Search Results for "Statin" - 146 interactions found in 21 entries.

Entry-ID
Interactor1 (Subject) Interaction type Interactor2 (Object) additional information
PubMed-ID
Diseases
703
3948 Atorvastatin decreases_activity of VLDL secretion in insulin-resistant Syrian golden hamsters
3949 Atorvastatin increases_activity of increased insulin sensitivity
11597827 Diabetes mellitus, type II
Insulin resistance
1,572
11256 Atorvastatin decreases_quantity of Cholesterol in blood
11257 Atorvastatin decreases_quantity of LDL in blood
11258 Atorvastatin increases_quantity of HDL in blood
13618 Atorvastatin decreases_activity of atherosclerotic lesions in type 2 diabetics
20134099 Diabetes mellitus, type II
Insulin resistance
Atherosclerosis
2,246
19172 Simvastatin decreases_activity of cognitive impairment
19176 Simvastatin NOT affects_quantity of Amyloid beta peptide (42) in CSF
19177 Simvastatin NOT affects_quantity of MAPT in CSF
18376061 Alzheimer disease
2,249
19213 Statin affects_activity of response to oxidative stress in mouse models of AD Alzheimer-relevant and Abeta-induced
19214 Statin decreases_phosphorylation of MAPT in CFS; of patients, Alzheimer-relevant and Abeta-induced
19227 Atorvastatin decreases_activity of neurodegeneration neuroprotection against cell degeneration induced by Abeta (1-40)
19228 Atorvastatin decreases_activity of inflammatory response
19229 Atorvastatin decreases_activity of response to oxidative stress
19230 Atorvastatin increases_expression of Glutamatergic transporter
19233 Atorvastatin NOT affects_quantity of Amyloid beta peptide
19236 Atorvastatin decreases_quantity of BACE1
19237 Atorvastatin decreases_activity of lipid peroxidation
19252 Atorvastatin decreases_activity of protein oxidation
19253 Atorvastatin decreases_activity of protein nitrosylation
19254 Atorvastatin increases_quantity of Glutathione cholesterol- and Abeta-independent and specific for brain
19256 Atorvastatin decreases_quantity of Ubichinon-10 side effects of long-term statin treatment
19259 Atorvastatin increases_activity of abnormal aerobic energy metabolism in heart, skeletal muscle, and liver; as side effect of long-term statin treatment
19266 Statin decreases_activity of Alzheimer disease
19267 Statin decreases_activity of Dementia
19268 Statin NOT decreases_activity of cognitive impairment in elderly subjects with a median age of 72 years
19269 Pravastatin NOT decreases_activity of cognitive impairment (PROSPER study)
19270 Atorvastatin NOT decreases_activity of cognitive impairment (LEADe study)
19279 Simvastatin NOT decreases_activity of Alzheimer disease (CLASP study)
19280 Atorvastatin decreases_activity of cognitive impairment (ADCLT trial)
19282 aging decreases_activity of Statin
21536132 Alzheimer disease
Dementia
2,269
19373 Atorvastatin NOT increases_activity of memory in aged dogs
19388 Atorvastatin decreases_quantity of LDL in aged dogs
19389 Atorvastatin decreases_quantity of HDL in aged dogs
19390 Atorvastatin decreases_quantity of Triacylglycerol in aged dogs
19391 Atorvastatin decreases_quantity of Cholesterol in aged dogs
19405 Atorvastatin affects_quantity of Omega-6 fatty acid CHEBI: 36009 omega-6 fatty acid
19407 Atorvastatin affects_quantity of Omega-3 fatty acid CHEBI: 25681 omega-3 fatty acid
19411 Atorvastatin NOT affects_quantity of APP
20847439 Alzheimer disease
2,371
20808 Atorvastatin decreases_activity of lipid peroxidation in parietal cortex of aged beagles
20810 Atorvastatin decreases_activity of protein oxidation in parietal cortex of aged beagles
20812 Atorvastatin decreases_activity of protein nitrosylation in parietal cortex of aged beagles
20813 Atorvastatin increases_quantity of Glutathione in parietal cortex of aged beagles
20814 Atorvastatin affects_activity of cholesterol catabolic process in cortex; formation of cholesterol oxidation products was affected
21193043 Alzheimer disease
3,870
39434 Statin decreases_activity of ROCK
39443 Statin decreases_quantity of Amyloid beta peptide (42)
23162743 Alzheimer disease
Huntington disease
3,872
38984 Statin affects_activity of Polyunsaturated fatty acid, omega-3
38996 Statin increases_quantity of Arachidonic acid
