Search Results for "Metformin" - 829 interactions found in 124 entries.

Entry-ID
Interactor1 (Subject) Interaction type Interactor2 (Object) additional information
PubMed-ID
Diseases
341
1339 Metformin decreases_activity of Fatty liver disease, nonalcoholic in ob/ob mice
1343 Metformin decreases_activity of SREBF1 in liver
1344 Metformin decreases_expression of TNF in liver
1348 Metformin decreases_expression of UCP2 in liver
1356 Metformin decreases_expression of FASN in liver
10973319 Diabetes mellitus, type II
Insulin resistance
Fatty liver disease, nonalcoholic
346
1396 Metformin increases_activity of AMPK in liver; via phosphorylation of Thr172 of AMPK alpha chain
1398 Metformin increases_phosphorylation of AMPK in liver; at Thr172 of AMPK alpha chain
1406 Metformin decreases_activity of ACACA in liver
1410 Metformin increases_activity of fatty acid beta-oxidation in liver
1435 Metformin decreases_expression of FASN in liver
1436 Metformin decreases_expression of THRSP in liver
1437 Metformin NOT affects_activity of HMGCR in liver
1442 Metformin decreases_activity of hepatic glucose production in liver; via AMPK activation
1466 Metformin increases_quantity of (R)-3-Hydroxybutanoate in liver
12346 Metformin decreases_expression of SREBF1 in liver
12347 Metformin decreases_expression of FASN in liver
12348 Metformin decreases_expression of THRSP in liver
11602624 Diabetes mellitus, type II
Insulin resistance
Fatty liver disease, nonalcoholic
361
1463 Metformin increases_activity of AMPK in epitrochlearis muscle
11602624 Diabetes mellitus, type II
Insulin resistance
459
2052 STK11 affects_activity of Metformin
2053 Metformin increases_phosphorylation of AMPK in liver; if STK11 is present
2054 Metformin decreases_quantity of Glucose in blood; in wild-type mice on high-fat diet, in ob/ob mice
2059 AMPK affects_activity of Metformin
12753 Metformin decreases_activity of gluconeogenesis in liver
16308421 Diabetes mellitus, type II
Peutz-Jeghers syndrome
Insulin resistance
468
2120 Metformin NOT affects_quantity of Triacylglycerol in blood
2123 Metformin NOT affects_quantity of Fatty acid in blood
2126 Metformin NOT affects_activity of glucose metabolic process after lipid infusion
2183 Metformin NOT affects_expression of FBP in liver; after lipid infusion
2189 Metformin NOT affects_expression of PCK1 in liver; after lipid infusion
2196 Metformin affects_activity of hepatic glucose production
2197 Metformin increases_quantity of Glycogen in liver; during lipid infusion and clamp
2198 Metformin increases_activity of AMPK in liver
2200 Metformin increases_phosphorylation of ACACB in liver
2202 Metformin NOT increases_expression of AMPK alpha chain in liver
2225 Metformin NOT increases_quantity of ACACB in liver
2231 Metformin increases_quantity of NFKBIA in liver
2245 Metformin NOT affects_phosphorylation of IRS1 in liver
2246 Metformin NOT affects_expression of IRS1 in liver
2247 Metformin decreases_expression of MAPK8 in liver
2251 Metformin decreases_expression of MAPK9 in liver
2252 Metformin decreases_activity of Insulin resistance in liver; if acute lipid-induced insulin resistance
15561958 Diabetes mellitus, type II
Insulin resistance
480
2255 Metformin increases_activity of AMPK in skeletal muscle; in the absence of an increase in the AMP:ATP ratio
11994296 Diabetes mellitus, type II
Insulin resistance
549
2821 Metformin decreases_activity of Cancer
2823 Metformin increases_activity of AMPK
20028864 Breast cancer
Colorectal cancer
Diabetes mellitus, type II
Obesity
Insulin resistance
Metabolic syndrome
559
2995 Metformin increases_activity of AMPK in MEF cells
