|
5,504
|
| 53442 |
smoothened signaling pathway
|
|
affects_activity of
|
PDLIM3
|
|
|
25473003
|
Medulloblastoma
|
|
5,841
|
| 55181 |
smoothened signaling pathway
|
|
increases_activity of
|
impaired glucose tolerance
|
in adult pancreatic beta cells
|
| 55184 |
smoothened signaling pathway
|
|
decreases_activity of
|
insulin secretion involved in cellular response to glucose stimulus
|
in adult pancreatic beta cells
|
| 55185 |
smoothened signaling pathway
|
|
decreases_activity of
|
reduced pancreatic beta cell function
|
in adult pancreatic beta cells
|
| 55186 |
smoothened signaling pathway
|
|
increases_expression of
|
BCL2
|
in adult pancreatic beta cells
|
| 55187 |
smoothened signaling pathway
|
|
decreases_expression of
|
KCNJ11
|
in adult pancreatic beta cells
|
| 55188 |
smoothened signaling pathway
|
|
decreases_expression of
|
ABCC8
|
in adult pancreatic beta cells
|
| 55189 |
smoothened signaling pathway
|
|
decreases_expression of
|
SLC2A2
|
in adult pancreatic beta cells
|
| 55190 |
smoothened signaling pathway
|
|
decreases_expression of
|
PDX1
|
in adult pancreatic beta cells
|
| 55191 |
smoothened signaling pathway
|
|
decreases_expression of
|
MAFA
|
in adult pancreatic beta cells
|
| 55192 |
smoothened signaling pathway
|
|
decreases_expression of
|
NEUROD1
|
in adult pancreatic beta cells
|
| 55193 |
smoothened signaling pathway
|
|
decreases_expression of
|
NKX6-1
|
in adult pancreatic beta cells
|
| 55194 |
smoothened signaling pathway
|
|
increases_expression of
|
SOX9
|
in adult pancreatic beta cells
|
| 55195 |
smoothened signaling pathway
|
|
increases_expression of
|
HES1
|
in adult pancreatic beta cells
|
| 55196 |
smoothened signaling pathway
|
|
increases_activity of
|
increased pancreas tumor incidence
|
in adult pancreatic beta cells
|
|
21969560
|
Diabetes mellitus, type II
Insulin resistance
|
|
5,856
|
| 55371 |
LZTFL1
|
|
affects_activity of
|
smoothened signaling pathway
|
|
| 55372 |
BBSome
|
|
affects_activity of
|
smoothened signaling pathway
|
|
|
22072986
|
Diabetes mellitus, type II
Insulin resistance
Bardet-Biedl syndrome 17
|
|
5,860
|
| 55398 |
BBSome
|
|
affects_activity of
|
smoothened signaling pathway
|
|
|
22228099
|
Diabetes mellitus, type II
Insulin resistance
|
|
5,861
|
| 55401 |
IFT27
|
|
affects_activity of
|
smoothened signaling pathway
|
|
|
25446516
|
Diabetes mellitus, type II
Insulin resistance
Bardet-Biedl syndrome 19
|
|
5,868
|
| 55446 |
SHH
|
|
increases_activity of
|
smoothened signaling pathway
|
in primary cilium
|
| 55449 |
PTCH1
|
|
decreases_activity of
|
smoothened signaling pathway
|
in primary cilium; in the absence of SHH
|
| 55450 |
CDON
|
|
increases_activity of
|
smoothened signaling pathway
|
in primary cilium; via increased binding of SHH to PTCH1
|
| 55451 |
BOC
|
|
increases_activity of
|
smoothened signaling pathway
|
in primary cilium; via increased binding of SHH to PTCH1
|
| 55452 |
GAS1
|
|
increases_activity of
|
smoothened signaling pathway
|
