General Information:

Id: 999
Diseases: Alzheimer disease - [OMIM]
Mus musculus
APPswe/PS1d9 transgenic mouse
article
Reference: Garcia-Alloza M et al.(2006) Plaque-derived oxidative stress mediates distorted neurite trajectories in the Alzheimer mouse model J. Neuropathol. Exp. Neurol. 65: 1082-1089 [PMID: 17086105]

Interaction Information:

Comment Generation of reactive oxygen species occurs by amyloid deposits (senile plaques).
Formal Description
Interaction-ID: 6204

increases_quantity of

drug/chemical compound

Reactive oxygen species

Comment Both Ginkgo biloba extract and vitamin E reduced the oxidative stress resulting from senile plaques in vivo.
Formal Description
Interaction-ID: 6205

affects_activity of

Comment Both Ginkgo biloba extract and vitamin E lead to a progressive reversal of the structural changes in dystrophic neurites associated with senile plaques.
Formal Description
Interaction-ID: 6206

drug/chemical compound

Ginkgo biloba

decreases_activity of

phenotype

dystrophic neurites

Drugbank entries Show/Hide entries for Ginkgo biloba
Comment Both Ginkgo biloba extract and vitamin E lead to a progressive reversal of the structural changes in dystrophic neurites associated with senile plaques.
Formal Description
Interaction-ID: 6207

drug/chemical compound

alpha-Tocopherol

decreases_activity of

phenotype

dystrophic neurites

Comment Both Ginkgo biloba extract and vitamin E reduced the oxidative stress resulting from senile plaques in vivo.
Formal Description
Interaction-ID: 6208

drug/chemical compound

Ginkgo biloba

decreases_activity of

Drugbank entries Show/Hide entries for Ginkgo biloba
Comment Both Ginkgo biloba extract and vitamin E reduced the oxidative stress resulting from senile plaques in vivo.
Formal Description
Interaction-ID: 6209

drug/chemical compound

alpha-Tocopherol

decreases_activity of