Search Results for "tricarboxylic acid cycle" - 124 interactions found in 63 entries.

Entry-ID
Interactor1 (Subject) Interaction type Interactor2 (Object) additional information
PubMed-ID
Diseases
787
4437 LPIN1 increases_activity of tricarboxylic acid cycle if LPIN1 is overexpressed
16950137 Diabetes mellitus, type II
Insulin resistance
Fatty liver disease, nonalcoholic
1,662
12216 IL6 affects_activity of tricarboxylic acid cycle after high-fat diet
20697689 Diabetes mellitus, type II
Obesity
Insulin resistance
Fatty liver disease, nonalcoholic
1,957
15197 tricarboxylic acid cycle increases_quantity of Reactive oxygen species in mitochondria; originating from multiple reactions in the tricarboxylic acid (TCA) cycle and/or the respiratory chain
15271 Alzheimer disease affects_activity of tricarboxylic acid cycle in brain of AD patients; via changing the activities of enzymes of the TCA cycle
15310 Pyruvate dehydrogenase complex increases_activity of tricarboxylic acid cycle
15311 Oxoglutarate dehydrogenase increases_activity of tricarboxylic acid cycle
15315 Isocitrate dehydrogenase increases_activity of tricarboxylic acid cycle
19076444 Alzheimer disease
2,083
16809 hyperglycemia affects_activity of tricarboxylic acid cycle
16810 tricarboxylic acid cycle increases_quantity of Reactive oxygen species
10783895 Diabetes mellitus, type II
Insulin resistance
3,387
31538 Carnitine affects_activity of tricarboxylic acid cycle
11802770 Diabetes mellitus, type II
Carnitine deficiency, systemic primary
Insulin resistance
3,471
32305 tricarboxylic acid cycle affects_quantity of Oxaloacetate
32306 tricarboxylic acid cycle increases_quantity of Citrate
32307 tricarboxylic acid cycle increases_quantity of Isocitrate
32352 overnutrition NOT increases_activity of tricarboxylic acid cycle
32393 PPARA affects_activity of tricarboxylic acid cycle
19875619 Diabetes mellitus, type II
Obesity
Insulin resistance
3,503
32547 tricarboxylic acid cycle affects_quantity of Succinylcarnitine
18945875 Diabetes mellitus, type II
Insulin resistance
3,564
33284 impaired glucose tolerance affects_activity of tricarboxylic acid cycle
20676218 Diabetes mellitus, type II
Insulin resistance
3,605
33880 tricarboxylic acid cycle affects_quantity of Malate
18682704 Diabetes mellitus, type II
Insulin resistance
3,804
37914 high-fat diet decreases_activity of tricarboxylic acid cycle
37917 high-fat diet decreases_activity of tricarboxylic acid cycle in liver, in muscle
37918 leucine supplementation increases_activity of tricarboxylic acid cycle in liver, in muscle; in mice on high-fat diet
21731668 Diabetes mellitus, type II
Insulin resistance
Fatty liver disease, nonalcoholic
3,884
39183 Fenofibrate decreases_activity of tricarboxylic acid cycle
19458390 Diabetes mellitus, type II
Lipodystrophy
Insulin resistance
3,991
40887 Diabetes mellitus, type II increases_activity of tricarboxylic acid cycle in liver; in diabetic db/db mouse
20567778 Diabetes mellitus, type II
Insulin resistance
3,992
40697 tricarboxylic acid cycle affects_quantity of (S)-Malate
40698 tricarboxylic acid cycle affects_quantity of 2-Oxoglutarate
40699 tricarboxylic acid cycle affects_quantity of cis-Aconitate
40700 tricarboxylic acid cycle affects_quantity of Citrate
40701 tricarboxylic acid cycle affects_quantity of Fumarate
40702 tricarboxylic acid cycle affects_quantity of Succinate
40767 MDH2 affects_activity of tricarboxylic acid cycle
40770 FH affects_activity of tricarboxylic acid cycle
40775 SDHA affects_activity of tricarboxylic acid cycle
40777 SDHB affects_activity of tricarboxylic acid cycle
40792 SUCLG1 affects_activity of tricarboxylic acid cycle
40793 SUCLG2 affects_activity of tricarboxylic acid cycle
40796 Oxoglutarate dehydrogenase affects_activity of tricarboxylic acid cycle
40800 DLD affects_activity of tricarboxylic acid cycle
40805 ACO2 affects_activity of tricarboxylic acid cycle
40807 CLYBL affects_activity of tricarboxylic acid cycle
40813 ACLY affects_activity of tricarboxylic acid cycle
40827 CS affects_activity of tricarboxylic acid cycle
40837 PC affects_activity of tricarboxylic acid cycle
40856 Isocitrate dehydrogenase [NAD], mitochondrial affects_activity of tricarboxylic acid cycle
40861 Isocitrate dehydrogenase [NADP], mitochondrial affects_activity of tricarboxylic acid cycle
20567778 Diabetes mellitus, type II
Insulin resistance
4,462
45372 Pyruvate dehydrogenase complex affects_activity of tricarboxylic acid cycle via PPARGC1A and PDK4