in primary cilium; via increased binding of SHH to PTCH1
|
| 55473 |
GPR161
|
|
decreases_activity of
|
smoothened signaling pathway
|
in primary cilium
|
| 55475 |
SUFU
|
|
decreases_activity of
|
smoothened signaling pathway
|
|
| 55477 |
smoothened signaling pathway
|
|
increases_activity of
|
embryo development
|
|
| 55478 |
smoothened signaling pathway
|
|
affects_activity of
|
Cancer
|
|
| 55480 |
smoothened signaling pathway
|
|
increases_quantity of
|
cholangiocyte
|
upon liver damage
|
| 55481 |
smoothened signaling pathway
|
|
increases_quantity of
|
myofibroblast
|
upon liver damage
|
| 55483 |
smoothened signaling pathway
|
|
decreases_quantity of
|
hepatic stellate cell
|
upon liver damage
|
| 55486 |
smoothened signaling pathway
|
|
increases_activity of
|
epithelial to mesenchymal transition
|
upon liver damage
|
| 55487 |
smoothened signaling pathway
|
|
increases_activity of
|
liver fibrosis
|
upon liver damage
|
| 55489 |
smoothened signaling pathway
|
|
increases_activity of
|
aerobic glycolysis
|
in hepatic stellate cells; upon liver damage
|
| 55490 |
smoothened signaling pathway
|
|
increases_activity of
|
reverse Warburg effect
|
in hepatocellular carcinoma cells
|
| 55491 |
smoothened signaling pathway
|
|
affects_activity of
|
endocrine pancreas
|
|
| 55492 |
smoothened signaling pathway
|
|
affects_activity of
|
exocrine pancreas
|
|
| 55493 |
smoothened signaling pathway
|
|
affects_activity of
|
Pancreatic cancer
|
|
| 55494 |
smoothened signaling pathway
|
|
affects_expression of
|
INS
|
|
| 55495 |
smoothened signaling pathway
|
|
affects_activity of
|
insulin secretion
|
|
| 55498 |
smoothened signaling pathway
|
|
decreases_activity of
|
fat cell differentiation
|
in white adipose tissue
|
|
24862854
|
Diabetes mellitus, type II
Insulin resistance
|
|
5,886
|
| 55637 |
LZTFL1 rs431825171
|
|
increases_activity of
|
smoothened signaling pathway
|
in dermal fibroblasts
|
|
22510444
|
Bardet-Biedl syndrome 17
|
|
6,977
|
| 68420 |
IFT27
|
|
increases_activity of
|
smoothened signaling pathway
|
|
|
26023097
|
Diabetes mellitus, type II
Insulin resistance
Bardet-Biedl syndrome 19
|
|
6,979
|
| 68532 |
SDCCAG8
|
|
increases_activity of
|
smoothened signaling pathway
|
|
|
27224062
|
Bardet-Biedl syndrome 16
|
|
6,981
|
| 68588 |
WDPCP
|
|
affects_activity of
|
smoothened signaling pathway
|
|
|
24302887
|
Bardet-Biedl syndrome 15
|
|
7,065
|
| 69507 |
TCTN2
|
|
decreases_activity of
|
smoothened signaling pathway
|
|
|
|
Nephronophthisis
Senior-Loken syndrome 3
|
|
7,069
|
| 69519 |
B9D1
|
|
affects_activity of
|
smoothened signaling pathway
|
|
| 69558 |
B9 complex
|
|
affects_activity of
|
smoothened signaling pathway
|
|
|
|
Bardet-Biedl syndrome
Joubert syndrome
Meckel syndrome
|
|
7,083
|
| 69600 |
Intraflagellar transport complex A
|
|
increases_activity of
|
smoothened signaling pathway
|
|
|
|
Nephronophthisis 13
Senior-Loken syndrome 8
|
|
7,085
|
| 69721 |
TRAF3IP1
|
|
affects_activity of
|
smoothened signaling pathway
|
|
|
|
Senior-Loken syndrome 9
