quantity of APOH in plasma; in a group of APOE4 alelle carrier from Australia
74147 APOE (isoform E4) increases_quantity of APOB in plasma; in a group of APOE4 alelle carrier from Australia
22701550 Alzheimer disease
7,522
74174 APOE (isoform E4) decreases_activity of spartial memory in APOA4 female mice
74176 APOE (isoform E4) decreases_activity of memory in APOA4 female mice
74185 APOE (isoform E4) decreases_activity of AR
74190 APOE (isoform E4) interacts (colocalizes) with AR in cortical extracts; in Apo-/- mice
74196 APOE (isoform E4) decreases_quantity of AR-positive neurons in female
74197 APOE (isoform E4) NOT affects_quantity of AR-positive neurons in male
18395206 Alzheimer disease
Metabolic
7,527
74357 SORT1 interacts (colocalizes) with APOE (isoform E4)
25702058 Diabetes mellitus, type II
Insulin resistance
Cardiovascular disease
7,567
74975 APOE (isoform E4) decreases_quantity of APOA1 in plasma
74981 APOE (isoform E4) decreases_quantity of APOA2 in plasma
74982 APOE (isoform E4) decreases_quantity of APOB in plasma
74983 APOE (isoform E4) decreases_quantity of APOC3 in plasma
74984 APOE (isoform E4) decreases_quantity of APOH in plasma
74985 APOE (isoform E4) decreases_quantity of APOE in plasma
74986 APOE (isoform E4) decreases_quantity of CLU in plasma
28419892 Metabolic
7,773
77653 APOE (isoform E4) increases_quantity of Cholesterol in plasma
28697566 Alzheimer disease
7,815
77782 APOE (isoform E4) increases_quantity of Ceramide C20-C26 in CSF in CN with a parental history of AD
24952994 Alzheimer disease
7,848
78037 APOE (isoform E4) increases_activity of Alzheimer disease
78301 APOE (isoform E4) decreases_activity of sterol metabolic process in AD but not normal brain
78302 APOE (isoform E4) decreases_activity of sphingolipid metabolic process in AD but not normal brain
78329 APOE (isoform E4) increases_quantity of Cholesterol in the MFG (middle frontal gyrus) grey matter of AD patients (in the cell bodies but not in the fiber tracks); compared with AD patients expressing ApoE3
78335 APOE (isoform E4) decreases_quantity of SM C22:0 in the MFG grey matter in ApoE4 compared with ApoE3 AD brain; (12.5-fold decrease)
78337 APOE (isoform E4) increases_quantity of Ceramide C22:0 in the MFG white matter in ApoE4 vs. ApoE3 brain; (2.6-fold increase)
78338 APOE (isoform E4) increases_quantity of 4-Hydroxynonenal in the MFG grey matter of ApoE4 compared with ApoE3 AD brain; (4.9-fold increase)
78339 APOE (isoform E4) increases_quantity of Ceramide C18:0 in the MFG grey matter of ApoE4 AD patients
78369 APOE (isoform E4) increases_quantity of Cholesterol ester C18:1 in the MTG (middle temporal gyrus) grey matter in AD patients expressing ApoE4, (in the cell bodies but not in the fiber tracks); (2.4-fold increase), compared with AD patients expressing ApoE3
78370 APOE (isoform E4) increases_quantity of Cholesterol ester C16:0 in the MFG (middle frontal gyrus) grey matter of AD patients (in the cell bodies but not in the fiber tracks); compared with AD patients expressing ApoE3
78371 APOE (isoform E4) increases_quantity of Cholesterol ester C18:1 in the MFG (middle frontal gyrus) grey matter of AD patients (in the cell bodies but not in the fiber tracks); compared with AD patients expressing ApoE3
78372 APOE (isoform E4) decreases_quantity of SM C24:0 in the MFG grey matter in ApoE4 compared with ApoE3 AD brain; (6.2-fold decrease)
78373 APOE (isoform E4) decreases_quantity of Ceramide C24:0 in the MFG white matter in ApoE4 vs. ApoE3 brain; (1.2-fold decrease)
78374 APOE (isoform E4) increases_quantity of Sulfatide in the MFG white matter in ApoE4 vs. ApoE3 brain; (1.7-fold increase)
78377 APOE (isoform E4) increases_quantity of Ceramide C24:1 in the MFG grey matter of ApoE4 AD patients
78378 APOE (isoform E4) increases_quantity of Sulfatide in the MFG grey matter of ApoE4 AD patients
17888544 Alzheimer disease
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