Search Results for "ACE2" - 392 interactions found in 87 entries.

Entry-ID
Interactor1 (Subject) Interaction type Interactor2 (Object) additional information
PubMed-ID
Diseases
1,976
15479 ACE2 decreases_quantity of Glucose in blood; after fasting
15480 ACE2 increases_activity of improved glucose tolerance intraperitoneal
15481 ACE2 increases_quantity of Insulin in pancreas, in pancreatic islets
15482 ACE2 affects_activity of type B pancreatic cell proliferation in pancreas, in pancreatic islets
15483 ACE2 affects_activity of type B pancreatic cell apoptotic process in pancreas, in pancreatic islets
15484 ACE2 NOT affects_activity of increased insulin sensitivity
15485 MAS1 affects_activity of ACE2
15486 ACE2 affects_activity of Diabetes mellitus, type II
20660625 Diabetes mellitus, type II
Insulin resistance
8,605
88900 ACE2 affects_quantity of Tryptophan
88903 ACE2 decreases_activity of abnormal gut flora balance
28069752 Gastrointestinal
Metabolic
9,687
102338 ACE2 increases_quantity of Alamandine
102339 ACE2 decreases_quantity of Angiotensin A
23446738 Cardiovascular disease
11,676
116034 ACE2 increases_activity of viral entry into host cell by functioning as receptor for the virus surface protein spike SARS-S
116055 TMPRSS2 affects_activity of ACE2 via proteolytic processing to improve SARS-S-driven transduction
116056 TMPRSS11D affects_activity of ACE2 via proteolytic processing to improve SARS-S-driven transduction
116057 HPN affects_activity of ACE2 via proteolytic processing
117128 SARS-CoV S protein interacts (colocalizes) with ACE2
117211 ADAM17 decreases_quantity of ACE2 via proteolytic processing
119246 ACE2 increases_quantity of ACE2, soluble via proteolytic activity of ADAM17
24227843 Immunological
SARS-CoV infection
11,680
116080 ACE2 decreases_activity of response to endoplasmic reticulum stress decreasing ER stress via activation of ACE2
116081 ACE2 increases_activity of lipid metabolic process in mouse skeletal muscle in vivo and in vitro
116082 ACE2 increases_activity of IKBKB/NFKB1/IRS1 signaling in mouse skeletal muscle in vivo and in vitro; improving the lipid metabolism
116085 ACE2 increases_activity of mitochondrion ameliorating mitochondrial function via activation of ACE2
116086 ACE2 decreases_quantity of Triacylglycerol in db/db mice; slightly reducing TG content via activation of ACE2
116087 ACE2 decreases_expression of lipogenic proteins in db/db mice; down-regulated expression of skeletal muscle lipogenic proteins via activation of ACE2
116098 ACE2 KO mouse decreases_quantity of ACE2 in the skeletal muscle of the ACE2 KO mice; concerning ACE2 mRNA content
116107 ACE2 increases_expression of PPARA in ACE2-overexpressing C2C12 cells; concerning PPARA mRNA; ACE2 has also been proved to be overexpressed after the adenoviruses infect
116108 ACE2 increases_expression of PPARG in ACE2-overexpressing C2C12 cells; concerning PPARG mRNA; ACE2 has also been proved to be overexpressed after the adenoviruses infect
116109 ACE2 increases_expression of CPT1A in ACE2-overexpressing C2C12 cells; concerning CPT1A mRNA; ACE2 has also been proved to be overexpressed after the adenoviruses infect
116110 ACE2 increases_activity of fatty acid oxidation in ACE2-overexpressing C2C12 cells
116113 ACE2 increases_activity of endoplasmic reticulum playing a notable role on intramuscular fat regulation by improving endoplasmic reticulum and mitochondrial function
116114 ACE2 decreases_activity of response to endoplasmic reticulum stress in ACE2-overexpressing C2C12 cells
116115 ACE2 increases_activity of mitochondrion playing a notable role on intramuscular fat regulation by improving endoplasmic reticulum and mitochondrial function
116142 ACE2 decreases_expression of ACACA in ACE2-overexpressing db/db mice
116143 ACE2 decreases_expression of SREBF1 in ACE2-overexpressing db/db mice
116929 ACE2 decreases_activity of abnormal mitochondrial physiology reasoned via ACE2 KO mice in skeletal muscles
120293 ACE2 decreases_expression of HSPA5 in the skeletal muscle of ACE2 KO mice; GRP78 protein was down-regulated
31775868 Metabolic
Muscular
11,681
116054 ACE2 increases_activity of insulin secretion involved in cellular response to glucose stimulus the presence of H2O2 in INS-1 cells; ACE2 over-expression restored glucose-stimulated insulin secretion