|
|
7,102
|
| 69880 |
TTC21B
|
|
affects_activity of
|
smoothened signaling pathway
|
|
| 69899 |
cilium
|
|
affects_activity of
|
smoothened signaling pathway
|
|
|
|
Nephronophthisis
|
|
7,103
|
| 69969 |
GLIS2
|
|
affects_activity of
|
smoothened signaling pathway
|
|
| 69970 |
CEP290
|
|
affects_activity of
|
smoothened signaling pathway
|
|
|
|
Nephronophthisis
|
|
7,108
|
| 70025 |
TTC21B
|
|
decreases_activity of
|
smoothened signaling pathway
|
|
|
|
Nephronophthisis 12
|
|
7,110
|
| 70027 |
TTC21B
|
|
decreases_activity of
|
smoothened signaling pathway
|
|
|
|
Diabetes mellitus, type II
Insulin resistance
Nephronophthisis 12
|
|
7,111
|
| 70065 |
TTC21B rs140511594
|
NOT |
affects_activity of
|
smoothened signaling pathway
|
|
|
|
Diabetes mellitus, type II
Insulin resistance
Nephronophthisis 12
|
|
7,121
|
| 70145 |
GLIS2
|
|
affects_activity of
|
smoothened signaling pathway
|
|
|
19118152
|
Nephronophthisis
|
|
7,124
|
| 70188 |
ZNF423
|
|
affects_activity of
|
smoothened signaling pathway
|
|
|
|
Nephronophthisis 14
|
|
7,127
|
| 70218 |
CC2D2A
|
|
affects_activity of
|
smoothened signaling pathway
|
|
|
|
Joubert syndrome 9
Meckel syndrome, type 6
|
|
7,156
|
| 70401 |
GLIS2
|
|
decreases_activity of
|
smoothened signaling pathway
|
in postnatal kidney
|
|
|
Nephronophthisis 7
|
|
7,157
|
| 70442 |
smoothened signaling pathway
|
|
increases_transport of
|
GLI3
|
into the nucleus
|
| 70477 |
smoothened signaling pathway
|
|
increases_expression of
|
INS
|
|
|
|
Diabetes mellitus, type II
Diabetes mellitus, type I
Insulin resistance
Nephronophthisis 7
|
|
7,164
|
| 70527 |
WNT5A
|
|
decreases_activity of
|
smoothened signaling pathway
|
in embryonic lung
|
|
|
Nephronophthisis 11
COACH syndrome
Meckel syndrome, type 3
Joubert syndrome 6
|
|
7,168
|
| 70562 |
DZIP1
|
|
affects_activity of
|
smoothened signaling pathway
|
|
|
|
Nephronophthisis 15
|
|
7,171
|
| 70587 |
DCDC2
|
|
affects_activity of
|
smoothened signaling pathway
|
|
|
|
Nephronophthisis 19
|
|
7,172
|
| 70417 |
smoothened signaling pathway
|
|
affects_activity of
|
stem cell population maintenance
|
|
| 70596 |
smoothened signaling pathway
|
|
affects_activity of
|
neoplasm
|
|
| 70597 |
cilium
|
|
increases_activity of
|
smoothened signaling pathway
|
|
| 70598 |
intraciliary transport
|
|
increases_activity of
|
smoothened signaling pathway
|
|
| 70599 |
smoothened signaling pathway
|
|
affects_activity of
|
positive regulation of embryonic development
|
|
| 70607 |
KIF3A
|
|
increases_activity of
|
smoothened signaling pathway
|
|
| 70631 |
DYNC2H1
|
|
affects_activity of
|
smoothened signaling pathway
|
|
|
|
Joubert syndrome
Short-rib thoracic dysplasia 3 with or without polydactyly
Acrocallosal syndrome
|
|
7,202
|
| 70910 |
INPP5E
|
|
affects_activity of
|
smoothened signaling pathway
|
|
|
|
Joubert syndrome 1
|
|
9,268
|
| 98436 |
ENPP1
|
|
decreases_activity of
|
smoothened signaling pathway
|
|
|
30111653
|
Arterial calcification, generalized, of infancy, 1
|
CIDeR