Search Results for "Pioglitazone" - 144 interactions found in 25 entries.

Entry-ID
Interactor1 (Subject) Interaction type Interactor2 (Object) additional information
PubMed-ID
Diseases
486
2283 Pioglitazone increases_activity of AMPK in liver and adipose tissue; in vivo
2289 Pioglitazone increases_phosphorylation of AMPK alpha chain in liver
2290 Pioglitazone decreases_activity of ACACB in liver
2291 Pioglitazone decreases_quantity of Malonyl-CoA in liver
2292 Pioglitazone increases_phosphorylation of AMPK alpha chain in subcutaneous adipose tissue
2293 Pioglitazone decreases_activity of ACACA in subcutaneous adipose tissue
2294 Pioglitazone decreases_quantity of Malonyl-CoA in subcutaneous adipose tissue
2295 Pioglitazone decreases_quantity of ATP in liver
2296 Pioglitazone increases_quantity of ADP in liver
2297 Pioglitazone increases_quantity of AMP in liver
14733947 Diabetes mellitus, type II
Insulin resistance
488
2301 Pioglitazone increases_quantity of ADIPOQ in blood
2302 Pioglitazone affects_phosphorylation of AKT1 in muscle
2315 Pioglitazone decreases_quantity of Triacylglycerol in blood
2316 Pioglitazone decreases_quantity of Fatty acid in blood
2317 Pioglitazone decreases_quantity of LEP in blood
2318 Pioglitazone decreases_quantity of Insulin in blood
2320 Pioglitazone NOT affects_quantity of Glucose in blood
2321 Pioglitazone increases_quantity of Triacylglycerol in blood
2322 Pioglitazone NOT affects_quantity of Glycogen in muscle, in liver
12754 Pioglitazone increases_activity of increased insulin sensitivity
12446579 Diabetes mellitus, type II
Insulin resistance
1,203
8032 Pioglitazone decreases_expression of CCR2 in obese mice
8033 Pioglitazone decreases_expression of CCL2 in obese mice
8034 Pioglitazone decreases_expression of CCL7 in obese mice
8035 Pioglitazone NOT decreases_expression of CCL8 in obese mice
16341265 Diabetes mellitus, type II
Obesity
Insulin resistance
1,504
10654 Pioglitazone affects_activity of insulin secretion in pancreas, in pancreatic islets; if IL1B or glucose is increased
10656 Pioglitazone affects_activity of type B pancreatic cell apoptotic process in pancreas, in pancreatic islets; if IL1B or glucose is increased
10659 Pioglitazone affects_activity of interleukin-1 beta secretion in pancreas, in pancreatic islets; if glucose level is high
10662 Pioglitazone affects_activity of NF-kappaB complex in pancreas, in pancreatic beta cells; if glucose level is high
15472206 Diabetes mellitus, type II
Insulin resistance
1,567
11202 Pioglitazone increases_quantity of HMW adiponectin complex in adipose tissue
11210 Pioglitazone NOT affects_expression of ADIPOQ in adipose tissue
19088251 Diabetes mellitus, type II
Insulin resistance
2,278
19534 Pioglitazone affects_quantity of Amyloid beta peptide (42)
19535 Pioglitazone decreases_activity of microglial cell activation in aged APPV717I transgenic mice
19536 Pioglitazone decreases_activity of astrocyte activation in aged APPV717I transgenic mice
19537 Pioglitazone decreases_quantity of amyloid beta deposits in aged APPV717I transgenic mice
19538 Pioglitazone decreases_activity of cerebral dysfunction in mouse models overexpressing the Swedish and Indiana mutations of human APP
19539 Pioglitazone affects_activity of microglial cell activation in mouse models overexpressing the Swedish and Indiana mutations of human APP
19540 Pioglitazone affects_activity of response to oxidative stress in mouse models overexpressing the Swedish and Indiana mutations of human APP
19541 Pioglitazone affects_activity of innervation overexpressing the Swedish and Indiana mutations of human APP
19542 Pioglitazone decreases_expression of BACE1 in APP transgenic mice
21345168 Alzheimer disease
2,402
21394 Pioglitazone decreases_activity of Insulin resistance
21395 Pioglitazone decreases_activity of increased circulating insulin level in blood plasma
21396 Pioglitazone decreases_quantity of Fatty acid in blood plasma
21397 Pioglitazone decreases_quantity of Triacylglycerol in blood plasma
21398 Pioglitazone increases_activity of increased food intake