17476214 Diabetes mellitus, type II
Insulin resistance
4,686
46601 canonical glycolysis increases_activity of tricarboxylic acid cycle in pancreas, in pancreatic islet beta cells
46602 tricarboxylic acid cycle increases_quantity of ATP in pancreas, in pancreatic islet beta cells
24114586 Bipolar disorder
Diabetes mellitus, type II
Schizophrenia
Insulin resistance
5,241
51078 PPARGC1A decreases_activity of tricarboxylic acid cycle in skeletal muscle; via increased PDK4 expression
20005308 Diabetes mellitus, type II
Insulin resistance
5,308
52177 PPARGC1A increases_activity of tricarboxylic acid cycle
15087503 Diabetes mellitus, type II
Insulin resistance
6,123
57331 PPARGC1A affects_activity of tricarboxylic acid cycle in clear cell renal cell carcinoma cells
26119730 Renal cell carcinoma, clear cell
6,362
59764 tricarboxylic acid cycle decreases_quantity of Acetyl-CoA in mitochondrion
59765 tricarboxylic acid cycle increases_activity of oxidative phosphorylation in mitochondrion
59783 2-Oxoglutarate increases_activity of tricarboxylic acid cycle in mitochondrion
59817 GLS2 increases_activity of tricarboxylic acid cycle in mitochondrion
22212478 Diabetes mellitus, type II
Cancer
Insulin resistance
6,365
60040 2-Oxoglutarate increases_activity of tricarboxylic acid cycle in mitochondria of pancreatic beta cells
60041 tricarboxylic acid cycle increases_quantity of GTP in mitochondria of pancreatic beta cells
60043 tricarboxylic acid cycle increases_quantity of NADH in mitochondria of pancreatic beta cells
60056 Acetyl-CoA increases_activity of tricarboxylic acid cycle in pancreatic beta cells
60067 pyruvate cycle affects_activity of tricarboxylic acid cycle in pancreatic beta cells; via citrate, isocitrate, and malate exchange
60097 anaplerosis increases_activity of tricarboxylic acid cycle in pancreatic beta cells
60098 tricarboxylic acid cycle increases_activity of cataplerosis in pancreatic beta cells
25070829 Diabetes mellitus, type II
Insulin resistance
6,380
60285 PPARGC1A affects_activity of tricarboxylic acid cycle
60289 ESRRA affects_activity of tricarboxylic acid cycle
24304688 Breast cancer
Diabetes mellitus, type II
Insulin resistance
6,415
60472 PCK2 affects_activity of tricarboxylic acid cycle in liver
23466304 Diabetes mellitus, type II
Insulin resistance
6,588
63928 tricarboxylic acid cycle increases_quantity of Citrate in mitochondrial matrix
63961 tricarboxylic acid cycle decreases_quantity of Oxaloacetate
63993 Glutamine affects_activity of tricarboxylic acid cycle in MYC-transformed cells
19460998 Cancer
6,646
64073 canonical glycolysis increases_activity of tricarboxylic acid cycle in differentiated normal cells; in the presence of oxygen
64074 tricarboxylic acid cycle increases_activity of oxidative phosphorylation in differentiated normal cells; in the presence of oxygen
64093 Acetyl-CoA increases_activity of tricarboxylic acid cycle in mitochondria, in differentiated normal cells; in the presence of oxygen
64094 tricarboxylic acid cycle increases_quantity of NADH in mitochondria, in differentiated normal cells; in the presence of oxygen
64095 tricarboxylic acid cycle increases_quantity of GTP in mitochondria, in differentiated normal cells; in the presence of oxygen
64096 tricarboxylic acid cycle increases_quantity of FADH2 in mitochondria, in differentiated normal cells; in the presence of oxygen
64109 aerobic glycolysis decreases_activity of tricarboxylic acid cycle in tumor cells; in the presence of oxygen
25672512 Cancer
6,660
64481 Long-chain acyl-CoA increases_activity of tricarboxylic acid cycle in mitochondria
64505 tricarboxylic acid cycle affects_quantity of Acylcarnitine
26108617 Diabetes mellitus, type II
Insulin resistance
6,832
66495 CISD2 affects_activity of tricarboxylic acid cycle
26621032 Breast cancer
Diabetes mellitus, type II
Insulin resistance
Wolfram syndrome 2
7,611
76125 Acetyl-CoA increases_activity of tricarboxylic acid cycle
27895387 Chronic kidney disease
7,619
76238 Myocardial infarction decreases_activity of tricarboxylic acid cycle in the heart; 22 wks after infartion due to lower PDH complex activity
25201905 Myocardial infarction
7,640
76573 Stearoylcarnitine affects_activity of tricarboxylic acid cycle
28591636 Diabetes mellitus, type II
Insulin resistance
7,652
76632 Succinyl-CoA affects_activity of tricarboxylic acid cycle
22661206 Metabolic
Methylmalonic aciduria
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