2996 Metformin NOT increases_activity of AMPK in LKB1-deficient MEF cells
14985505 Diabetes mellitus, type II
Peutz-Jeghers syndrome
Cancer
Insulin resistance
613
3245 Metformin increases_quantity of Amyloid beta peptide (40) in a dose-dependent manner
3253 Metformin increases_quantity of Amyloid beta peptide (42) in a dose-dependent manner
3254 Metformin decreases_quantity of sAPP-alpha
3255 Metformin increases_quantity of APP (C-terminal fragment)
3256 Metformin increases_quantity of CTF-beta
3257 Metformin NOT affects_quantity of PSEN1
3258 Metformin NOT affects_quantity of PSEN1 (N-terminal fragment)
3261 Metformin NOT affects_activity of MME
3262 Metformin NOT affects_quantity of MME
3263 Metformin NOT affects_activity of IDE
3264 Metformin NOT affects_quantity of IDE
3265 Metformin NOT affects_activity of beta-amyloid catabolic process
3266 Metformin NOT affects_expression of APP
3268 Metformin affects_quantity of APP
3274 Metformin increases_activity of AMPK in vitro and in vivo
3295 Metformin increases_activity of ACACA in brain frontal region; in wild-type C57B6 mice; in vivo
3296 Metformin increases_activity of BACE1 in brain frontal region; in wild-type C57B6 mice; in vivo
3298 Metformin increases_activity of Insulin insulin's beta-amyloid lowering effect
3304 Metformin affects_activity of Alzheimer disease via BACE1 expression
12924 Compound C affects_activity of Metformin via AMPK
19237574 Diabetes mellitus, type II
Insulin resistance
1,408
9902 Metformin decreases_quantity of MIF in blood; in obese patients
9903 Metformin decreases_activity of Cardiovascular disease in type 2 diabetics
15472203 Diabetes mellitus, type II
Obesity
Insulin resistance
Cardiovascular disease
1,574
11273 Metformin increases_activity of AMPK in umbilical vein endothelial cells
11286 Metformin decreases_activity of NF-kappaB complex in umbilical vein endothelial cells
11289 Metformin increases_activity of ACAC in umbilical vein endothelial cells
11290 Metformin decreases_activity of I-kappa-B kinase complex in umbilical vein endothelial cells
11291 Metformin decreases_expression of VCAM1 in umbilical vein endothelial cells
11292 Metformin decreases_expression of SELE in umbilical vein endothelial cells
11293 Metformin decreases_expression of ICAM1 in umbilical vein endothelial cells
11294 Metformin decreases_expression of CCL2 in umbilical vein endothelial cells
11300 Metformin decreases_activity of inflammatory response in umbilical vein endothelial cells
16636195 Diabetes mellitus, type II
Insulin resistance
2,204
18475 Metformin NOT affects_quantity of TNF in streptozotocin-diabetic rats
21655062 Diabetes mellitus, type II
Insulin resistance
2,514
23415 Metformin affects_activity of TCF7L2 rs7903146
23420 Metformin affects_activity of TCF7L2 rs12255372
16855264 Diabetes mellitus, type II
Insulin resistance
2,517
23439 TCF7L2 rs1225537 NOT affects_activity of Metformin the risk allele is T
23441 TCF7L2 rs7903146 NOT affects_activity of Metformin the risk allele is T
17519421 Diabetes mellitus, type II
Insulin resistance
2,556
23809 ATM rs11212617 affects_activity of Metformin in Europeans, the effective allele is C
21186350 Diabetes mellitus, type II
Insulin resistance
2,558
23821 ATM affects_activity of Metformin
21186350 Diabetes mellitus, type II
Ataxia-telangiectasia
Insulin resistance
2,580
24317 KCNJ11 rs5219 decreases_activity of Metformin
17259403 Diabetes mellitus, type II
Insulin resistance
2,581
24319 ATM rs11212617 affects_activity of Metformin the effective allele is C
21845381 Diabetes mellitus, type II
Insulin resistance
2,784
25723 Metformin increases_quantity of Glucagon-like peptide 1 in blood plasma