116144 ACE2 increases_expression of mitochondria-related genes in INS-1 cells; when ACE2 is overexpressed
116147 ACE2 increases_activity of increased intracellular calcium ion level in islets from db/db mice; when ACE2 is overexpressed, via increased intracellular calcium influx
116149 ACE2 increases_activity of mitochondrial oxidation in db/db mouse islets; when ACE2 is overexpressed, causing an increase in GSIS
116151 ACE2 affects_activity of mitochondrial metabolism increasing intracellular calcium influx and improving insulin secretion in pancreatic beta-cells
116221 ACE2 increases_activity of positive regulation of mitochondrial membrane potential the presence of H2O2 in INS-1 cells; ACE2 over-expression restored mitochondrial membrane potential (MMP)
116248 ACE2 decreases_activity of abnormal mitochondrial physiology in islets from db/db mice; when ACE2 is overexpressed, restoring impaired mitochondrial oxidation
116273 ACE2 increases_expression of ATP6V1C2 in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
116280 ACE2 increases_expression of COX6C in INS-1 cells treated with ACE2 plasmid; also concerning mRNA, when ACE2 is overexpressed
116282 ACE2 increases_expression of NDUFA2 in INS-1 cells treated with ACE2 plasmid; also concerning mRNA, when ACE2 is overexpressed
116283 ACE2 increases_expression of ATP6V1E2 in INS-1 cells treated with ACE2 plasmid; also concerning mRNA, when ACE2 is overexpressed
116284 ACE2 increases_expression of UQCRH in INS-1 cells treated with ACE2 plasmid; but not concerning the mRNA, when ACE2 is overexpressed
116286 ACE2 increases_expression of ATP5MC3 in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
116287 ACE2 increases_expression of COX6A1 in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
116288 ACE2 increases_expression of ATP6V1G3 in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
116289 ACE2 increases_expression of COX7B in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
116295 ACE2 increases_expression of COX4I1 in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
116296 ACE2 increases_expression of LDHA in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
116298 ACE2 increases_expression of ATP5F1A in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
116299 ACE2 increases_expression of ATP5F1B in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
116301 ACE2 increases_expression of COX5B in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
116303 ACE2 increases_expression of NDUFS3 in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
116306 ACE2 increases_expression of SLC25A10 in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
116308 ACE2 increases_expression of B2M in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
116309 ACE2 increases_expression of ATP5MC2 in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
116311 ACE2 increases_expression of NDUFA7 in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
116312 ACE2 increases_expression of NDUFB3 in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
116313 ACE2 increases_expression of NDUFV2 in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
116314 ACE2 increases_expression of COX8A in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
116317 ACE2 increases_expression of ATP5ME in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
116320 ACE2 increases_expression of NDUFB6 in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
116321 ACE2 increases_expression of COX7A2 in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
116322 ACE2 increases_expression of ATP5PF in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
116325 ACE2 increases_expression of NDUFS5 in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
116326 ACE2 increases_expression of ATP4A in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
116327 ACE2 increases_expression of NDUFA5 in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
116328 ACE2 increases_expression of NDUFB7 in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
116330 ACE2 increases_expression of COX5A in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
116332 ACE2 increases_expression of ATP6V0A2 in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
116334 ACE2 decreases_expression of SDHC in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
