Search Results for "Lithium" - 280 interactions found in 84 entries.

Entry-ID
Interactor1 (Subject) Interaction type Interactor2 (Object) additional information
PubMed-ID
Diseases
122
494 Lithium decreases_activity of GSK3B
570 Lithium increases_activity of canonical Wnt signaling pathway
583 Lithium decreases_quantity of AXIN1
588 Lithium decreases_quantity of MAPT-phos
864 Lithium affects_activity of Amyloid beta peptide
64421 Lithium decreases_phosphorylation of MAPT
11527574 Alzheimer disease
240
998 Lithium decreases_expression of GSK3B in embryonic (E18) and adult rat brain
18932008 Alzheimer disease
474
2203 Lithium decreases_activity of Amyotrophic lateral sclerosis in G93A mutant mice
2204 Lithium increases_quantity of interneuron in G93A mutant mice
2209 Lithium decreases_quantity of SOD1 protein aggregates in G93A mutant mice, counted in lamina VII
2226 Lithium decreases_activity of vacuole organization in mitochondria
2232 Lithium increases_quantity of autophagic vacuole
2233 Lithium increases_activity of autophagy
2237 Lithium decreases_activity of motor neuron degeneration
18250315 Amyotrophic lateral sclerosis
478
2238 Lithium decreases_activity of Amyotrophic lateral sclerosis
18250315 Amyotrophic lateral sclerosis
580
3093 Lithium decreases_activity of GSK3A
3095 Lithium decreases_expression of Amyloid beta peptide
3096 Lithium decreases_quantity of Amyloid beta peptide in brain; of mice
3097 Lithium decreases_activity of GSK3B
3103 Lithium affects_processing of APP
12761548 Alzheimer disease
645
3448 Lithium affects_activity of GSK3B
3449 Lithium decreases_quantity of Amyloid beta peptide
41789 Lithium affects_activity of Alzheimer disease
14651959 Alzheimer disease
672
3593 Lithium affects_activity of Status epilepticus
20149694 Status epilepticus
717
4011 Lithium affects_processing of APP
4016 Lithium decreases_quantity of Amyloid beta peptide (40)
10902 Lithium decreases_quantity of Amyloid beta peptide (42)
15170327 Alzheimer disease
718
4013 Lithium affects_processing of APP
4018 Lithium decreases_quantity of Amyloid beta peptide (40)
4028 Lithium decreases_quantity of amyloid beta deposits in hippocampus
5839 Lithium decreases_quantity of Amyloid beta peptide (42)
15170327 Alzheimer disease
1,089
6902 Lithium decreases_activity of Amyotrophic lateral sclerosis
6904 Lithium decreases_activity of astrocyte activation
6905 Lithium increases_quantity of interneuron
6907 Lithium increases_activity of autophagy
6908 Lithium decreases_activity of Kainic acid
18250315 Amyotrophic lateral sclerosis
1,090
6903 Lithium decreases_activity of Amyotrophic lateral sclerosis
18250315 Amyotrophic lateral sclerosis
1,093
6942 Lithium increases_quantity of HSPA5
6943 Lithium increases_quantity of HSP90B1
6944 Lithium increases_quantity of CALR
6951 Lithium NOT affects_activity of cell death
16236328 Bipolar disorder
Amyotrophic lateral sclerosis
1,841
13938 Lithium decreases_activity of GSK3B
16611012 Alzheimer disease
1,866
14126 Lithium decreases_activity of Bipolar disorder
14129 Lithium decreases_activity of GSK3B
14135 Lithium decreases_activity of ARRB2
19754466 Bipolar disorder
2,909
26712 Lithium decreases_activity of GSK3B
20615469 Alzheimer disease
Tauopathy
3,175
29137 Lithium increases_quantity of period of locomotor rhythm
29138 Lithium increases_expression of PER2
29139 Lithium increases_quantity of oscillation amplitude of central pacemaker
29140 Lithium increases_quantity of oscillation amplitude of peripheral pacemaker
22428012 Bipolar disorder
Circadian rhythm
4,266
43588 Lithium decreases_activity of Alzheimer disease by down-regulation of TNF
43593 Lithium decreases_expression of TNF
43631 Lithium decreases_expression of IL1B if coadministered with antipsychotics
21399480 Alzheimer disease
5,448
53176 Lithium increases_activity of DNA biosynthetic process in pancreas, in pancreatic islets; via Wnt signaling
23650507 Diabetes mellitus, type II
Insulin resistance
6,487
61547 Lithium decreases_activity of Bipolar disorder
61548 Lithium increases_quantity of IL10
61550 Lithium increases_quantity of IL4
61551 Lithium decreases_quantity of IL2
61553 Lithium decreases_quantity of TNF in rat primary glial cells
61554 Lithium decreases_quantity of IL1B in rat primary glial cells
61555 Lithium decreases_quantity of Prostaglandin E2 in rat primary glial cells
61556 Lithium decreases_quantity of NO in rat primary glial cells
61557 Lithium decreases_expression of PTGS2
61558 Lithium decreases_expression of NOS2
61559 Lithium decreases_quantity of TNF in serum; if expression has been upregulated in a CLP-induced lung injury model