21399 Pioglitazone increases_activity of Obesity
21400 Pioglitazone increases_activity of CS in adipose tissue
21401 Pioglitazone increases_activity of FASN in adipose tissue
21402 Pioglitazone increases_activity of lipid metabolic process in adipose tissue
21403 Pioglitazone increases_quantity of abdominal adipose tissue
11473050 Diabetes mellitus, type II
Obesity
Insulin resistance
2,404
21407 Pioglitazone increases_quantity of 2-Deoxy-D-glucose after TNF treatment
21409 Pioglitazone increases_quantity of Insulin receptor after TNF treatment
21410 Pioglitazone increases_phosphorylation of Insulin receptor after TNF treatment, at Tyr residues
21411 Pioglitazone increases_phosphorylation of IRS1 after TNF treatment, at Tyr residues
21412 Pioglitazone increases_activity of Phosphatidylinositol 3-kinase after TNF treatment
11334412 Diabetes mellitus, type II
Insulin resistance
2,405
21418 Pioglitazone decreases_expression of TLR2 in monocytes
21419 Pioglitazone decreases_expression of TLR4 in monocytes
21420 Pioglitazone decreases_activity of inflammatory response in monocytes
21421 Pioglitazone decreases_quantity of IL1B in monocytes; after induction with Pam or LPS
21422 Pioglitazone decreases_quantity of IL6 in monocytes; after induction with Pam or LPS
21423 Pioglitazone decreases_quantity of CCL2 in monocytes; after induction with Pam or LPS
21424 Pioglitazone decreases_quantity of TNF in monocytes; after induction with Pam or LPS
21425 Pioglitazone decreases_activity of NF-kappaB complex in monocytes; after induction with Pam or LPS
19389833 Diabetes mellitus, type II
Insulin resistance
2,406
21426 Pioglitazone decreases_expression of TLR2 in peritoneal macrophages
21427 Pioglitazone decreases_expression of TLR4 in peritoneal macrophages
21428 Pioglitazone decreases_activity of toll-like receptor signaling pathway in peritoneal macrophages
21429 Pioglitazone decreases_phosphorylation of IRAK1 in peritoneal macrophages
21430 Pioglitazone decreases_phosphorylation of p38 MAPK in peritoneal macrophages
21431 Pioglitazone decreases_phosphorylation of MAPK3/1 in peritoneal macrophages
21432 Pioglitazone decreases_expression of MYD88 in peritoneal macrophages
21433 Pioglitazone decreases_expression of TICAM1 in peritoneal macrophages
21434 Pioglitazone decreases_quantity of RELA in peritoneal macrophages
21435 Pioglitazone increases_activity of PPARG in peritoneal macrophages
21436 Pioglitazone decreases_activity of NF-kappaB complex in peritoneal macrophages
21437 Pioglitazone decreases_activity of inflammatory response
21438 Pioglitazone decreases_quantity of IL1B
21439 Pioglitazone decreases_quantity of IL6
21440 Pioglitazone decreases_quantity of CCL2
21441 Pioglitazone decreases_quantity of TNF
19389833 Diabetes mellitus, type II
Insulin resistance
2,876
26480 Pioglitazone decreases_expression of RETN in adipose tissue
11201732 Diabetes mellitus, type II
Obesity
Insulin resistance
3,084
28311 Pioglitazone decreases_activity of neuron death in the substantia nigra pars compacta
28312 Pioglitazone decreases_activity of microglial cell activation in the substantia nigra pars compacta
12153485 Diabetes mellitus, type II
Parkinson disease
Insulin resistance
3,085
28315 Pioglitazone decreases_activity of neuron death
28316 Pioglitazone decreases_activity of microglial cell activation in striatum, in substantia nigra pars compacta
28317 Pioglitazone decreases_quantity of NOS2 in striatum, in substantia nigra pars compacta
28318 Pioglitazone decreases_quantity of GFAP in striatum, in substantia nigra pars compacta
28319 Pioglitazone increases_activity of PPARG
28320 Pioglitazone increases_activity of NFKBIA
28321 Pioglitazone decreases_activity of NF-kappaB complex
28322 Pioglitazone decreases_activity of NOS2
28324 Pioglitazone decreases_activity of inflammatory response
14690537 Diabetes mellitus, type II
Parkinson disease
Insulin resistance
3,091
28381 Pioglitazone decreases_activity of MAOB
18332857 Diabetes mellitus, type II
Insulin resistance
3,649
34748 Pioglitazone affects_activity of PPARG