38999 Statin increases_activity of abnormal mitochondrial physiology
39000 Statin decreases_quantity of Ubiquinone
39002 Statin decreases_activity of ubiquinone biosynthetic process
39007 Statin decreases_activity of HMGCR
39013 Statin increases_activity of myalgia exacerbated by exercise
39014 myalgia increases_activity of decreased physical activity
39017 Statin increases_activity of Insulin resistance
39018 Statin increases_activity of Diabetes mellitus, type II
39026 Statin decreases_activity of memory
39027 Statin increases_activity of fatigue
23289647 Diabetes mellitus, type II
Insulin resistance
3,875
39046 Statin increases_activity of decreased circulating cholesterol level in blood plasma
39048 Statin increases_activity of decreased circulating LDL cholesterol level in blood plasma
39051 Statin increases_activity of increased circulating arachidonic acid level in blood plasma
39052 Statin increases_activity of arachidonic acid biosynthetic process
39053 Statin increases_activity of FADS1
11434193 Diabetes mellitus, type II
Insulin resistance
3,877
39067 Simvastatin increases_activity of decreased fatty acid level in blood serum
39070 Simvastatin decreases_quantity of alpha-Linolenic acid in blood serum
39071 Simvastatin decreases_quantity of Eicosatetraenoic acid in blood serum
39072 Simvastatin decreases_quantity of Docosahexaenoic acid in blood serum
39073 Simvastatin decreases_quantity of Myristic acid in blood serum
39074 Simvastatin decreases_quantity of Palmitic acid in blood serum
39075 Simvastatin decreases_quantity of Linoleic acid in blood serum
39076 Simvastatin decreases_quantity of alpha-Linolenic acid in blood serum
39077 Simvastatin increases_quantity of gamma-Linolenic acid in blood serum
39079 Simvastatin increases_quantity of Eicosatrienoic acid in blood serum
39086 Simvastatin increases_quantity of Arachidonic acid in blood serum
39087 Simvastatin increases_activity of ELOVL6
39088 Simvastatin increases_activity of FADS2
39089 Simvastatin increases_activity of FADS1
39093 Simvastatin increases_activity of long-chain polyunsaturated fatty acid biosynthetic process
16020749 Diabetes mellitus, type II
Insulin resistance
3,890
39327 Statin decreases_activity of Coronary artery disease in subjects with diabetes, elevated systolic blood pressure, low HDL, and elevated BMI
39328 Statin increases_activity of Diabetes mellitus, type II
39329 Statin increases_activity of decreased circulating LDL cholesterol level in blood plasma
39331 Statin decreases_activity of increased circulating apolipoprotein B level in blood plasma
39332 Statin NOT affects_activity of increased circulating triglyceride level
39334 Statin NOT affects_activity of decreased circulating HDL cholesterol level
39365 Statin NOT decreases_activity of Coronary artery disease in part of the diabetic and metabolic syndrome patients, even in combination with intensive lifestyle intervention
22941588 Diabetes mellitus, type II
Insulin resistance
Fatty liver disease, nonalcoholic
Metabolic syndrome
3,911
39686 Statin increases_activity of Diabetes mellitus, type II in postmenopausal women
22231607 Diabetes mellitus, type II
Insulin resistance
3,917
39760 Atorvastatin decreases_activity of LDL in blood plasma
39761 Atorvastatin decreases_quantity of APOB in blood plasma
39762 Atorvastatin increases_activity of increased circulating insulin level in blood plasma; after fasting
39770 Atorvastatin increases_quantity of Glycated hemoglobin in blood plasma
39771 Atorvastatin increases_activity of decreased insulin sensitivity
39772 Atorvastatin increases_activity of Insulin resistance
20298928 Diabetes mellitus, type II
Insulin resistance
3,919
39779 Simvastatin increases_quantity of SERPINA12 in blood serum; in type 2 diabetic patients
39780 Simvastatin increases_activity of decreased circulating cholesterol level in blood serum; in type 2 diabetic patients
39798 Simvastatin increases_activity of decreased circulating triglyceride level in blood serum; in type 2 diabetic patients
39799 Simvastatin NOT affects_activity of decreased systemic arterial blood pressure in type 2 diabetic patients
39800 Simvastatin NOT affects_activity of decreased circulating glucose level in type 2 diabetic patients