61560 Lithium decreases_quantity of IL1B in serum; if expression has been upregulated in a CLP-induced lung injury model
61561 Lithium decreases_quantity of IL6 in serum; if expression has been upregulated in a CLP-induced lung injury model
61562 Lithium increases_activity of SOD in lung tissue of a CLP-induced lung injury model
61563 Lithium decreases_activity of inflammatory response in lung tissue of a CLP-induced lung injury model
61576 Lithium decreases_activity of respiratory distress in lung tissue of a CLP-induced lung injury model
61578 Lithium decreases_activity of cytokine production in serum; if expression of cytokines has been upregulated in a CLP-induced lung injury model
61580 Lithium decreases_quantity of 8-Isoprostane in lung tissue of a CLP-induced lung injury model
61583 Lithium decreases_quantity of Glutathione in lung tissue of a CLP-induced lung injury model
61585 Lithium decreases_activity of response to oxidative stress
23542012 Metabolic
Lung disease
6,488
61549 Lithium affects_quantity of Arachidonic acid of phospholipids in brain
61784 Lithium decreases_quantity of PTGS2 in brain
61785 Lithium decreases_quantity of Prostaglandin E2 in brain
12232777 Metabolic
6,491
61600 Lithium decreases_activity of GSK3B
63413 Lithium increases_activity of KCNQ2 via inhibiting GSK3beta activity
16733521 Bipolar disorder
Metabolic
6,492
61634 Lithium affects_quantity of Mg2+
61636 Lithium decreases_activity of INPP1
61637 Lithium decreases_activity of IMPase
61638 Lithium decreases_activity of FBP
61639 Lithium decreases_activity of BPNT1
61640 Lithium decreases_activity of PGM
61659 Lithium decreases_activity of GSK3B
61667 Lithium decreases_quantity of Inositol
61742 Lithium increases_quantity of BDNF in the brain; via inducing cAMP-mediated signaling leading to activation of CREB-induced gene transcription
61770 Lithium increases_activity of MAPK cascade in human neuroblastoma SH-SY5Y cells and in limbic areas of rat brain
61772 Lithium increases_activity of RPS6K
61773 Lithium increases_activity of CREB1 via inducing cAMP-mediated signaling and MAPK/ERK cascade
61810 Lithium affects_activity of cAMP-mediated signaling
61814 Lithium decreases_activity of SLC5A3
61815 Lithium decreases_expression of SLC5A3
62196 Lithium increases_quantity of Inositol 1-phosphate
62972 Lithium affects_activity of Adenylate cyclase
15471909 Metabolic
6,504
61788 Lithium decreases_expression of TP53
61789 Lithium decreases_quantity of BAX
61790 Lithium increases_quantity of BCL2
61791 Lithium decreases_expression of BAX
61792 Lithium decreases_quantity of TP53
61793 Lithium increases_expression of BCL2
10037682 Metabolic
6,505
61794 Lithium increases_quantity of IMPA1
12551726 Metabolic
6,508
61819 Lithium increases_activity of Diabetes insipidus, nephrogenic
61821 Lithium decreases_quantity of AQP2 in inner medulla membrane of kidney
7535800 Metabolic
6,510
61884 Lithium increases_expression of SQSTM1
61887 Lithium increases_expression of TMEM74
61888 Lithium increases_expression of TM9SF1
61889 Lithium increases_expression of EVA1A
61890 Lithium increases_quantity of ATG5
61892 Lithium increases_quantity of ATG12
61893 Lithium increases_activity of autophagy
61908 Lithium increases_expression of CASP12
61916 Lithium increases_expression of GSK3B
61917 Lithium increases_expression of ARRB2
61918 Lithium increases_expression of IMPA1
61919 Lithium decreases_quantity of IMPA1
61920 Lithium decreases_quantity of ARRB2
23759441 Metabolic
Ophtalmological
6,516
61954 Lithium decreases_activity of IMPA1 Sensitivity of IMPA2 to lithium is lower than sensitivity of IMPA1 to lithium.
61956 Lithium decreases_activity of IMPA2 Sensitivity of IMPA2 to lithium is lower than sensitivity of IMPA1 to lithium.
17068342 Metabolic
6,517
61967 Lithium increases_activity of autophagy via inhibiting IMPase activity resulting in lower IP3 levels
61973 Lithium decreases_quantity of Inositol 1,4,5-trisphosphate
16186256 Metabolic
6,527
62100 Lithium increases_expression of COX5A
62110 Lithium increases_expression of NDUFAB1
62111 Lithium increases_expression of NDUFS7
62112 Lithium increases_expression of UQCRFS1
62113 Lithium decreases_expression of GAA
62114 Lithium decreases_expression of GEMIN4
62115 Lithium decreases_expression of RC3H1
23924600 Neurological
6,530
62126 Lithium decreases_activity of GSK3B in adipocytes
62136 Lithium increases_activity of glycogen biosynthetic process in adipocytes
10364240 Metabolic
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