Search Results for "canonical Wnt signaling pathway" - 294 interactions found in 136 entries.

Entry-ID
Interactor1 (Subject) Interaction type Interactor2 (Object) additional information
PubMed-ID
Diseases
122
463 canonical Wnt signaling pathway affects_activity of GSK3B
570 Lithium increases_activity of canonical Wnt signaling pathway
11527574 Alzheimer disease
457
2073 canonical Wnt signaling pathway affects_activity of Alzheimer disease
2076 canonical Wnt signaling pathway affects_activity of GSK3B
19712582 Alzheimer disease
574
3050 GSK3B affects_activity of canonical Wnt signaling pathway
17298085 Alzheimer disease
614
3248 PSEN1 decreases_activity of canonical Wnt signaling pathway
3294 canonical Wnt signaling pathway decreases_quantity of CTNNB1-phosSer33Ser37Thr41 (= sequentially phosphorylated CTNNB1 at sites 33,37,41)
3299 canonical Wnt signaling pathway NOT decreases_quantity of CTNNB1-phosSer45
45038 CTNNB1 increases_activity of canonical Wnt signaling pathway
12297048 Alzheimer disease
710
3950 PRKN affects_activity of canonical Wnt signaling pathway
3953 WNT3A affects_activity of canonical Wnt signaling pathway
3955 canonical Wnt signaling pathway affects_activity of dopaminergic neuron differentiation
3966 canonical Wnt signaling pathway increases_activity of re-entry into mitotic cell cycle in differentiated ventral midbrain neurons
19591802 Parkinson disease
715
3985 PRKN affects_activity of canonical Wnt signaling pathway in ventral midbrain dopaminergic neurons
19591802 Parkinson disease
824
5007 canonical Wnt signaling pathway decreases_activity of white fat cell differentiation
5010 canonical Wnt signaling pathway decreases_activity of PPARG
19770177 Diabetes mellitus, type II
Obesity
Insulin resistance
1,347
9202 SFRP5 NOT affects_activity of canonical Wnt signaling pathway in epididymal adipose tissues; after high-fat high-sucrose diet
20558665 Diabetes mellitus, type II
Obesity
Insulin resistance
Fatty liver disease, nonalcoholic
2,532
23582 TCF7L2 variant B1 decreases_activity of canonical Wnt signaling pathway in pancreas, in pancreatic islets
23586 TCF7L2 variant B3 increases_activity of canonical Wnt signaling pathway in pancreas, in pancreatic islets
23587 TCF7L2 variant B7 increases_activity of canonical Wnt signaling pathway in pancreas, in pancreatic islets
21357677 Diabetes mellitus, type II
Insulin resistance
2,759
25529 ZBED3 increases_activity of canonical Wnt signaling pathway
19141611 Diabetes mellitus, type II
Insulin resistance
3,632
34487 NR1H4 decreases_activity of canonical Wnt signaling pathway
21431855 Diabetes mellitus, type II
Obesity
Insulin resistance
Fatty liver disease, nonalcoholic
4,308
44132 canonical Wnt signaling pathway increases_quantity of APP (intracellular domain AICD) due to the increased protein stability by Wnt/beta-catenin
44139 canonical Wnt signaling pathway increases_activity of APP (intracellular domain AICD) concerning the transcriptional activity of AICD
44600 WNT1 increases_activity of canonical Wnt signaling pathway
21798242 Metabolic
4,309
44903 MTOR decreases_activity of canonical Wnt signaling pathway in H9 cells
19416884 Metabolic
4,327
44751 Lovastatin increases_activity of canonical Wnt signaling pathway to reduce the effect of Abeta (42)
17234346 Alzheimer disease
Metabolic
4,333
44333 canonical Wnt signaling pathway increases_expression of AHR if AhR RNA is up-regulated;
15059908 Prostate cancer
Metabolic
4,335
44356 canonical Wnt signaling pathway increases_expression of CYP1A1 the induction is supported by AHR
44357 canonical Wnt signaling pathway increases_expression of CYP1B1 the induction is supported by AHR
44363 WNT3A increases_activity of canonical Wnt signaling pathway
44439 AHR decreases_activity of canonical Wnt signaling pathway by reducing mRNA levels of Wnt/beta-Catenin target genes and disrupting cytokeratin expression pattern
44472 2,3,7,8-Tetrachlorodibenzodioxin decreases_activity of canonical Wnt signaling pathway
21602191 Metabolic
4,409
44811 canonical Wnt signaling pathway increases_activity of MTOR synaptic stimulation of mTOR is mediated by Wnt signaling
44817 canonical Wnt signaling pathway affects_activity of MTOR
44823 canonical Wnt signaling pathway affects_activity of GSK3B
44924 canonical Wnt signaling pathway decreases_activity of Beta-catenin destruction complex if the canonical pathway is activated;
22131415 Metabolic
4,538
45192 WNT2 affects_activity of canonical Wnt signaling pathway
23043943 Metabolic
4,563
45524 CTNNB1 increases_activity of canonical Wnt signaling pathway
53316 canonical Wnt signaling pathway increases_activity of embryo development
19619488 Metabolic
5,262
51318 Estradiol NOT affects_activity of canonical Wnt signaling pathway in MPCs (mesenchymal progenitor cells)
24340027 Metabolic
5,266
51321 Simvastatin increases_activity of canonical Wnt signaling pathway
51324 Statin increases_activity of canonical Wnt signaling pathway through regulation of isoprenoid synthesis and not through cholesterol
51327 isoprenoid biosynthetic process affects_activity of canonical Wnt signaling pathway if regulated via statins
51332 Cholesterol NOT affects_activity of canonical Wnt signaling pathway via statins
51338 Lovastatin increases_activity of canonical Wnt signaling pathway
51339 Fluvastatin increases_activity of canonical Wnt signaling pathway
51343 Simvastatin increases_activity of canonical Wnt signaling pathway in the mammalian adult hippocampus; via depletion of isoprenoids and not cholesterol
51348 HMGCR decreases_activity of canonical Wnt signaling pathway HMGCR loss of function is sufficient to enhance the Wnt pathway.