116336 ACE2 decreases_expression of UQCRC1 in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
116337 ACE2 decreases_expression of NNT in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
116338 ACE2 decreases_expression of PPA1 in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
116339 ACE2 decreases_expression of NDUFV1 in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
116340 ACE2 decreases_expression of UQCRFS1 in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
116342 ACE2 decreases_expression of NDUFS1 in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
116344 ACE2 decreases_activity of mitochondrial depolarization in INS-1 cells
116349 ACE2 increases_activity of insulin secretion in pancreatic beta-cells
29128354 Metabolic
Diabetes mellitus
11,684
116062 sex affects_activity of ACE2 in cardiac tissue
116065 Estradiol decreases_activity of ACE2 in cardiac tissue
116066 Testosterone increases_activity of ACE2 in cardiac tissue
116069 sex, female decreases_activity of ACE2 in cardiac tissue; compared to male
116070 sex, male increases_activity of ACE2 in cardiac tissue; compared to female
Cardiovascular disease
COVID-19
11,710
116266 ACE2 affects_activity of heart left ventricle hypertrophy
116269 ACE2 affects_activity of Diabetes mellitus, type II
30227878 Diabetes mellitus, type II
Insulin resistance
Cardiovascular disease
11,717
116331 ACE2 is_expressed_in pancreatic islet
116346 ACE2 decreases_quantity of Angiotensin II
116348 ACE2 increases_quantity of Angiotensin (1-7)
116381 ACE2 affects_activity of increased pancreatic islet vascularization
116382 ACE2 increases_activity of insulin secretion involved in cellular response to glucose stimulus
116389 ACE2 affects_activity of Diabetes mellitus, type II
116390 ACE2 affects_activity of type B pancreatic cell proliferation
116395 ACE2 affects_expression of AGTR1 in pancreas
116396 ACE2 affects_activity of response to oxidative stress in pancreas
116407 ACE inhibitor increases_activity of ACE2 in pancreatic islets
116408 ACE2 increases_activity of mitochondrion in pancreatic beta cells
30404071 Diabetes mellitus, type II
Insulin resistance
11,748
116293 SARS-CoV-2 interacts (colocalizes) with ACE2
116365 ACE2 increases_quantity of Angiotensin (1-9)
116366 ACE2 decreases_quantity of Angiotensin I
116369 ACE2 increases_quantity of Angiotensin (1-7)
116370 ACE2 decreases_quantity of Angiotensin II
116388 ADAM17 affects_activity of ACE2 via proteolysis
116406 SARS virus decreases_activity of ACE2 by binding to ACE2
116440 SARS virus decreases_expression of ACE2
32333398 COVID-19
11,756
116443 ACE2 is_expressed_in cardiac muscle fiber
116444 ACE2 is_expressed_in alveolar cell type II
116635 ACE2 decreases_activity of lung injury
32333398 COVID-19
11,758
116457 TGFB1 decreases_expression of ACE2 in A549 cells; via inhibiting SIRT1 expression
116458 TGFB1 decreases_quantity of ACE2 in A549 cells; via inhibiting SIRT1 expression
116460 SIRT1 increases_expression of ACE2 in A549 cells
31387171 Pulmonary fibrosis, idiopathic
11,776
116580 ACE2 decreases_quantity of Angiotensin I
116581 ACE2 increases_quantity of Angiotensin (1-9)
116588 ACE2 decreases_quantity of Angiotensin II
116589 ACE2 increases_quantity of Angiotensin (1-7)
116609 ACE2 decreases_activity of Nephropathy, diabetic
116613 ACE2 affects_activity of Cardiomyopathy, diabetic
116626 ACE2 affects_activity of insulin secretion in pancreas
23463883 Diabetes mellitus, type II
Insulin resistance
Cardiovascular disease
11,777
116541 embryo development affects_expression of ACE2
26029927 Diabetes mellitus, type II
Insulin resistance
11,778
116650 SARS-CoV S protein interacts (colocalizes) with ACE2
116651 SARS-CoV-2 S protein interacts (colocalizes) with ACE2
116653 ACE inhibitor increases_quantity of ACE2
116654 Angiotensin II type 1 receptor blocker increases_quantity of ACE2
116655 SARS-CoV decreases_expression of ACE2
116656 Ibuprofen increases_quantity of ACE2
116657 Thiazolidinedione increases_quantity of ACE2
32278764 Diabetes mellitus, type II
Insulin resistance
COVID-19
11,821
116756 SARS-CoV-2 interacts (colocalizes) with ACE2
116757 ACE2 decreases_quantity of Angiotensin II
116758 ACE2 increases_quantity of Angiotensin (1-7)
116761 SARS-CoV S protein interacts (colocalizes) with ACE2