34750 Pioglitazone decreases_quantity of NOS2 in primary Schwann cells; Inhibition of LPS-induced iNOS production by several different pathways
34754 GW9662 decreases_activity of Pioglitazone
19942298 Multiple sclerosis
3,747
36432 Pioglitazone NOT decreases_activity of hyperglycemia in blood; in streptozotocin-induced diabetic rats
36433 Pioglitazone NOT decreases_quantity of Glycated hemoglobin in blood; in streptozotocin-induced diabetic rats
36434 Pioglitazone decreases_activity of albuminuria
36435 Pioglitazone decreases_activity of renal glomerulus hypertrophy
36436 Pioglitazone decreases_expression of TGFB
36438 Pioglitazone decreases_expression of COL4A
36439 Pioglitazone decreases_expression of ICAM1
36441 Pioglitazone decreases_activity of macrophage migration
36442 Pioglitazone decreases_activity of NF-kappaB complex in kidney
17190910 Diabetes mellitus, type II
Insulin resistance
Nephropathy, diabetic
3,749
36460 Pioglitazone increases_activity of albuminuria
36461 Pioglitazone decreases_quantity of CCL2 in urine
36463 Pioglitazone decreases_activity of glomerulosclerosis
36465 Pioglitazone decreases_expression of NFKB1 in kidney
36467 Pioglitazone decreases_expression of CCL2 in kidney
36468 Pioglitazone decreases_expression of TGFB1 in kidney
36469 Pioglitazone decreases_expression of SERPINE1 in kidney
36471 Pioglitazone decreases_expression of VEGFA in kidney
36474 Pioglitazone decreases_activity of macrophage migration into kidney
36475 Pioglitazone decreases_activity of NF-kappaB complex in kidney
36476 Pioglitazone decreases_expression of COL4A1 in kidney
36478 Pioglitazone decreases_activity of inflammatory response
18388116 Diabetes mellitus, type II
Insulin resistance
Nephropathy, diabetic
3,752
36499 Pioglitazone NOT affects_activity of increased circulating homocysteine level in blood plasma; in diabetic mice
36501 Pioglitazone decreases_activity of decreased renal glomerular filtration rate in diabetic mice
36503 Pioglitazone decreases_expression of NOX4 in kidney; in diabetic mice
36505 Pioglitazone increases_expression of NOS3 in kidney; in diabetic mice
36507 Pioglitazone decreases_expression of HAVCR1 in kidney; in diabetic mice
36510 Pioglitazone decreases_activity of MMP2 in blood plasma, in kidney; in diabetic mice
36511 Pioglitazone decreases_activity of MMP9 in blood plasma; in diabetic mice
36513 Pioglitazone decreases_quantity of Homocysteine in kidney, in renal glomerulus; in diabetic mice
36515 Pioglitazone increases_quantity of NO in kidney, in renal glomerulus; in diabetic mice
16609149 Diabetes mellitus, type II
Insulin resistance
4,329
44325 Pioglitazone increases_activity of PPARG in NIH-3T3 cells
22872237 Metabolic
Lipodystrophy
4,362
44533 Pioglitazone interacts (colocalizes) with PPARG
44534 Pioglitazone increases_activity of PPARG
22654722 Alzheimer disease
Metabolic
4,523
45374 Pioglitazone decreases_quantity of O2- in SMCs (smooth muscle cells), via activation of PPARgamma
16580578 Metabolic
Cardiovascular disease
4,547
45375 Pioglitazone increases_activity of PPARG
16580578 Metabolic
Cardiovascular disease
4,904
48555 CYP2C8 decreases_quantity of Pioglitazone
48556 CYP3A4 decreases_quantity of Pioglitazone
48557 Gemfibrozil affects_activity of Pioglitazone
48558 Itraconazole NOT affects_activity of Pioglitazone
48559 Trimethoprim affects_activity of Pioglitazone
48561 Pioglitazone NOT affects_activity of Glipizide
48573 Pioglitazone NOT affects_activity of Oral contraceptive
48576 Pioglitazone NOT affects_activity of Repaglinide
48577 Pioglitazone NOT affects_activity of Warfarin
48597 Pioglitazone decreases_activity of SLCO1B1
48631 Linagliptin NOT affects_activity of Pioglitazone
48658 Pioglitazone NOT affects_activity of Vildagliptin
22475684 Diabetes mellitus, type II
Insulin resistance
4,975
49213 pioglitazone increases_quantity of ABCA1 during LDLox loading
49217 pioglitazone increases_activity of PPARG
24394674 Cardiovascular disease
Atherosclerosis
6,831
66479 pioglitazone decreases_activity of CISD2
23717386 Diabetes mellitus, type II
Insulin resistance
Wolfram syndrome 2
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