51477 Geranylgeranyl pyrophosphate decreases_activity of canonical Wnt signaling pathway in the mammalian adult hippocampus; via depletion of isoprenoids and not cholesterol
51478 Farnesyl pyrophosphate decreases_activity of canonical Wnt signaling pathway
24511465 Alzheimer disease
Metabolic
5,399
52696 Simvastatin increases_activity of canonical Wnt signaling pathway if decreased by high glucose
52697 high glucose medium decreases_activity of canonical Wnt signaling pathway
18004065 Diabetes mellitus, type II
Insulin resistance
Nephropathy, diabetic
5,410
52803 hyperglycemia increases_activity of canonical Wnt signaling pathway
52806 canonical Wnt signaling pathway affects_activity of Cancer
52808 canonical Wnt signaling pathway affects_activity of fat cell differentiation
52809 canonical Wnt signaling pathway affects_activity of Obesity
52810 TCF7L2 affects_activity of canonical Wnt signaling pathway
52811 canonical Wnt signaling pathway increases_activity of incretin hormone biosynthetic process
52813 canonical Wnt signaling pathway increases_expression of GIPR
52814 canonical Wnt signaling pathway increases_activity of incretin hormone signaling
52815 canonical Wnt signaling pathway increases_expression of INS
52816 canonical Wnt signaling pathway increases_activity of insulin secretion
52817 canonical Wnt signaling pathway increases_expression of INSR
52818 canonical Wnt signaling pathway increases_expression of IGF1R
52822 canonical Wnt signaling pathway increases_transport of CTNNB1 into the nucleus; amplified by hyperglycemia
24049067 Diabetes mellitus, type II
Cancer
Insulin resistance
5,411
52758 Melanin-concentrating hormone increases_activity of canonical Wnt signaling pathway in mouse
22848656 Metabolic
5,412
52842 Simvastatin increases_activity of canonical Wnt signaling pathway in embryonic stem cells
52843 canonical Wnt signaling pathway increases_activity of osteogenic differentiation in embryonic stem cells
22058016 Diabetes mellitus, type II
Obesity
Insulin resistance
5,413
52880 Pravastatin increases_activity of canonical Wnt signaling pathway
24510055 Diabetes mellitus, type II
Insulin resistance
5,414
52882 APP (intracellular domain AICD) decreases_activity of canonical Wnt signaling pathway if induced by LRP6, Dishevelled1/2/3 and beta-catenin wild-type (wt);
22613765 Metabolic
5,417
52894 LRP5 rs121908665 decreases_activity of canonical Wnt signaling pathway the effective allele is T (TGG=Trp)
52913 LRP5 rs61889560 decreases_activity of canonical Wnt signaling pathway the effective allele is A (CAG=Gln)
52914 LRP5 rs369471051 NOT affects_activity of canonical Wnt signaling pathway
19673927 Diabetes mellitus, type II
Insulin resistance
5,425
52979 Peroxynitrite increases_activity of canonical Wnt signaling pathway
52980 Urate decreases_activity of canonical Wnt signaling pathway if Wnt signaling is induced by peroxynitrite
52988 4-Hydroxynonenal increases_activity of canonical Wnt signaling pathway
52997 hyperglycemia increases_activity of canonical Wnt signaling pathway
23066786 Diabetes mellitus, type II
Insulin resistance
Retinopathy, diabetic
5,427
52965 IRS1 increases_activity of canonical Wnt signaling pathway
52966 IRS2 increases_activity of canonical Wnt signaling pathway
24616100 Metabolic
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