39801 Simvastatin NOT affects_activity of abnormal circulating HDL cholesterol level in type 2 diabetic patients
39802 Simvastatin NOT affects_activity of abnormal circulating LDL cholesterol level in type 2 diabetic patients
39803 Simvastatin NOT affects_activity of decreased leukocyte cell number in type 2 diabetic patients
39804 Simvastatin NOT affects_activity of abnormal circulating creatine kinase level in type 2 diabetic patients
23449848 Diabetes mellitus, type II
Insulin resistance
3,922
39828 Mevastatin increases_expression of HMGCR in MCF-7 breast cancer cells
39831 Docosahexaenoic acid decreases_activity of Mevastatin in MCF-7 breast cancer cells
39833 Eicosapentaenoic acid NOT decreases_activity of Mevastatin in MCF-7 breast cancer cells
15914273 Diabetes mellitus, type II
Insulin resistance
4,948
48913 Statin increases_expression of SCARB1
21076037 Metabolic
5,011
49465 Statin increases_quantity of LysoPC(20:4)
49466 Statin increases_quantity of LysoPE(20:4) in blood serum
49467 Statin decreases_quantity of 7alpha-Hydroxy-3-oxo-4-cholestenoate in blood serum
49468 Statin decreases_quantity of 1-Palmitoylglycerophosphoinositol in blood serum
49469 Statin decreases_quantity of Lathosterol in blood serum
49470 Statin increases_quantity of Isobutyrylcarnitine in blood serum
49471 Statin increases_quantity of LysoPC(22:6) in blood serum
49472 Statin increases_quantity of alpha-Tocopherol in blood serum
49473 Statin decreases_quantity of Glycochenodeoxycholate in blood serum
49477 Statin increases_quantity of Uridine in blood serum
24816436 Diabetes mellitus, type II
Insulin resistance
5,266
51324 Statin increases_activity of canonical Wnt signaling pathway through regulation of isoprenoid synthesis and not through cholesterol
51325 Statin affects_activity of isoprenoid biosynthetic process
51326 Statin NOT affects_activity of cellular response to cholesterol
51340 Statin decreases_activity of HMGCR
51353 Statin decreases_quantity of Farnesyl pyrophosphate via antagonizing HMGCR
51354 Statin decreases_quantity of Geranylgeranyl pyrophosphate via antagonizing HMGCR
51355 Statin decreases_quantity of Cholesterol via antagonizing HMGCR
24511465 Alzheimer disease
Metabolic
5,412
52826 Simvastatin increases_activity of osteogenic differentiation in embryonic stem cells
52828 Simvastatin increases_activity of ALPL in embryonic stem cells
52829 Simvastatin increases_expression of RUNX2 in embryonic stem cells
52830 Simvastatin increases_expression of SP7 in embryonic stem cells
52831 Simvastatin increases_expression of BGLAP in embryonic stem cells
52836 Simvastatin increases_quantity of BGLAP in embryonic stem cells
52837 Simvastatin increases_quantity of SPP1 in embryonic stem cells
52838 Simvastatin increases_quantity of COL1A1 in embryonic stem cells
52842 Simvastatin increases_activity of canonical Wnt signaling pathway in embryonic stem cells
52843 canonical Wnt signaling pathway increases_activity of osteogenic differentiation in embryonic stem cells
22058016 Diabetes mellitus, type II
Obesity
Insulin resistance
5,413
52827 Pravastatin decreases_activity of Steroid-induced osteonecrosis of the femoral head
52875 Pravastatin decreases_expression of PPARG in femoral head
52876 Pravastatin increases_expression of WNT3A in femoral head
52877 Pravastatin increases_expression of LRP5 in femoral head
52878 Pravastatin increases_expression of CTNNB1 in femoral head
52879 Pravastatin increases_expression of RUNX2 in femoral head
52880 Pravastatin increases_activity of canonical Wnt signaling pathway
52881 Pravastatin decreases_activity of hyperlipidemia in steroid-induced osteonecrosis of the femoral head
24510055 Diabetes mellitus, type II
Insulin resistance
6,361
59715 Statin decreases_activity of Hepatocellular carcinoma
59752 Statin decreases_activity of HMGCR
59753 Statin decreases_activity of Ras protein signal transduction
59755 Statin increases_quantity of CDKN1A via decreased degradation
59756 Statin increases_quantity of CDKN1B via decreased degradation
59758 Statin affects_activity of phosphatidylinositol 3-kinase signaling
26052399 Hepatocellular carcinoma
Diabetes mellitus, type II
Insulin resistance
-->