116763 ACE2 affects_activity of SARS-CoV infection
116764 SARS-CoV infection decreases_quantity of ACE2 in lung
116768 Influenza A H5N1 infection decreases_expression of ACE2 in lung
116771 Angiotensin II type 1 receptor blocker increases_quantity of ACE2
116774 ACE inhibitor NOT decreases_activity of ACE2
32341442 COVID-19
11,822
116784 ACE2 decreases_quantity of Angiotensin II
116790 ACE2 increases_quantity of Angiotensin (1-7)
116793 ACE2 increases_quantity of Angiotensin (1-9)
116794 ACE2 decreases_quantity of Angiotensin I
32336612 COVID-19
11,823
116801 Cl- increases_activity of ACE2
116803 Fluoride increases_activity of ACE2
116804 ACE2 decreases_quantity of Angiotensin II
116809 ACE2 increases_quantity of Angiotensin (1-7)
116812 ACE2 decreases_quantity of Apelin-13
116814 ACE2 decreases_quantity of Apelin-36
116846 ACE2 decreases_quantity of Dynorphin A (1-13)
116849 ACE2 increases_quantity of Dynorphin A (1-12)
116852 ACE2 decreases_quantity of des-Arg9-bradykinin
116855 ACE2 decreases_quantity of Neurotensin 1-8
116859 ACE2 decreases_quantity of Angiotensin I with low activity as for angiotensin II
11815627 Metabolic
11,826
116858 SARS-CoV-2 interacts (colocalizes) with ACE2
32015507 COVID-19
11,827
116824 SARS-CoV-2 S protein interacts (colocalizes) with ACE2
32142651 COVID-19
11,828
116825 SARS-CoV-2 S protein interacts (colocalizes) with ACE2
32155444 COVID-19
11,829
116826 SARS-CoV S protein interacts (colocalizes) with ACE2
14647384 SARS-CoV infection
11,830
116827 SARS-CoV interacts (colocalizes) with ACE2
116880 SARS-CoV infection decreases_expression of ACE2
116881 SARS-CoV S protein decreases_expression of ACE2
119082 SARS-CoV infection decreases_quantity of ACE2 in the lung
16007097 SARS-CoV infection
11,837
116869 ACE2 decreases_quantity of Angiotensin I
116870 ACE2 increases_quantity of Angiotensin (1-9)
10969042 Endocrine
11,841
116900 ACE2 decreases_activity of renin-angiotensin system ACE2 is a negative regulator of the renin-angiotensin system (RAS)
116901 ACE2 is_expressed_in lung
116902 ACE2 increases_activity of SARS-CoV-2 infection as the SARS-CoV-2 receptor provides a critical link between immunity, inflammation, ACE2, and cardiovascular disease
116903 SARS-CoV-2 infection decreases_activity of ACE2 driven by endocytosis and activation of proteolytic cleavage and processing
116904 ACE2 affects_activity of gut dysbiosis
116905 ACE2 increases_activity of viral entry into host cell at the epithelial surface
116906 ACE2 decreases_activity of SARS-induced tissue injuries
116907 ACE2 increases_activity of amino acid transport
116908 ACE2 interacts (colocalizes) with SARS-CoV-2 ACE2 is a SARS-CoV-2 receptor
116909 ACE2 interacts (colocalizes) with SARS-CoV ACE2 is a SARS-CoV receptor
116910 ACE2 is_expressed_in kidney
116911 ACE2 is_expressed_in gut
116912 ACE2 is_expressed_in cardiovascular system
116913 ACE2 is_expressed_in central nervous system
116914 ACE2 is_expressed_in adipose tissue
116916 ACE2 affects_activity of regulation of vascular permeability
116918 ADAM17 increases_processing of ACE2 via proteolytic cleavage
116922 endocytosis decreases_activity of ACE2 concerning ACE2-mediated cardiovascular protection
116955 ACE2 increases_activity of cardiovascular protection this is lost following endocytosis of the enzyme
116962 SARS-CoV S protein decreases_expression of ACE2 concerning downregulation of surface ACE2 expression
116963 SARS-CoV-2 S protein decreases_expression of ACE2 concerning downregulation of surface ACE2 expression
32264791 COVID-19
SARS-CoV infection
11,842
116928 ACE2 increases_quantity of Angiotensin (1-7) in kidney ; at neutral to basic pH
23392115 Endocrine
11,846
121044 ACE2 interacts (colocalizes) with SARS-CoV S protein
121117 ACE2 increases_activity of SARS-CoV infection
121118 SARS-CoV infection decreases_expression of ACE2
121119 SARS-CoV S protein decreases_expression of ACE2
19411314 SARS-CoV infection
11,847
133580 SARS-CoV S protein decreases_quantity of ACE2 in the cytoplasm
18490652 SARS-CoV infection
11,848
116997 SARS-CoV S protein decreases_quantity of ACE2
19864379 SARS-CoV infection
11,849
116999 Calmodulin interacts (colocalizes) with ACE2 decreased by calmodulin inhibitors
18070603 SARS-CoV infection
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