General Information:

Id: 9 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type I - [OMIM]
Rattus norvegicus
BTO:0001185 RINm5F cell
article
Reference: Lee JH et al.(2009) Overexpression of SIRT1 protects pancreatic beta-cells against cytokine toxicity by suppressing the nuclear factor-kappaB signaling pathway Diabetes 58: 344-351 [PMID: 19008341]

Interaction Information:

Comment iNOS mRNA and protein expressions were markedly increased in cells treated with cytokine, whereas SIRT1-overexpressing cells showed suppressed expression of both the mRNA and protein levels of iNOS.
Formal Description
Interaction-ID: 42

gene/protein

SIRT1

decreases_expression of

gene/protein

NOS2

if SIRT1 is overexpressed
Drugbank entries Show/Hide entries for NOS2