General Information:

Id: 98 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
BTO:0000078 microglia
article
Reference: Zhao W et al.(2010) Extracellular mutant SOD1 induces microglial-mediated motoneuron injury Glia 58: 231-243 [PMID: 19672969]

Interaction Information:

Comment Extracellular mutant superoxide dismutase mSOD1(G93A) or mSOD1(G85R) did induce the morphological and functional activation of microglia, increasing their release of pro-inflammatory cytokines and free radicals.
Formal Description
Interaction-ID: 319

gene/protein mutant

SOD1-p.G93A

increases_activity of

in microglia cultures