25727 Metformin NOT affects_quantity of GIP in blood plasma
25728 Metformin NOT affects_quantity of Peptide YY in blood plasma
25730 Metformin increases_activity of improved glucose tolerance
25731 Metformin increases_activity of gastric emptying
25734 Metformin increases_expression of GLP1R in pancreas, in pancreatic islets
25736 Metformin increases_expression of GIPR in pancreas, in pancreatic islets
25738 Metformin increases_expression of PPARA in pancreas, in pancreatic islets
20972533 Diabetes mellitus, type II
Insulin resistance
2,808
25895 Metformin increases_activity of HK1 in skeletal muscle, in liver, in adipose tissue; in streptozotocin-induced diabetic mice
25896 Metformin increases_activity of PFKM in skeletal muscle, in liver, in adipose tissue; in streptozotocin-induced diabetic mice
25898 Metformin decreases_activity of hyperglycemia in streptozotocin-induced diabetic mice
25899 Metformin decreases_activity of decreased circulating lactic acid levels in blood; in streptozotocin-induced diabetic mice
25900 Metformin affects_activity of canonical glycolysis
20117072 Diabetes mellitus, type II
Insulin resistance
2,814
26054 Metformin increases_activity of AMPK
26055 Metformin decreases_quantity of AKT1
26056 Metformin decreases_quantity of Insulin
21912508 Diabetes mellitus, type II
Cancer
Insulin resistance
Metabolic syndrome
2,829
26123 Metformin decreases_activity of Mitochondrial respiratory chain complex I
10617608 Diabetes mellitus, type II
Insulin resistance
2,831
26127 Metformin decreases_activity of hepatic glucose production in liver
26128 Metformin decreases_activity of hyperglycemia in blood plasma; after fasting
26131 Metformin decreases_activity of gluconeogenesis in liver
11118008 Diabetes mellitus, type II
Insulin resistance
2,836
26175 Metformin decreases_activity of Cancer
19564453 Diabetes mellitus, type II
Cancer
Insulin resistance
2,837
26176 Metformin decreases_activity of Cancer in diabetic patients
20947488 Diabetes mellitus, type II
Cancer
Insulin resistance
2,838
26178 Metformin decreases_activity of Cancer in diabetic patients
19918015 Diabetes mellitus, type II
Cancer
Insulin resistance
2,839
26181 Metformin decreases_activity of Cancer in diabetic patients
19082520 Diabetes mellitus, type II
Cancer
Insulin resistance
2,840
26192 Metformin decreases_activity of Cancer in diabetic patients
16443869 Diabetes mellitus, type II
Cancer
Insulin resistance
2,842
26194 Metformin decreases_expression of PDE3B
26195 Metformin decreases_expression of SSR3
26196 Metformin decreases_expression of TP53
26197 Metformin decreases_expression of CCDC14
26198 Metformin affects_activity of tumor necrosis factor-mediated signaling pathway
26199 Metformin increases_expression of TGFB1
26200 Metformin increases_expression of MAP3K1
26201 Metformin decreases_expression of CDC42
26202 Metformin affects_activity of TOR signaling
26203 Metformin affects_activity of AMPK signaling pathway
26204 Metformin decreases_expression of TP53
26205 Metformin decreases_expression of BRCA1
26206 Metformin decreases_activity of cell cycle
26207 Metformin decreases_activity of Breast cancer
21655990 Breast cancer
Diabetes mellitus, type II
Insulin resistance
2,843
26209 Metformin decreases_activity of translational initiation
26210 Metformin decreases_activity of MTOR
26211 Metformin decreases_phosphorylation of RPS6KB1
26212 Metformin decreases_phosphorylation of RPS6
26213 Metformin decreases_phosphorylation of EIF4EBP1
26214 Metformin affects_activity of AMPK
26221 Metformin increases_activity of AMPK
18006825 Diabetes mellitus, type II
Cancer
Insulin resistance
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